Articles tagged with Dna Polymerases
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Researchers at University of Pittsburgh discovered that loss of pol zeta's activity in mouse cells leads to chromosomal instability and tumor development. The study suggests that pol zeta may act as a tumor suppressor gene, preventing double-stranded breaks in chromosomes.
Researchers at Lawrence Livermore National Laboratory used fluorescence resonance energy transfer (FRET) to study the transcription of genes in DNA. They found that the initial and final stages of this process occur simultaneously, contradicting earlier theories that proposed separate processes for these stages.
A study found that larger DNA bases can lead to increased efficiency in DNA replication, allowing for more genetic mutations. This discovery sheds light on the mechanisms underlying genetic evolution.
Two DNA polymerases, Pol III and Pol IV, coordinate their action to cross obstacles in the replication process. Pol III copies DNA while proofreading for errors, but can stall if it encounters a problem, allowing Pol IV to take over.
Researchers at Scripps Research Institute create DNA with a third pairing, allowing for replication of unnatural bases. The development improves fidelity to near-perfect levels, paving the way for applications in biotechnology, medicine, data storage, and security.
A fourth kind of RNA polymerase, Pol IV, has been found in plants, playing a crucial role in maintaining genome integrity. It helps direct DNA methylation to specific sequences, ensuring proper gene expression and preventing developmental problems. The discovery sheds light on the unique features of plant biology.
Researchers have discovered that actin acts as a binding protein in the nucleus, recruiting other proteins to facilitate DNA transcription. This process is crucial for cellular activity and understanding its dysregulation is essential for developing new treatments for diseases like cancer.
Researchers discovered a DNA repair enzyme that bypasses damaged spots in the DNA sequence to ensure cell survival. POL-Q's two-step process is the most efficient of any known DNA polymerase, making frequent errors in the process.
A DNA mutation called 8-oxoguanine can evade detection by DNA replication enzymes, allowing it to persist in the DNA strand and potentially lead to stable incorporation of a lethal mutation. This discovery sheds light on how oxidative lesions affect DNA replication and has implications for cancer risk.
The grant will fund studies on how the enzyme, DNA polymerase, accurately copies genetic information, revealing its unique catalytic selectivity and minimizing errors, which could inform cancer research.
Researchers have discovered that the DNA copying enzyme, DNA polymerase, retains a "short-term memory" of mismatches and halts itself past the point of the mismatch. The study found that mismatch structures differ dramatically from previous indirect biochemical studies, revealing why stalling occurs.
Researchers at Stanford Medicine have made groundbreaking discoveries about the structure of RNA polymerase, a crucial enzyme in gene expression. The team's findings reveal intricate details about the enzyme's interactions with helper molecules and DNA, providing a deeper understanding of transcription and protein production.
Researchers discovered a specialized DNA polymerase that can rescue stalled replication processes when encountering foreign material, even if it contains damage. This shows the remarkable ability of cells to reproduce and cope with genetic errors.
Scientists have directly observed RNA 'proofreading' for the first time using nanotech instruments, revealing a backtracking motion that corrects genetic errors. The study provides strong evidence for the self-correcting mechanism of RNA polymerase, improving our understanding of gene expression and potentially informing human health.
E. coli cells quadruple Pol IV enzyme production as they starve, allowing them to adapt and survive through increased genetic variation. This discovery could help hospitals combat nosocomial infections by developing new strategies for quickly mutating bacteria.
Researchers discovered TB bacteria use an error-prone DNA polymerase, DnaE2, to introduce mutations and increase drug resistance. The enzyme plays a key role in the emergence of multidrug-resistant tuberculosis.
Using optical tweezers, researchers have observed the dynamic structure of individual nucleosomes for the first time. They found that DNA in these units can be released from histones through a three-stage process, allowing enzymes like RNA polymerase to access genetic information.
Researchers found that HBV polymerase mutations can restore viral replication rate while maintaining drug resistance, affecting treatment efficacy. Entecavir proved effective against even the most vigorous drug-resistant mutants, offering a promising alternative to lamivudine.
Duke University researchers discovered an enzyme that copies DNA in living cells can also function in crystal form, revealing details of its intricate machinery. The study sheds light on the enzyme's ability to incorporate only correct nucleotide pieces into DNA, a critical process for life.
A new DNA polymerase, dubbed zeta, allows yeast cells to replicate damaged DNA, increasing their odds of survival but also the risk of mutations. This enzyme is a last-gasp option for cells when all attempts to fix damaged DNA have failed, and its discovery sheds light on how organisms cope with this constant problem.