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Researchers at Rockefeller University reveal a crucial link between the Ezh2 protein and chromatin modifications, enabling the development of a wide range of antibodies. The discovery provides new insights into B cell biology and the immune system.

Study helps explain gene silencing in the developing embryo

Researchers have linked Polycomb gene silencing to histone protein methylation, explaining the permanence of Hox gene silencing. The study found that Polycomb proteins function through methylating a specific lysine residue on histone 3, leading to permanent gene silencing.

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'Ping-Pong' mechanism seen in gene-controlling enzyme

Scientists have identified a unique mechanism used by the Esa1 enzyme to relax DNA packaging, differing from other enzymes in its family. This discovery opens up new possibilities for developing targeted cancer therapies.

U. Va. scientists find new piece of gene expression puzzle

Researchers have found a new piece of the gene expression puzzle, revealing how histone proteins interact with each other and with other molecules to regulate gene activity. The discovery sheds light on potential causes of male infertility and highlights the complex mechanisms at play in chromatin.

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Optical tweezers show how DNA uncoils

Using optical tweezers, researchers have observed the dynamic structure of individual nucleosomes for the first time. They found that DNA in these units can be released from histones through a three-stage process, allowing enzymes like RNA polymerase to access genetic information.

New light on molecular switch that turns genes off

A new enzyme called Set2 has been discovered, which regulates gene expression by methylating histone protein H3. This process can help turn genes off, potentially offering a new approach to treating human diseases such as cancer.

Protein discovery tied to DNA master switch

Researchers have identified a critical protein, SET7, that regulates gene expression by modifying histone H3. This discovery may lead to new treatments for diseases and provide insights into using stem cells to generate organs. The study reveals that SET7 makes chromatin structure more open, allowing other proteins to access genes.

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Required activation 'cascade' identified for p53 tumor-suppressor protein

Researchers at The Wistar Institute have identified a carefully orchestrated series of molecular modifications to p53 that must occur for it to perform its normal function. This discovery may suggest new ways to combat cancers where p53 is dysfunctional, and could also provide insights into the regulation of other DNA-binding proteins.

A closer look at the genome’s ‘black holes’

Research suggests centromeric DNA and histones evolve rapidly, influencing species compatibility. Continuous evolution of centromeric histones may be driving adaptation to changing DNA sequences, contributing to the 'centromere paradox' and species sterility.

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Common mode of action likely in gene-activation molecules linked to cancers

Scientists have identified a common mode of action among gene-activation molecules linked to cancers, according to a study published in Molecular Cell. The researchers found structural similarities among the molecules, suggesting they may share a unified mechanism of action despite chemical dissimilarities.

Wistar Institute scientists find key piece in gene regulation puzzle

Wistar Institute scientists have determined the three-dimensional structure of a key enzyme involved in gene activation, GCN5. The study reveals details on how the enzyme carries out its function and identifies the structural adjustments needed for proper regulation of gene activation.