Articles tagged with Enzymes
Researchers used ex vivo lentiviral gene therapy to treat MPS IVA in mice, achieving partial correction of bone pathology and complete correction of heart pathology. The study suggests potential for novel therapies to treat patients with MPS IVA.
Researchers discovered a beneficial gut bacterium that produces an enzyme capable of metabolizing key molecules involved in regulating appetite, immune responses, and neuronal function. The discovery highlights the importance of gut microbes in human physiology and may lead to new strategies for maintaining health and treating diseases.
Researchers found specific gene mutations in barley affect starch synthesis, forming elongated starch granules with altered properties. Mutations disrupt enzymes, altering glucose chain formation and branching.
Scientists have characterized enzymes involved in the degradation of ethane, a process that plays a crucial role in the biological filter at marine seeps. The study reveals a key aspect of the ethane-degrading microbes and their ability to adapt to different environments.
Researchers at Emory University have discovered a family of enzymes that work to reduce IgG-mediated pathologies in diseases like Myasthenia Gravis. The newly found enzyme was used to treat various IgG-mediated pathologies in mice and found to be extremely effective, requiring only 4,000 times less of the enzyme than current treatments.
Genetic variations in carbohydrate-active enzymes may predict which IBS patients benefit from low-carb diets, offering potential personalized treatment options. A study of 250 IBS patients found that those with defective genes showed marked improvement on a low-FODMAP diet.
Researchers found that ACLY activity activates the senescence-associated secretory phenotype (SASP), a pro-inflammatory environment associated with chronic inflammation and aging. Blocking ACLY activity reduces inflammation-related genes in aged cells, suggesting a potential strategy for managing aging and age-related diseases.
Researchers discovered GAME15, a crucial protein for controlling steroidal glycoalkaloids and saponin production in Solanum plants. The study also showed that steroidal saponins play an ecological role in insect defense, with GAME15 knockout plants being more susceptible to herbivores.
A team of researchers has identified mangrove bacteria that can transform polyethylene terephthalate (PET) particles, which are a major contributor to ocean pollution. The discovery of novel enzymes and bacterial species with the ability to break down PET could potentially be used to develop new strategies for plastic waste cleanup.
Researchers at Nagoya University developed an innovative synthesis technology to produce high-purity, fully chemically synthesized mRNA. This breakthrough cuts down the production time and can be used to address concerns about purity and speed in mRNA vaccine development.
Researchers found Itaconate stimulates immune cells to produce anti-viral proteins called interferons by blocking an enzyme called SDH, offering a potential therapy for autoimmune and infectious diseases.
Researchers at the Hebrew University of Jerusalem have developed a highly selective inhibitor for Matrix Metallopeptidase 7 (MMP7), an enzyme crucial for cancer spread and progression. The novel peptide D'20 demonstrates remarkable stability and selectivity, targeting MMP7 while leaving similar enzymes unaffected.
Researchers at UC San Diego developed a fluorescent biosensor to observe PKC activity in real time and 3D space. The study revealed designated signaling territories where different types of PKC are active, shedding light on their critical role in human disease.
The red milkweed beetle's genome has been sequenced, providing insights into how it safely feeds on toxic plants. The study found an apparent expansion of genes related to toxin sequestration and metabolic enzymes.
Researchers successfully designed and engineered novel enzyme systems that can degrade various types of plastics. By replacing the binding module with different modules, they created chimera LPMOs capable of recognizing and breaking down different types of plastics, including biosourced polyhydroxyalkanoate.
A UC Irvine-led team has engineered an efficient new enzyme that can produce synthetic genetic material called threose nucleic acid. This advancement advances the discovery of potentially more powerful, precise therapeutic options for cancer and autoimmune diseases.
The team created a new method by adding two different enzymes to the existing reaction, increasing conversion rates from 46% in 7 hours to 80% in 5 hours. This approach also improved fumaric acid production efficiency from 10% to 16%.
Researchers review UBA1 loss of function in VEXAS Syndrome, a hematoinflammatory disorder characterized by severe inflammation, cytopenias, and oncogenicity. They explore therapeutic options, including clone-targeting drugs, to combat this challenging disease.
Researchers discovered that wastewater bacteria can break down plastic into small pieces called nanoplastics and use a specialized enzyme to further degrade it. The bacteria then use the broken-down plastic as a food source, providing new possibilities for developing bioengineering solutions to clean up difficult-to-remove plastic waste.
A University of North Florida biologist has received a four-year NIH grant to investigate the functional role of dual-specificity phosphatase 4 (Dusp4) in skeletal muscle atrophy. The study aims to characterize Dusp4's role in modulating muscle size and strength.
Researchers identified a crucial protein, TIMP3, overproduced in AMD and found that blocking its activity can reduce drusen formation, suggesting a promising treatment strategy. The study offers new avenues for preventing AMD and improving the lives of millions affected by this disease.
A new study reveals that two specific genes in the RNA interference pathway play a crucial role in preventing virus transmission from parent to progeny in plants. This discovery could lead to healthier crops and potentially reduce the transmission of diseases like Zika from mothers to human children.
Researchers found that certain C4 crops can control water loss through non-stomatal mechanisms, allowing them to absorb carbon dioxide despite raised temperatures and increased atmospheric demand. This discovery has significant implications for improving water-use efficiency in these crops.
A new study reveals that soil pH sets the stage for microbial interactions and community composition, with bacteria cooperating to survive in acidic environments. The research sheds light on global nitrogen cycling and provides insights into reducing potent greenhouse gas emissions.
Researchers identified protein kinase N as a key regulator of heart fibrosis, which threatens heart function. Deleting this enzyme reduced cardiac dysfunction, suggesting anti-PKN treatments may protect against heart failure.
Scientists are investigating the basic biology of protein arginine methyltransferase 5 (PRMT5), an enzyme found in 15% of human cancers. The goal is to understand its normal functions and avoid potential side effects when targeting it for cancer treatment.
Researchers found that certain proteins called killer toxins produced by brewer's yeast can suppress diastatic strains and prevent spoilage. Adding these killer yeasts at the point of contamination may be a remediation procedure to curb the issue.
Researchers at WVU are working on a project to inhibit the myeloperoxidase enzyme, which feeds pancreatic cancer growth. By targeting this enzyme, they hope to boost the body's immune system to fight cancer, showing promise in mouse models and potential for future clinical trials.
New research reveals that downregulating the enzyme EGLN2 can protect motor neurons and mitigate ALS symptoms in animal models. This discovery brings hope to understanding how to slow or prevent this devastating disease.
Researchers from Osaka Metropolitan University have discovered that disruptions in the basement membrane zone between the epidermis and dermis could make it harder for pigment-producing cells to adhere. An enzyme called matrix metalloproteinase 2 (MMP2) may be overexpressed, leading to disturbance of the basement membrane.
A study by researchers from Brazil and Germany found that a surface protein on Aspergillus fumigatus spores suppresses the release of pro-inflammatory substances by immune cells, making it easier for the fungus to infect the body. The enzyme glycosylasparaginase plays a crucial role in this process.
Over 12,000 years ago, humans in Europe increased their ability to digest carbohydrates by expanding the number of genes for enzymes that break down starch. This rapid increase in gene copies provided a survival advantage and tracks the spread of agriculture across Europe.
Researchers have developed a novel, more selective inhibitor of the human immunoproteasome using a bacterially derived natural product. The new compound targets autoimmune diseases without disrupting other cellular mechanisms.
A newly developed compound, MOD06051, targets neutrophils and reduces harmful inflammation in rat models. This approach differs from current treatments that may have broader immunosuppressive effects, offering a safer alternative.
New research compares four methods for extracting edible insect protein, finding that alkali extraction boosts protein content while enzyme treatment improves nutritional value. Additionally, salt-assisted extraction reveals anti-inflammatory effects and anti-diabetic properties.
Researchers at Tokyo University of Science discovered a natural tyrosinase inhibitor from Corynebacterium tuberculostearicum that inhibits melanin synthesis and provides an alternative to toxic hydroquinone-based products. The compound, cyclo(L-Pro-L-Tyr), exhibits low toxicity and potential benefits for hyperpigmentation treatment.
Researchers identified a new enzyme XccOpgD in Xanthomonas that enhances pathogenicity, leading to potential anti-bacterial pesticides. The discovery offers sustainable solutions to global agricultural challenges and promotes environmental stewardship.
Researchers at the University of Illinois developed an eco-friendly method to precisely mix fluorine into olefins using natural enzymes and light, offering a more efficient strategy for creating high-value chemicals with potential applications in agriculture, pharmaceuticals, renewable fuels and more.
Researchers at Ohio State University are exploring the role of caspase 11 in SARS-CoV-2 infection, aiming to prevent inflammation and tissue injury. They will use human cell samples and experimental inhibitors to develop new treatment strategies for long COVID.
Researchers have developed a smart RNA capable of regulating gene expression in response to various signals, enabling the precise design of gene therapies and advanced personalized treatments for diseases.
A Montana State University researcher has developed nano-scale materials that can convert carbon dioxide into chemical building blocks, marking a potential step forward in reducing atmospheric CO2. The materials mimic enzymes and have the ability to selectively capture CO2 from the air.
A recent UNIGE study highlights the risks of high-protein diets, also known as Paleolithic diets, which can lead to severe neurological disorders. Excess protein increases ammonium production, overwhelming the liver and potentially causing coma in severe cases.
Researchers investigate chemical modifications to genetic regulation mechanisms, finding that Set8 controls gene activity through a mechanism other than histone modification. This study refines our understanding of genetic regulation relevant to human diseases like cancer.
Researchers isolated three bacterial strains that produce amylase enzymes from sugar factory waste, showing great potential for production. The optimal conditions for amylase production were found to be 37°C and pH 7.0, leading to increased enzyme activity.
Researchers have discovered that the Greenland shark's metabolism remains unaltered over time, suggesting a key role in its exceptional longevity of at least 270 years. The study also found that metabolic enzymes were more active at higher temperatures, challenging previous assumptions about the species' adaptation to cold environments.
Han Xiao aims to develop cells that can biosynthesize and utilize non-canonical amino acids as in vivo sensors for enzymes involved in posttranslational modifications. This research could lead to new strategies in treating diseases by providing real-time insights into enzyme activities.
A study at Umeã University reveals that an enzyme breaks down the bacteria's protective outer layer, facilitating the transfer of genes for resistance to antibiotics. The researchers identified that only the SLT domain was active in PrgK, but it has an important role in regulation.
Researchers develop an artificial fusion protein combining UndB with catalase, creating a whole cell biocatalyst that converts fatty acids to alkenes with high efficiency. The biocatalyst produces pure 1-alkene as a valuable biofuel and can be used to generate a large number of hydrocarbons.
Researchers at Howard University have identified a new therapeutic strategy to combat prostate cancer by depleting amino acids. This depletion induces oxidative stress and DNA damage in cancer cells, making them more susceptible to treatment with DNA repair-targeted and immune checkpoint blockade therapies.
Researchers developed a permeable and robust polymer-silica hybrid armor on cell catalyst, enhancing enzyme stability and inhibiting leakage. The new technology showed improved permeability and mechanical strength, leading to higher yields and longer half-lives in biomanufacturing processes.
Researchers discovered that enzyme METTL6 interacts with tRNA synthetase to recognize specific tRNAs, enabling precise modification and potential application in cancer treatment. This discovery provides new insights into the molecular machinery of protein production.
Researchers have devised an algorithm to rationally engineer enzymes for improved performance, taking into account evolutionary history. The new method successfully introduced up to 84 mutations over a sequence of 280, resulting in improved activity and stability at higher temperatures.
Scientists have identified a mechanism that enables enzymes to communicate and produce organic molecules with disease-fighting properties. This breakthrough could aid in the discovery of new drugs by allowing researchers to design or modify enzymes to create novel natural products.
A research team has developed a biocatalytic process to produce nitriles using enzymes, eliminating the need for highly toxic cyanide. The process works at room temperature and produces less harmful waste, making it a promising technology for the fragrance industry.
Scientists at Hokkaido University have created a new technique for building nanoparticles using enzymes, enabling the production of various nanomaterials with controlled size and properties. This method has potential applications in technology, medicine, and quantum computing.
Researchers from Tokyo Institute of Technology developed a biocatalyzed carboxylation reaction using Thermoplasma acidophilum malic enzyme to fix CO2, increasing the yield and sustainability of the process. The method can be tailored for selective synthesis of wider carboxylation products, unlocking new avenues for renewable resources.
Researchers identify UBE2J1's role in degrading the androgen receptor, a key player in prostate cancer progression. The study suggests targeting this ubiquitination machinery may help overcome antiandrogen resistance in cancer therapy.
A recent study suggests that inhibiting epigenetic control enzymes in immune cells, specifically HDAC1, improves anti-tumor immunity and tumor surveillance. This finding could lead to new therapeutic strategies in cancer immunotherapy.
Scientists aim to create a spray-on bandage that breaks down within 48 hours, providing time for proper treatment. The project uses enzymes to degrade polymer complexes, which will allow for controlled degradation and potential applications in drug delivery.
Researchers at King's College London have developed a novel drug delivery system using biologically compatible peptides found in chicken feathers and skin tissue. This innovative approach enables targeted delivery of chemotherapy drugs and repair of faulty enzymes, potentially reducing side effects and improving treatment outcomes.