Articles tagged with Aptamers
Researchers at Duke University Medical Center have devised a way to deliver the right therapy directly to tumors using special molecules called aptamers. A tumor-targeting RNA aptamer was found to specifically bind to RNA helicase p68 in colorectal tumors, offering a promising approach for cancer treatment and therapy delivery.
Researchers at Duke University Medical Center have engineered a way to design drugs and their antidotes together, improving patient care. The new approach allows for the creation of universal antidotes for aptamers, which can reverse the action of any aptamer drug, regardless of sequence, shape, or target.
Researchers at University of Illinois create a new cancer drug delivery system using aptamers, achieving high cell killing efficiency while sparing healthy cells. The approach integrates small molecules and antibodies, offering a general toolbox for treating various cancers.
New DNA and RNA aptamers have shown promise as treatments for various diseases, including macular degeneration and cancer. Their ease of production, stability, and chemical modifications enhance their drug-like properties.
Researchers have developed a novel biosensor using carbon nanotubes and aptamers to detect Salmonella typhi bacteria at concentrations as low as one bacterium in 5 mL. The technique enables fast, simple, and precise detection of micro-organisms.
Researchers discovered that an RNA aptamer specific to ricin's catalytic chain can protect cells from ricin-induced damage. The aptamer, called 31RA, inhibits the toxin's enzymatic activity and neutralizes its translation-inhibiting effects.
Researchers have identified broad-spectrum aptamers that can treat many subtypes of HIV-1 by inhibiting reverse transciptase. These synthetic molecules can reduce viral infectivity and block the normal action of RT enzyme.
University of Florida chemists develop a new tool to identify biomarkers for serious diseases, potentially leading to earlier detection and improved treatment. The technique uses aptamers to recognize cancer cells and could have applications in disease detection, imaging, and therapy.
Researchers at the University of Florida have developed a new method to detect subtle differences in leukemia cells using molecular probes called aptamers. This technique has the potential to improve diagnosis and treatment for cancer patients by providing more precise and personalized care.
Researchers created hairpin-shaped RNA molecules that can differentiate between riboswitches in on and off states. These aptamers could help find new antibiotics by binding to the switches of pathogens, blocking essential protein synthesis.
Researchers at the University of Illinois developed a rapid diagnostic test for cocaine detection using tiny gold spheres and aptamers. The test strip, which can be used with just a sample dip, accurately identifies cocaine presence and has broad practical application potential.
Researchers at the University of Florida have successfully tested a new method to detect leukemia cells and believe it can be used to diagnose cancer at the molecular level. The technique uses aptamers, short strands of DNA that can recognize cancerous cells without prior knowledge of molecular changes associated with the disease.
Aptamers may have therapeutic effects against cancer by blocking RET downstream signaling events. The study uses whole-cell SELEX to identify macromolecules with potential therapeutic effects against other transmembrane receptors involved in tumorigenesis.
Researchers at Duke University Medical Center have developed a method to create a class of drugs with controllable effects, allowing for the creation of matching antidotes. The new approach uses aptamers, which are compounds made of nucleic acid that bind directly to target proteins, to inhibit protein activity.
NeXstar Pharmaceuticals has created an aptamer-based diagnostic assay for its VEGF inhibitor, enhancing cancer treatment possibilities. The ELONA system uses an aptamer to detect small amounts of clinically important substances, overcoming limitations of traditional antibodies in diagnostic assays.