Articles tagged with Oncology
A Phase I trial evaluated a novel multi-targeted T-cell therapy for children with deadly brain tumors, offering early evidence that the patient's own immune cells can reach and fight tumors while producing fewer severe side effects. The study suggests a safer and more effective approach for pediatric brain cancers.
Researchers develop novel PROTACs to target molecular drivers of cancer, showing effectiveness against aggressive tumor cells and limited side effects. The new approach offers a promising strategy for treating treatment-resistant cancers and improving survival rates.
Combined hepatocellular-cholangiocarcinoma is a rare and aggressive form of primary liver cancer that poses significant diagnostic and therapeutic challenges. The absence of standardized treatment guidelines limits effective management, emphasizing the need for thorough pathological evaluation and multidisciplinary management.
Researchers found frequent silencing of TRAIL-R2 in breast tumors through promoter hypermethylation, associated with invasive ductal carcinoma and advanced tumor stage. Lower TRAIL-R2 expression was linked to more aggressive disease and reduced overall survival.
A new blood test, Stockholm3, detected significantly more aggressive prostate cancers than the PSA test without increasing unnecessary follow-ups. The study shows that Stockholm3 identifies 90% of aggressive cancer cases, compared to 74% for PSA.
Researchers found a genetic mutation, TGFBR1*6A, associated with lower risk of colorectal cancer. Carriers of this mutation have a reduced risk of developing the disease, even in those with familial adenomatous polyposis.
Access to fertility preservation (FP) care is restricted among female adolescents and young adults with cancer due to costly and invasive interventions. The review highlights disparities in FP delivery and access based on age, socioeconomic status, and cancer type.
Dr. Nowicki's research aims to develop a next-generation CAR-T cell therapy targeting GD2, a protein found on osteosarcoma cells, with enhanced immune-signaling molecule TNF-alpha. The grant will support preclinical studies to evaluate safety and effectiveness in laboratory and animal models.
Researchers discovered Paneth cell metaplasia can act as a protective response in ulcerative colitis by promoting healing and regeneration of the intestinal lining through REG3A. However, persistent changes may still carry risks, including increased cancer risk.
Researchers found that GATA6 expression is reduced in liver metastases, correlating with poorer clinical outcomes. Losing GATA6 allows cancer cells to change their identity and become more adaptable, leading to metastasis.
A cross-sectional study found that colorectal cancer screening participation increased after an organized population screening program, but socioeconomic disparities remained. Younger age groups, single households, and lower-income individuals still lag behind in screening uptake.
Researchers discover recurrent COPA mutations driving intestinal tumorigenesis through an independent route. These mutations activate the Wnt pathway in a way that bypasses essential amplifiers, leading to cancer progression.
Extracellular vesicle-encapsulated microRNAs (EV-miRNAs) form a precise communication network for organ crosstalk, mediating immune regulation and disease outcomes. EV-miRNAs display organ tropism, influencing tumor growth, anti-tumor immunity, and inflammation.
Researchers at UCLA Jonsson Comprehensive Cancer Center have been awarded a $3.2 million NIH grant to develop advanced imaging and surgical strategies for improving glioblastoma outcomes. The team aims to use pH-based imaging to guide precise tumor removal and explore targeted therapies that target the tumor's acid-regulating systems.
A study published in JAMA Network Open found that high consumption of sugar-sweetened beverages was linked to an increased risk of liver cancer. In contrast, artificially sweetened beverage intake showed no significant association with liver cancer risk.
A 28-year-old woman was misdiagnosed with intussusception due to imaging similarities, but surgical removal revealed a rare ileal leiomyoma. Histopathology and immunohistochemistry confirmed the diagnosis, emphasizing the importance of combining imaging, histopathology, and immunohistochemistry for accurate diagnosis.
A new study found that HPV-DeepSeek, an ultrasensitive blood test, can identify patients with HPV-associated head and neck cancer who may benefit from additional treatments. The test detected circulating tumor DNA in 98.1% of patients at diagnosis, significantly improving detection rates compared to existing methods.
A new study published in Genes & Cancer identifies activated beta-catenin as a key driver of aggressive pediatric osteosarcoma progression. The researchers found that cells expressing active beta-catenin exhibited enhanced invasive capacity and cancer-associated traits, suggesting a potential therapeutic target for this aggressive cancer.
Researchers identified specific gene mutations and characteristics associated with early-onset breast cancer in young Black women. The study highlights the importance of genetic testing for this population, which faces lower screening rates than other groups.
A pilot study of the Participant Engagement Portal (PEP) tool shows that 84% of participants had a positive experience, with high usability and satisfaction rates. PEP facilitates two-way communication between patients and clinicians, allowing for self-reporting of social risk factors and future research opportunities.
A recent study found that melanoma disproportionately affects Florida's senior population, with older men experiencing twice as many skin cancer-related deaths as women. The study highlights gaps in prevention and early detection, particularly among men and non-Hispanic populations.
Researchers investigated polyisoprenylated cysteinyl amide inhibitors (PCAIs) for their anticancer effects on pancreatic cancer cells with KRAS mutations. The compounds demonstrated strong activity against cell survival, migration, and invasion pathways. PCAI treatment caused hyperactivation of MAPK and PI3K/AKT pathways, leading to ox...
A study of over 229,000 obese adults without diabetes found that weight loss drugs, such as semaglutide and tirzepatide, were associated with a 41% decrease in the overall risk of developing obesity-related cancers. GLP-1 RAs also showed larger reductions in certain subgroups, including men and gynaecologic cancers.
Sebaceous adenoma is a rare, slow-growing benign tumor arising from sebaceous glands. A new case report describes the clinical, histopathological, and immunohistochemical features of this tumor, highlighting its diagnostic challenges and importance of distinguishing it from more aggressive conditions.
A cross-sectional study found early age–onset colorectal cancer patients with improved overall survival but delayed treatment experienced worse outcomes. Language barriers may be a modifiable risk factor contributing to these delays.
Researchers analyzed data from over 50,000 adults who started taking aspirin and found a similar bladder cancer prevalence but lower invasive stage. Aspirin initiators received more cystoscopies, which uncovered the cancer. The study suggests that aspirin may unmask otherwise asymptomatic bladder cancer.
Prediagnostic statin use showed no association with higher survival rates, but postdiagnostic use was linked to lower all-cause and breast cancer-specific mortality among hormone receptor-positive subtypes. Statin therapy may improve survival of these patient groups.
City of Hope launches nationwide platform to share messages of encouragement with cancer survivors and their loved ones, offering tailored survivorship care and coordination between specialists and primary care physicians. The organization's data-driven model integrates supportive care from diagnosis through decades of follow-up.
Researchers found that CTHRC1, a secreted protein in tumor microenvironment, promotes colorectal cancer growth by limiting effective immune surveillance. The study suggests targeting CTHRC1 as a promising new strategy for future therapies.
Researchers analyzed tumor samples from over a thousand patients and found that TP53 gene mutations can worsen prognosis and reduce effectiveness of targeted therapies. The study suggests incorporating genetic testing into public health services to guide personalized treatment choices.
A comprehensive review of breast cancer risk models in women with a family history found that none are highly accurate at identifying which women will develop the disease. The BOADICEA model showed balanced performance, while others had significant limitations, emphasizing the need for continued improvement.
Adding fovinaciclib to first-line aromatase inhibitor therapy confers significant progression-free survival benefits and consistent improvements in efficacy outcomes. The treatment also has manageable safety profiles with no negative impact on quality of life.
The study found that adjuvant nivolumab did not improve disease-free survival in patients with resected non–small cell lung cancer. The treatment was also not effective in sensitizing EGFR and ALK alterations.
A randomized clinical trial found that an app-facilitated palliative care intervention maintained health-related quality of life and reduced acute care use. This digital self-management approach also boosted patient self-efficacy.
The study found that population-based pathogenic variant testing reveals different subsets of high-risk women than clinical risk factors and polygenic risk scores. This highlights the importance of incorporating PV testing into risk-based screening for breast cancer.
A multicenter clinical trial found that implanting collagen tiles during brain surgery improved tumor control and lowered the risk of recurrence by 12.1% compared to current standard of care. Patients treated with tile-based radiation therapy (TBRT) had a median overall survival of 42.5 months, more than double the 17.6 months seen wit...
A population-based screening trial evaluating a cell-free DNA multicancer early detection test found modest increases in diagnostic delay rates for head and neck, lung, and upper gastrointestinal cancers. These findings suggest that future trials may need to consider system-level spillover effects on healthcare resources.
The American Cancer Society has endorsed two new types of stool tests and recommends limiting the use of blood tests for colorectal cancer screening. The guidelines aim to encourage people to get screened while improving detection rates.
Researchers discovered lung cancer cells change identity to resist treatment by reactivating a process involved in early lung development. This could help doctors predict which patients respond well to treatment and provide personalized care.
The National Comprehensive Cancer Network (NCCN) has launched a new free service providing weekly email updates on changes to evidence-based guidelines for cancer prevention, screening, treatment, and supportive care. The service aims to keep healthcare providers up-to-date with rapidly evolving evidence-based recommendations.
Dropping the cancer label from grade group (GG)1 prostate disease redefines it as a precancerous lesion, leading to a net reduction in estimated prostate cancer deaths. This relabeling strategy may have minimal impact on screening rates.
Researchers from Mass General Brigham Cancer Institute presented various studies on cancer treatments, including the efficacy of lung cancer drug neladalkib and a psychosocial digital app for patients with multiple myeloma. An electronic frailty index was also used to identify high-risk older adults receiving CAR-T cell therapy.
A new study reveals that nitrosylcobalamin, a vitamin B12 analog, selectively crosses the blood-brain barrier and targets glioblastoma tissue, demonstrating broad antitumor activity. The therapy also shows synergistic activity with existing treatments, offering a promising new strategy for treating this deadly brain cancer.
Researchers from ECOG-ACRIN Cancer Research Group will present updated outcomes from the STAMP study on Merkel cell carcinoma, primary results from studies in glioblastoma and non-small cell lung cancer, and emerging approaches in precision oncology. AI-driven insights from the TAILORx breast cancer trial will also be showcased.
Dr. Michele Carbone received the 2026 Szent-Görgyi Prize for his groundbreaking discovery that mesothelioma can be transmitted through families in a Mendelian fashion, driven by inherited mutations in the BAP1 gene. His research has transformed how the disease is understood, diagnosed, treated and prevented worldwide.
The National Comprehensive Cancer Network has launched a new version of its Distress Thermometer and Problem List in over 70 languages to screen patients for mental, physical, social, or spiritual distress. The tool aims to enhance cancer care by identifying psychological distress and providing support.
The Endocrine Society and Keystone Symposia will host their first joint conference in October to explore discovery in cancer, diabetes, and cardiometabolic disease. The conference series aims to strengthen the exchange of scientific knowledge through coordinated programming, facilitating discovery and collaboration among researchers.
Davis Joseph's groundbreaking discovery identifies three universal cancer types based on protein and RNA malfunction, paving the way for an organ-agnostic treatment. The research also developed a unified apoptosis network flowsheet, comprising approximately 100 pathways, which can be applied to various cancers.
The Alliance A082402 study evaluates the effectiveness of involved-station I²-PORT in reducing NSCLC recurrence without long-term side effects. Participants will undergo randomized treatment with or without targeted radiation therapy after surgery.
A landmark EORTC trial with over 20 years of follow-up found that irradiation of internal mammary and medial supraclavicular lymph nodes reduces breast cancer mortality, but does not improve overall survival. Long-term cardiac and pulmonary toxicity was reported more frequently after IM-MS irradiation.
A rare case of high-grade laryngeal leiomyosarcoma was successfully treated with extended laryngectomy, left neck dissection, and adjuvant chemotherapy. Complete surgical excision remains the cornerstone of therapy, while multidisciplinary-guided adjuvant treatment may benefit selected high-grade or high-risk patients.
At ASCO 2026, City of Hope experts will present research on innovative treatments for various types of cancer. Their findings include the efficacy and safety of immunotherapy combinations, as well as the potential use of CBM588 to enhance immune checkpoint blockade in metastatic renal cell carcinoma.
A new editorial proposes the use of agentic AI systems to address cancer-related malnutrition, a prevalent issue affecting up to 80% of patients. These systems aim to coordinate multiple functions simultaneously and support ongoing clinical decision-making throughout treatment.