Articles tagged with Double Stranded Dna
Researchers have discovered that reverse transcriptase, the target of major anti-HIV drugs, can flip between binding orientations to facilitate two distinct catalytic activities. This dynamic behavior is regulated by nonnucleoside RT inhibitors, which hinder the enzyme's ability to convert single-stranded DNA to double-stranded DNA.
Scientists have determined the crystal structures of two DNA-repair proteins, AlkB and ABH2, which repair alkylation damage to DNA. This discovery could lead to designing molecules that interfere with the repair process, making cancer treatment more effective.
Researchers have created a DNA nanoscale object, a regular dodecahedron, by using programmed oligonucleotides with three branches. The structure is formed through a self-assembly process and exhibits unique properties, such as being flexible under pressure.
Scientists have developed a method to produce rigid DNA nanorings with a tailored gap, allowing for the incorporation of functional molecules. The rings can be equipped with desired properties, such as anchors that precisely bind them to other components.
Researchers at Brookhaven National Laboratory discovered a way to control the assembly of gold nanoparticles using rigid, double-stranded DNA, which can lead to more efficient energy generation and data storage. The technique takes advantage of DNA's natural tendency to pair up components, allowing for more efficient assembly.
Researchers at the University of Illinois have developed a DNA-based sensor that can detect lead ions in real-time. The sensor uses catalytic DNA with high metal ion selectivity and sensitivity to fluorescence detection, making it an ideal candidate for environmental monitoring and clinical toxicology applications.
Researchers at Northwestern University have developed a novel DNA detection method that is more accurate, less expensive, and easier to use than conventional methods. The scanometric DNA array detection method uses gold nanoparticles and a flatbed scanner to detect target DNA with high sensitivity and selectivity.
Eric T. Kool, a Stanford University professor, has developed a new understanding of how enzymes make copies of DNA by surrounding the double-stranded molecule and using it as a template. He aims to apply this technique to genetic therapy to inhibit genes linked to inherited diseases.
Researchers at HHMI discover XRCC4, a new type of genomic caretaker that helps repair double-stranded DNA breaks. In mice without p53, XRCC4-deficient mice survive embryonic development and show normal behavior.
Harvard researchers have created the first atomic-resolution image of a donut-shaped enzyme that unwinds the DNA double helix for replication. The structure reveals how six individual polypeptide lobes arrange themselves to look like a ring of bread buns, providing new insights into the molecular motor's mechanism.
Scientists at the Technion-Israel Institute of Technology have successfully created a working electronic component using DNA to assemble a conducting wire. The wire, 100 nanometers wide, has potential properties that could be used to make computer memories, and its narrow size allows for potentially much faster computer chips.
A new DNA production method dubbed 'rolling circles' has been developed by University of Rochester chemist Eric Kool, allowing for easy and inexpensive production of large quantities of DNA. This technique uses circular DNA strands that can be replicated exponentially without the need for expensive enzymes or complex equipment.
Duke University researchers discovered an enzyme that copies DNA in living cells can also function in crystal form, revealing details of its intricate machinery. The study sheds light on the enzyme's ability to incorporate only correct nucleotide pieces into DNA, a critical process for life.
Scientists have detailed the structure of yeast topoisomerase II, a key player in cell division. This knowledge could lead to the development of new anticancer drugs that target this enzyme. The discovery also has implications for the design of antimicrobial drugs and the treatment of cancer.