Gynecology

Global experts establish new name for PCOS to reflect multisystem disease

Loss of the X chromosome is associated with reduced chance of natural pregnancy

A study by Osaka Metropolitan University found that women with a higher proportion of LOX cells in their white blood cells had a lower likelihood of achieving natural pregnancy. The researchers suggest combining AMH analysis with LOX measurement may improve prediction of natural conception.

1 in 3 women unaware surgery can fix pelvic prolapse, survey finds

Pelvic organ prolapse affects up to half of all women, causing incontinence and chronic pain. A new survey reveals one in three women suffer in silence due to common misconceptions about the condition.

Mount Sinai experts present on PCOS and disparities in hypertensive disorders of pregnancy at 2026 ACOG Annual Clinical and Scientific Meeting

Researchers present findings on sociodemographic disparities in hypertensive disorders of pregnancy, highlighting the need for better characterization and management of these conditions. Dr. Basma S. Faris discusses reframing PCOS as a chronic disease requiring longitudinal care.

Study suggests fibroid rates in Latina women may be lower than previously thought

A new study published in the American Journal of Obstetrics and Gynecology finds that approximately 11.8% of reproductive-age Latina women have fibroids, lower than previously estimated rates. The study, led by Michigan Medicine researchers, used ultrasound-confirmed diagnoses to confirm fibroid cases.

Yōni.Fit® bladder support for stress urinary incontinence adds menstrual indication

The Yōni.Fit device is FDA-cleared for temporary management of stress urinary incontinence and also collects menstrual fluid and/or vaginal discharge. Clinical trials show a 96% clinically significant reduction in SUI bladder leaks.

ESCEO-IOF Young Investigator Awards presented to researchers from 16 countries

Twenty-three young investigators from 16 countries received the ESCEO-IOF Young Investigator Awards for their outstanding abstracts submitted to the WCO-IOF-ESCEO 2026 Congress. The awards aim to support and attract young researchers to the field of musculoskeletal research.

International Osteoporosis Foundation CNS Medal awarded to Professor Radmila Matijevic

Professor Radmila Matijevic received the IOF CNS Medal for her outstanding work in advancing bone health awareness, diagnosis, and management. Her contributions to osteoporosis research and clinical practice have improved patient care in Serbia and the wider Balkan region.

Clinical trial aims to address vaginal complaints after breast cancer diagnosis

A clinical trial aims to evaluate whether laser therapy reduces vaginal dryness caused by breast cancer treatment. The study, REVITALIZE, plans to enroll approximately 250 women with a history of breast cancer who experience moderate to severe vaginal dryness.

Practice-defining NRG Oncology trial finds chemotherapy followed by letrozole is the standard for advanced, low grade serous gynecologic carcinoma

The phase III NRG GY019 trial found that paclitaxel/carboplatin followed by letrozole is the standard treatment for patients with stage II-IV low-grade serous ovarian carcinoma. The study also showed that letrozole monotherapy did not demonstrate non-inferiority to the combination, but was associated with fewer serious side effects.

Scientists from the University of Maryland School of Medicine and colleagues create the first-ever immune-capable “cervix-on-a-Chip” to study sexually transmitted infections (STIs)

Researchers developed an immune-capable 'cervix-on-a-Chip' model to study sexually transmitted infections (STIs), enabling a more accurate understanding of these conditions and the potential for better treatments. The model replicated key aspects of human biology, including the cervical microenvironment, microbiomes, and immune system.

Ragon Institute study reveals how a live bacterial therapy reshapes the vaginal microbiome and identifies predictors of treatment success

A study from the Ragon Institute reveals how a live bacterial therapy works to prevent recurrent bacterial vaginosis (BV) and why it works better for some women than others. The therapy, LACTIN-V, was found to successfully colonize the beneficial bacterium Lactobacillus crispatus in 30% of women, leading to improved vaginal health.

Emily Lukacz, MD, named president of American Urogynecologic Society

Dr. Emily Lukacz has been named the 2026 President of American Urogynecologic Society, a prestigious position that recognizes her innovative leadership in the complex field of urogynecology. As president, she aims to streamline treatment by educating primary care providers and allied health professionals.

Even temporary lack of oxygen may impact brain development for preterm babies

Researchers found that mild hypoxia in preterm babies can compromise neural communication, impacting the hippocampus region responsible for memory and learning. Abnormal neuronal maturation and loss of synaptic function may lead to academic difficulties and behavioral concerns later in life.

Development of build better bones: A global resource for osteoporosis self management

A new platform, Build Better Bones, offers evidence-based guidance and practical resources for osteoporosis management. The platform, developed by the International Osteoporosis Foundation, provides a trusted place for people with osteoporosis to start their journey, with a focus on exercise, nutrition, and home safety.

Society of Interventional Radiology publishes practice guidance for treatment of chronic pelvic pain

The Society of Interventional Radiology has published new practice guidance for treating chronic pelvic pain in women with venous-origin disorders, emphasizing interventional radiology's role in care. The guidance provides evidence-based recommendations on diagnosis, treatment options, and imaging.

Have abortion-related laws affected broader access to maternal health care?

A study found that Targeted Regulation of Abortion Providers (TRAP) laws significantly reduced the supply of obstetricians and gynecologists, particularly older and newly trained doctors. This led to a decline in more than 2 obstetrician-gynecologists per 100,000 females aged 15–44 years.

Periods may trigger pain for many who have sickle cell disease

A nationwide study found that periods can trigger severe pain in many women and girls with sickle cell disease, leading to emergency department visits and hospitalizations. The study's authors recommend a routine menstrual history screening as part of annual sickle cell care and connecting patients with reproductive health specialists.

Treatment strategies after denosumab discontinuation in non-metastatic breast cancer treated with AI

A new review highlights the need for planned sequential bone therapy to reduce the risk of spontaneous vertebral fractures after denosumab therapy. Denosumab discontinuation can trigger a 'rebound phenomenon' marked by rapid bone turnover, bone loss, and potentially multiple vertebral fractures.

Scientists now know why ovarian cancer spreads so rapidly in the abdomen

Ovarian cancer cells recruit protective mesothelial cells in abdominal fluid to form hybrid cell clusters that resist chemotherapy. These clusters use spike-like structures called invadopodia to invade surrounding tissue. The discovery opens new treatment possibilities and could help doctors monitor disease progression.

University of Maryland School of Medicine researchers discover that vaginal bacteria don’t always behave the same way

Researchers at the University of Maryland School of Medicine discovered 25 distinct vaginal microbiome types, challenging the long-standing view of a simplified

Discovery of eleven novel factors essential for mouse zygote development

A research team has identified eleven novel factors essential for mouse zygote development, which modulate embryonic development through precise mechanisms. These findings suggest the existence of previously unrecognized regulatory factors and indicate potential for molecular-level control of embryo development.

Why this little-known birth control option deserves more attention

A new study found that only a quarter of reproductive health experts prescribe self-administered injectable contraceptives, despite its safety and effectiveness. The study identified barriers such as concerns about patient ability, medication availability, and lack of standardized counseling approaches.

Rates of opioid use in pregnancy have more than doubled, study finds

A recent study has found that rates of opioid use during pregnancy have risen two-fold over the past decade, with significant increased risks of maternal and infant health complications. The study emphasizes the urgent need for accessible, wraparound health care for mothers and families affected by opioid addiction.

HPV vaccine can protect against severe lesions of the vulva and vagina

A new study published in JAMA Oncology found that the HPV vaccine can protect against severe precancerous lesions of the vulva and vagina. Vaccination before the age of 17 offers the strongest protection, with a 55% lower risk compared to unvaccinated women.

Studies reveal Asian and Singaporean women with PCOS may experience longer reproductive lifespans and more favorable reproductive outcomes than peers without PCOS

Researchers found that Asian and Singaporean women with PCOS have better reproductive outcomes, including higher pregnancy rates and oocyte retrieval per cycle, compared to women without PCOS. Women with PCOS tend to maintain a higher ovarian reserve as they age, allowing for more robust responses to fertility treatment.

Icahn School of Medicine at Mount Sinai named member of the Milken Institute’s Women’s Health Network

The Icahn School of Medicine at Mount Sinai is advancing women's health through cutting-edge research and compassionate care, with a focus on addressing knowledge gaps and promoting seamless treatment journeys. The institution joins the Milken Institute's Women's Health Network to bring its expertise in clinical excellence, research in...

NEJM Group launches NEJM Clinician

NEJM Clinician curates highly relevant clinical insights from over 150 peer-reviewed journals to give physicians clear guidance without the noise. The weekly publication delivers summaries and commentary in a concise, 30-minute read, helping healthcare providers stay informed and confident in their decisions.

Survey: Nearly all Americans not aware midwives provide care beyond pregnancy, birth

A survey by Ohio State University Wexner Medical Center reveals that nearly all Americans are unaware of the comprehensive women's health services provided by certified nurse-midwives. Only 20% know about annual gynecology exams, while 93% are aware of pregnancy and birth support.

Depression more common among women with gynecological disorders

A new study from the University of Southern Denmark reveals that depression is significantly more common among women with gynaecological disorders—both before and after receiving a diagnosis. The study highlights the need for earlier detection and a more integrated approach between somatic and psychiatric care.

9th IOF Asia-Pacific Bone Health Conference set to open in Tokyo

The 9th IOF Asia-Pacific Bone Health Conference will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the region. The conference will feature keynote lectures, sponsored sessions, and a launch of the IOF Asia-Pacific Regional Audit 2025.

Teeth of babies of stressed mothers come out earlier, suggests study

Research shows that infants of stressed mothers have an earlier and faster tooth eruption, with more teeth by six months of age. Cortisol levels during late pregnancy are associated with this accelerated process.

Finnish study reveals association between severe nausea during pregnancy and depression

A recent Finnish study found an association between severe nausea during pregnancy and depression, both before and after childbirth. Women who experienced severe nausea were more likely to develop depression and receive earlier diagnoses.

Cesarean delivery: the technique used for closing the uterus must be reconsidered

Researchers Drs Emmanuel Bujold and Roberto Romero propose a new closure technique for cesarean delivery that respects the natural anatomical structure of the uterus. This approach may reduce long-term complications such as abnormal placenta attachment, uterine rupture, and pelvic pain.

Antibody-drug conjugates emerge as potent anti-tumor agents for gynecological cancers

ADCs use targeted antibodies to deliver cytotoxic payloads directly into cancer cells, destroying tumors while minimizing harm to healthy cells. Two ADCs have been approved by the FDA for gynecological cancer treatment, and numerous others are in clinical trials.

Rare vulvar cyst case report sheds light on diagnostic challenges

A rare case of a mucinous vulvar cyst was reported, which resembled a benign lipoma and caused lower abdominal and back pain. The cyst was surgically removed and confirmed to be non-malignant. The case underscores the importance of careful clinical examination in reproductive-age women presenting with vulvar masses.

Lactylation in gynecological malignancies: a bridge between lactate metabolism and epigenetic therapy

Lactate accumulation drives lactylation, a critical post-translational modification promoting tumor proliferation, metastasis, and therapy resistance. Emerging strategies targeting lactate production, transport, and lactylation hold significant anticancer potential.

FDA approves new menopause drug to treat hot flashes, night sweats

The FDA has approved elinzanetant for treating hot flashes and night sweats in postmenopausal women. The drug significantly reduces the frequency and severity of symptoms while improving sleep quality and quality of life.

New survey reveals inconsistent use of containment in gynecologic surgery

A national survey of first-year fellows in minimally invasive gynecologic surgery found significant gaps in the use of FDA-cleared containment systems during laparoscopic hysterectomy and myomectomy. The majority of fellows cited cost as the main reason for using less expensive, off-label retrieval bags instead of FDA-cleared systems.

Nationally-recognized pathologist Paul N. Staats, MD, named Chair of Pathology at University of Maryland School of Medicine

Paul N. Staats, MD, has been appointed Chair of the University of Maryland School of Medicine's Department of Pathology, overseeing clinical services to multiple hospitals and laboratories. He will drive partnerships and expand outpatient laboratory services.

Too heavy for medical care: Over 40% of specialty clinics turn away patients weighing 465 pounds

A new study found that over 40% of specialty clinics in the US turn away patients weighing 465 pounds or more due to lack of accessibility features. The study highlights a need for staff training on inclusive care and accommodations for patients with severe obesity.

Menopause drug reduces hot flashes by more than 70%, international clinical trial finds

A large international clinical trial found that elinzanetant significantly reduces hot flashes and night sweats in postmenopausal women by over 73%. The drug also shows secondary benefits such as improved quality of life and reduced sleep disturbances, with no harmful effects on the liver or bone density.

Gestational diabetes linked to elevated risk of cognitive decline in mothers, ADHD and autism in children

A landmark study found gestational diabetes during pregnancy is associated with declines in intellectual function for mothers and higher risks of developmental, behavioural and autism spectrum disorders in children. Mothers with GDM scored 2.47 points lower on cognitive assessments than peers without GDM.

Closing the care gap: IOF position paper identifies barriers and solutions to global undertreatment of osteoporosis

The International Osteoporosis Foundation identifies critical global barriers to osteoporosis care, including limited DXA scanning and outdated treatment criteria. The IOF advocates for a paradigm shift in bone health management worldwide, recognizing high fracture risk as a valid criterion for treatment and reimbursement.

Mayo Clinic physician awarded Dr. Scott C. Goodwin Grant for Adenomyosis

Dr. Wendaline M. VanBuren has been awarded a grant to develop an AI-powered model for diagnosing and treating adenomyosis and endometriosis. The study aims to enhance detection, treatment planning, and patient outcomes.

Two thirds of reproductive-aged women have at least one modifiable risk factor for birth defects, study reveals

A new study in the American Journal of Preventive Medicine found that two-thirds of women of reproductive age in the US have at least one modifiable risk factor for birth defects. The analysis highlights the need for improved preconception health and identifying and addressing these changeable risk factors before pregnancy.

Access to vaginal labor after C-section is limited to some 16% of U.S. counties

According to UMass Amherst research, only 16% of US counties offer access to vaginal labor after C-section. Despite the American College of Obstetricians and Gynecologists' guidelines supporting this option, access remains limited due to factors such as hospital availability and provider comfort.

Catheryn Yashar named President-Elect of National Society

Dr. Catheryn Yashar, a renowned radiation oncologist, has been appointed president-elect of the American Society for Radiation Oncology (ASTRO). She will champion innovative radiation therapies and advance health policy reform to improve cancer care outcomes.

New guidance on the management of aromatase inhibitor-associated bone loss in women with hormone-sensitive breast cancer

The International Osteoporosis Foundation has issued an updated joint position statement on managing aromatase inhibitor-associated bone loss in women with hormone-sensitive breast cancer. The guidelines incorporate recent clinical trials and systematic reviews to provide evidence-based treatment algorithms for assessing fracture risk ...

Chinese Medical Journal article review explores extracellular vesicles in oocyte health and therapies

Extracellular vesicles play a crucial role in regulating oocyte maturation, follicular growth, and quality. In pathological conditions, EVs can disrupt communication, leading to impaired oocyte development and ovarian failure. Therapeutic EVs show promise in reversing ovarian pathologies by delivering functional molecules.

Pediatric investigation study finds sex-based fetal responses to maternal hypertension

A pediatric investigation study reveals that male fetuses prioritize growth while female fetuses focus on placental development under gestational hypertension. The findings support the growth strategy hypothesis and suggest sex-specific differences in fetal responses to prenatal stressors.

The Mount Sinai Hospital ranked among top in the nation by US News & World Report®

The Mount Sinai Hospital has been listed among the nation's top 20 hospitals for care excellence by U.S. News & World Report for 2025-26, with top-10 rankings in five specialties and top-20 rankings in nine. The hospital was also rated High Performing in all 22 procedures and conditions assessed by U.S. News.

Offering self-collection kits in routine GP appointments could prevent 1,000 women a year from developing cervical cancer

A new study suggests that offering self-collection kits during routine GP appointments can increase participation rates among women overdue for cervical screening. The approach shows promise in reducing the number of cases and saving lives.

Breaking the silence: MyMenoplan.org empowers women to take charge of menopause

A recent clinical trial found MyMenoplan.org effective in increasing treatment intentions and menopause knowledge among users. The website offers personalized information and decision-making tools, guiding women through symptom discussions and outlining treatment options.

Stopping HRT leads to a period of higher risk of bone fracture for most women

A study of 6 million women found that stopping menopausal hormone therapy (MHT) leads to a higher risk of bone fractures, particularly in the first three years. The fracture risk then decreases over time and becomes similar to that of women who never used MHT.

Good professional advice means women more likely to use contraception after giving birth

A new study by University College London found that nearly 58% of women who had given birth in the last year were not using contraception two months later, despite the risk of back-to-back pregnancies. Women who received high-quality contraceptive advice were more likely to use contraception sooner after giving birth.

Association of grandmaternal and maternal age difference at delivery with maternal pregnancy cardiometabolic disorders

A study found that a grandmaternal age difference of ≤-9 years significantly increases the risk of pregnancy cardiometabolic disorders. The researchers analyzed data from 2,235 grandmother-mother pairs and discovered a nonlinear association between age differences and CMDs.

Moderate caloric restriction may slow ovarian aging in primates

A new study found that moderate caloric restriction can preserve youthful ovarian follicles and reduce age-related tissue stiffness in rhesus macaques. This suggests that lifestyle-based strategies may help delay the decline in reproductive function associated with aging.

Central adiposity increases the risk for urinary incontinence

A recent study at the University of Jyväskylä found that central adiposity increases the risk for stress urinary incontinence in middle-aged women. Larger fat mass and waist circumference are key factors associated with this increased risk, highlighting the importance of body composition in understanding pelvic floor disorders.

Abnormal uterine bleeding and insulin resistance are on the rise: Is there a connection?

A new study found a significant association between hyperinsulinemia and abnormal uterine bleeding, with body mass index playing a unique role. The study suggests that addressing insulin resistance and obesity may be key to preventing abnormal uterine bleeding.