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Protein study could help researchers develop new antibiotics

A team of researchers has created a water-soluble version of the bacterial enzyme histidine kinase, which could be used in high-throughput screens to rapidly test potential drugs that target this enzyme. The new protein retains its natural functions despite being converted from a hydrophobic protein.

Study reveals how bacterial pathogen adapts to nutritional stress

Researchers at Illinois provided insight into the signal transduction mechanism utilized by Staphylococcus aureus's TCS ArlRS in response to host-imposed manganese and glucose starvation. The study found that histidine kinase ArlS is necessary for activation of response regulator ArlR under both manganese and glucose-limited conditions.