New research suggests that ocean turbulence and horizontal stirring will dramatically increase in the Arctic and Southern Oceans due to human-induced Global Warming. The study uses ultra-high-resolution simulations to investigate how mesoscale horizontal stirring (MHS) responds to warming, revealing a pronounced future intensification ...
Researchers have developed a new compound, SHP1705, that selectively attacks glioblastoma stem cells by hijacked circadian clock proteins. The compound was found to be safe and well-tolerated in humans during a phase 1 clinical trial.
A multidisciplinary team of researchers will investigate how animals detect magnetic fields, building on existing knowledge that a blue-light sensing protein called Cryptochrome plays a key role. The study's findings may lead to the development of non-invasive measurement tools and magnetic cell therapies.
Researchers analyzed genomes of 363 bird species and found significant variations in cryptochrome 4 gene, indicating adaptation to environmental conditions. This specialization could be related to magnetoreception in migratory birds.
A new bioelectronic system has been developed to measure electrical conductivity in microorganisms without requiring biofilm formation on electrodes. This approach has revealed that Pseudomonas aeruginosa and Bacillus subtilis possess conductive properties, with potential applications in environmental energy technologies.
Researchers at Johannes Gutenberg University Mainz discovered a unique cryptochrome protein in marine bristle worms that distinguishes between sunlight and moonlight. The protein's structure reveals an unusual light-induced change from dimer to monomer arrangements, allowing it to synchronize reproduction with lunar phases.
Researchers discovered a unique protein in bristle worms that distinguishes between sunlight and moonlight. The protein, L-Cry, disassembles under intense light and forms a stable connection in the dark.
Researchers have identified the structure of the circadian rhythm photosensor and its target in fruit flies, revealing key components of the circadian clocks. The study also shed light on how DNA damage is repaired in a cell and found genetic variations that help flies adapt to changing latitudes.
Research at the University of Massachusetts Amherst shows that circadian disruption from jet lag can harm adult neurogenesis, which supports learning and memory. The study found that the Cryptochrome 1 gene regulates this process and that misalignment can lead to adverse health effects such as dementia and mental illness.
The study found that cryptochromes are conserved across various green organisms, influencing cell structures responsible for photosynthesis. The researchers discovered that a specific cryptochrome can actually lead to increased growth despite appearing darker green due to denser packed cell membranes.
Researchers have identified a light-sensitive protein in birds' eyes that is also sensitive to magnetic fields. The discovery sheds light on how migratory birds navigate using the Earth's magnetic field.
Researchers discover that cryptochrome 4, found in birds' retinas, is sensitive to magnetic fields and could be the long-sought magnetic sensor. The team deciphered the mechanism behind this sensitivity, which arises from electrons moving within the molecule after blue-light activation.
A study by researchers at UC Santa Cruz reveals the molecular mechanisms behind the 'night owl' sleep disorder, which affects one in 75 people of European descent. The genetic mutation identified alters a key component of the biological clock, causing people to stay up late and sleep in late.
Researchers discovered a new protein called cryptochrome that repairs DNA damage caused by ultraviolet radiation, a function previously attributed to photolysis in cells. This breakthrough highlights how proteins can evolve and acquire new functions over time.
Scientists have developed a tiny device to study the avian magnetic orientation mechanism, challenging the prevailing photochemical theory. The experiment found that birds with portable devices attached were not disoriented when exposed to local oscillating magnetic fields, suggesting alternative components of the magnetoreception system.
Researchers discovered a sustained light response in central brain neurons to blue and ultra violet light, informing internal circadian processes about the time of day. The study sheds light on non-image-forming vision and its role in regulating circadian rhythms.
Scientists have found that cryptochromes from migratory birds have evolved a mechanism that enhances their ability to respond to light, allowing them to sense and respond to magnetic fields under nighttime conditions. This discovery sheds light on how vertebrate cryptochromes function in low-light environments.
A study found that weak magnetic fields stimulate the production of reactive oxygen species in human cells, which can be beneficial or harmful. The protein cryptochrome is involved in this process, helping to explain the effects of PEMF-based therapies on diseases like depression and Parkinson's disease.
Researchers at Lund University discovered that Cry4 protein in birds' eyes is a key magnetoreceptor, providing constant levels throughout the day. This finding supports the idea that other animals have magnetic receptors and may aid in developing new navigation systems.
Migratory birds use a light-dependent protein called cryptochrome 4 to navigate, which is specifically expressed in the outer segment of double-cone photoreceptor cells. This discovery provides new insights into magnetoreception and could help protect wildlife from human disturbances.
A UCLA-led team reports the discovery of blue-light inhibitor of cryptochromes (BICs) that regulate plant growth, growing Arabidopsis plants at least twice as tall without cryptochromes. BICs likely have counterparts in human circadian clocks and other organisms.
Researchers have uncovered the mechanism by which cryptochrome 2, a key photoreceptor, is switched on and off in plants. This desensitization mechanism allows plants to maintain homeostasis of their blue light responsiveness in fluctuating light environments.
Researchers have used radical pair analysis to enhance the performance of cryptochrome-based magnetic compass sensors, finding that electron spin relaxation can improve sensitivity. The study's findings could lead to the development of low-cost and environmentally-friendly electronic devices capable of detecting weak magnetic fields.
Researchers at Goethe University Frankfurt discovered that birds use a light-independent radical pair to detect the Earth's magnetic field lines. This finding indicates a special evolutionary adaptation in birds, as cryptochrome is used exclusively for light perception in other organisms.
Researchers detect cryptochrome 1 in photoreceptors of dog-like carnivores and primates, hinting at a magnetic sense linked to the visual system. The molecule's presence suggests that these animals may use it to perceive the Earth's magnetic field.
Scientists at the Salk Institute discovered a way plants assess shade to outgrow menacing neighbors, triggering accelerated growth through molecular sensors. This finding could improve crop productivity and help farmers grow crops closer together.
Researchers at the University of Tokyo have developed a new microscope that can observe magnetic sensitivity in photochemical reactions within sub-cellular structures. The microscope, called TOAD imaging, allows for the detection of radical pairs formed from flavin adenine dinucleotide (FAD) and their response to weak magnetic fields.
Researchers found that PASD1, a protein associated with cancer cells, suppresses the circadian clock. The discovery offers new insights into the molecular mechanisms of the biological clock and its potential role in driving cancer growth. Understanding how PASD1 regulates the clock could lead to developing new therapies.
Researchers have found that birds can sense the earth's magnetic field and use it to orient themselves. The cryptochrome protein is thought to play a key role in this process.
Researchers at UNC School of Medicine discovered how Period and Cryptochrome genes interact to control the circadian clock. The findings have implications for developing drugs for diseases such as cancer, diabetes, and metabolic syndrome.
Researchers at UC San Diego have discovered a chemical called KL001 that affects the activity of cryptochrome, a key protein regulating our circadian rhythm. This finding offers a promising direction for developing new treatments for type 2 diabetes.
Research by UMass Chan Medical School shows that the human retina protein CRY2 can function as a light-sensitive magnetic sensor in Drosophila. This finding may pave the way for further investigation into human magnetoreception and its potential applications.
Researchers at UCI have found a second form of phototransduction light sensing derived from vitamin B2, which challenges the long-held understanding of this process. This discovery may reveal new information about cellular processes controlled by light and has implications for optogenetics.
Scientists have found a key protein regulating biological clocks also regulates glucose production in the liver, improving diabetic mice health. Altering this protein can open new treatments for obesity and type 2 diabetes.
Researchers found that superoxide plays a key role in bird migration by influencing the protein cryptochrome in their eyes. The molecule allows birds to 'see' Earth's magnetic field, enabling them to navigate. However, humans lack this ability due to evolutionary trade-offs between longevity and orientational ability
Researchers have determined the molecular structure of a plant photolyase protein similar to two cryptochrome proteins controlling the human clock. The study reveals key differences between human and plant cryptochromes, shedding light on the complexities of the human sleep/wake cycle.
Researchers discovered that mammalian clock proteins respond directly to light, similar to plant cryptochromes. In humans and animals, this response affects circadian rhythms differently than in mice, where missing cryptochromes lead to complete loss of rhythm behaviors.
Researchers at Washington University ophthalmology discovered that a non-opsin protein, cryptochrome, plays a dominant role in controlling pupil constriction independently of light-sensitive photoreceptor cells. The study found that reducing cryptochrome production by 50% resulted in a corresponding loss of sensitivity to light.
Researchers investigated sleep regulation in mice lacking cryptochrome molecules, revealing a new model for understanding sleep mechanisms. The study found that these mice did not exhibit increased non-REM sleep duration after sleep deprivation.
Researchers identify a crucial pathway in the retina that allows the pupil to respond to light, even when rods and cones are absent. This discovery suggests a complex non-visual photoreceptive system in the inner retina that helps regulate the body's internal clock and unconscious activities.
Researchers at TSRI have uncovered a mechanism by which plants adjust their flowering cycles to optimize productivity. By manipulating the timing of plant development, crops may be able to produce faster and more nutritious yields.
Researchers have discovered a new light-sensitive pigment called cryptochrome, which controls the circadian rhythm in mammals, regulating bodily functions such as body temperature and blood pressure. The discovery may lead to better treatment for depression and reduce accidents during late-night shifts.