Articles tagged with Biotinylation
Researchers at the Lewis Katz School of Medicine found that calcium sensor MICU1 regulates mitochondrial ultrastructure, governing inner and outer mitochondrial membrane structure. This discovery provides a framework for understanding cellular energetics and cell death, with implications for diseases such as cardiovascular disease.
Researchers developed ancestral biotinylation enzymes to improve proximity-dependent biotin identification. The new AirID enzyme showed higher activity, specificity, and lower toxicity than previous types, enabling comprehensive analysis of protein interactions.
Scientists at Cincinnati Children's Hospital Medical Center have discovered how a rare nerve tumor works and found a potential new way to fight it. The study identifies a key protein called Merlin and its connections to other proteins in the brain, which may lead to a breakthrough in treatment.
Researchers have engineered a novel variant of streptavidin that forms a stable monomer and binds biotin without crosslinking, allowing for efficient biotinylation of targets. The optimized monomeric streptavidin (mSA) can be fused to proteins to create a bi-functional molecule, enabling proximity-dependent biotinylation techniques.