Articles tagged with Histones
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Researchers at UC Davis have discovered a potential strategy to combat HIV latency by modulating histone crotonylation, which regulates HIV transcription. Increasing crotonylation increased viral transcription in both cell models and patient samples, suggesting a promising approach for developing an HIV cure.
Researchers profiled the epigenomic landscape of Alzheimer's disease brains, revealing a protective epigenetic link between aging and AD. The study found that certain normal aging changes in the epigenome may protect against AD, while dysregulated aging may induce disease-specific changes.
A University of Iowa biologist discovered a virus family whose set of genes is similar to that of eukaryotes, helping clarify the evolution of eukaryotes after branching from prokaryotes. Giant viruses like Marseilleviridae may have been the source of these genes.
Researchers have gained insight into the structure and regulation of Polycomb Repressive Complex 2 (PRC2), a gene regulator that controls cell differentiation and cancer development. The study's findings hold promise for developing new therapies for cancer by targeting PRC2 dysfunction.
Researchers analyzed over 500 cases of DIPG and related tumors to find that tumors with histone mutations that haven't invaded surrounding brain tissue have better outcomes. Patients with non-invasive tumors had approximately 4-5 times longer survival rates compared to those with invasive tumors.
A new homogeneous assay detects succinate using luminescence, enabling the investigation of a large number of structurally conserved enzymes belonging to the Fe(II)/2-oxoglutarate-dependent dioxygenase superfamily. This method has significant applications in dioxygenase research and has the potential to impact human diseases.
Researchers at IRB Barcelona identify BigH1 histone as crucial for male fertility and sex cell differentiation, promoting reproductive health. The study provides new insights into the role of histones in regulating gene expression and understanding infertility.
Using computer models, researchers analyzed epigenetic marks to predict how chromosomes fold in three dimensions. By training a neural network on these marks, they were able to identify the structural types of chromatin and validate their findings with additional data.
Scientists have discovered two new classes of histone modifications that couple cellular metabolism to gene activity, providing a potential mechanism for environmental influences on gene expression. The novel marks, propionylation and butyrylation, are linked to fatty acid metabolism and can drive transcription in test tube experiments.
Researchers found that NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation, leading to increased invasiveness and poor clinical outcomes. Depletion of NatD suppresses EMT via repression of Slug expression, suggesting a new therapeutic target for cancer treatment.
Scientists have identified a crucial protein called RSF1 that plays a vital role in gene silencing during normal embryo development. The discovery has significant implications for understanding the mechanisms of gene regulation and its potential application in cancer treatment.
A recent study on the protein CLAMP in fruit flies identifies two essential roles: coordinating gene expression on X and Y chromosomes. This research offers a promising model for understanding how proteins function differently in specific contexts, crucial for developing targeted therapies with minimal side effects.
Researchers reveal histone 1 prevents accumulation of lethal R-loops and genome instability in heterochromatin, contradicting long-held hypothesis.
Researchers from Princeton University discovered that ISWI chromatin remodelers use the 'acidic patch' to remodel chromatin. The study reveals that this feature is a general requirement for chromatin remodeling to occur, and certain chemical modifications can enhance or inhibit ISWI remodeling activity.
Studies of microbe DNA structure reveal surprising similarities to human DNA folding, suggesting an early common ancestor. The discovery hints at the evolutionary origins of genome folding in eukaryotes.
Gene silencing is crucial for plant development and growth, and a recent study has shed light on its mechanisms. The researchers discovered that Polycomb-group proteins play a key role in this process, using histone modifications to silence genes.
A study published in Molecular Cancer Research reveals that a histone mutation turns off the tumor suppressor gene p16 in up to 70% of childhood brain tumors called diffuse intrinsic pontine glioma (DIPG). Restoring p16 using a drug approved for adult leukemia treatment slows down tumor growth.
Researchers from Mayo Clinic have made significant progress in understanding the DNA damage response proteins and their role in repairing double-strand breaks. The study reveals how these proteins work together to fix damaged DNA, potentially leading to new therapeutic strategies for cancer treatment.
A team of researchers at Johns Hopkins Medicine has identified a crucial enzyme, RAG-2, that enables precise DNA rearrangement during white blood cell development. This process is essential for producing novel antibodies that recognize and combat viruses and bacteria.
Researchers at Uppsala University have found a new principle for epigenetic changes, involving the tryptase enzyme that cleaves histone tails. This mechanism is crucial for maintaining cellular identity and preventing uncontrolled cell proliferation.
Researchers at the Institute for Basic Science found a new epigenetic mechanism controlling flowering time in Arabidopsis thaliana. Plants lacking this protein complex bloom earlier, indicating compromised regulation of stem cells activity.
Researchers at Helmholtz Zentrum München found a mechanism controlling cell division after fertilization, allowing for diverse cellular development. The study reveals that the molecule Suv4-20h2 attaches methyl groups to histones, arresting cell progression and enabling totipotency.
Researchers discovered that enzyme KDM4B selectively binds to specific epigenetic marks on histone proteins, enabling its
Researchers at UNC School of Medicine discovered that tight DNA packaging in chromosomes mainly guards against virus-like genetic elements known as transposons or 'jumping genes,' which can copy and paste themselves throughout the genome, potentially destroying important genes. The discovery clarifies the role of heterochromatin and ad...
A study at The University of Texas MD Anderson Cancer Center reveals protein ZMYND8's ability to block metastasis-linked gene expression in prostate cancer. ZMYND8 cooperates with histone mark eraser JARID1D to suppress metastasis-linked genes.
Researchers at Osaka University have identified H4K20ac, a novel histone modification associated with gene repression. This finding has significant implications for understanding the development of metabolic disorders, cardiovascular diseases, and cancer.
Core proteins partially disassemble to facilitate gene activation, according to Rice University researchers. Their detailed models support the idea that DNA unwrapping and core protein unfolding are coupled, with histone tails playing a crucial role in nucleosome stability.
Researchers at Rockefeller University discover a rare form of cancer caused by a mutation in histone proteins that package DNA. The mutation triggers a proliferative state, leading to tumor development without other DNA mutations present.
A single defect in a histone gene has been linked to pediatric cancers, with researchers finding that the mutation can form a tumor on its own. The discovery could lead to new treatment options for metastatic breast cancer and provide insights into human development.
Researchers at Princeton University have discovered the two-step process that activates Suv39h1, an essential enzyme responsible for organizing large portions of human DNA. The study reveals how the enzyme employs a positive feedback loop to chemically tag unnecessary regions of DNA.
A high-fat diet during pregnancy and lactation leads to epigenetic changes in the offspring, affecting metabolic pathways regulated by the gut hormone GIP. Adult offspring are more susceptible to obesity and insulin resistance, similar mechanisms cannot be ruled out in humans.
A team of researchers found that specific patterns of histone modifications, known as acetylation motifs, play a crucial role in regulating gene expression. The study suggests that the distribution of these motifs depends on the neighboring marks, providing new insights into epigenetic mechanisms.
Studies reveal crucial role of histone chaperone protein in maintaining epigenetic landscape and genomic fidelity. Deletion of key protein leads to severe developmental defects, DNA damage, and compromised gene regulation.
Researchers have discovered a new function of Histone H1 that helps summon repair proteins, leading to improved understanding of how cells protect and repair DNA damages. This discovery may eventually result in targeted treatments for diseases such as cancer and immune deficiency syndrome.
Scientists at McGill University have discovered that histones, previously underappreciated molecules, play a crucial role in transmitting environmental memories over several generations. This finding has the potential to profoundly change our understanding of inheritance and could lead to new avenues for disease prevention and treatment.
The study reveals how lysine acetylation in histone tails influences gene activity by altering their structure. This modification makes DNA molecules more accessible to effector proteins, leading to increased gene expression.
A new database, Histone Antibody Specificity Database, has been launched to improve the accuracy of histone antibodies used in epigenetics research. The database provides validated test results for over 100 commonly used antibodies, allowing researchers to select reliable options for their experiments.
Researchers at the University of Liverpool discovered that nuclear proteins called histones induce damage to heart muscle cells in sepsis. Histone levels in blood can predict which patients are at risk of developing deadly heart complications. The study also identified a novel targeted treatment using specific antibodies.
Research at Rockefeller University discovered that the recycling of a specific type of histone, H3.3, is essential for forming connections among neurons and facilitating learning throughout life. The study found that increased turnover of H3.3 is linked to neural activity and gene expression changes necessary for synapse formation.
Researchers discovered a new epigenetic mechanism in brain cells that enables genetic adaptation to the environment through histone turnover. Histone replacement, or turnover, allows genes to be switched on and off in response to external stimuli.
Scientists developed ICeChIP, a new technique to calibrate chromatin immunoprecipitation (ChIP) experiments with an internal standard. This improves accuracy and reproducibility in epigenetic studies, enabling comparisons between experiments and discovery of new findings, including the prevalence of bivalency in stem cells.
A new purpose for histone variant H3.3 has been discovered, preventing genetic mutations by keeping retrotransposons in place. This study reveals a basic mechanism of epigenetics in stem cells, which helps maintain the stability of the genome.
Researchers have found a possible treatment for diffuse intrinsic pontine gliomas (DIPG), a lethal form of pediatric brain cancer. Panobinostat, an epigenetic drug, may slow DIPG growth and extend survival rates in patients.
Scientists have developed a method to introduce non-native chromatin into cells, allowing them to systematically interrogate transcriptional signaling pathways. This approach enables researchers to propose mechanistic pathways and validate hypotheses in vivo, paving the way for potential therapeutic applications.
Researchers found that changes to histone proteins can be sustained from one generation to the next and influence trait inheritance. This discovery paves the way for studying epigenetic mechanisms and their link to health conditions and specific traits.
Scientists from UNC-Chapel Hill have developed a groundbreaking research tool to investigate epigenetic mechanisms, shedding light on the critical role of histone proteins in gene regulation. This breakthrough may lead to new insights into diseases such as Alzheimer's, diabetes, obesity, and cancer.
A novel analytical method enables characterization of epigenetic tags, revealing that the system adapts to the loss of single epigenetic writer and eraser enzymes. The study also finds that biological systems can compensate for the loss of individual functional components by attaching novel acetylation tags at nearby sites.
A study led by Mount Sinai researchers found that the clipping of histone protein H3.3 silences genes regulating cell division and duplication, potentially limiting abnormal cell growth in tumors. This discovery has implications for understanding cellular senescence and its role in cancer prevention.
Researchers at MD Anderson Cancer Center discovered a new 'reader' protein, YEATS, that plays a crucial role in gene activation and DNA packaging. The study suggests that manipulating YEATS domains could lead to the development of new cancer treatments.
Researchers at San Francisco State University found that embryonic cells receive distinct epigenetic marks from parents, influencing development and behavior. The study identifies unique histone marks in sperm and embryos, potentially aiding proper cell division and human function.
Researchers at the University of Tokyo have found that PTX3, a protein involved in innate immunity, can reduce mortality from sepsis by protecting endothelial cells from damage. The study's findings suggest that PTX3 may be used to develop a novel therapy for sepsis.
Mutations in histone H3.3 drive cancer by repressing PRC2 and recruiting demethylases like KDM3B. This alters chromatin structure, allowing oncogenes to be derepressed, potentially leading to tumorigenesis. The specific role of these mutations remains an open question.
Research reveals that lipid droplets play a crucial role in regulating histone proteins in fruit fly embryos, helping to maintain the 'perfect' balance required for development. The findings suggest that manipulating this process could potentially treat diseases linked to chromosome malfunction.
The 'human hairless' gene plays a crucial role in regulating hair growth, with mutations contributing to atrichia with papular lesions. Researchers discovered the gene's histone demethylase function, offering hope for developing new approaches to treat skin disorders and rare forms of hair loss.
A team of scientists has discovered that a single amino acid difference in histone H3.3 enables it to serve as a memory device for the cell, marking genes that need to remain active. This epigenetic modification acts as a flag, signaling to the cell that genes in the vicinity should be inactive.
Researchers identified an enzyme called TLK1 that regulates the transport of histones to DNA copying hubs, crucial for maintaining normal gene function. The study found that TLK1 boosts the supply of histones at critical time points, ensuring correct chromatin architecture and cellular identity.
Researchers found a new application of physics tools in understanding epigenetic memory, which is how organisms create a biological memory of certain conditions. The study highlights the interdisciplinary nature of modern molecular biology and shows how mathematical models can help clarify complex biological problems.
Researchers from RIKEN in Japan have identified a duo of histone proteins, TH2A and TH2B, that dramatically enhance the generation of induced pluripotent stem cells (iPSCs). The study demonstrates that these proteins function as substitutes for two Yamanaka factors and increase iPSC cell generation by twentyfold and speed up the process.
Researchers used biochemical, structural, and global sequencing techniques to study the H3K4 trimethylation mechanism in a cancer-associated protein complex. They found that the methylase's activity was directed towards specific targets through COMPASS factors that bind to the SET1/MLL front end.
Researchers at the University of Pennsylvania School of Medicine found that HDAC3 can repress gene expression and prevent fatty liver even without enzyme activity. This study challenges the molecular targets of HDAC inhibitors, warranting reassessment of their mechanisms.