Articles tagged with Drug Resistance
Researchers have uncovered a potential strategy to eliminate cancer cells that survive KRAS inhibition, preventing relapse. By targeting the metabolic pathways that support the survival of drug-tolerant persister cells, treatment regimens could be designed to shrink tumors and prevent cancer recurrence.
Cancer cells develop multiple resistance mechanisms to antibody-drug conjugates, including antigen downregulation and mutation, internalization deficits, and payload efflux. Researchers propose innovative strategies, such as bispecific ADCs, dual-payload designs, and combination regimens, to overcome these defenses.
A new study forecasts global antimicrobial resistance threats for the next two decades, identifying 210 traits that could pose the greatest future risk. The research uses machine learning and forecasting to predict which genetic factors will become more prevalent and which may decline over time.
Researchers found that temperature and calcium levels inside cells can dramatically impact how drugs interact with their targets. This discovery could lead to smarter medicine design and more effective treatments.
A study analyzing nearly 2,000 human infections with Shiga-producing E. coli found increasing resistance to antibiotics, particularly for tetracycline and sulfisoxazole. The researchers propose a 'One Health' approach to address the issue, focusing on antibiotic stewardship in agriculture, food safety, and environmental controls.
Research finds that antibiotics and their breakdown products can contribute to resistance, even after treatment. The study suggests that wastewater treatment plants act as hidden reservoirs of bioactivity, leading to increased antibiotic resistance. Human usage of antibiotics is also identified as a major driver of this issue.
New research shows that antibiotics can drive bacterial resistance even after they are broken down in wastewater treatment plants and discharged into rivers and seas. The study found that some metabolites form when antibiotics break down retain the ability to promote antibiotic resistance.
A CDC study found that most NDM-CRE cases were caused by a few high-risk strains, primarily from Klebsiella pneumoniae and Escherichia coli. The discovery of new high-risk clones highlights the importance of genomic surveillance to catch emerging threats early.
The center will develop new phage-based treatments for antibiotic-resistant bacterial infections, predicting which phage to use for which patient and designing more effective phages. The goal is to generate unprecedented data and train AI models to identify the right phage for any patient's infection.
A new preclinical study suggests that targeting tumor-specific inflammatory processes could enhance the efficacy of some anticancer therapies and prevent drug resistance. The researchers found that tumors treated with KRAS inhibitors often developed inflammation-related gene expression changes, which contributed to drug resistance.
Europe's bacterial STI cases reached record highs in 2024, driven by gonorrhoea and syphilis, with men who have sex with men disproportionately affected. The near doubling of congenital syphilis cases highlights the need for improved antenatal screening protocols to prevent transmission to newborns.
Researchers used wastewater surveillance to detect drug-resistant Candida auris strains up to five months before patients showed symptoms, opening a new frontier for hospitals. The study found higher detection rates and concentrations of the pathogen in hospital wastewater compared to community-scale treatment plants.
Researchers have developed a new combination therapy that shows promising results in treating patients with Crohn's disease and ulcerative colitis. The treatment, which combines two mechanisms of action, has been shown to improve clinical remission rates by more than 20 percentage points compared to existing therapies.
Researchers identified how Mycobacterium abscessus evades treatment and proposed a strategy to overcome resistance, offering a pathway towards more effective treatments. A combination therapy targeting both smooth and rough variants proved more effective than single-phage treatment.
EGFR-TKIs have significantly improved OS and quality of life for EGFR-mutant NSCLC patients. However, ongoing research is needed to refine therapies for precise individualized treatment, addressing resistance mechanisms and optimal combination strategies.
A preclinical study found that mice stopped and restarted GLP-1s gained less weight over time, with a significant decrease in muscle mass. The researchers suggest that clinicians help patients preserve muscle mass while on these medications through exercise or nutrition.
Researchers at the University of British Columbia have developed a new method to target intrinsically disordered proteins, which are difficult to treat with medication. The approach has shown promise in slowing prostate cancer growth and could lead to new treatments for various diseases.
A new study reveals that bacteria can actively limit the spread of antibiotic resistance genes by deploying molecular gatekeepers called YokF. This mechanism blocks the transfer of beneficial genes, giving microbes a competitive advantage in dense microbial communities.
New findings render antibiotic-resistant bacteria vulnerable by disabling individual resistance and cross-protection. This approach offers new possibilities for treating resistant infections associated with cystic fibrosis and may inform the treatment of a broad range of antibiotic-resistant infections.
A study analyzing meconium samples from newborns found high prevalence of antibiotic resistance genes, including those linked to carbapenem resistance. The findings suggest that maternal transmissions and early hospital exposure contribute to the establishment of these genes in the neonatal gut.
A new study reveals that cancer cells may begin escaping therapy much earlier, triggered by a stress response that drives them into a temporary drug-tolerant state. Researchers identified an early molecular trigger: NF-κB, which acts as a regulator of cellular stress and survival.
The Microbiology Society's Annual Conference 2026 will bring together researchers from around the world to discuss antimicrobial resistance and its impact on global health. The conference will explore ways to slow the spread of superbugs through scientific research, policy, and international collaboration.
Scientists at the University of Virginia Health System have developed a suite of AI-powered tools, called YuelDesign, YuelPocket and YuelBond, to transform how new drugs are created. These tools can design drug molecules tailored to fit their protein targets exactly, even accounting for protein flexibility.
Researchers discovered that mutations in a key protein make yeast found in dogs with common outer ear infections more resistant to topical antifungals. The team recommends using shorter-tailed azoles as initial therapy for dogs with yeast ear infections, reserving longer-tailed azoles for recurrent or non-responsive cases.
A long-term public study found that phytochemicals from oregano and rosemary supported favorable gut health and growth performance in weaned pigs, preserving microbial diversity to improve nutrient utilization. The natural agents outperformed antibiotic growth promoters in terms of final body weight and gain-to-feed ratio.
Researchers discovered that antibiotic resistance genes were present in all groups, including patients with COPD, asthma, pulmonary fibrosis, and sarcoidosis, as well as healthy individuals. The study also found that recent antibiotic use was linked to higher prevalence of resistance genes.
A growing body of evidence suggests that daily use of antibacterial soaps, wipes, and other household products contributes to the global rise of antimicrobial resistance. Researchers call for policymakers to restrict these ingredients when there is no evidence of efficacy, reducing chemical pollution and protecting public health.
The European Region is struggling to detect and treat tuberculosis, with 1 in 5 cases going undiagnosed or unreported. Drug-resistant strains are also a major concern, with the region accounting for a disproportionate share of global cases.
Using azithromycin within one day triggers antibiotic resistance in the respiratory tract, according to a study published in Nature Microbiology. The researchers followed hospitalized COVID-19 patients and found that azithromycin changed the mix of microbes in the upper airway, leading to persistent changes for more than a week.
Research shows that bacteria harbor resistance genes may respond differently to antibiotics under non-standard conditions. This affects treatment efficacy and contributes to understanding antimicrobial resistance development and spread. Understanding these variations is crucial to combat global public health threats.
A University of Sydney-led study found that honey made from mixed floral sources has superior performance against bacteria, with high levels of bioactive compounds. The findings could help develop new treatments for drug-resistant infections while supporting bushfire recovery and sustainable beekeeping practices.
Researchers design nanoagents to carry antibiotics deep into bacterial infections, releasing them upon gentle ultrasound activation. This approach reduces antibiotic resistance and improves treatment of biofilm-related infections.
Researchers at Ohio University discovered that blocking the growth hormone receptor may help make lung cancer treatments more effective. Patients with low GHR tumors survived significantly longer than those with high GHR tumors, highlighting a potential new target for therapy.
Researchers developed a novel CRISPR-based technology called pPro-MobV that can remove antibiotic-resistant elements from bacterial populations. The new tool uses gene-drive thinking and has the potential to combat antibiotic resistance in healthcare settings, environmental remediation, and microbiome engineering.
Researchers have designed antibodies that recognize a unique sugar found on bacterial cells, providing a potential new treatment for multidrug-resistant hospital-acquired infections. The target of the antibody is pseudaminic acid, a sugar molecule produced exclusively by bacteria and used to evade immune responses.
A new hydrogel gel, inspired by nature's NETs, uses near-infrared light to kill bacteria and calm the immune system, promoting wound healing. Trials in mice and pigs show significant reduction in bacterial load and accelerated healing.
A study published in PNAS successfully eliminated pancreatic tumours in mice completely and durably, with no significant side effects. The treatment, combining three molecular targets, induced robust regression of experimental PDACs without causing tumor resistance.
Researchers at NUS Medicine discovered that genetic vectors can efficiently spread antibiotic resistance within the gut, enabling even highly virulent bacteria to acquire drug resistance. This finding sheds light on the emergence of 'superbugs' in healthcare settings.
Researchers have demonstrated that Janus nanoparticles can disrupt drug-resistant bacteria's defenses, restoring the effectiveness of conventional antibiotics. The approach uses nanoparticles to create pores in bacterial membranes, allowing antibiotics to flood in and execute their killing function.
Researchers at the University of Oulu have developed a pine-bark-based water-treatment medium that efficiently removes antibiotics and other pharmaceuticals from wastewater treatment plant effluent. The method uses modified pine bark and combination materials, achieving removal efficiencies in the tens of percent to over 90%.
Researchers from New England Biolabs and Yale University have developed a first fully synthetic bacteriophage engineering system using the High-Complexity Golden Gate Assembly platform. This method simplifies strain engineering techniques, allowing for rapid creation of tailored therapeutic strains to overcome antibiotic resistance.
Salk Institute scientists found distinct disease courses and tolerance mechanisms in younger and older mice with sepsis, indicating a need for age-tailored therapies. The study suggests that future treatments may focus on controlling infection-generated damage rather than just targeting the pathogen.
Researchers analyzed faecal samples from 82 captive and 16 wild marsupials, revealing new microbial species and antimicrobial resistance. The study found that host family, location, and diet contributed to variance between different microbiomes.
Researchers developed a new method to measure how effectively antibiotics kill bacteria, crucial for treating complex infections. The 'antimicrobial single-cell testing' method predicts treatment success by observing individual bacteria under different conditions.
Researchers at McMaster University have identified a molecule called butyrolactol A, which can synergize with echinocandin drugs to kill fungi that the drugs alone cannot. The discovery marks a breakthrough in the fight against drug-resistant fungal infections, including those caused by Cryptococcus neoformans and Candida auris.
Researchers found that pitavastatin directly inhibits the anti-apoptotic protein Mcl-1, a key driver of survival and resistance in TNBC cells. The study showed pitavastatin effectively eliminates cancer stem-like cell populations and reduces tumor growth, angiogenesis, and lung metastasis.
The new clinical standards for antimicrobial stewardship in tuberculosis care aim to integrate TB into existing AMS frameworks, strengthening surveillance and resistance monitoring. The standards prioritize effectiveness, safety, and resistance prevention, promoting structured expert consultation services and targeted testing.
Researchers create a novel mathematical framework to control biological noise, enabling precise single-cell control. The 'Noise Robust Perfect Adaptation' technology suppresses stochastic fluctuations while maintaining stable average behavior, with promising applications in cancer therapy and synthetic biology.
Researchers at Harvard Medical School have uncovered crucial insights into how a new class of antiviral drugs works, shedding light on an important tool for fighting drug-resistant strains of herpes simplex virus. The discovery may lead to new pathways for treating herpesviruses and other kinds of DNA viruses.
The review highlights alarming trends in AMR, including rising resistance to last-line antibiotics, regional disparities, and the rapid spread of resistant genes through global travel and agriculture. Innovative drug combinations and precision-based treatment strategies offer hope in reclaiming control over this growing crisis.
Researchers at UT Health San Antonio are developing APOBEC inhibitors to block tumor mutation rates and slow cancer's evolution. The goal is to strengthen current therapies and improve their long-term effectiveness.
Researchers discovered a tiny RNA molecule called PreS that helps viruses copy their DNA more efficiently and boost replication in bacterial cells. This discovery provides important insights for designing smarter phage-based therapies against antibiotic-resistant infections.
Researchers discovered glioblastoma cells use PRDM9 to survive chemotherapy and regrow tumors. By blocking PRDM9 or cutting off cholesterol supply, persister cells can be wiped out, improving survival in mice. This breakthrough offers new strategies for treating the deadliest brain cancer.
Researchers at the University of Plymouth investigate why drugs used to treat other tumours are ineffective against NF2-related schwannoma and meningioma tumours. They explore repurposing clinically tested cancer drugs to target MDR mechanisms, which may lead to effective therapies for patients with these tumours.
A UBC Okanagan study found that microdosing psychedelics temporarily improves mood, creativity, and wellbeing, but these effects do not persist on non-dosing days. The study, tracking over 1,435 participants from 49 countries, suggests that microdosing may 'reactivate' or build upon prior effects of larger-dose psychedelic experiences.
Cholera-causing bacteria show substantial genetic diversity and widespread multi-drug resistance to commonly used antibiotics in Africa. A new study analyzed genomic data from 104 isolates across Cote d'Ivoire, Ghana, Zambia, and South Africa, highlighting the urgent need for antimicrobial stewardship.
A study found that viral interactions inside cells influence antiviral resistance outcomes, while a less potent drug may ironically improve its future utility by promoting social interactions in viruses. The researchers suggest a trade-off between hitting the virus hard and allowing resistance to rise.
A specific protein, RASH3D19, activates the RAS signaling pathway involved in aggressive tumor growth and resistance to KRAS inhibitors. Blocking RASH3D19 improves outcomes in preclinical models, suggesting a potential therapeutic strategy.