Articles tagged with Immune Disorders
Researchers at Salk Institute discover SSRIs like Prozac regulate immune response, preventing sepsis in mice. The findings suggest a potential new use for the popular drug, which could lead to life-saving treatments and enhanced global preparedness for pandemics.
Researchers at TUM found that cystic fibrosis causes changes in the immune system as early as birth, leading to frequent inflammation and infections. These changes are not affected by CFTR modulator therapies.
A multi-institutional study identified the specific milk protein triggering a patient's case of eosinophilic esophagitis, an inflammatory disease of the esophagus. The findings represent the first time any research team has described molecular details of food antigen recognition in EoE.
Researchers have identified a key protein called Apex1 as a potential therapeutic target for stopping the immune system from attacking itself. By inhibiting this protein, harmful T cells that cause autoimmune diseases and allergies can be eliminated.
A study published in Nature Metabolism found that four percent of Greenland's Inuit population has a gene variant that increases their risk of type 2 diabetes by tenfold. Exercise has been shown to increase insulin sensitivity in these individuals, suggesting it may be an effective way to reduce their risk of developing the disease.
Researchers found that neuroinflammation in the hippocampus significantly alters motivation and behaviour in mice, particularly in females. This study suggests that treatments targeting hippocampal neuroinflammation could help reduce cognitive and behavioural symptoms in diseases such as Alzheimer's and Depression.
Researchers at RCSI University of Medicine and Health Sciences have discovered that macrophages, a type of immune cell, work differently throughout the day due to the body's internal clock. This daily rhythm determines when immune cells are most efficient at detecting threats and mounts a response.
Researchers discovered a protein variant acting like a tuning dial to regulate interferon signaling, impacting immune function and disease susceptibility. The balance between this variant and the normal protein may vary from person to person, contributing to individual differences in immune responses.
The InteReg project aims to create interactive biomaterials that instruct cells to regenerate after brain or spinal cord injuries, potentially treating MS and other neurological disorders. The project, funded by the Carl Zeiss Foundation, brings together experts in biology, chemistry, medicine, and polymer research.
A small cohort study found that children raised on farms or with pets tend to have a lower risk of developing allergies due to the diversity of their gut microbiome. The study analyzed fecal samples from children and discovered more anaerobic commensals, which may contribute to this reduced allergy risk.
A new project at the University of Kansas aims to examine medical ableism and its effects on health outcomes among people with disabilities. The study will gather information directly from individuals with disabilities through the National Survey on Health and Disability.
A new study from Tulane University finds that historical race-based lending practices are still impacting health today, linking discriminatory policies to 15% longer delays in achieving viral suppression of HIV. This delay can impact individual health outcomes and public health efforts to curb the spread of HIV.
The CRISPR tool was successfully used to correct a genetic defect in cells affected by chronic granulomatous disease. However, the repair process also introduced new genetic defects, highlighting the need for caution when using CRISPR technology in clinical settings.
Treatment-emergent nirmatrelvir resistance mutations were commonly detected in immunosuppressed individuals, but at low frequencies and transient nature. The study suggests a low risk for the spread of nirmatrelvir resistance in the community with current variants and drug usage patterns.
A recent study has revealed that oral bacteria, specifically Aggregatibacter actinomycetemcomitans, can exacerbate rheumatoid arthritis. The study found that the infection led to increased inflammation and joint damage in animal models.
Researchers at UBC have identified a specific cascade of events that lead to allergies and asthma after early-life antibiotic use. The study found that butyrate-producing bacteria play a key role in halting the allergic response, and that targeting ILC2 cells may provide new treatment options.
Researchers identified a mutated version of the TNIP1 protein that causes chronic autoimmune disease similar to Sjogren's Syndrome. The study suggests that targeting this protein may lead to new and tailored treatments for these conditions.
A study published in the Journal of Clinical Immunology found alemtuzumab to be safe and effective in treating Asian patients with inborn errors of immunity after allogeneic hematopoietic cell transplantation. The drug was shown to improve overall survival rates, with 94.7% of patients surviving post-transplantation.
Patients with 18q deletion syndrome exhibit both cellular and humoral immunodeficiency, characterized by low immunoglobulin levels and impaired T-cell function. Regular testing for both cellular and humoral immunity can allow for early detection of combined immune deficiencies and improve clinical outcomes.
Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.
Researchers develop optogenetic system to precisely target cancer cells using light, inducing inflammatory cell death and triggering immune response. The approach aims to modulate the immune suppressive environment around cancer cells, helping T cells recognize and attack the disease.
Scientists at Brigham and Women's Hospital have identified a metabolic switch in the gut that helps regulate immune tolerance and protect against harmful intestinal inflammation. This discovery could lead to new strategies for promoting remission in patients with inflammatory bowel disease.
Researchers found auto-antibodies against type I interferons in severe and critical COVID-19 patients, compromising their immune response. This discovery highlights the importance of detecting these auto-antibodies in regular health checkups to better prepare for viral infections.
Researchers at University of Turku have discovered a novel RNA that controls the development and function of regulatory T cells. This finding may enable the development of precision medicine treatments for autoimmune diseases and cancer.
A study by Chiba University researchers reveals that a specific variant of the HLA gene can trigger an endoplasmic reticulum stress response in skin cells when exposed to certain drugs, leading to drug eruptions. This newfound knowledge may form the basis for innovative treatment options.
A team of researchers found that immune cells maintain their alertness through the JAK-STAT signalling pathway when there is no immediate threat. This discovery could lead to new approaches for enhancing the immune system's attention and preventing autoimmune diseases.
Researchers highlight the risk of novel SARS-CoV-2 variants emerging due to prolonged viral replication in immunocompromised individuals. Close genomic surveillance and early diagnostic tests are crucial to mitigate potential public health threats.
Researchers found that children born to mothers with HIV infection have an increased risk of immune abnormalities, impaired growth, and development. Infants exposed to HIV had a 41% higher mortality rate than those not exposed, with systemic inflammation being strongly associated with infant mortality.
A team of researchers from the Australian National University has identified a gene mutation responsible for causing psoriasis, which can also lead to psoriatic arthritis. The discovery could improve diagnosis and treatment for patients with these conditions, reducing stigma in the community.
A new study by Duke University researchers provides fundamental insights into autoimmune diseases, including systemic lupus erythematosus. They developed a system to test how DNA attached to nanoparticles interact with the immune system, revealing that larger nanoparticles provide more protection for DNA.
Women with selected rheumatic diseases experience a higher prevalence of childlessness, while risks for pre-eclampsia, low birth weight, and preterm delivery are increased for many conditions. Men with rheumatic conditions also face a higher risk of childlessness, although the impact on fertility varies among different diseases.
A new study from EPFL reveals how the CRL5–SPSB3 ubiquitin ligase targets and degrades nuclear cGAS, preventing it from mistakenly attacking the body's own tissues. This regulation ensures a sophisticated balance between immune readiness and protecting the integrity of the cell's genome.
A new study from the University of British Columbia has found that sublingual immunotherapy (SLIT) is safe and effective for older children with multiple food allergies, who cannot risk consuming allergens orally. The treatment involves placing smaller amounts of food allergens under the tongue, allowing patients to build up their resi...
Researchers decode underlying mechanisms of DCM, hippocampal neurotoxicity, and dysbiosis mediated AD progression using mass spectrometry imaging. The studies found metabolic changes in DCM rat hearts and regulation of CYPs in the hippocampus, providing new perspectives on treatment strategies.
Researchers at Texas A&M discovered that immune genes are frequently exchanged between Myotis bat species during seasonal mating swarms, potentially helping humans fight emerging diseases. The study's findings have opened new questions about the importance of hybridization in evolution and its impact on genomicists' knowledge.
Researchers from Pusan National University discovered a link between diabetes and periodontitis, showing pro-inflammatory cytokines rise in classical monocytes. The study highlights the systemic impact of these conditions on immune regulation and suggests a potential therapeutic target to reduce diabetes risk.
A recent study published in the Journal of Clinical Medicine identifies potential biomarkers for ME/CFS diagnosis and treatment. Researchers found that patients can be divided into subgroups based on immune system function, revealing differences in intestinal barrier function and immune competence.
Researchers have developed a gene editing technique that can repair defective immune cells using CRISPR-Cas9, showing promise in treating rare diseases like Familial Hemophagocytic Lymphohistiocytosis. The therapy involves repairing genetic defects in cytotoxic T cells to normalize the immune response.
Scientists found that short-chain fatty acids produced by gut bacteria suppress allergic reactions by modulating mast cell activation and epigenetic modifications. This study provides new insights into the relationship between diet and immune system regulation, with potential applications in allergy treatment.
Researchers found that the complement system remains activated in Long Covid patients, causing cell damage and tissue destruction. This abnormal activity can lead to thromboinflammation and other symptoms of the condition.
A study published in Cell Genomics reveals that specific changes in CD4+ T cell categories and gene programs are associated with autoimmune diseases, including distinct patterns related to aging and sex. The findings provide a comprehensive catalog of CD4+ T cell changes linked to 20 different autoimmune diseases.
Researchers uncover a link between hyperactive Rac2 and human immune deficiency, shedding light on a mysterious condition. They also find promise in using cellular cannibalism to enhance cancer treatment.
Researchers discovered distinct mechanisms controlling different types of immune cells and found a way to selectively eliminate 'problematic' cells driving autoimmune disorders. This breakthrough offers precise targets for potential treatment strategies, potentially revolutionizing the way we treat skin conditions.
Researchers have developed a new method, SECRE, to identify genetic regulators of cytokine secretion in autoimmune diseases. The technique has been validated on cells known to play a crucial role in inflammatory bowel disease (IBD) and shows promising results for treating conditions with few therapeutic options.
A recent study found that transient inflammatory pain causes persistent mitochondrial and metabolic disturbances in sensory neurons, leading to failure in pain resolution. Targeting the cellular redox balance prevents and treats chronic inflammatory pain in rodents.
A new study found that the gut microbiota plays a significant role in prostate inflammation in aging men, particularly those with metabolic syndrome. The researchers discovered a strong relationship between IL-6 and IL-18 expression and lipid parameters in the prostate tissue of men with BPH + MetS.
Salk researchers identify Foxp3 as the protein that determines regulatory T cell genome structure and fate, enabling manipulation to treat autoimmunity or fight cancer. The study reveals Foxp3's essential role in creating unique chromatin architecture of regulatory T cells.
Scientists have discovered a new small molecule called Feeblin that inhibits the interaction of SLC15A4 with TASL, a key player in pro-inflammatory signalling pathways. This finding offers promising new treatment options for patients with autoimmune diseases like systemic lupus.
Scientists have discovered a TB vaccination strategy that prevents lung infection in monkeys infected with SIV, despite the vaccine being contraindicated for people living with HIV. The results show promise for protecting people with HIV against TB, which is the leading cause of death among them.
Researchers aim to identify genetic risk factors and mechanisms underlying virus-induced asthma, using artificial intelligence-based techniques and patient-derived models. The study may lead to personalized prevention campaigns and mechanism-targeted drugs.
Research reveals that T-cell infiltration into the brain is the primary cause of pulmonary dysfunction in Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS). The study provides new insights into the condition and potential treatment pathways.
A new study has found that children raised in rural areas with plenty of outdoor time and animal exposure develop better-regulated immune systems than urban counterparts. Early life immune development is highly dependent on living environment and lifestyle factors, and researchers say this can have long-term consequences for disease risk.
Researchers found that all 22 babies achieved a reduced sensitivity to peanuts after completing the treatment. After an oral food challenge, 91% of them could tolerate peanuts without triggering any allergic reactions.
Eosinophilic esophagitis (EoE) is triggered by food allergies or airborne allergens, causing inflammation and damage to the esophagus. A new study found that inhibiting the NLRP3 pathway and releasing Interleukin-18 prevents EoE development.
Researchers discuss treatment refractory forms of chronic sinusitis, highlighting the importance of interdisciplinary diagnostics and therapy. Fungal infections are a rare cause, yet crucial to consider when treating this condition.
Patients with GATA2 deficiency have impaired ability to produce immune cells, leading to increased risk of recurrent infections and blood cancers. The study's findings suggest that a zebrafish model may help develop new treatments to slow or reverse the disease.
A recent study published in the Journal of Clinical Immunology suggests that cutaquig infusions at higher infusion rates and volumes are well-tolerated and effective, with reduced infusion time, fewer injection sites, and improved compliance. The study results will be presented at the Clinical Immunology Society 2023 Annual Meeting.
A team of researchers developed a multi-organ chip on-a-chip that applies 3D cell printing technology to closely replicate the pathological environment of type 2 diabetes. The chip shows a correlation between visceral fat and T2D, as well as impaired retina cell function, indicating potential complications.
A protein called PI3K plays a crucial role in immune cell function, and genetic variations disrupting its signalling have been identified as the root cause of two immunodeficiency disorders. The study reveals how minor disruptions in immune cell signalling can lead to immune deficiency or dysfunction.
Researchers at UCLA successfully used base editing to correct a mutation causing rare immune deficiency CD3 delta SCID. The treatment corrected an average of 71% of patient stem cells and allowed them to produce fully functional T cells, suggesting long-term persistence of corrected blood stem cells.