Articles tagged with High Throughput Screening
Researchers proposed rational design of nanocatalysts using metal-support interaction descriptor, identifying optimal balance between adhesion and cohesion energies. This theory guides the design of ultrastable heterogeneous metal nanocatalysts, overcoming sintering issues and improving productivity.
Researchers have identified a molecule that slows cells' production of alpha-synuclein, a protein forming toxic aggregates in Parkinson's brains. The compound, A-443654, also reduces cell stress and may help degrade existing alpha-synuclein aggregates.
Researchers developed lab-grown cochlear organoids to screen FDA-approved drugs for hair cell-inducing properties. The study identified Regorafenib as a potent stimulator of hair cell formation, even regenerating lost cells in mouse tissues.
The European Lead Factory uses microscale thermophoresis to prioritize small molecule hits from high-throughput screening, improving the efficiency of drug discovery. This technology measures biomolecule movement through temperature gradients and avoids spurious mechanisms that can lead to costly failures.
Scientists at Scripps Research Institute have developed a device called LIGHTSABR that can screen millions of compounds in a week for about $500. The device overcomes technical challenges in miniaturized screening and allows users to adjust the dose of the compound being tested.
Researchers at Mahidol University have created a rapid prenatal test for diagnosing alpha-thalassemia. The new assay boasts high sensitivity and specificity, as well as a decreased risk of contamination, making it suitable for large-scale screening in Southeast Asia.
A new screening approach can accurately profile compounds in large chemical libraries, speeding the production of data for biological activities and identifying potential drug targets. This advance enables a more complete pharmacological characterization of compounds than traditional methods.
The University of Pittsburgh has been awarded $9 million to develop research tools for drug discovery as part of NIH's Roadmap initiative. The Molecular Libraries Screening Centers Network aims to accelerate medical discoveries by conducting high-throughput screenings of molecules.
By applying combinatorial techniques, scientists can test thousands of polymeric materials in a single experiment, reducing the time and effort required to develop new materials. This technology has the potential to revolutionize fields such as biomedical and electronic engineering.