Articles tagged with Drug Discovery
Researchers at UCI School of Medicine have discovered the molecular basis for therapeutic actions of an African folk medicine used to treat various illnesses, including diabetes and epilepsy. The study found two components of the Mallotus leaf extract bind to a previously unrecognized binding site on KCNQ1 potassium channels.
A multidisciplinary research team has provided fundamental new insight into the mechanism of dimethyl fumarate, a medical drug used to treat multiple sclerosis and psoriasis. The results describe an allosteric covalent inhibition of p90 ribosomal S6 kinases, pointing to an effective mechanism of kinase inhibition.
Researchers at Kanazawa University have identified three new compounds from the leaves of a threatened tropical plant species with potent antiproliferative activities against various human tumor cell lines. The study highlights the potential of rainforest plants as a rich source of bioactive natural products for cancer drug discovery.
Researchers at University of Montreal discovered how metformin affects cell glucose uptake and metabolism, revealing a link to iron distribution. This finding may explain metformin's potential benefits beyond diabetes treatment, including prevention of chronic diseases like cancer.
Purdue researchers, including Nobel Prize winner Ei-ichi Negishi, developed a new chemical process to synthesize drug-like molecules with ultra-high purity. The technology produces high yields and has a broad scope for use among boron-based drugs.
The special issue brings together contributions from top academics and industry experts, highlighting the use of generative chemistry and GANs for de-novo molecular design. Experimental validation of generated molecules demonstrates high activity and selectivity in a novel inhibitor of Janus Kinase 3.
Researchers found a new mechanism involving KCNB1 potassium channels that builds up toxins in brains affected by Alzheimer's disease. The build-up is caused by oxidation and can also contribute to other conditions such as traumatic brain injury.
Researchers at OHSU have discovered the three-dimensional structure of a membrane channel critical in controlling blood pressure. The breakthrough provides a starting point for developing better treatments for diseases associated with this channel, including severe hypertension and heart failure.
Researchers at GC/CUNY have made a major breakthrough in controlling the 3D structure of molecules, enabling the rapid modification of molecular structures used in drug discovery. This new process offers tremendous promise for developing novel drug molecules with medicinal or industrial applications.
The research collaboration aims to create human organs-on-chips using miniature devices that mimic specific tissues and organs. These organs-on-chips have the potential to predict drug activity and toxicity more accurately than animal models.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have found that amodiaquine suppresses blood vessel formation through both the apelin and VEGF pathways, reversing vascular eye damage in animal models. The compound blocks the receptor's function by binding to a unique area, inhibiting apelin's ability to drive blood ve...
Researchers at Insilico Medicine developed an Entangled Conditional Adversarial Autoencoder (ECAAE) that generates molecular structures based on various properties. The generated molecule demonstrated high activity and selectivity against a specific protein, laying the foundation for AI-powered drug discovery.
Pharmaceutical companies are adopting improved safety screening strategies to enhance the drug discovery process, including integrated screening paradigms and computational methods. These approaches aim to identify higher-quality drug candidates and mitigate off-target toxicity.
Researchers at UTSA made a groundbreaking discovery involving the regulation of thiols in mammals. The study found that human bodies may be capable of breaking fluorine-carbon bonds in drugs, opening new possibilities for pharmaceutical treatments.
Researchers have crystallized serotonin receptors bound to several compounds, revealing why some drugs cause severe side effects while others do not. The study provides valuable insight into the receptor's structure and binding mechanisms, enabling drug developers to create safer and more effective medications.
Researchers at the University of Zurich have developed a new method for alleviating chronic itch by targeting specific neurons in the spine that prevent itch signals from being relayed to the brain. The experimental drug has been shown to be effective in mice and dogs, with significant reductions in scratching and improved skin healing.
The Harrington Discovery Institute has announced three new scholars in collaboration with FFB and ADDF, selected through a competitive review process for their research on therapies for retinal degenerative diseases and Alzheimer's disease. The institute provides financial support and drug development assistance to accelerate these pro...
Scripps Research scientists have developed a powerful new strategy for synthesizing molecular skeletons of chemicals used in drugs and other important products. The method combines two chemical reactions, C-C cross coupling and cycloaddition, providing unprecedented flexibility and control over chemical synthesis.
A new compound with potential to treat visceral leishmaniasis has been discovered through collaboration between the University of Dundee, GSK and Wellcome. The compound works by inhibiting an enzyme called CRK12, offering a novel approach to tackling the disease.
This special issue showcases recent advances in high-throughput flow cytometry for drug discovery, including novel applications and expert insights. Examples include HTFC for single-cell analysis, biologic drugs, and CAR-T therapy.
Researchers at the University of Pennsylvania and Syracuse University have developed a compound that effectively controls hyperglycemia in animal trials without causing nausea and vomiting. The modified compound is less absorbed into brain regions that trigger these side effects, leading to vastly improved tolerance.
Researchers at Cardiff University have developed a potential new treatment for schistosomiasis and fascioliasis, two devastating tropical diseases. The goji berry-derived drug compound shows promise in combating the parasites that cause these conditions.
Scientists have identified two small-molecule compounds that specifically target the STING protein, which plays a key role in triggering an immune response. These compounds effectively blocked STING-mediated cellular activation and demonstrated therapeutic potential in mouse models of autoinflammatory disease.
Researchers at University of Otago have discovered a novel property of Bedaquiline, a new anti-tuberculosis drug that could help develop more effective treatments for tuberculosis. The study's findings suggest that the drug works by disrupting energy generation in Mycobacterium tuberculosis cells, offering potential for designing more ...
Insilico Medicine introduces a novel deep neural network architecture called Reinforced Adversarial Neural Computer (RANC) for de novo molecular design. RANC outperforms other methods in generating unique structures and passing medical chemistry filters.
AcuraStem has been awarded a $3.7 million SBIR grant to continue research on a small molecule therapeutic for ALS, utilizing induced motor neuron cellular models and precision platform iNeuroRx°. The grant supports the development of AS2015, targeting expansion repeats in the C9ORF72 gene.
A new study by Scripps Research reveals that bacteria-derived molecules called thiocarboxylic acids have potential as warheads and could be used to create more effective drugs. The discovery was made after researchers found that these natural products can bind to biological targets better than lab-made molecules.
A recent international agreement emphasizes the need for human-relevant research in drug discovery, citing a significant decline in successful new drug approvals. The agreement proposes standardized data sharing, consistent ontologies, and prioritization of human-based methods to revitalize the drug development process.
Researchers discovered a chemical compound that lowers sugar levels as effectively as metformin but with a 30-times lower dose, providing an alternative treatment option for patients unresponsive to the current medication. The study published in PLOS One could lead to the development of a new and effective drug to fight diabetes.
Researchers at UBC's Okanagan campus found that men who have used psychedelic drugs are less likely to engage in partner violence. The study suggests that psychedelics may help improve emotion regulation and reduce violent tendencies.
Clinical Trials in a Dish (CTiD) offers a novel strategy to test drugs on patient cells before moving into actual clinical trials. CTiD studies have opened up new avenues for screening cell-based safety and toxicity at the population level, enabling efficient testing with reduced costs.
Researchers have found a link between bacteria metabolism and cell-to-cell communication, which could lead to the development of new drugs that block toxic molecules or prevent biofilm formation. By disrupting quorum sensing and biofilm forming in bacteria, these drugs may prevent infections such as urinary tract infections.
The study reveals unexpected molecular behavior in ultra-nanoscale channels, where neutral molecules behave as though carrying a charge. The team developed an algorithm for selecting optimal nanochannel size for each drug, but found that current theories were unable to explain the observed effects.
Researchers at Duke University have developed a technique to capture RNA molecules in precise images, revealing new opportunities for drug discovery. The method identifies potential anti-HIV compounds from millions of possibilities, showcasing its accuracy and potential to treat various ailments.
Eight out of ten transformative medicines in the US between 1985 and 2009 originated from fundamental discoveries, with an average time to approval of 30 years. Curiosity-driven science is essential for discovering new medicines.
Researchers have discovered an alternative strategy to combat antimicrobial resistance by repositioning colloidal bismuth subcitrate, which effectively paralyzes multi-resistant superbugs and suppresses the development of antibiotic resistance. The findings offer a promising new approach to treat deadly infections caused by CRE and CRKP.
Researchers at Nagoya University have successfully determined the crystal structure of the gastric proton pump, a key enzyme in stomach acid secretion. The study sheds light on how the pump expels hydrogen ions into the stomach despite its acidic environment.
Biogerontology Research Foundation's Chief Science Officer, Professor Alexander Zhavoronkov, will share his projections on how AI is set to revolutionize biopharma for aging and biomarker discovery. He will reveal the latest progress in AI and drug discovery at Pioneers18 in Vienna.
Researchers at Trinity College Dublin have discovered a potential 'off-switch' for inflammation by identifying the molecule itaconate, which can block production of inflammatory factors and protect against lethal inflammation. This breakthrough could lead to new anti-inflammatory medicines for diseases such as arthritis and heart disease.
A study discovered that an experimental drug connected to fat regulation prevents the formation of kidney stones in mice. The researchers found that the β3-agonist reduced inflammation in kidneys by consuming free fatty acids, potentially preventing both obesity and kidney stones. Further studies are needed to confirm these findings.
LSU researchers developed a computer-assisted drug repositioning process to identify existing drugs for rare diseases. They matched protein structures and functions with existing drug interactions to help patients receive effective treatment.
Researchers at TSRI have developed a new desulfonylative cross-coupling reaction that simplifies the synthesis of drug-like molecules, including alkyl-fluorinated compounds. This method paves the way for creating new types of compounds and facilitating the synthesis of pharmaceuticals.
University of Alberta researchers have found the Ebola polymerase enzyme, which may lead to more effective research and better treatments for the often fatal infection. The discovery allows for the study of Ebola inhibitors in any lab environment, accelerating the search for antiviral medicines.
Researchers at Australian National University have identified molecular similarities across six pharmaceutical drugs to reduce unwanted side effects. The study, published in Proceedings of the National Academy of Sciences, aims to inform future scientists on how to design more specific drugs with fewer side effects.
Researchers propose roadmap for making humans resistant to radiation and stress damage, with a focus on radioresistance. The strategies aim to maximize productive life years in space, addressing challenges like high-LET radiation.
McMaster University engineers have developed a printed paper-based device that speeds up and improves the accuracy of drug screening. The technology uses a printable hydrogel to filter out inaccurate results, reducing the time and cost associated with drug discovery.
Researchers at U of T have designed a new antimicrobial material to minimize recurrent caries under fillings, affecting 100 million patients annually. The novel material packs 50 times more bacteria-fighting drugs than traditional options, offering a potential solution to this common dental problem.
Researchers at University of Toronto have developed technology for creating durable disease-fighting molecules that can last longer in the body, reducing frequent drug injections. Mirror-image versions of existing drugs, such as GLP1 and PTH, have been created using computational approach, showing longer-lasting effects on cells.
Researchers at University of Bristol have successfully trapped objects larger than the wavelength of sound in an acoustic tractor beam, paving the way for levitation of humans. The discovery uses rapidly fluctuating acoustic vortices, which are stabilised by controlling the rate of rotation.
Researchers at the University of Kansas have developed a method to screen millions of human antibodies for rapid therapeutic discovery, overcoming limitations of single-cell cloning. The breakthrough technology identifies highly potent antibodies and provides insights into human immune responses to vaccines and infections.
A novel deep-learning based hematological human aging clock predicts the biological age of individual patients with high accuracy. The model outperforms chronological age in predicting all-cause mortality, highlighting population-specific patterns of aging.
A new machine-learning model can accurately predict protein-drug interactions based on a few reference experiments or simulations, accelerating the screening of candidate molecules thousands of times over. The algorithm can also tackle materials-science problems, revolutionizing materials and chemical modeling.
Researchers at The University of Manchester have discovered that uranium can perform reactions previously thought impossible, opening the door to new ways of producing materials and chemicals. This breakthrough could lead to the creation of truly biodegradable hard plastic and new medicines.
Researchers have validated five new genes responsible for Amyotrophic Lateral Sclerosis (ALS), a fatal neurological disorder. The study uses AI-powered technology to accelerate the discovery of new treatments by identifying key proteins linked to the disease.
Aric Rogers' research discovered that NMD plays a critical role in extending lifespan under dietary restriction conditions. The grant will help expedite the development of 'DR mimetics,' drugs that mimic the effects of DR on longevity, potentially leading to new therapies.
The new Connectivity Map includes over 1.3 million gene expression profiles from multiple cell lines treated with chemical or genetic perturbations, enabling the study of small molecule and gene function. This expanded resource accelerates drug discovery efforts by predicting how small molecules work and discovering compounds with spec...
A study published in the Journal of Consumer Psychology found that consumers are more likely to engage in dishonest behavior, such as shoplifting or piracy, if they perceive a company as harming the environment or people. This effect occurs even when consumers have not personally had a bad experience with the company.
A UCL-led study found that inhibiting RNA polymerase III, a common enzyme in all animals, extends the lifespans of yeast cells and animals by an average of 10%. This discovery may lead to targeted anti-aging therapies, similar to the effects of rapamycin.
Scientists at the University of Edinburgh have identified two molecules, SMAD2 and SMAD3, that enhance cellular reprogramming efficiency. This breakthrough could accelerate production of induced pluripotent stem cells for studying diseases like multiple sclerosis and Parkinson's disease.
Researchers from Insilico Medicine and BitFury Group present a blockchain-based life data interchange system to decentralize and accelerate biomedical research. The system utilizes deep learning technologies to analyze human life data, reducing biases and democratizing healthcare access.