High Throughput Screening
Articles tagged with High Throughput Screening
Challenging diseases addressed in vol. 39 of SLAS Discovery
Volume 39 of SLAS Discovery highlights novel assays and AI-assisted workflows to accelerate personalized cancer immunotherapy. The journal aims to advance life sciences discovery through education, knowledge exchange, and global community building.
High-throughput proteomics accelerates the era of precision medicine
Advances in high-throughput proteomics and artificial intelligence are transforming biomarker discovery, disease prediction, and drug development. Proteomic technologies enable comprehensive snapshots of physiological and pathological states, driving breakthroughs in early diagnosis and personalized treatments.
New AI technology to speed drug development
Scientists at the University of Virginia Health System have developed a suite of AI-powered tools, called YuelDesign, YuelPocket and YuelBond, to transform how new drugs are created. These tools can design drug molecules tailored to fit their protein targets exactly, even accounting for protein flexibility.
New volume from SLAS Discovery: Protocols in 3D biology
The latest volume of SLAS Discovery highlights advances in 3D cell culture and novel technologies for drug discovery. Small molecule cytokine antagonists and a versatile ELISA for PPI inhibitor screening are among the key findings.
SLAS Technology Vol. 36 charts the next era of intelligent laboratory automation
This issue highlights advancements in drug discovery, synthetic biology, and laboratory digitalization. SLAS Technology emphasizes scientific and technical advances that enable improved biomedical research and development.
AI-powered drug discovery meets field-ready diagnostics in SLAS Technology vol. 37
The latest SLAS Technology volume showcases how AI, automation, and portable technologies are transforming drug discovery and diagnostics. This advancement enables the development of innovative therapeutic solutions and improved patient care.
Contraception without hormones: Goethe University researches alternatives to “the pill”
Researchers at Goethe University are developing non-hormonal contraceptives to address declining pill use and side effects. The PREVENT project aims to create safe and effective alternatives, focusing on small molecules that block proteins in sperm or egg cells.
Chemically ‘stapled’ peptides used to target difficult-to-treat cancers
Researchers have developed a bacterial system to create millions of potential drug molecules that can target difficult-to-treat cancers. The approach combines chemical peptide stabilisation with the TBS assay to screen for effective peptides, which can then be tested in more complex tissue models and animal studies.
A novel technology to explore peptides as drug targets with high precision without using cells
Researchers developed a novel method to immobilize proteins onto magnetic microbeads, allowing precise measurement of binding strength and efficient selection of target peptides. The technique achieved a 10,000-fold concentration in a single sorting step, significantly enhancing the efficiency of drug discovery research.
Scientists demonstrate first-time use of AI for genetic circuit design
Researchers developed a new technique called CLASSIC that enables large-scale testing of complex DNA circuits in human cells. The approach uses artificial intelligence and machine learning to analyze vast numbers of complete circuits at once, providing scientists with a clearer picture of the rules governing genetic part behavior.
Much-needed new drug approved for deadliest blood cancer
Researchers at the University of Virginia Health System have developed a new treatment for acute myeloid leukemia, a deadly form of blood cancer. The FDA-approved medication works by disrupting cellular protein interactions that drive leukemia cell growth and survival, offering patients a potential cure.
Researchers diagnose disease with a drop of blood, a microscope and AI
A team of scientists at the University of Tokyo has developed an automated, high-throughput system that uses machine learning to analyze droplets of biofluids for disease diagnosis. The technology relies on imaging drying processes to distinguish between normal and abnormal samples.
Turbo Platform for Plant Research
Scientists have created a micro-algal platform that allows for automated and fast testing of chloroplast genetic modifications, opening up plant chloroplasts to high-throughput applications. This platform enables researchers to fine-tune genetic circuits and identify which modifications have real potential.
SLAS Technology unveils AI-powered diagnostics & future lab tech
The latest issue of SLAS Technology highlights significant advancements in biomedicine and diagnostics, with AI-powered tools achieving 99.9% accuracy in detecting monkeypox. Additionally, the journal showcases innovative lab technologies, including multi-camera zebrafish assays and infection-proof titanium implants.
SLAS Discovery: Advancing tools for cancer fibrosis and drug discovery
The journal features novel FAK-paxillin inhibitors, a venom toxin screening platform, and AI-driven solubility prediction for compound discovery. SLAS Discovery highlights innovative technologies to understand and treat human disease.
SLAS Discovery and SLAS Technology demonstrate research impact with 2024 impact factors
The Society for Laboratory Automation and Screening's two scientific journals, SLAS Discovery and SLAS Technology, have achieved substantial impact factor increases due to open access publishing. This shift has led to higher citations and visibility for authors, with SLAS Technology experiencing a notable rise of 1.2 points to 3.7.
SLAS Discovery Volume 33 showcases new innovations in drug discovery
Researchers tackle pressing challenges in drug discovery with innovative approaches, including high-throughput TRIP13 inhibitors and tau aggregation blockers. The journal focuses on advancing life sciences discovery and technology via education, knowledge exchange and global community building.
SLAS Technology Vol. 32: AI, Robotics and Precision Diagnostics
This issue of SLAS Technology features a high-precision microfluidic flow splitter that outperforms commercial alternatives, enabling even flow division and simplifying multi-inlet perfusion. The journal showcases technological leaps in the life sciences, including rapid pathogen detection and AI-driven insights into schizophrenia.
C-Path’s translational therapeutics accelerator announces new grant award for drug development project in type 1 diabetes
Critical Path Institute's Translational Therapeutics Accelerator awards $250,000 to researchers advancing a promising therapeutic pathway for type 1 diabetes. The project aims to address key challenges in T1D treatment, including beta-cell preservation and immune system modulation.
Computational drug discovery: Exploring natural products targeting SARS-CoV-2
A recent study identifies 11 natural compounds that can inhibit the SARS-CoV-2 spike protein, including caffeine, which exhibits high binding stability and excellent solubility. The discovery highlights the potential of natural products in combating COVID-19 and demonstrates the versatility of widely known compounds like caffeine.
New automated method increases the efficiency of bioactive natural product discovery
Researchers developed FAST-NPS, a new automated method to discover and scale up bioactive natural products from Streptomyces. The method uses self-resistance genes as markers to prioritize biosynthetic gene clusters with bioactivity.
NUS researchers pioneer DNA-tagged gold nanoparticles for targeted cancer treatment
The team's novel technique enables high-throughput screening of nanoparticle shapes, sizes, and modifications, reducing associated screening costs. The research demonstrates the distinct preferences of tumour cells for certain nanoparticle configurations, enabling personalized cancer treatments that are safer and more effective.
Webinar highlight: High-throughput sequencing accelerates global thalassemia prevention
Genetic testing using high-throughput sequencing (HTS) technology has significantly improved detection rates for thalassemia, offering a valuable model for high-prevalence regions. HTS-based genetic testing offers greater sensitivity and specificity without adding significant costs.
High-tech tracking technology streamlines drug discovery
Researchers have developed a large-scale drug screening technique that tracks drug targets inside cells, allowing for the identification of potential new drugs. The technology screens candidate drugs 100 times faster than standard manual techniques, enabling the discovery of previously unknown drugs.
Precision robotics offers hope for heart disease treatment
A research team at SickKids and U of T has developed a robotic system that allows scientists to test numerous potential therapeutics in arrhythmogenic cardiomyopathy, a leading cause of sudden cardiac death among young adults. The technology enables the identification of five potential therapies for the condition.
Collaborative three-campus QB3 research team awarded $12 million CIRM grant to study origins of autism in diverse population
Researchers will classify autism types, identify responsible genes, and develop precision therapy for autistic patients. The team will employ neural organoids derived from diverse brain samples to accelerate autism research.
Researcher earns NIH grant to study thousands of natural products for anticancer properties
A University of Oklahoma researcher has been awarded a NIH grant to evaluate thousands of natural products with therapeutic potential. The goal is to identify specific components of these products that have anticancer properties and understand how they work.
Advanced sperm selection system signals breakthrough in assisted reproduction
Researchers at City University of Hong Kong announce an advanced sperm selection system that signals a breakthrough in assisted reproduction. The system, called BLASTO-chip, uses microfluidic droplet technology to select live sperm from immotile samples with over 90% accuracy.
Electrical impedance tomography–extracellular voltage activation technique simplifies drug screening
Researchers developed a novel EIT-EVA PCB sensor for non-invasive assessment of drug inhibition on ion channels. The system enables real-time monitoring of ion flow changes in response to drug exposure, offering a faster and more efficient alternative to traditional methods.
New screening tool could improve the survival rate of patients with hepatocellular carcinoma from 20% to 90%
A new machine-learning model using serum fusion-gene levels predicts HCC with an accuracy of 83-91%, significantly improving upon current biomarkers like serum alpha-fetal protein. This breakthrough tool may help identify patients at risk and monitor cancer recurrence, leading to improved survival rates.
SLAS Technology presents: Advances in Synthetic Biology
The latest SLAS Technology issue highlights recent breakthroughs in skin cutaneous melanoma, glycan-bead coupling, and acoustic ejection mass spectrometry. Researchers adapt technological advancements for life sciences exploration and experimentation in biomedical research and development.
Innovative techniques open new avenues in drug discovery for brain diseases
Researchers develop an in vitro model to study tau aggregation, a process linked to neurodegenerative diseases like Alzheimer's and frontotemporal dementia. The approach offers a short timeline for generating data and facilitates the study of potential therapeutic interventions.
Study reports new compound halting replication of COVID by targeting ‘Mac-1’ protein in cell models
Researchers at University of Kansas discover a new compound that inhibits SARS-CoV-2 replication in cell models by targeting the 'Mac-1' protein. This finding offers hope for developing new treatments and preventing future pandemics.
Dartmouth engineering team discovers new high-performance solar cell material
A Dartmouth Engineering-led study discovered a new high-performance solar absorber material that is stable and earth-abundant. The researchers used a unique high-throughput computational screening method to evaluate approximately 40,000 candidate materials, leading to the discovery of the Zintl-phosphide BaCd2P2.
The fate of drug discovery in academia; dumping in the publication landfill?
The lack of synergy between academia and industry in drug discovery hinders the development of effective treatments. Researchers discuss why many therapeutic molecules fail to reach clinical trials despite pre-clinical efficacy.
New NIH-funded center could soon reduce the need for pharmaceutical trials on animals
The University of Rochester is establishing a new NIH-funded center focused on developing FDA-qualified drug development tools related to barrier functions in disease. Researchers will create microphysiological systems with ultrathin membranes of human cells, aiming to reduce animal trials and improve drug efficacy.
A neuromuscular model for drug development
Scientists have created a self-organizing neuromuscular junction model from human pluripotent stem cells to study complex neuromuscular diseases. The 2D and 3D cultures mimic the physiological situation, allowing researchers to perform high-throughput drug screening for novel treatments.
A Special Collection collaboration between SLAS and SBI2
This special collection in SLAS Discovery highlights the significant impact of high-content imaging in basic and translational research. Researchers have made advancements in cell painting and phenotypic profiling, offering new therapeutic approaches for diseases such as Gaucher's.
Life sciences assay developments and sustainability progress
The SLAS Technology October 2023 issue focuses on reducing laboratory automation waste through machine learning and novel systems. Researchers adapt technological advancements for life sciences exploration and experimentation, enabling improved biomedical research and development.
"Two-factor" screening of newborns enhances congenital hearing loss management
A study involving 119,606 Chinese newborns found that concurrent hearing and high-throughput genetic screening significantly enhances congenital hearing loss management. The detection rate of certain gene mutations was also reported, highlighting the importance of considering multiple factors for accurate diagnosis.
Looking at the latest in Life Sciences Discovery and Technology
The August 2023 issue of SLAS Technology features original research articles on nanodiamonds, automated buffer exchange, and epidermal growth factor. A new scheduling method called SAGAS is proposed to optimize life science experiments in laboratory automation.
Screening genes for the right treatment: new hope for children with cancer
A new study improves the chances of finding the right drug to kill individual cancers in children by incorporating high-throughput drug screening into precision medicine. The approach reveals additional drug sensitivities and predicts clinical response, leading to better treatment options.
New advancements in assay development research
The latest issue of SLAS Discovery features novel technologies and approaches to develop and characterize chemical and biological tools for human disease treatment. The journal reports on high-throughput screening-related research, including fluorescence polarization assay use and glycomimetics.
Proof of concept study shows improvements for personalized drug testing
A proof-of-concept study demonstrates the effectiveness of two supporting matrices in growing spheroids derived from patient cells for 3D drug sensitivity and resistance testing. This finding offers promising prospects for automating this process in drug testing.
SLAS Technology provides insight into the future of bioprinting
The June special issue of SLAS Technology highlights the latest developments in bioprinting, a transformative technology poised to revolutionize many aspects of medicine. Bioprinting is advancing at a rapid pace, with novel materials, fabrication techniques, and bio-ink compositions being developed.
Plant based compound Peruvoside could prevent spread of diverse medically important viruses: NUS Medicine
Peruvoside has been discovered to prevent up to 12 medically important viruses, including SARS-CoV-2, Hand, Foot and Mouth Disease (HFMD), and Influenza. The compound acts on GBF1 protein, disabling its functionality and stopping virus production.
A novel high-throughput method for screening protein-secreting microbial strains
A novel method combines biosensors and microfluidics to quickly identify mutant bacterial strains that produce industrially useful proteins. The approach enables the extraction of high-performing strains in a fraction of the time required by traditional methods.
Circumventing the renal toxicity associated with cisplatin treatment
Researchers have found a compound that can prevent cisplatin-induced renal toxicity and improve the outcomes of cancer treatment. The aromatic ketone 2',4',6'-trihydroxyacetophenone (THA) inhibits the CCBL1-mediated metabolism of cisplatin, reducing its toxic effects without affecting its potency.
Ibogaine inspires new compounds to treat addiction, depression
Researchers have created two new drug candidates that mimic ibogaine's impact on serotonin transporters, showing promise in treating addiction and depression. The new compounds replicate ibogaine's desirable effects while avoiding its dangerous side effects.
Analyzing CAR-T cells with image cytometry for potential solid tumor treatments
Researchers developed a high-throughput assay to analyze CAR-T cells' effects on 3D tumor spheroid models using plate-based image cytometry. This study demonstrates the potential benefits of this method for assessing potency, specificity, and location of CAR-T cells in relation to spheroids.
Innovative automated algorithm improves detection of neuronal fitness in synucleinopathy
A new automated algorithm enhances the assessment of human neuron survival in synucleinopathy by tracking cell death and markers of neuronal fitness. The developed method offers improved accuracy and consistency compared to manual counting.
How can we fight blood cancer more effectively?
Researchers at ETH Zurich have developed a new method called pharmacoscopy to test treatment options for multiple myeloma patients. This high-throughput screening platform analyzes the reactions of cancer cells to various treatments, offering personalized therapeutic strategies.
On the horizon: Painless way to check for bladder cancer
A University of Houston team has discovered new biomarkers for early detection of bladder cancer, including D-dimer and IL-8, which may identify disease progression. The study's findings could lead to a simple urine test as the new standard for bladder cancer diagnosis.
SLAS discovery highlights protocols in drug discovery for March special issue
The March special issue of SLAS Discovery introduces protocol articles highlighting detailed scientific methods and procedures in drug discovery. The issue covers topics such as 3D imaging, cancer treatments, and high-throughput screening, emphasizing transparency and rigor in research methodology.
Oregon State researchers develop new model for quickly evaluating potential cervical cancer drugs
Researchers at Oregon State University have created a new model for evaluating potential cervical cancer drugs. The study, led by Kaitlin Fogg, enables the simultaneous and rapid testing of multiple drug compounds, opening the door to large-scale screenings that can uncover new therapies and personalized medicine options.
Assessing the benefits of digital microfluidics for bacterial protocols
The article analyzes digital microfluidics' (DMF) benefits for bacterial protocols, highlighting its versatility and potential applications in synthetic biology and diagnostics. DMF's electrostatic forces manipulate microdroplets on a plate, enabling sample preparation and nucleic acid detection.
Announcing the SLAS Discovery Editor's top 10 for 2022
The SLAS Discovery Editor's Top 10 for 2022 showcases articles on COVID-19 drug discovery, 3D organoid systems, and treatments for diseases such as autism spectrum disorder and obesity. These top articles demonstrate the impact of high-throughput screening approaches and innovative technologies in advancing scientific collaboration.
Reimagining drugs for rare brain disorder
A team of researchers has developed a new method to screen FDA-approved drugs to determine if they could be repurposed or improved to help patients with spinocerebellar ataxia type 5 (SCA5), a rare and debilitating disease. The pipeline uses cutting-edge spectroscopy to examine the interaction between mutant β-III-spectrin and actin, i...
A new Assay screening method shows therapeutic promise for treating auto-immune disease
A new high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of ERAP1 has been developed, demonstrating improved stability, reproducibility, and robustness compared to existing assays. The assay's ability to detect other difficult targets makes it a valuable tool in drug discovery.