Articles tagged with Drug Development
Research finds gut hormone cells, previously thought to contain one hormone, actually secrete six hormones including ghrelin. The discovery sheds light on how weight-loss surgery can cure diabetes, with understanding these hormonal changes crucial for a potential cure.
A group of industry and regulatory scientists released consensus recommendations for assessing the safety pharmacology evaluations of oligonucleotide-based therapeutics. The guidelines emphasize the importance of safety pharmacology studies to evaluate cardiovascular function effects.
Individuals hospitalized for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have a high risk of recurrence, with over 7% of patients experiencing subsequent episodes.
Researchers identified a tiny mutation in BTK as the cause of drug resistance to ibrutinib in CLL patients, which destabilizes binding and allows leukemic cells to multiply freely. The finding could guide development of new agents to treat drug-resistant disease.
Researchers at NIH screened 290 approved compounds and identified 27 with activity against both MERS-CoV and SARS coronavirus. These compounds, from various pharmaceutical classes, inhibited the viruses' ability to enter and infect cells. The study provides a potential solution for outbreaks due to emerging viruses.
Researchers found 27 compounds with antiviral activity against MERS-CoV and SARS-CoV in cell culture. Experimental compound also inhibits replication of other coronaviruses, including mouse hepatitis virus.
A study found that parental disapproval is associated with lower rates of prescription drug misuse, particularly in African American and Hispanic teens. Strong parental disapproval of substance use was a stronger factor for these groups than peer attitudes.
New targets for drug therapy have been identified in the mast cell system, including enzymes and receptors. These targets include serine proteinases tryptase, chymase, cathepsin G, and proinflammatory cytokines.
Researchers have identified various transcription mechanisms in zebrafish during embryonic development, which may help understand the formation of abnormalities or cancer. The study reveals that different starting points are used for transcription before and after activation of the embryonic genome.
A team of researchers has developed the first lab-grown epidermis with a functional permeability barrier, enabling the testing of drugs and cosmetics without animal subjects. The new epidermis, grown from human pluripotent stem cells, can be scaled up for commercial use and tailored to study specific skin conditions.
Dr. Richard Plemper is developing novel therapeutics against Respiratory Syncytial Virus (RSV) infection. He aims to identify an anti-RSV drug and at least one distinct alternative compound to address the unmet clinical need for RSV therapeutics.
A survey of emergency contraceptive pills in Peru found that 28% were either substandard or falsified, posing serious health risks. Researchers developed a sophisticated approach using mass spectrometry to detect counterfeit drugs, highlighting a growing concern for women's health in developing nations.
A new JAMA article suggests creating an unbiased review and certification process for mHealth apps to evaluate their clinical performance and data security. The authors propose multiple organizations that could be created to review and certify apps, similar to the role of Health On the Net Foundation in evaluating online medical content.
Researchers from the University of Granada have patented a technique that allows for real-time and non-invasive measurement of phosphate ions inside osteoblasts, precursors to bone cells. This breakthrough could lead to the development of new drugs against osteoporosis.
Researchers at UCL have developed a new technology that can deliver the AMD drug Avastin via eye drops, potentially replacing painful injections. The system uses nanoparticles to transport the drug across biological barriers and could be customized for different medications.
Researchers have found that an ancient Chinese medicine extract blocks pathways to treat pancreatic cancer by inhibiting scarring and inflammation. The compound also appears to suppress Cox-2, an enzyme that causes inflammation, and has been shown to be safe for use in patients.
A research team led by USF Health's Michael White and Elena Suvorova aims to identify new factors required for malaria-related parasites' growth. The study may lead to the development of new therapies against malaria, a deadly mosquito-borne disease.
The emerging class of ADCs holds great promise in cancer treatment, with two approved drugs expected to be blockbusters and over 100 more in preclinical pipeline. Challenges in manufacturing are being addressed by contract manufacturers expanding capacity.
Patients with a single illness and polypharmacy face higher hospital admission risk, while those with multiple conditions have near-normal risk. Sophisticated approaches to assessing medication appropriateness are needed.
A new study has found that levetiracetam does not appear to be associated with thinking, movement, and language problems in preschool children born to mothers who took the drug during pregnancy. In contrast, valproate was linked to some difficulties in preschoolers.
A computer algorithm developed by Tel Aviv University identifies genes that could be transformed to stop the aging process. The algorithm predicts which genes can be turned off to create the same anti-aging effect as calorie restriction, potentially leading to new treatments for aging and other metabolic disorders.
Researchers evaluated mangafodipir, an MRI contrast agent with antioxidant properties, for relief of oxaliplatin-induced neurotoxicity. Mangafodipir treatment reduced neurotoxicity and decreased neurological symptoms in both mouse models and human patients.
Researchers developed biodegradable nanomotors inspired by plant corkscrew structures for targeted drug delivery. The low-cost, plant-based microswimmers can efficiently navigate liquids with magnetic control.
New research suggests that 55% of bilateral adrenal Cushing's syndrome patients have genetic mutations predisposing to adrenal tumors. Genetic screening may help identify affected family members, potentially preventing disease progression and eliminating current treatment practices.
The study found that perinatal exposure to estrogen-like compounds may be associated with a host of health problems. The researchers aim to review the latest advances in morphological definition, developmental mechanisms, and environmental factors that can influence the development of the sexually dimorphic nucleus.
Researchers developed new methods for synthesizing coumarin-based drugs, which showed promise as anti-inflammatory agents. The study revealed one of the pathways in which coumarins act, and understanding this pathway may help develop future treatments for chronic inflammation diseases.
A collaborative team, led by Prof. Mark Williams, reveals how the APOBEC3G protein forms a roadblock to prevent HIV replication, offering new avenues for HIV therapy and drug development.
A study led by TGen found that reduced SMG1 expression may contribute to alpha-synuclein pathology in Parkinson's disease and dementia. The researchers identified SMG1 as a regulator of alpha-synuclein aggregation, suggesting potential new therapeutic targets for treatment.
A study examined expedited FDA drug approvals, finding that new drugs approved under accelerated review took a median of 5.1 years to get marketing approval compared to 7.5 years for standard-reviewed drugs. Fewer patients were studied in these expedited reviews, raising concerns over the safety and efficacy of these medications.
A recent study highlights the issue of poor antibody performance due to contaminating hitchhiker antigens. This can lead to misdiagnosis, incorrect conclusions about disease mechanisms, and costly mistakes in drug development.
A new method developed by researchers could help diagnose and treat thousands of young adults and teens who end up in emergency rooms after taking synthetic marijuana. The study found significant differences in how individuals' bodies process the drugs, which could explain why some people experience more severe effects.
A study published in JAMA Neurology found that prenatal exposure to antiepileptic drugs was associated with impaired fine motor skills in children at age 6 months. However, breastfeeding by mothers taking these medications was not linked to adverse development in children up to 36 months old.
The NIH's Therapeutics for Rare and Neglected Diseases program aims to develop treatments for rare diseases affecting fewer than 200,000 Americans. Four new pre-clinical projects target retinitis pigmentosa, hypoparathyroidism and LEOPARD syndrome, marking the first use of stem cells and collaboration with Eli Lilly.
Researchers identified two pathways that recombine DNA repeats to rearrange chromosomes, which can be targeted to prevent cancer and inherited disorders. The study used mouse embryonic stem cells and found large, complicated rearrangements on multiple chromosomes.
Researchers at UCLA have identified a new form of irritable bowel syndrome (IBS) that occurs after an acute bout of diverticulitis. The study, published in Clinical Gastroenterology and Hepatology, found that patients who developed IBS-like symptoms after diverticulitis may also experience mood disorders such as depression and anxiety.
Chemists at IRB Barcelona and PharmaMar develop synthesis method for pipecolidepsin A, a compound active against eleven types of cancers. The new approach simplifies production, reducing time and cost to produce large quantities of the molecule.
Scientists have developed a new form of aspirin that could extend its benefits to people who don't respond to the drug, addressing 'aspirin resistance'. The new aspirin form is linked to a carrier protein that delivers aspirin directly to damaged blood vessels, releasing it and stopping clot-formation.
Researchers identified a mechanism that limits the body clock's ability to adjust to changes in light patterns, slowing down recovery from jet-lag. Blocking this gene in mice allowed them to recover faster.
A new review highlights recent advances in the scientific understanding of bitter taste to improve drug acceptance and compliance in pediatric populations. The paper focuses on applying this knowledge to formulate pediatric medications that are more palatable for children.
Children exposed to antiepileptic drugs in utero are at risk for motor development issues, language skills difficulties, and autistic traits. The study also found no increased risk of developmental delays in children born to mothers with epilepsy who did not use AEDs during pregnancy.
Researchers have developed artificial peroxisomes that mimic natural organelles, transforming toxic free radicals into water and oxygen. This innovation enables direct cellular targeting, paving the way for novel patient-oriented treatments.
Researchers have identified key regions in the dengue virus genome that can be targeted to prevent replication. Artificial microRNAs were constructed to specifically target these sites, leading to effective inhibition of viral replication in humans. This innovative approach offers new hope for treating millions affected by dengue fever.
University of Oklahoma Norman campus researchers received $135,000 OCAST grants for three-year health research projects. The recipients will study advanced treatments for bone defects, viral RNA structure to develop new drugs, and the control of mosquito-transmitted diseases.
Researchers found that a protein controlling Alzheimer's disease also affects muscle development and coordination in mice. The study suggests that inhibitors of this protein, currently being tested for Alzheimer's treatment, might disrupt muscle spindle formation and impair movement.
A new drug has been shown to prevent PTSD-like symptoms in mice by targeting the Oprl1 receptor, a gene variant linked to increased risk of developing PTSD in humans. The results suggest that the drug could have a similar preventive effect on PTSD in humans.
A new skin test called Skimune has been developed by Newcastle University to predict adverse reactions to new drugs and cosmetics. The test uses real human skin and immune cells to identify potential risks, providing a faster and more accurate alternative to animal testing.
A team of researchers at the University of Pittsburgh School of Medicine has identified the underlying cause of noise-induced tinnitus, a chronic condition characterized by phantom sounds. They have also developed a drug that can prevent its development in animal models.
A genome-wide lethality screen using RNA interference technology identified 239 gene candidates essential for cell survival. The researchers developed a high-stringency analysis method to determine which genes result in cell death when knocked down.
The U.S. Food and Drug Administration has approved only one new antibiotic since the Infectious Diseases Society of America launched its 10 x '20 Initiative in 2010. Despite this, only seven new drugs are in development to treat infections caused by multidrug-resistant gram-negative bacilli bacteria.
A study found modest but meaningful improvements in children with fragile X syndrome who received minocycline treatment. The antibiotic yielded significant improvements in anxiety and mood-related behaviors, while behavior problems and verbal functioning showed little change.
Researchers have identified four genes newly associated with severe childhood obesity and found an increased burden of rare structural variations in severely obese children. These variations can delete sections of DNA that help maintain protein receptors involved in weight regulation, promising new drug targets against obesity.
A Loyola University Chicago study found that disabling a specific calcium channel called TRPM2 could reduce painful inflammation in gout. The researchers also discovered that liposomes with a positive or negative electric charge can stimulate the immune system to attack pathogens.
Researchers developed biodegradable nanoparticles that selectively target and resolve inflammation, potentially treating atherosclerosis and neurodegenerative diseases. The nanoparticles release an inflammation-resolving peptide drug, promoting tissue repair and reducing chronic inflammation.
The American Academy of Neurology warns against prescribing neuroenhancing drugs to healthy children and teens, citing potential long-term health risks and impaired decision-making abilities. The organization emphasizes the importance of exploring alternative solutions, such as improved sleep habits, nutrition, and study regimens.
Researchers have developed an algorithm that can explain how traditional medicinal compounds work in the body, bridging the gap between Western and traditional medicine. This breakthrough may lead to more effective treatments for various diseases.
Experts at Yale University and the American Academy of Neurology call for limiting or ending the use of memory-enhancing drugs in healthy children. They cite concerns over long-term health safety, incomplete decision-making capacity, and risks of over-medication and dependency.
Research finds no significant linear trend pointing to a decline in UK new drug introductions between 1982-2011, contrary to widely-held views. The number of new drugs introduced has fluctuated, with dips followed by surges, indicating an overall slight increase over the past 40 years.
Researchers have found that immature malaria parasites are significantly less sensitive to artemisinin-based drugs than mature ones. This discovery may lead to more effective treatments for malaria and a better understanding of how the parasite develops resistance to drugs.
A new patent issued for an experimental compound RTX, which represents a potential new class of drugs to alleviate intractable pain. The method patent covers intrathecal administration of RTX, promising to improve lives of people with severe pain.
Scientists have developed a new and more efficient way to make paliperidone, a widely used medication for severe mental illness, reducing solvent use and increasing yield.