Articles tagged with Immune Disorders
Researchers have identified HERC4 as a crucial component of the TNF-induced cell death pathway, linking survival and death signalling. The protein's ubiquitination of RIPK1 initiates the formation of Complex II, triggering cell death through apoptosis or necroptosis.
A novel autologous gene therapy for Wiskott-Aldrich syndrome has demonstrated durable clinical benefits in a phase 3 study, with 96% survival at 1 and 5 years. The treatment, etu-cel, has also reduced severe infections and moderate-to-severe bleeding events.
An international study has established age-specific ultrasound reference values to distinguish normal joint changes from early signs of inflammatory arthritis. The study analysed over 28,000 joints from 802 healthy volunteers and developed new thresholds for normal and abnormal findings, which will help clinicians identify inflammatory...
Researchers identified MLC1 antibody as a possible trigger for NMOSD, a rare autoimmune disease affecting the central nervous system. The study found that MLC1 antibodies bind to astrocytes, damaging them, and suggest a new approach for therapy.
Researchers investigating Group B Streptococcus colonization in the birth canal may lead to improved preventative measures for neonatal meningitis. The study aims to understand how GBS attaches to and stays in the vaginal tract, potentially reducing cases of meningitis in newborns.
Researchers have made breakthroughs in deleting yeast DNA using CRISPR, with potential to save lives from fatal candidiasis infections. The team is expanding the technology to diverse fungi and using AI models to predict its success.
Christopher Goodnow's work challenged the concept of complete clonal deletion, revealing self-reactive B cells' ability to acquire self-tolerance and potentially cause autoimmune disease. His research discovered that these cells are essential for immune function and can be converted into functional B cells through 'clonal redemption'.
A new study reveals striking biological similarities between five major illnesses, including long Covid and PTSD, suggesting common underlying mechanisms. Chronic fatigue syndrome, rheumatoid arthritis, and multiple sclerosis may be driven by shared regulatory networks in immune and metabolic systems.
A new drug patch is being developed to promote the repair of damaged myelin sheaths in multiple sclerosis patients. The patch, which delivers a low dose of theophylline, is being tested in a Phase I clinical trial for its safety and tolerability.
Researchers have created a high-resolution functional map of human immune cells, revealing intricate circuits that govern health and disease. The dataset provides a powerful framework for designing cancer immunotherapies and treating autoimmune conditions, and serves as a foundation for AI models of biology.
A new book by University of Virginia Health System expert Daniel J. Cox outlines a practical alternative to medication for managing pre-diabetes and type 2 diabetes. The GEM program emphasizes smart eating, physical activity, and listening to the body to regulate blood sugar levels.
A new theory proposes that critical illness arises from loss of physiological coordination, not just organ failure. The Entropic Critical Illness Theory views living organisms as open systems with a continuous need to regulate entropy.
Researchers identify a combination of classical and emerging viral biomarkers to predict functional cure in chronic hepatitis B. Multimarker models exhibit superior predictive discrimination compared to single viral markers, enabling more accurate treatment decisions.
Researchers tracked nearly 80,000 adults with type 2 diabetes over ten years, finding those who consistently took their prescribed medication stayed free of serious heart and circulatory complications for over seven extra months. Low adherence was linked to a higher risk of cardiovascular disease, especially in younger adults.
Researchers have identified new genes linked to Crohn's disease and other autoimmune conditions by mapping the 3D genome in rare immune cells. The study reveals how subtle genetic differences can alter immune cell behavior, providing a clearer picture of disease mechanisms.
A recent Finnish study found that exposure to dog-associated microbes in early childhood reduces the risk of respiratory tract infections and antibiotic courses. Dog ownership is linked to higher richness and diversity of microbiota, but not directly associated with reduced infection rates.
A new online test, MEDWACS, can detect people with prediabetes or undiagnosed type 2 diabetes with high accuracy. The test measures seven parameters, including thigh length, which is linked to a person's risk of developing the condition.
Researchers at La Jolla Institute for Immunology discovered that immune cells in lung tissue express genes associated with autoimmune disease risk. These tissue-resident immune cells may actively drive the development of autoimmune diseases, particularly in women.
A 16-week personalized exercise intervention improved glycemic regulation, physical fitness and reduced abdominal fat while increasing skeletal muscle mass. Cognitive impairment also showed significant improvements in working memory, perceptual speed and executive function.
Researchers have identified transmembrane 4 L six family member 1 (TM4SF1) as a highly selective surface marker of senescent β-cells in both mice and humans. This discovery provides an important step toward developing targeted senotherapies that could preserve insulin secretion and slow the progression of type 2 diabetes.
Exercise produces small improvements in pain and physical function for people with hip osteoarthritis, but those improvements may not be large enough to make a meaningful difference in daily life. Quality of life showed little to no improvement with exercise.
Researchers at the University of Calgary have developed a new method to analyze cellular behavior in sepsis infections, identifying 18 different clusters of behaviors involved. This breakthrough could lead to targeted therapeutics and improved survival rates for patients.
A novel salvage surgical approach combining internal neurolysis and targeted glycerol injection has provided durable pain relief for a patient with severe, treatment-resistant MS-TN. The procedure was successful in preserving sensation and reducing medication use.
Dr. Rui Yang receives a Burroughs Wellcome Fund Career Award for Medical Scientists to uncover genetic causes of life-threatening immune disorders and identify new treatment paths. The research aims to advance diagnosis and understanding of rare diseases while fostering the next generation of scientists.
Researchers created a platform to study chronic pancreatitis pathogenesis and identify potential treatments by generating patient-derived organoids. The organoids revealed consistent dysfunction in the CFTR protein, which may be a future effective therapeutic target.
Researchers found that yeast-based supplements can reprogram early-stage immune cells to produce enhanced anti-tumor responses. The study suggests a potential solution for obesity-related immune dysfunction and cancer, using a food-grade supplement with an excellent safety record.
The new journal features cutting-edge research across basic, clinical, and translational immunology. It is designed to connect researchers across the full breadth of immunology, deepening understanding of the immune system in health and disease.
Researchers will study blood samples and environmental exposures over 10 years to identify genetic, environmental, and cellular factors contributing to autoimmune diseases. The goal is to develop prevention strategies and treatments by understanding the earliest biological triggers of SARDs.
A French multicenter study found that nearly half of ICU survivors had unfavourable functional outcomes 1 year after intensive care for bacterial meningitis. Hearing loss, depressive symptoms, and impaired physical quality of life were common among survivors.
Researchers have developed a gene-editing tool that unlocks the secrets of fungi, a kingdom rich in antibacterial compounds. The tool, called fPE7max, enables precise control over DNA sequences and has identified three novel molecules with anti-cancer properties.
Researchers present a roadmap for developing Tregs as adaptable therapies to restore immune balance and support tissue repair. This approach holds promise for treating conditions such as metabolic and cardiovascular disease, as well as neurodegeneration.
Researchers are developing a new gene therapy to treat CTLA-4 insufficiency, a life-limiting inherited immune disorder. The treatment involves replacing a faulty gene in a patient's own immune cells using CRISPR/Cas9 technology.
New therapies using regulatory T cells, known as Tregs, could target diseases with inflammation, such as cancer and autoimmune conditions. Early evaluations show good tolerance and safety profiles, but precision is key to tailoring treatments for specific patients.
Two studies found that certain fungal species in the gut play a key role in immune dysregulation and pediatric allergic diseases, positioning the infant mycobiome as a promising target for therapies. Infants' early-life antibiotic use may have a direct impact on these fungi, leading to immune dysregulation and allergic asthma.
Scientists have identified a unique chimeric RNA called UBA1-CDK16 that plays important roles in women's blood cell development and disease severity. The findings suggest the chimeric RNA may serve as a natural brake to protect women from excessive autoimmune activity.
A USC-led team has developed a way to grow and genetically engineer progenitor cells that give rise to macrophages, a type of immune cell promising for cancer immunotherapies. The team successfully expanded these cells in the laboratory and engineered them to target specific cancer markers.
Researchers found that over-the-counter probiotics contain only 36 unique species of bacteria, with most common species being forms of Lactobacillus. The analysis suggests a lack of consistency in the combination of species used to support gut health and vaginal health claims.
A study has identified a genetic cause for pediatric-onset pyoderma gangrenosum, a rare inflammatory skin condition. The researchers discovered that a mutation in the OTULIN gene leads to the condition, which is characterized by recurrent ulcerating skin sores.
A new study found that chronic pancreatitis (CP) impairs multiple quality-of-life domains, including mobility, self-care, daily activities, mental health, and pain. Employment status is a powerful protective factor, while older age correlates with milder QoL impairments.
Scientists discover autoimmune vicious cycle in Sjögren's disease, where CD4+ T cells recognize Ro60 protein and sustain antibody production. This process forms a self-reinforcing loop, contributing to chronic disease, and could lead to targeted therapies with fewer side effects.
A large-scale study on Swedish children with asthma found that living with cats did not worsen asthma outcomes. The study of 30,277 children over 24 months showed similar asthma severity and lung function in cat-exposed and non-exposed groups.
The PediQEESI is a new pediatric adaptation of the QEESI questionnaire to assess chemical intolerance in children. It can help identify patterns among symptoms, exposures, and daily functioning, enabling parents and clinicians to avoid future exposure and trigger symptoms.
A new review highlights advances in preventing bone loss in people with rheumatoid arthritis, showing that modern antirheumatic therapies can significantly reduce both localized erosions and generalized bone loss. Emerging imaging technologies like HR-pQCT have been found to detect subtle bone erosions earlier and more sensitively.
LRBA deficiency, a rare inherited condition, impairs kidney function by disrupting water and sodium balance, leading to polyuria and electrolyte abnormalities. Treatment with desmopressin may help manage excessive urination in some patients.
A new study found that dihydropyridine calcium-channel blockers (DCCBs) may be associated with poorer kidney outcomes in people with type 2 diabetes, even among those receiving modern kidney-protective treatments. DCCBs were linked to a higher risk of major adverse kidney events.
Researchers from Pennington Biomedical will showcase their latest findings on prevention, care, and cures for diabetes and obesity at the American Diabetes Association's 2026 Scientific Sessions. The sessions will highlight cutting-edge advancements driving progress in diabetes research and management.
The global incidence of type 1 diabetes nearly tripled over the past three decades, while health inequalities worsened. Lower-income countries carry a disproportionately large share of T1DM-related deaths and years of life lost due to disparities in access to insulin treatment and healthcare resources.
Researchers at Mount Sinai have found that autoimmunity is responsible for the symptoms of long COVID in a subset of people. The study suggests that therapies already validated for managing autoimmunity, such as IVIG and FcRn inhibitors, could be effective in reducing symptom burden.
Activated memory B cells can recognize and target ovarian cancer cells, producing effective antibodies. The discovery advances the development of vaccines and therapies based on immune memory against cancer.
UCLA researchers have found that patients with severe Valley Fever had abnormal immune responses, including overactive or underactive T cells. The team discovered two underlying immune programs that contribute to life-threatening disseminated Valley Fever and developed a new treatment approach using immunomodulation.
Researchers at CNIC identify mitochondrial complex I as a key checkpoint for dendritic cell activation. Restoring its function restores immune responses against viruses and tumors. The study paves the way for new strategies in vaccines and cancer immunotherapies.
A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.
A new study suggests that ultrasound stimulation can bring about functionally meaningful changes in pain perception and brain connectivity. The research found a delayed analgesic effect, with participants reporting reduced pain intensity after 28-55 minutes following TUS application.
The Complex Disorders Alliance (CODA) is funding research on microvascular dysfunction and immune-mediated clotting processes in complex chronic disorders. Professor Resia Pretorius of Stellenbosch University and Dr. Mikki Tal of MIT are collaborating to expand understanding of these conditions.
A study from the University of Bath reveals widespread psychological distress among people who remain isolated due to Covid-19. The research found a vicious cycle of fear driving withdrawal from social contact, reducing confidence to re-engage with the world and reinforcing isolation.
Researchers at Garvan Institute of Medical Research discovered key immune cells malfunction in mevalonate kinase deficiency (MKD), a rare but devastating autoinflammatory disorder. Current treatments targeting inflammatory signals produced by macrophages fail in half of patients, but JAK inhibitors may provide relief.
A new study from Cornell University found that delaying the first dose of hepatitis B vaccine after birth leads to increased infections and higher healthcare costs. The longer the delay, the more severe the consequences for newborns, who are at high risk of developing chronic infections and premature death.
A new analysis found that prescriptions for curable hepatitis C drugs have declined sharply in recent years, leaving millions without treatment. The researchers urge swift actions to deliver the drugs to those who need them, including increased screening and system-level changes.
Researchers have mapped the molecular mechanism behind allergic reactions and developed tailored antibodies to block life-threatening responses. The findings suggest a new approach to targeting the most important allergens and provide a starting point for developing more precise treatments for severe allergy.
Researchers from Chiba University found that antibody therapeutics with stronger Fcγ receptor binding are more likely to be recognized as foreign and associated with higher anaphylaxis risk. High affinities for Fcγ receptors critical determinants of anaphylaxis, study suggests.