Articles tagged with Cancer Patients
A University of Cincinnati researcher is studying how cancer treatments could impact patients who also have COVID-19 and blood clots. The study aims to understand the thrombotic risk posed by certain cancer treatments and hopes to contribute data that could prevent complications for millions of patients.
A retrospective analysis found that Black pediatric patients are less likely to receive proton therapy, which may lead to increased side effects and long-term health disparities. The study calls for addressing barriers to access and promoting equitable distribution of this high-cost treatment.
Researchers developed a prognostic tool that identifies immune cell interactions with tumour cells and reports on immune-checkpoint activation status. The tool predicts which cancer patients are most likely to benefit from checkpoint inhibitor therapy, allowing clinicians to tailor treatments specifically to patients.
The partnership aims to galvanize the global research community to make transformative leaps in cancer research. Researchers will be encouraged to think creatively and act boldly to address major challenges in understanding cancer.
Researchers from Kanazawa University found that IL-17A triggers cellular changes in the peritoneum, leading to stromal fibrosis in gastric cancer patients. The study suggests that suppressing mast cell degranulation may be a promising treatment strategy for patients with peritoneal dissemination.
The Herbert Irving Comprehensive Cancer Center has been renewed as a designated Comprehensive Cancer Center by the National Cancer Institute, with a five-year support grant of $26.5 million. The center will continue to provide cutting-edge care and research for cancer patients in the New York City metropolitan area.
Researchers have identified a metabolic vulnerability in cells that may represent a therapeutic target for treating small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). A new treatment agent has been shown to starve cancer cells by eliminating arginine, an amino acid necessary for protein production.
The Phase I/II LIBRETTO-001 trial found that selpercatinib achieved durable objective responses in the majority of participants with RET gene fusions, including an ORR of 85% in previously untreated patients. The study also showed promising results in patients with brain metastases and thyroid cancers.
Prof. Hans-Joachim Schmoll receives the ESMO Award 2020 for his pioneering work in developing medical oncology as a specialty, while Prof. Nadia Harbeck wins the Lifetime Achievement Award for her global cancer research and education contributions.
A new device developed by Dartmouth engineers has the potential to improve patient outcomes for prostate cancer patients who undergo radical prostatectomy. The device, which uses microendoscopic electrical impedance sensing probe technology, aims to detect positive surgical margins and prevent disease recurrence.
Researchers have developed a novel STAR assay to measure absolute telomere length, enabling rapid diagnosis of cancer and age-related diseases. The method can process up to 48 samples from low DNA amounts, providing critical information for precision therapy.
Researchers at Thomas Jefferson University have developed a cancer vaccine that shows promise in treating gastric, pancreatic, esophageal, and colon cancers. The new vaccine, Ad5.F35, is more effective than the original version due to its ability to evade the immune system's natural defenses.
The European Society for Medical Oncology has issued its first recommendations on the use of next-generation sequencing (NGS) for patients with metastatic cancers. The guidelines recommend routine NGS use for four specific cancer types, while also allowing patients to order larger gene panels if feasible and cost-effective. The recomme...
The National Cancer Institute (NCI) and Cancer Research UK will establish the Cancer Grand Challenges program to tackle cancer research challenges. The initiative aims to facilitate global collaboration, foster innovation, and accelerate progress against cancer.
A Cedars-Sinai study found that robotic surgery for oropharyngeal cancer is associated with improved health outcomes, including better long-term survival rates and reduced risks of positive surgical margins. The procedure's increased use since FDA approval in 2009 was linked to these benefits.
A new database of 40 breast cancer cell lines will help speed the development of new gene-targeted therapies by providing genomic and proteomic information. Researchers aim to identify functional genes that drive cancer growth and develop targeted therapies based on unique gene changes in each patient's cancer.
Researchers discovered that removing copper from blood can destroy some deadly cancers resistant to immunotherapy. High levels of copper in cancer cells increase expression of PD-L1, a protein that hides cancer cells from the immune system.
A recent survey of UK professionals found that COVID-19 has caused significant disruptions to psycho-social care for cancer patients, leading to delays in accessing support. The study highlights the need for innovative solutions to address the growing demand for psychological support during the pandemic.
A recent study found that extrachromosomal DNA (ecDNA) is common in human cancer and drives poor patient outcomes. ecDNA is a circular unit of DNA containing functional genes located outside cells' chromosomes, which rapidly replicate within cancer cells causing high numbers of oncogene copies.
A Phase II trial conducted at the University of Texas M. D. Anderson Cancer Center found a 51% overall response rate in patients with BRAF-mutated cholangiocarcinoma treated with dabrafenib plus trametinib, providing a much-needed treatment option for patients with treatment-resistant advanced disease.
A new liquid biopsy test has been developed to detect cancer by analyzing protein biomarkers from tumors in the blood. The study found that this approach showed a high sensitivity and specificity for detecting different types of cancer, including breast, colon, and lung cancers.
A study examined the association between radiotherapy timing and overall survival in patients with prostate cancer. The analysis of National Cancer Database data found that delaying radiotherapy relative to androgen deprivation therapy was associated with improved overall survival.
The COVID-19 pandemic worsens existing health disparities in cancer patients, with marginalized communities facing poorer treatment outcomes. Healthcare providers must acknowledge these disparities to deliver equitable care.
A Phase III trial led by the University of Texas MD Anderson Cancer Center found that combining venetoclax and azacitidine improved overall survival and achieved a 66.4% complete remission rate in patients with acute myeloid leukemia.
Recent advances in treatment have led to a sharp reduction in lung cancer mortality rates in the US, with non-small cell lung cancer deaths decreasing faster than incidence. The study found significant improvements in survival for both men and women, particularly after the introduction of targeted therapies.
A Singapore team identified a mutation in the PD-L1 gene as a reliable biomarker for patients with natural-killer T-cell lymphoma who are likely to respond positively to anti-PD-1 therapy. The study found an overall response rate of 47% and complete responses in 7 out of 19 patients.
The new guidelines offer additional recommendations for photobiomodulation therapy and benzydamine, as well as a stronger guideline statement for cryotherapy. Researchers also found that natural honey may help prevent mucositis in head and neck cancer patients, although long-term effects are unclear.
A new study shows that men treated for testicular cancer at public safety net hospital and academic tertiary care center have the same outcomes, despite differences in demographics. The study eliminated sociodemographic disparities in survival and cancer recurrence rates.
A qualitative study proposes a practical communication guide to assuage the fear, anger and anxiety of cancer patients during the COVID-19 pandemic. The guide aims to improve patient care in oncology settings.
A team of researchers at Michigan Medicine developed a guide to help oncologists navigate difficult conversations with patients due to the pandemic. The guide provides three core communication strategies and examples of language that can be used to respond empathetically, addressing concerns around risk, delays, and changes in treatment.
Researchers at Ohio State University Comprehensive Cancer Center have found that molecular characteristics can refine prognostic recommendations for AML patients under age 60. The study detected mutations in several categories, which were associated with better or worse outcomes and may help improve treatment choices.
A rapid and affordable test for breast cancer has been developed to combat delayed diagnoses in developing regions. The compact CytoPAN test uses image cytometry to analyze individual cells, yielding results in under 1 hour and requiring minimal training, making it ideal for resource-limited settings.
Researchers at Huntsman Cancer Institute develop new models to study molecular characteristics of lung and pancreas tumors driven by NTRK1 mutations. The findings aim to identify effective treatments for patients with NTRK1-driven cancers, which have proven resistant to current therapies.
The COVID-19 pandemic has led to changes in the number of new cancer diagnoses in US patients. Researchers analyzed data from 2020 and found that there was a significant increase in new cases during the pandemic.
Dr. Emmanuel Katsanis is studying a new chemotherapy treatment for patients with blood-related cancers who undergo a specific type of bone marrow transplant procedure. The treatment, known as haploidentical BMT, has shown promising results in improving survival rates and reducing post-transplant complications.
A blood test can predict which cancer patients will benefit from immunotherapy, a treatment option for advanced cancers. The test analyzes changing levels of tumour fragments in the blood to identify those who will respond well to the treatment.
A large international study analyzed genetic and clinical data from 4,444 MDS patients to assess the impact of TP53 gene mutations on cancer outcomes. The study found that having two mutated copies of TP53 led to worse outcomes, while one copy had similar effects as a non-mutated copy.
Cancer patients at low risk of severe COVID-19; treating cancer can impact overall survival. ESMO recommends continuing anti-cancer treatments to prioritize tumour control.
A new study by NYU Langone Health found that women receiving standard treatment for ovarian, uterine, and cervical cancers are not at increased risk of hospitalization or death from COVID-19. In fact, 75% of gynecologic cancer patients with COVID-19 had a mild form of the disease and recovered
The study found that social distancing policies implemented in the US and globally led to significant reductions in SARS-CoV-2 transmission, with an estimated 1.57 million cases prevented over a two-week period. The researchers also observed a strong correlation between decreased mobility and reduced virus transmission.
A case series evaluates radiotherapy delivery to 209 cancer patients during the COVID-19 outbreak. Key findings include improved outcomes and reduced treatment delays.
A consensus statement evaluates the use of prognostic genetic expression profile testing in melanoma, cautioning against routine use due to limitations. The statement aims to assist clinicians in determining when and how gene expression profiling should be adopted in clinical practice.
Researchers developed an AI algorithm to analyse tissue samples from cancer patients, distinguishing between healthy and cancerous tissues and identifying patterns of DNA and RNA changes. The study highlights the potential of AI for improving cancer diagnosis, prognosis, and treatment.
Researchers discovered that almost 20% of patients with unexplained intestinal polyps had tumors with mutations similar to those caused by colibactin, a bacterial toxin. Regular tooth brushing may have prevented the bacterial infection that triggered these cancer-causing DNA mutations.
Research from the Sidney Kimmel Cancer Center found significant decreases nationwide in cancer-related care, including a -56.9% decline in any neoplasm encounters and a 74% drop in new incidence neoplasms. Mammograms declined by 89.2% and colorectal cancer screenings fell by 84.5% during the pandemic.
The COVID-19 pandemic has exacerbated social isolation and distress among cancer patients, emphasizing the importance of human connection in their care. Clinicians can support these patients by fostering connections through non-clinical interventions.
A new study suggests that a simple urine test could significantly improve the detection of adrenal cancer by detecting excess adrenal steroid hormones. The test was found to be more accurate than imaging tests in diagnosing cancerous adrenal masses, potentially reducing unnecessary surgeries and healthcare costs.
Dr Patricia Ganz shares her expertise on assessing quality of life in cancer patients, with a focus on breast cancer survivorship. She highlights the importance of centering patients' needs in both US and UK healthcare systems.
Researchers at Hollings Cancer Center are studying T-cell exhaustion in the tumor microenvironment to discover ways to revitalize immunity against tumors. The team's work may lead to a new approach for immunotherapy by targeting the stress response that undermines T-cell function.
Research has found that cancer patients diagnosed over 24 months ago are more likely to experience severe COVID-19 infection. Patients from Asian ethnicity or receiving palliative treatment were also at a higher risk of death from COVID-19.
Newly released CCC19 data show a racial disparity in access to Remdesivir, an antiviral drug that shortens hospital stays, and increased mortality associated with dexamethasone, a steroid. Black patients were half as likely to receive Remdesivir as white patients.
Researchers found that some mutations actually generate 'noise' that can counteract cancer development, leading to a dead end. New drug combinations aim to reactivate suppressed pathways to disrupt oncogenic signal transduction in cancer cells.
A new study found that delays in cancer diagnosis due to the pandemic could result in more than 1,000 excess deaths in England. The researchers suggest prioritizing certain tumor types and ramping up diagnostic capacity to mitigate the impact of these delays.
Preliminary data suggests that immunotherapy won't worsen complications in patients with both conditions. Researchers found that an anti-diabetic drug metformin can reduce protein production by immune cells, offering a potential treatment option for COVID-19 complications.
A $204,000 grant from the NCI will support research on sustainability of telemedicine for rural cancer patients. The study aims to identify factors allowing telemedicine to be sustained over time and its impact on patients.
Researchers investigate how antibodies affect varying outcomes in coronavirus patients, with potential implications for vaccine efficacy and treatment approaches. The team aims to identify conditions under which antibody-dependent enhancement occurs and develop new assays for therapeutic antibody screening.
The rapid adoption of telehealth services during the COVID-19 pandemic has raised concerns about care quality and safety. Experts warn that integrating essential components of traditional doctor visits into virtual care poses challenges, including physical exams, lab work, and imaging. However, telehealth also holds promise for improvi...
A new testing method has shown promise in rapidly identifying radiation sickness based on biomarkers measured through a single drop of blood. The test uses microRNAs to quantify the actual radiation dose absorbed, allowing for early and real-time identification of the condition to enable timely clinical interventions.
Researchers at Ohio State University found that blocking an enzyme used by glioblastoma cells to store fats may be a new way to treat the deadly disease. This approach could also apply to other types of cancers that use lipid droplets for energy.
A new study published in JNCI Cancer Spectrum found significant disparities in cancer mortality rates between one-star and five-star hospitals. The research examined 105,823 patients who underwent complex cancer procedures at 3,146 hospitals between 2013 and 2016.