Articles tagged with Heparin
A team led by Professor Ram Sasisekharan at MIT has created designer drugs for preventing blood clots that can cause strokes and heart disease during surgery. The new formulations are more potent and effective than conventional forms of the drug, offering a potential alternative to existing treatments.
Researchers at Duke University Medical Center have developed a method to create a class of drugs with controllable effects, allowing for the creation of matching antidotes. The new approach uses aptamers, which are compounds made of nucleic acid that bind directly to target proteins, to inhibit protein activity.
Researchers discovered that heparin inhibits the adhesion of sickle red blood cells to P-selectin on blood vessel walls, preventing blockages and organ damage. The study suggests that oral heparin preparations may provide a convenient and safe treatment option for patients with sickle cell disease.
A randomized trial of 17,000 patients from 46 countries shows that bivalirudin reduces the risk of recurrent heart attack by 30% compared to heparin. The study also found no significant increase in severe bleeding or intracerebral bleeding in patients given bivalirudin.
Researchers find that heparin and compression stockings can effectively prevent deep-vein thrombosis (DVT) in people at high risk for clots, particularly those with a history of heart disease or stroke. Compression stockings were found to significantly reduce DVT incidence by 18.75 times compared to controls.
A new combination therapy has shown promise in reducing ischemic complications after a heart attack. The study found that combining full-dose tenecteplase with prolonged subcutaneous administration of enoxaparin resulted in significantly fewer endpoints compared to other treatments.
The MIT researchers used their new analytical tool to determine the sequence of a heparin fragment and produced a surprising result that contradicts earlier findings. The correct sequence reveals that the heparin fragment contains only a partial active site, affecting drug activity.
Chemists at the University of Georgia have developed a new approach to synthesizing key components of Heparin, a widely used anti-coagulant. This method could lead to novel ways to fight disease or improve human health by understanding the structure-function relationships of Heparin.