Articles tagged with Enzymes
Researchers discovered a crucial amino acid exchange that enables PsiM to carry out double methylation during evolution. The enzyme plays a key role in psilocybin production, with implications for biotechnological production of the active ingredient.
A new research project, PHOTOZYME, aims to develop photobiocatalytic tools to convert basic chemicals into chiral molecules. The project combines biocatalysis, photochemistry, and directed evolution to create sustainable molecular synthesis.
Researchers at Baylor College of Medicine have discovered how DNA gyrase resolves DNA entanglements, revealing the first step in the mechanism. The study used advanced imaging techniques to visualize the interactions between supercoiled DNA and the enzyme, showing that gyrase is attracted to the looped structure.
Researchers at Nagoya University discover aldehydes cause DNA damage and contribute to premature aging in humans. The team proposes a link between aldehyde-derived DNA damage and premature aging, highlighting potential targets for therapeutic intervention.
Researchers mapped the evolution of a specific regulatory protein over millennia, revealing a novel pattern where function gain and loss occur rapidly. This study may reveal similar patterns in other regulatory proteins, enabling new discoveries in biomedical and biotechnological applications.
A new study published in Microbiology Spectrum shows that an enzymatic cocktail can effectively kill a variety of mycobacterial species, including those causing tuberculosis. The research delivers the enzymes inside host macrophages where mycobacteria grow, increasing efficacy and reducing toxicities associated with current treatments.
A retrospective cohort study found that PERT significantly reduced the incidence of acute pancreatitis episodes among children with recurrent or chronic pancreatitis. The study also identified genetic markers, such as SPINK1 mutation, that influence treatment outcomes and suggest a tailored approach to patient care.
Researchers at the University of Toronto have found that two enzymes, APOBEC3C and APOBEC3D, promote resistance to chemotherapy drug gemcitabine in pancreatic cancer cells. Removing these enzymes can kill cancer cells by stymieing DNA repair.
A team of scientists discovered new fusion sites in protein evolution that enable faster and more targeted drug development. By combining evolutionary processes with synthetic biology, they created customized biological drugs with improved therapeutic properties.
Researchers at the University of Waterloo have developed a patented contact lens material that acts as a bandage for corneal wounds, releasing drugs in a controlled manner to enhance healing. The material, which uses collagen-based technology, achieves complete wound healing within five days in human cell culture studies.
Researchers at Rensselaer Polytechnic Institute have developed a patented process to produce heparin in the lab, offering a consistent and safe supply of the essential medicine. The discovery has the potential to revolutionize the production of heparin, reducing reliance on animal-derived sources and addressing global supply chain issues.
Researchers discovered T1-spanin's exceptional capability to penetrate bacterial defenses and effectively kill nearly 120 strains. A novel phage-based technology delivers T1-spanin genes into target bacteria, providing a potential solution for tackling drug-resistant pathogens.
Researchers at Martin-Luther-Universität Halle-Wittenberg developed novel RNA- or DNA-based substances that reliably fight off viral infections in plants. The new approach uses antisense oligonucleotides to target specific viral RNA molecules, achieving an impressive up to 90% success rate against a common virus.
Researchers developed a portable, droplet-based millifluidic device to monitor patients in the critical first days after surgery. The device measures drainage fluid's alpha-amylase activity in real time, reducing test duration from six hours to two minutes.
Rumbaugh's lab aims to understand the effects of dispersing bacteria from a biofilm on their susceptibility to antibiotics and on the host. They will use enzymes as tools to break up biofilms, allowing researchers to better comprehend the relationship between bacterial dispersal and infection outcomes.
A rapid diagnosis protocol using a luminescent paper-based platform has been developed to detect the presence of antibiotic-resistant bacteria. The approach uses a supramolecular hydrogel matrix containing terbium cholate that emits green fluorescence when UV light is shined on it.
Researchers at Lawrence Berkeley National Laboratory have developed a new technique to study the breakdown of cellulose by enzymes, revealing that hydrogen bonds in the complex molecule act as obstacles. The approach uses infrared light and operando spectroscopy to provide real-time snapshots of the sample, overcoming past limitations.
Researchers at Duke-NUS Medical School discovered a novel enzyme, FAXDC2, that plays a pivotal role in cholesterol synthesis and cancer progression. The study highlights the potential vulnerability of cancer cells to targeted therapeutic intervention. Further research is needed to explore the therapeutic potential of targeting FAXDC2 i...
Researchers have developed a novel imaging method to study the intricate relationships within a fungal garden cultivated by leafcutter ants. The technique revealed crucial metabolites and enzymes driving plant degradation, highlighting the fungus as the primary degrader of plant materials.
Indiana University researchers have found that nicotinamide nucleotide adenylyl transferase 2 (NMNAT2) plays a critical role in protecting the brain from aging and neurodegenerative diseases. The enzyme provides energy to axons, enabling them to carry out nerve impulses and maintain healthy function.
Researchers developed a new enzyme that uses formamides as a substrate for biocatalysis, achieving equivalent or slightly better results than traditional formate-based systems. The enzyme converts formamides into NADPH, producing CO2 as a waste product and opening up new possibilities for asymmetric reductive amination.
A recent study published in Nature Plants reveals that O-glycosylation of the transcription factor SPATULA promotes Arabidopsis style development. The experimental study sheds new light on the mechanisms underlying plant organ symmetry.
Scientists have successfully replicated QS-21, a potent vaccine adjuvant, in an alternative plant host for the first time. This breakthrough enables the production of this highly valued compound in a more sustainable manner.
Researchers develop enzyme that can break silicon–carbon bonds in siloxanes, a first step towards rendering chemicals biodegradable. The discovery opens possibilities for natural organisms to degrade siloxane contaminants in wastewater and treat them in the environment.
A research team at the University of Göttingen has discovered 'protective switches' in the SARS-CoV-2 virus that shield it from attacks by the immune system. These molecular structures were found to stabilize the protein's structure against oxidative damage, allowing the virus to replicate effectively.
Researchers created a network of 4.9 billion plausible chemical reactions using blockchain, shedding light on prebiotic molecules and primitive metabolism. The study also demonstrates how blockchain can be used to solve complex problems in science at a lower cost.
Sezáry syndrome patients face a vicious circle where cancer and treatment weaken the immune system, allowing bacteria like S. aureus to thrive. Eliminating these bacteria may make cancer cells more susceptible to anti-cancer drugs.
A new catalyst developed by researchers at Nagoya University successfully synthesized a key intermediate for the incontinence drug oxybutynin in 5-30 minutes, significantly faster than existing methods. The discovery represents a major advance in chiral drug synthesis and holds great promise for future drug discovery efforts.
A team of scientists has identified a previously unrecognized control point in DNA repair processes, which could lead to novel cancer therapies by inhibiting the repair of damaged cancer cells. The newly discovered GSE1-CoREST complex contains three enzymes that control DNA repair and may form the basis for improved cancer treatments.
Research reveals bacteria in human gut use diverse enzymes to generate energy from organic compounds, producing metabolites with implications for human health. The study identifies 22 alternative metabolites used by three families of gut bacteria, showcasing their remarkable adaptability.
Researchers from Brazil have discovered two novel peptides with biotechnological potential in the venom of the pit viper Cotiara and the South American bushmaster. The peptides, including Bc-7a and Lm-10a, show promise as potential treatments for high blood pressure.
Researchers identify microbial enzyme bilirubin reductase that converts bilirubin into urobilinogen, causing urine's yellow color. The discovery sheds light on the gut microbiome's role in ailments like jaundice and IBD.
Researchers at NTNU have developed a new method to extract better alginate from cultivated kelp by using epimerases. This breakthrough allows for cost-effective production and opens up new market opportunities, benefiting both the kelp farmers and the industry.
Researchers at Pohang University of Science & Technology discovered a breakthrough approach to stabilize aptamers using ionic liquids. The team found that these liquid-based environments can shield nucleic acids from enzymes, preserving their functions up to 6.5 million times longer than conventional methods.
Researchers have discovered the structural proof of DNA and RNA breakdown by PLD3, an enzyme linked to Alzheimer's disease. The study provides a map of the protein, which could lead to better understanding of its role in certain diseases.
Scientists have introduced a new class of protease-activity sensors using gold nanoparticles equipped with peptide DNA, which can detect multiple active proteases in parallel. The method works at room temperature and does not require complicated sample preparation or elaborate instruments.
Researchers have identified a new enzyme, KtzT, that can form a rare nitrogen-nitrogen bond in molecules. The discovery enables the efficient production of tailored compounds with specific effects on organisms and their metabolic processes.
Scientists at Case Western Reserve University identified a novel enzyme, SCAN, which attaches nitric oxide to proteins, including the receptor for insulin action. Blocking this enzyme protects from diabetes, suggesting it may be a cause of the disease.
A team of Kyoto University researchers found that macrophages produce granulomas through a hyperactive metabolic pathway called the pentose phosphate pathway. Inhibition of this pathway showed therapeutic efficacy in reducing granuloma formation in vitro and in mouse tissue models.
Researchers discovered the PanH enzyme, which catalyzes the selective epoxidation of cyclohexenones, a challenging reaction to achieve through chemical synthesis. The study shows that this enzyme can produce a large library of substances with improved and more specific activities in biomedical research.
Microorganisms in the intestinal flora utilize beta-elimination to break down glycosides, enabling humans to absorb healthy plant natural products. The 'enzyme scissors' mechanism is a universal catalytic principle allowing for efficient cleavage of various glycosides.
Researchers at the University of Bath have created a novel bacterial system to mass-produce cyclic proteins and peptides, addressing a significant bottleneck in the development of new therapeutic treatments. By harnessing the natural cyclization process from the Oldenlandia flower, they improved heat and chemical stability, as well as ...
Researchers establish new standards for laboratory experiments to improve PET recycling efficiency. Four engineered enzymes were tested, with LCC-ICCG outperforming the others in terms of depolymerisation rate and enzyme requirement. The study aims to accelerate the development of industrial-scale solutions for PET waste management.
Scientists discovered that malate decarboxylase CsNADP-ME2 mediates the balance of carbon and amino acid metabolism in cucumber fruit. The enzyme plays a crucial role in promoting the production of soluble sugars and starch, while down-regulating its expression leads to increased malate accumulation.
Researchers used tiny beads to immobilize enzymes from edible fungus Agrocybe aegerita, protecting them from plasma treatment and increasing stability up to 44 times. The study paves the way for new biocatalytic applications combining enzymes with technical plasmas.
Researchers at Chalmers University of Technology have discovered a new method for capturing proteins in nano-sized traps to study difficult-to-treat diseases. The technique allows for the trapping of hundreds of proteins in a small volume, enabling the study of early development and potential drug countermeasures.
A team of researchers has made a significant leap forward in molecular chemistry by modifying azaarenes, unique molecular puzzle pieces crucial to many everyday products. Using photoenzymatic systems, they have discovered novel chemical reactions that were previously thought to be out of reach.
A new MIT study proposes a theoretical model that helps explain how cells maintain the memory of their cell type despite losing chemical modifications during DNA replication. The research team suggests that the 3D folding pattern of the genome determines which parts will be marked by these chemical modifications.
Researchers have summarized recent advances in enzyme-activated near-infrared fluorescent probes for non-invasive visualization of enzyme dynamics and disease status. These probes offer high specificity, sensitivity, and biocompatibility, making them valuable assets in biomedical research and healthcare.
A recent study published in Plant Physiology reveals the inner workings of photosynthesis and plant productivity by investigating the interaction between RBL10 and ACP4 proteins. The researchers identified that these proteins act independently in parallel ways to affect lipid biosynthesis, paving the way for engineering crop plants wit...
Researchers have discovered two new cofactorless oxygenases, TnmJ and TnmK2, which enable bacteria to produce compounds for targeting and breaking up DNA. This breakthrough offers a potentially easier way to study and manufacture complex natural chemicals, including those that could become medicines.
Researchers at Brookhaven National Laboratory engineered enzymes to modify grass plant cell walls, reducing lignin content and making sugars more accessible. This led to up to 30% more sugar collection through fermentation, enabling potential conversion into biofuels like ethanol.
A team of researchers at Kyoto University has found that a deficiency in the enzyme B4GALT3 inhibits tumor growth in mice. The study shows that reduced glycosylation on T cell surfaces correlates with increased CD8+ immune cells infiltrating tumors.
A new yeast-based screening method has been developed to unravel how plants synthesize medicinal compounds, identifying key enzymes in a kratom tree. The method complements traditional approaches by capturing protein-protein interactions between plant enzymes.
The team created a glycoengineering platform that simplifies the production of customized sugar carbohydrates, known as glycans, which play a crucial role in various therapeutic applications. This innovation enables the engineering of new glycans with unprecedented flexibility, addressing limitations in existing approaches.
Researchers have discovered a novel enzyme family related to bacterial pathogenicity in Gram-negative bacteria. The study revealed that enzymes involved in OPG synthesis and regulation play crucial roles in bacterial infection capability.
Researchers have found that benzoxazinoids, a special plant defense compound, evolved independently in distantly related plant families. The study used two species, golden dead-nettle and zebra plant, to elucidate the metabolic pathway of these compounds, revealing unexpected diversity in enzymes performing the same reactions.
Scientists have identified a bacterial strain that can break down the toxic tomatine in tomato roots, providing new understanding of how soil microbes interact with plants. This discovery could lead to the development of new bioactive compounds for human applications.
Researchers classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describing its involvement in key canonical cancer signaling pathways. Methods to inhibit UGDH and its downstream products are also identified.
Scientists at IISc have developed an enzyme mimetic called NanoPtA that can degrade toxic chemicals in industrial wastewater effectively in the presence of sunlight. The nanozyme is highly specific and robust, making it suitable for large-scale industrial use.