Articles tagged with Enzymes
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have developed atomically engineered nanozymes (AENs) that can precisely regulate reactive oxygen species, activate immune pathways, and remodel the tumor microenvironment to kill tumors. These nanostructures also show promise in antibacterial applications, wound healing, and mitigating drug-induced organ toxicity.
Research reveals that Sulf1 is essential for both reward-dependent and aversion learning, highlighting its critical role in adult brain function. The enzyme acts through distinct dopamine D1 and D2 receptor pathways, underscoring its importance in neural circuits involved in learning.
A multidisciplinary team at USC has developed selective compounds that inhibit an enzyme tied to brain inflammation in people at genetic risk for Alzheimer’s. The inhibitors preserve normal brain function and cross the blood-brain barrier, suggesting a promising therapeutic approach for neurodegenerative diseases.
Researchers have resurrected ancient nitrogenases, enabling a new window into the origins of life on Earth. The study provides insights into the evolution of early life and its relevance to understanding life elsewhere in the universe.
Researchers have developed a new AI method called Riff-Diff to construct artificial biocatalysts, resulting in enzymes that are significantly faster, more stable and versatile. The technology allows for precise design of protein structures around active centres, making enzyme design more accessible to the wider biotechnology community.
Combining enzymes with biochar breaks down pollutants into less harmful compounds, improving efficiency and durability. Biochar-immobilized enzymes have demonstrated impressive results in water treatment and soil remediation.
Researchers found that blocking Caspase-2 enzyme in mice increased chronic liver damage and cancer risk as they aged. The study highlights the need for caution when targeting this pathway to treat fatty liver disease.
Scientists create designer enzymes in yeast cells, enabling sustainable production of industrially important fatty acids. The new method reduces environmental issues associated with palm oil extraction.
Researchers at Northwestern University and Stanford University develop a new artificial metabolism that converts waste carbon dioxide into acetyl-CoA, a universal metabolite used by all living cells. The system, called Reductive Formate Pathway (ReForm), uses engineered enzymes to perform metabolic reactions never seen in nature.
A new study finds that human tyrosinase plays a central role in metabolizing hydroquinone into reactive intermediates causing dermal pigmentation. The research shows that these compounds accumulate differently depending on molecular size and bind to dermal proteins, forming ochronotic pigments.
Scientists at Leibniz-HKI discovered an enzyme called BurK that cleaves the toxic molecule malleicyprol in human pathogenic bacteria. This mechanism regulates toxin levels and renders it harmless to humans, offering a potential therapeutic approach for antibiotic-resistant infections.
A Danish research group has designed proteins that can detect specific DNA sequences and produce light, which can be captured by a phone's camera. This breakthrough enables quick and affordable analysis of samples in various fields such as healthcare, agriculture, and the pharmaceutical industry.
A new review highlights how high and extreme temperatures influence the ability of microorganisms to degrade microplastics. The study shows that heat can both accelerate and suppress microbial breakdown, depending on conditions and organisms involved.
Researchers found that alcohol causes DNA damage, which can lead to cancer, and discovered a repair mechanism using the SXE enzyme complex. Individuals with genetic mutations affecting DNA repair may be more susceptible to alcohol-related cancers.
Researchers have identified promising compounds that can combat resistant COVID-19 variants by targeting an enzyme similar to one used by Chagas disease. Compounds 5a and 5b, synthesized from older chemical libraries, demonstrated strong Mpro inhibition with low toxicity.
The new ProKAS technique provides scientists with a robust way to study kinase activity and its spatial patterns in living cells. By monitoring multiple kinases at once, researchers can track their activity over time and see exactly where they act inside cells.
Researchers found that the leptin-SCD pathway fuels breast cancer growth and motility, leading to poorer recurrence-free survival. Selectively blocking SCD activity can counteract pro-tumorigenic effects driven by leptin, revealing a potential therapeutic target for obese patients.
Researchers developed nanomachines that can function stably within living organisms, enabling starvation therapy to treat refractory pancreatic cancer. This approach improved treatment outcomes by depleting essential nutrients for cancer cell growth.
Researchers developed a highly efficient cell-free enzyme system that achieves remarkable increases in catalytic performance, reduces cofactor consumption, and produces high yields of 1-alkenes. The system overcomes challenges of whole-cell biocatalysts by mimicking the biological reaction environment.
Researchers at Nagoya University have developed a new technology that improves protein production efficiency in E. coli by reducing ribosome stalling. By identifying short translational-enhancing peptides, they created an AI prediction model to accurately predict translation enhancement strength for all 160,000 possible tetrapeptides.
Researchers have unveiled the molecular mechanisms underlying L1's retrotransposition and integration into genomic DNA. The study reveals that ORF2p interacts primarily with the DNA backbone through electrostatic forces, enabling site-specific cleavage during retrotransposition.
A new AI-powered tool, EZSpecificity, can predict the best enzyme-substrate combination for various applications. The tool outperformed existing models in accuracy, especially for halogenase enzymes.
Long-term exposure to fine air pollutants like PM2.5 can impair metabolic health by disrupting the normal function of brown fat through complex epigenetic changes. The study identified two enzymes, HDAC9 and KDM2B, as key drivers of this process.
Researchers discover two distinct methods for producing psilocybin in mushrooms, one in Psilocybe species and another in fiber cap mushrooms. The finding sheds light on convergent evolution and the unique biochemical strategies employed by fungi to produce the same molecule.
Pharmaceutical scientists at NUS developed DOMEK method to characterise enzyme-substrate interactions, enabling analysis of thousands of potential substrates. The technique combines mRNA display and next-generation sequencing to calculate specificity constant for each substrate.
Researchers found that combining biochar with starch accelerates oxytetracycline degradation and reduces its transfer into lettuce, a widely consumed leafy vegetable. The study's results suggest a cost-effective and sustainable solution for reducing antibiotic residues in farmland.
Researchers at the University of Konstanz are developing new methods to modify natural substances using enzymes, with potential applications in pharmaceuticals. Meanwhile, ecologist Catalina Chaparro-Pedraza is studying how organisms adapt to environmental changes and their impact on ecological resilience.
A team of researchers has developed a new method to produce sturdy and reusable bioplastics from domestic raw materials, reducing reliance on petroleum-based chemicals. The bioplastics, known as polyhydroxyalkanoates (PHAs), have similar levels of toughness and malleability to traditional plastics, but are infinitely recyclable.
A team of researchers at the University of Toronto has identified a protein, Shikimate kinase-like 1 (SKL1), that enables land plants to convert light into energy through photosynthesis. This discovery holds promise for improved herbicides and increased efficiency of photosynthesis in food crops.
Researchers at IBEC created an artificial cell that migrates towards specific substances like living cells do. The study demonstrates how microscopic bubbles can be programmed to follow chemical trails and explores the core principles behind chemotaxis.
Researchers developed enzyme–PS conjugates that improve PS stability and biocompatibility. Enzyme carriers remodel pathological microenvironments, enabling catalysis-augmented PDT. The study proposed a systematic criterion for assessing binding strength between enzymes and Ce6.
Researchers have developed new artificial nitrite reductases that can precisely generate nitric oxide under conditions relevant to medicine, food safety, and environmental protection. These synthetic catalysts promise low-cost supplements for hypertension or ischemia and precise antibiofilm treatments.
A team of researchers has identified a molecular mechanism regulating the activity of NMTs, enzymes that modify proteins to regulate biological functions. The study reveals a potential new starting point for developing improved drugs targeting certain types of cancer and viral infections.
Researchers at Charité analyzed the laws of enzyme evolution on a large scale, revealing that certain areas change faster than others. The findings have implications for the development of new antibiotics and other medicines.
A team of researchers, led by Bibek R. Karki, traced the evolutionary history of the PRPS enzyme complex to understand its functions and importance in cellular biochemistry. They found that all four enzymes are crucial for cell function and work together to form a large complex.
A randomized clinical trial found that cannabidiol (CBD) administration led to liver enzyme level elevations in 5.6% of participants and potential drug-induced liver injury in 4.9%. Hepatic enzymes returned to normal within weeks after discontinuation. Further research is needed on CBD's long-term effects and safety.
Scientists from the University of Bath have identified two new families of chemical compounds that inhibit alpha-methylacyl-CoA racemase (MCR) in Mycobacterium tuberculosis, a key enzyme for TB survival. This breakthrough could lead to new treatments for TB and potentially other diseases like prostate cancer.
Scientists have introduced an innovative approach to trap enzymes within nanoscale protein compartments, simplifying their use and extending their functional lifespan. This reduces costs and enhances reusability, offering a more sustainable pathway for PET recycling.
The University of Illinois team created a user-friendly process to improve enzyme performance using AI and automated robotics. By predicting sequence changes and testing variants, they increased the activity of two key industrial enzymes by up to 26 times and 90 times.
Scientists at The University of Texas at Arlington identified a new enzyme, IDO1, that plays a crucial role in inflammation and cholesterol regulation. By blocking this enzyme, macrophages regain their ability to absorb cholesterol, offering a potential new way to prevent heart disease.
The study identified two new families of natural compounds, syrilipamides and secimides, produced by the bacterium. These molecules show remarkable toxicity against competing microorganisms, particularly fungi and amoebae. The discovery also highlights the importance of the SecA enzyme in expanding the chemical repertoire of Pseudomona...
Scientists developed a precise, cost-effective way to make chiral ketones for medicines, agrochemicals, and more using photocatalysis. This approach solves the challenge of reaching remote stereocenters in molecules, allowing for eco-friendly production of valuable chemicals.
Researchers discovered that fungal enzymes cellobiose dehydrogenase (CDH) and lytic polysaccharide monooxygenase (LPMO) can efficiently degrade plant biomass, allowing for the extraction of valuable components. This breakthrough suggests a promising method for using diverse, non-edible plant biomass in biotechnology applications.
Researchers have successfully used insects as mini molecule-making factories to create and modify complex molecules, including fluorescent nanocarbons. The 'in-insect synthesis' technique enables the production of functional molecules with unprecedented precision and versatility.
A New Zealand study supports the theory of punctuated equilibrium, which suggests that evolution occurs in short, intense periods followed by long stretches of stability. The research confirms rapid evolutionary change coincides with species branching, potentially leading to its wider acceptance.
Researchers develop peptide-bridged fusion oxidoreductase, reducing NADP input and increasing conversion rates. The enzyme's electrostatic cofactor channeling enhances transportation effectiveness factors, suppressing side reactions.
A high-fat diet leads to metabolic enzyme dysregulation, insulin resistance, and accumulation of reactive oxygen species in cells. Reversing these effects with antioxidants can mitigate damage.
Researchers from Max Planck Institute for Dynamics and Self-Organization derived three golden rules to design functional enzymes. These rules prioritize interface coupling, conformational change speed, and reaction dynamics.
Researchers discovered that herpesvirus protein kinases mimic human cyclin-dependent kinases, regulating viral infection and latency. Phosphorylation of the viral enzyme contributes to its survival and persistence, while phosphorylation downregulates its activity, allowing for balance between host survival and viral persistence.
A new study at Stellenbosch University found that blocking the enzymes involved in glycolysis could cut off the malaria parasite's primary energy source and kill it. This approach has shown promise for developing new malaria drugs, particularly against resistant parasites.
Common prescription medications can disrupt sterol biosynthesis, potentially causing developmental disorders. The editorial highlights the need for mandatory sterol biosynthesis screening in clinical practice.
Mass General Brigham researchers developed a machine learning algorithm, PAMmla, to predict properties of genome editing enzymes. The approach helps reduce off-target effects and improves editing safety and efficiency, enabling customized enzymes for new therapeutic targets.
Research found that MPO promotes inflammation and inhibits protective mechanisms in perivascular adipose tissue, leading to poorer vascular function. Inhibiting MPO could be a promising therapeutic approach for obesity-related cardiovascular risk reduction.
Researchers have found that targeting PGM3 can help stop the growth of glioblastoma, a fast-growing brain tumor. By blocking this enzyme, tumors can be effectively suppressed.
Researchers found that SIRT2, a previously unknown enzyme, plays a key role in excessive GABA production associated with Alzheimer's disease. This process leads to brain inflammation and memory impairment. By targeting SIRT2, scientists can selectively block its harmful effects on memory without affecting other brain functions.
STITCHR uses an RNA system to replace entire genes, overcoming CRISPR limitations in targeting every mutation. The tool offers a one-and-done approach for gene therapy, addressing cystic fibrosis and other diseases with thousands of mutations.
Researchers have developed a new approach to overcome treatment resistance in estrogen receptor-positive (ER+) breast cancer. Dual aromatase-steroid sulfatase inhibitors (DASIs) show promise in effectively blocking both enzymes involved in oestrogen production, potentially reducing tumour growth.
Researchers used cryo-electron microscopy to visualize the dynamic motion of a human chromatin remodeler in action, capturing 13 distinct structures that reveal the full picture of nucleosome sliding. This comprehensive view sheds light on how chromatin remodeling affects gene access and expression.
Researchers discovered senolytics can target Alzheimer's disease-associated brain enzymes AChE and BChE without affecting healthy ones. This selective approach may lead to safer treatments that improve memory and reduce inflammation in older adults.
Researchers at the University of Surrey warn that mpox's sustained human-to-human transmission poses a significant risk to global health. The virus can cause a painful rash, fever, and swollen glands, and has the potential to spread among children, who are at greater risk of serious illness.