Articles tagged with Hormones
Research from the University of North Carolina finds that low adrenomedullin hormone levels may cause preeclampsia and other pregnancy complications. Pregnant mice with reduced adrenomedullin levels had smaller litter sizes, overcrowded embryo spacing, and poor fetal growth.
A hormone called BNP detects pulmonary hypertension in sickle cell disease patients and predicts mortality. High BNP levels correlate with greater pressure in pulmonary arteries and increased risk of death.
Researchers discovered a link between phosphodiesterase 11A enzyme deficiency and the development of rare tumors in patients with adrenal disorders. The study found four patients with mutant copies of the PDE11A gene, leading to higher levels of cyclic nucleotides that may stimulate tumor growth.
A new study found that calorie restriction decreases tumor necrosis factor alpha and lowers T3 levels in humans, suggesting it may slow the aging process. The researchers also found no association between body fat levels and serum T3 concentrations.
Researchers found that a loose connection between hormone and GPCR allows for stronger signal activation, potentially leading to more effective drug therapies. The study used thyrotropin-releasing hormone (TRH) as a model and suggests that a similar approach could be applied to other hormone-GPCR reactions.
Researchers received FDA approval for a nonhormonal contraceptive device that blocks sperm in the vas deferens, aiming to provide a long-term and reversible method. The Intra Vas Device has shown effectiveness in preliminary studies, with men citing benefits such as avoiding hormonal side effects.
A recent study published in the International Journal of Obesity discovered that oxyntomodulin, a hormone, can reduce food intake and increase energy expenditure in overweight volunteers. This finding holds promise for developing a new therapy to treat obesity, shifting focus from dieting alone to increasing spontaneous activity levels.
A study by Michigan State University zoology professor Kay Holekamp found that high-ranking hyena mothers pass on high levels of androgens to their offspring, making them more aggressive and sexually vigorous. This unique trait helps females secure food resources and dominate their social group.
Researchers found that high-dose CRF injections triggered intense bursts of sugar craving in response to a cue, but low doses or no injection had minimal effect. The study suggests a potential link between stress and binge behavior.
Scientists at the University of Oregon discovered that complexity evolved piecemeal through Molecular Exploitation. They found that old genes were recruited to participate in new interactions and functions, consistent with Darwinian evolution.
Researchers identified a liver-derived protein complex as the first essential brain signal governing seasonal adaptation in hibernating animals. This discovery may pave the way toward clinical therapies that protect humans from lethal diseases like hypothermia and ischemia.
Joan A. Steitz and Thomas D. Pollard, two Yale biologists, have been awarded the 2006 Gairdner International Award for their groundbreaking discoveries in understanding autoimmune disease and cell motility. Their work has significant implications for improving human quality of life.
Researchers found that people with smaller anterior cingulate cortex had higher levels of stress hormones, suggesting a potential cause-and-effect relationship. The discovery deepens understanding of ageing, depression, and Alzheimer's diseases, and may lead to treatments targeting reduced stress hormone levels.
Researchers propose that social systems arose as a group defense mechanism against predators, citing studies on male muriqui networks and affiliative hormones in primate species. Positive behaviors like grooming and physical touch increase levels of social bonding hormones.
Researchers found a direct link between aldosterone levels and the ability to hear normally as people age. Lower blood levels of aldosterone are associated with severe hearing loss, suggesting that the hormone plays a role in maintaining good hearing.
Researchers identified an abnormal variant of β-MSH in five out of 538 obese children, which was more common in overweight or obese family members than in normal-weight relatives. The mutation altered the hormone's structure and ability to stimulate brain receptors, leading to increased obesity risk.
Duke University biologists evolved a complex polyphenic trait in tobacco hornworms by applying temperature shocks to create two distinct strains with different color responses. The researchers discovered that the level of juvenile hormone regulated the color change, and their experiments demonstrated genetic accommodation.
Researchers found that Magellanic Penguins in Argentina's largest colony can handle up to 70,000 annual visitors without significant stress or harm. However, the study highlights the challenges of quantifying long-term consequences of human disturbance on wildlife.
Scientists have discovered male water fleas in a lab, revealing that pesticides can induce sex change and affect populations of fish and other organisms. The finding highlights the importance of considering non-target species in environmental monitoring and management.
A study of 2,730 men and women aged 70 to 79 found that subclinical hypothyroidism was associated with a higher rate of incident and recurrent congestive heart failure. In contrast, no association was found between subclinical hypothyroidism and coronary heart disease or stroke.
Researchers discovered Klotho protein increases cell resistance to oxidative stress by detoxifying harmful reactive oxygen species. This finding may lead to the development of anti-aging drugs, potentially useful as medicines.
Researchers found that the hormone PYY inhibits eating in the morning but not in the evening, resulting in mild weight loss. High doses of PYY are required for weight loss, and further studies are needed to understand its potential as a weight loss treatment.
Scientists at University of Cincinnati discover a hormone that regulates blood pressure and is linked to preeclampsia, a leading cause of fetal complications. By understanding how this hormone interacts with the sodium pump, researchers aim to develop a treatment for preeclampsia.
Researchers found that newly hatched magellanic penguin chicks in breeding grounds with large numbers of human visitors show a significant spike in stress-related hormone levels. As the chicks grew older, their behavior towards humans changed, with those in tourist areas becoming more tolerant but still exhibiting caution.
Reduced thyroid hormone signaling during development leads to extreme anxiety and memory impairments in adulthood. Dietary supplementation with thyroid hormone can suppress anxiety and improve memory in adult mice.
A Yale University study found that early use of hormone therapy is linked to fewer wrinkles and firmer skin. The researchers compared 11 non-users with nine long-term hormone therapy users and found significant decreases in wrinkle severity and rigidity.
A study by the American Thoracic Society found that measuring hormone levels can reduce antibiotic use in pneumonia patients. The study showed that patients with low procalcitonin levels were not given antibiotics and recovered similarly to those who received a full course of antibiotics.
Scientists have found that activating PPARd genes can increase calorie burning, reduce inflammation, and build resistance to weight gain. This discovery has significant implications for treating obesity, diabetes, and atherosclerosis, potentially using genetic engineering or experimental drugs.
Researchers found that curious female rats with spontaneous breast or pituitary tumors lived an average of six months longer than cautious ones. The study suggests that personality traits may have a significant impact on health and resilience to disease, consistent with earlier findings in human studies.
A new study challenges the traditional understanding of sex assignment, suggesting that genetics and brain development may influence gender identity. Researchers highlight the need for more nuanced laws and policies to protect individuals with ambiguous genitalia.
A study found that women with primary hypothyroidism had a 61% lower risk of developing invasive breast cancer. Women with breast cancer were also less likely to have hypothyroidism compared to healthy women, and those with the condition were diagnosed with earlier stage disease.
Researchers discover that the nuclear hormone receptor nhr-49 controls two opposing pathways regulating fat metabolism in nematodes. The discovery reveals a complex feedback system controlling fat consumption and composition, with potential implications for understanding human metabolic disorders such as diabetes and obesity.
Researchers have made a major breakthrough in understanding how the FSH hormone attaches to its receptor, paving the way for improved fertility drugs. The crystal structure of FSH and its receptor reveals key details about their interaction, which could lead to the development of new oral drugs for fertility treatments.
Researchers suggest that the parathyroid gland evolved from the gills of ancestral marine creatures to regulate calcium levels in land-living animals. The discovery supports the idea that humans and other tetrapods share a common evolutionary history with fish.
A study found that stress hormones lower the threshold for aggression, while aggression raises stress hormones, leading to a feedback loop. This cycle may contribute to the escalation of violent behavior under stressful conditions.
A recent study published in JAMA found that excessive maternal thyroid hormone levels can lead to miscarriage and negatively impact fetal growth, with unaffected fetuses being more susceptible to these effects. The study also discovered that high maternal thyroid hormone levels can induce a catabolic state during fetal life.
Researchers found that acute stress increases levels of DHEA-S in healthy humans and the DHEA-S-cortisol ratio is associated with reduced dissociation symptoms. The study suggests that augmentation of DHEA-S levels before stress exposure may provide a protective effect against stress-induced symptoms.
Researchers demonstrated the safety of combining MT-1 with UV-B light or sunlight to induce tanning in human subjects. The study showed that MT-1 can be safely administered with UV-B exposure, resulting in enhanced tanning without adverse effects.
Using fruit flies, scientists confirm bursicon's role in hardening exoskeletons after molting and enabling wing development. The discovery could lead to precise timing of pest control measures for migratory locust outbreaks.
A study published in Archives of Surgery found that patients who underwent Roux-en-Y gastric bypass surgery experienced significant declines in ghrelin levels, a hormone that stimulates appetite. The findings suggest that complete division of the stomach contributes to this decline and may play a key role in weight loss.
Researchers found that ghrelin was significantly elevated with weight loss in exercising subjects, indicating a potential role for ghrelin in returning the body to a prior set-point for body weight. The study suggests that exercise training itself has little impact on ghrelin levels.
A recent imaging study at Carnegie Mellon University has discovered persistent sex-based differences in brain structures of mice entering adulthood, as revealed by high-resolution magnetic resonance microscopy. The findings provide a more accurate representation of how circulating hormones affect brain development compared to human ima...
Low thyroid hormone levels affect an estimated 40,000 pregnant and 1.6 million nonpregnant women in the US, with 3.1% of reproductive age women having low levels. Targeted screening before pregnancy may prevent developmental issues.
Researchers discovered a new compound, T1 amine, that rapidly induces hypothermia, slows heart rate, and drops blood pressure in mice. This effect may provide a valuable tool to manage patients with acute hypermetabolic states, including hyperthyroidism.
Researchers at SLU School of Medicine discovered a new drug, Cinacalcet, that successfully treated hyperparathyroidism, a common side effect of kidney disease. The treatment works by fooling the parathyroid glands into thinking calcium levels are higher than they actually are.
USF researchers identify bone marrow-derived BNP as a potential candidate for treating stroke, spinal cord injury and neurological damage. Bone marrow stromal cells release levels of BNP far exceeding the amounts normally found in circulating blood and spinal fluid.
A study found a higher prevalence of congenital abnormalities related to testicular descent in boys exposed to endosulfan. Although the sample size was small, the results suggest a link between endosulfan exposure and delayed sexual maturity in males.
A meta-analysis found that caregivers experience higher levels of stress hormones and lower antibody responses, leading to increased risk for various health problems. The study highlights the need for interventions to support caregiver health, which can benefit both caregivers and their care recipients.
Researchers found that wild blueberry-enriched diets helped relax arteries, reducing blood pressure and potential damage to the endothelial layer. The study suggests that high concentrations of antioxidants in blueberries may preserve nitric oxide bioavailability, aiding in maintaining arterial relaxation.
A study of 1,204 men treated with radiation therapy found that hormone therapy significantly increases the risk of moderate to severe genitorurinary and gastrointestinal side effects. Hormone therapy can extend lives but complicates treatment decision-making.
A study by Carl Thummel and Tatiana Kozlova found that ecdysone signaling is crucial for major morphogenetic movements during embryonic development. The researchers discovered that the amnioserosa, an extraembryonic tissue, is a critical source of ecdysone, which controls cell movements and maturation in insects.
Researchers at FIRS Laboratories have identified a monoclonal autoantibody responsible for hyperthyroidism in patients with Graves' disease. This breakthrough discovery may lead to the development of new agents controlling the action of autoantibodies and treating related hormonal disorders.
Biotechnology Heritage Award honors William Rutter's significant contributions to the development of biotechnology through discovery, innovation, and public understanding. Rutter's entrepreneurial spirit and management skills played a crucial role in the growth of biotechnology as a discipline and global industry.
Studies found that patients with acute brain injury had lower levels of anti-inflammatory molecule a-MSH, which remained low over four days after injury. This impairment may have detrimental consequences for brain injury treatment.
Researchers found that female participants experienced reduced tension and increased relaxation when exposed to pheromones from male underarm secretions. The study also showed a shift in blood levels of luteinizing hormone, with the onset of smaller pulses shortened by an average of 20 percent.
Researchers identified ghrelin as a hormone that stimulates feeding when introduced to specialized brain cells. Increased ghrelin levels in response to weight loss or reduced caloric intake lead to increased appetite and eating in both mice and humans.
Researchers found that children living in orphanages for over eight months had elevated cortisol levels, while those adopted early did not. However, internationally adopted children from poor care showed no significant differences in cortisol levels.
The biogerontological community is at war with anti-aging medicine, threatening the status and funding of their own research. Binstock argues that this campaign may inadvertently undermine their own legitimacy and research support by blurring public understanding of the difference between their work and pseudoscientific products.
A study found that statin use doesn't reduce reproductive hormone levels in premenopausal, perimenopausal, or postmenopausal women with coronary risk factors. The results provide reassurance on the safety of statins for women in child-bearing age.
William J. Rutter, cofounder of Chiron Corporation and biotechnology pioneer, is the latest recipient of the Biotechnology Heritage Award from CHF and BIO. The award recognizes his significant contributions to biotechnology through discovery, innovation, and public understanding.