Articles tagged with Enzymes
Researchers have found that deleting certain sugar-adding enzymes from plants results in similar defects across distantly related species, highlighting the importance of these modifications. The addition of sugar molecules to proteins controls tip growth, a process critical for cell wall formation and seed production.
Researchers found that mice exercising on a wheel increased SIRT3 levels, protecting against neurodegeneration and degeneration. Bolstering mitochondrial function with gene therapy technology also offered protection against stress and age-related cognitive decline.
Researchers at the University of York have published research on the 3-D structure of human heparanase, an enzyme that degrades sugars and contributes to cancer cell proliferation. The study's findings will enable a more rational approach to drug design and the development of novel therapeutic agents.
Researchers have developed a gene therapy approach that delays symptoms and extends lifespan in dogs with a comparable disease to Batten disease. The treatment involves delivering a working version of a gene to produce a key enzyme, resulting in striking clinical improvements and slowed disease progression.
Researchers at the University of Michigan found that zinc oxide nanopyramids can disrupt the growth of methicillin-resistant Staphylococcus aureus (MRSA) on medical implants, reducing bacterial load by over 95%. The coating may enable antibiotic treatments to succeed or allow the human immune system to take over.
Scientists at WashU Medicine have discovered an enzyme that enables some fish and amphibians to supercharge their vision to detect red and infrared light, aiding navigation in murky waters. This discovery could lead to advances in biomedical research, particularly optogenetics, where light is used to control brain activity.
Researchers have detected how nature produces key chemicals similar to those in drugs that fight malaria, bacterial infections and cancer. The discovery sheds light on a complicated chemical process in nature that synthetic biologists can now borrow to engineer a whole new class of synthetic medicines.
Researchers have determined the structure of a key enzyme in Mycobacterium tuberculosis, which could lead to new drugs for the disease. The discovery provides a potential starting point for developing treatments that target this enzyme.
Researchers at Boyce Thompson Institute have made a breakthrough in developing cold-tolerant corn plants by increasing Rubisco enzyme levels, which can help them withstand harsh winter conditions. The new technology could enable farmers to harvest twice and increase crop yields.
Researchers have discovered a long-acting enzyme that rapidly and safely metabolizes cocaine, potentially providing a treatment option for cocaine overdose. The enzyme, E12-7Fc-M3, has been shown to eliminate cocaine from the bloodstream for extended periods of time.
Scientists have identified a new class of DNA repair enzyme that can recognize and remove positively charged lesions, including bulky ones. This discovery expands the understanding of DNA damage repair pathways and offers insights into alternative mechanisms for repairing genetic information.
Researchers discovered that inhibiting cGAS enzyme rescues mice from two lethal autoimmune diseases, suggesting a new therapy for AGS and SLE. The findings build on previous studies identifying cGAS as a sensor of innate immunity, paving the way for potential treatments.
Scientists have identified the enzyme responsible for synthesizing tenuazonic acid (TeA), a well-known fungus-killing toxin that affects rice and other crops. The unique TeA synthetase 1 (TAS1) enzyme has an NRPS-PKS structure, previously thought to be exclusive to bacteria.
Scientists at Umeå University have made a breakthrough discovery in extracting molecules from wood using enzymes that can function in switchable ionic liquids. The development opens up new possibilities for the production of biofuels and other industrial products.
A type of bacteria, Thiomicrospira crunogena, produces an enzyme, carbonic anhydrase, that can convert industrial carbon dioxide into bicarbonate. The enzyme has high thermal stability and could be used in industrial settings to neutralize greenhouse gases.
Researchers at the University of Florida have identified a type of deep-sea bacteria that can convert industrial carbon dioxide into bicarbonate, a process that could help neutralize greenhouse gases. The enzyme produced by the bacterium has high thermal stability, making it suitable for industrial applications.
Researchers discovered that mutant GlyRS enzyme blocks molecular signals essential for maintaining motor neuron health, leading to symptoms such as muscle weakness and decreased sensation. By amplifying the 'health' signal, they were able to reverse symptoms of Charcot-Marie-Tooth disease in mice.
Researchers at Jena University developed a cellular system to study inflammation processes in real time, providing a method for targeting new therapeutic approaches. The system allowed them to clarify the exact regulatory mechanism of 5-LO and FLAP interaction, enabling tests for active compounds.
Researchers found that nicotine increases the speed at which codeine is converted into morphine in the brain, leading to greater pain relief but also a higher risk of addiction. People with more of this enzyme may experience increased pain relief but be more prone to codeine dependence.
The WSU researcher will investigate genetic markers in UGT enzymes that indicate an increased risk of lung and head and neck cancers from tobacco smoke exposure. The study aims to develop personalized approaches to medicine and cancer treatment by understanding the detoxification pathway.
Researchers discovered that mice lacking both Pten and Shp2 enzymes are prone to lethal anemia, which can occur even if they lack one of the enzymes alone. This finding suggests that genomic screening before treatment may help prevent anemia in cancer patients.
A Johns Hopkins University biologist has made significant progress in understanding the mysterious shape-shifting ways of stem cells. The study found that an enzyme in the niche where stem cells are found can help sustain them and promote other cells to become like stem cells, which has medical implications for diseases such as cancer.
Researchers discovered that the Dengue virus NS1 protein binds to the host enzyme Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), increasing its glycolytic activity to support viral replication. This finding suggests that GAPDH is a crucial target for developing new treatments against dengue.
A new CRISPR-Cpf1 system offers a simpler approach to genome engineering with precise DNA cutting capabilities. The system, discovered by Feng Zhang and his colleagues, has potential to advance genetic engineering and cancer research.
Researchers developed a selective synthesis method using an enzyme from E. coli, assembling simple molecules to form complex carbohydrates with few steps and no waste, replicating prebiotic conditions. The process has great potential in chemistry for obtaining natural molecules and active ingredients.
Two Korean research teams have discovered the redox-switch of thiolase, a key enzyme involved in n-butanol biosynthesis. This finding enables increased n-butanol production using metabolic engineering approaches.
A recent study by TSRI researchers has uncovered a novel pathway between the cell's powerhouses (mitochondria) and the immune system. RIPK3, an enzyme involved in cell death, relays signals between mitochondria and NKT cells, regulating both cancer and inflammatory responses.
A Umeå University research group has identified two bacterial enzymes that can be used to modify proteins for use in medical drugs. The AnkX-Lem3 system allows for the addition and removal of a phosphocholine moiety, enabling fine-tuned control over protein function.
Biologists at the University of York have found a key plant enzyme that reacts with TNT, generating toxic compounds. The discovery raises hope for a new, sustainable method to remediate explosives-contaminated land and water.
Researchers at Kazan Federal University investigate the role of hydrolytic enzymes and metalloproteinases in making enterobacteria resistant to antibiotics. They find that these pathogens can cause severe diseases like meningitis, septicemia, and endocarditis, especially in individuals with weakened immune systems.
Researchers have discovered how bacteria convert phosphonate compounds into phosphate, using a complex of fourteen proteins. This mechanism could be used to develop techniques for removing pesticide residues from drinking water and understanding the greenhouse effect.
Researchers at Florida State University have uncovered a previously unknown activation mechanism for the glucokinase enzyme, which plays a crucial role in glucose regulation. This discovery sheds new light on how the enzyme's functional properties manifest in disease, including hyperinsulinemia and diabetes.
A team of scientists has identified a novel tungsten-containing enzyme in the bacterium Caldicellulosiruptor bescii, which shows potential for converting plant biomass into useful chemicals and fuels. The discovery could lead to more efficient production of commercial renewable fuels and reduce greenhouse emissions.
Researchers at University of California, San Diego School of Medicine reveal a more accurate structure of Protein Kinase C (PKC), providing new targets to fine-tune the enzyme's activity. The corrected structure suggests ways to turn PKC 'on' for cancer treatment and 'off' for neurodegenerative disease treatment.
The Toxoplasma parasite's ability to infect and grow within various cell types is attributed to its broad culinary tastes. However, this adaptability comes at the cost of energy expenditure. Researchers have identified a critical enzyme, TgFBP2, that plays a crucial role in the parasite's survival.
Researchers have identified a bacterial enzyme called NicA2 that breaks down nicotine in blood samples within 30 minutes. The enzyme also remained stable for several days and showed no observable side effects in mice, suggesting its potential as a new approach to help smokers quit.
Researchers from MDC and Charité elucidate the process of skeletal muscle atrophy in patients with congestive heart failure, identifying a new regulator and signaling pathway. The study reveals that angiotensin II induces muscle atrophy through the activation of MuRF1, but also highlights potential therapeutic targets to prevent furthe...
Researchers from LMU Munich have discovered that human DNA repair enzymes employ a 'pincer' strategy to target damaged DNA, using a sugar molecule as a key component. This finding sheds new light on the complex process of DNA repair and its importance in maintaining genome stability.
Scientists at Scripps Research Institute have discovered a bacterial enzyme that can degrade nicotine, offering a potential alternative to smoking cessation aids. The enzyme, NicA2 from Pseudomonas putida, has shown promising characteristics for drug development, including stability in lab settings and minimal toxic byproducts.
Researchers at Ruhr-University Bochum have successfully manufactured biocatalysts suitable for industrial applications by harnessing the power of cyanobacteria's photosynthesis. The production process uses carbon dioxide and water as source materials, eliminating the need for mineral oil-based resources.
Researchers have identified new genetic markers for mosquito resistance to insecticides, which could improve its detection in the field. The study also found that mutations affecting detoxification enzymes can increase the biodegradation of insecticides in resistant mosquitoes.
Researchers at Queensland University of Technology (QUT) have developed a new genetic technique using CRISPR-Cas9 to improve the nutritional value of feed for livestock. The method generates specific yeast that combine protein with digestive enzymes, reducing the need for supplements.
Researchers aim to improve crop productivity by optimizing photosynthetic efficiency, a process that has plateaued due to its inefficiency. Designs include smart canopies with layered plants and tailored light-absorbing pigments to minimize light saturation and maximize energy use.
University of Calgary scientists have characterized a novel gene that encodes the gateway enzyme in the formation of morphine. This discovery could lead to the development of alternative painkillers, such as codeine and oxycodone.
Researchers have created an artificial enzyme that can stimulate genes to work harder in specific tissues, offering hope for treating genetic diseases. The hybrid enzymes, which are fully synthetic and recognize target genes via RNA decoys, amplify gene expression in a limited way and only when the gene is active.
A new checkpoint enzyme, Plk1, has been discovered to play a crucial role in monitoring chromosome segregation during cell division. This finding may provide important clues for the development of new cancer treatments.
The study identifies two enzymes, KDM4A and KDM4C, which alter gene expression in embryonic stem cells to direct their differentiation into endothelial cells. The enzymes work through epigenetic modifications, changing the activity of genes without altering DNA itself.
Researchers have identified a fusion gene in poppy plants that facilitates important steps in the plant's morphine-producing pathway. The findings complete the metabolic pathway for morphine, enabling the production of the economically important drug without the need for cultivating poppy fields.
Researchers have identified a key mechanism behind diabetes-related heart damage and developed a potential treatment strategy. By targeting the movement of sugar molecules and enzymes inside heart cells, they were able to restore normal function in diabetic rat hearts.
Scientists have identified a gatekeeper enzyme that prevents cell death in Wolfram syndrome, a rare form of diabetes. Replacing or enhancing the enzyme strengthens cellular membranes and stops molecules from leaking into other parts of the cell.
A team of researchers from Purdue University has identified molecules that inhibit the MERS virus's essential 3C-like protease enzyme. The discovery could lead to better treatments for those infected with MERS. The unique properties of this enzyme make it an attractive target for potential treatments.
A gene previously suspected of influencing human obesity has been cleared of its connection, according to a new study. The researchers developed tools to analyze complex genomic regions, including the AMY1 locus, and found no association with body mass index.
In a study published in Nature Medicine, researchers found that disabling the production of NETs (neutrophil extracellular traps) can speed up wound healing in diabetic mice. By preventing neutrophils from producing NETs, wounds healed more quickly and tissue repair was improved.
Researchers from UNC School of Medicine provide direct experimental evidence for the rapid synthesis of two classes of proteins necessary to create life on Earth. They found that a single ancient gene probably used its two opposite strands of DNA to code for different catalysts that both activated amino acids.
The study found that Fam20C phosphorylates more than 100 different secreted proteins, directing numerous cellular processes. This discovery has significant implications for understanding cancer cell metastasis and developing new therapeutic targets.
Researchers have pioneered a new technique to pinpoint enzyme activity, shedding light on their efficiency in speeding up chemical reactions. This breakthrough could lead to new candidates for biological applications and more environmentally friendly industrial processes.
Researchers discover fructose's role in heart failure, finding it efficiently converts to fat and stimulates glycolysis. Fructose also activates HIF, leading to increased KHK-C production and a vicious cycle of growth and damage.
A team of scientists has discovered a new enzyme that plays a critical role in the biosynthesis of vitamin A in plants and its unexpected dependence on heme iron. The findings could help increase the levels of provitamin A carotenoids in food crops, reducing global vitamin A deficiency.
Researchers at Lehigh University present breakthroughs in capturing tumor cells, creating bioengineered enzymes to fight bacterial biofilms, and developing a stable chemical reagent. These innovations have the potential to positively impact industries such as food safety and medical devices.
Researchers at NYU have found that microRNA can serve as a decoder ring to understand complex biological processes, highlighting the potential for miRNA to shed light on diseases such as coronary artery disease and cleft palates. By analyzing miR-200, the team identified a trio of glycans critical to cell movement and tumor metastasis.