Articles tagged with Leptin
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Research on leptin reveals its multifaceted roles in MAFLD, including regulation of energy balance and metabolism. Leptin therapy shows promise in rare cases of leptin deficiency but is largely ineffective in obesity-associated hyperleptinemia.
Researchers found that the leptin-SCD pathway fuels breast cancer growth and motility, leading to poorer recurrence-free survival. Selectively blocking SCD activity can counteract pro-tumorigenic effects driven by leptin, revealing a potential therapeutic target for obese patients.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
A new study found that nearly one-third of individuals adopting healthy diets didn't lose weight but still experienced significant improvements in cardiometabolic markers, including increased HDL cholesterol and reduced visceral fat. The research suggests a healthy diet can have benefits beyond weight loss.
Researchers found that female rodents experience heightened pain sensitivity due to activation of Panx1 channels releasing leptin, a hormone associated with increased pain sensitivity. This study aims to personalize treatment for patients and may explain the over-representation of women experiencing chronic pain compared to men.
Researchers discovered that dysregulation of amino acids methionine and leucine leads to hyperactive mTOR in obese mice. Using rapamycin, an mTOR inhibitor, they reversed leptin resistance and found significant weight loss with minimal effects on muscle mass.
New research found that neuroestrogens produced in the brain help suppress appetite, as confirmed by experiments where aromatase expression was restored specifically in the brain. This suggests a link between neuroestrogen levels and body weight regulation.
Researchers at Rutgers University have discovered that a weekly injection of diabetes medication can replace painful daily hormone shots for people with a rare genetic form of lipodystrophy. The study found that the drug tirzepatide improved insulin resistance and normalized blood glucose levels in patients, reducing the burden and pai...
Researchers at Vanderbilt University have found that the hunger hormone leptin can direct neural development in a leptin receptor-independent manner. This discovery suggests a novel role for leptin in specifying the development of neural circuits involved in autonomic regulation and food intake.
A new review reveals how leptin resistance, a key feature of obesity, exacerbates metabolic syndrome by triggering pro-inflammatory pathways and mitochondrial dysfunction. The study identifies potential therapeutic targets for restoring leptin sensitivity and mitigating its metabolic effects.
A new study by UT Health San Antonio found that higher levels of leptin are associated with better signal-transmitting brain white matter in middle-aged adults. The researchers also discovered a link between leptin bioavailability and reduced risk of cognitive impairment, providing potential insights into obesity's role in dementia.
Research published in the Journal of Investigative Dermatology reveals that UV exposure increases energy expenditure by inducing the 'browning' of subcutaneous fat, thereby preventing weight gain. This breakthrough discovery opens up new possibilities for treating obesity and metabolic disorders.
Researchers found that middle-age obesity is caused by age-related changes in the shape of neurons in the hypothalamus, a region controlling metabolism and appetite. A protein called MC4R detects overnutrition and regulates metabolism to prevent obesity. Dietary restriction may help maintain brain anti-obesity systems as we age.
Jessica Faulkner, a physiologist at the Medical College of Georgia, has been awarded the Harry Goldblatt Award from the American Heart Association's Hypertension Council. Her research focuses on the role of leptin in preeclampsia and obesity-associated cardiovascular disease in women.
A mouse study suggests that a specific brain receptor, the leptin receptor, may be involved in the development of PCOS symptoms. Researchers found that mice exposed to excess androgens prenatally had improved estrous cycles and regulation of their menstrual cycles, offering potential therapeutic targets for people with PCOS.
New research reveals coffee consumption may help reduce the risk of type 2 diabetes by lowering inflammatory biomarkers in the body. A study published in Clinical Nutrition found that a one cup per day increase in coffee consumption was associated with a 4-6% lower risk of T2D.
Researchers found that GIPFA-085, a long-acting GIPRA, acutely inhibited feeding and lowered body weight in diet-induced obese mice. The hormone increased plasma leptin levels and activated satiety neurons, facilitating fat utilization and reducing body weight gain.
Dr. David McDougal's research project aims to find better therapies to prevent hypoglycemic episodes in people with type 1 diabetes, focusing on the role of leptin in regulating blood sugar responses. The grant-funded study seeks to identify novel treatments for preventing low blood glucose in these patients.
Researchers found that leptin receptor neurons prioritize social interaction over eating and drinking in moderately hungry mice. This system can only regulate moderate hunger, but not strong hunger, which may contribute to why diets don't work.
Researchers at Baylor College of Medicine discovered that Grb10 promotes leptin activity in the brain, which may help overcome leptin resistance. This finding suggests that increasing Grb10 activity could lead to weight loss by decreasing food intake and increasing energy expenditure.
Research by Virginia Tech scientist Sora Shin reveals how early life trauma alters the brain's signals to stop eating, increasing the risk of binge eating. The discovery identifies a specific brain circuit vulnerable to stress, providing new insights into therapeutic targets for treating the disorder.
A study published in Nature reveals that cancer stem cells' miscommunication with their environment can trigger a self-perpetuating series of events leading to malignancy. Leptin signaling plays a surprising role in this process, which could be blocked to prevent tumor progression.
A study found that leptin stimulates liver fat export and lowers liver fat content in healthy men, suggesting a new approach for treating fatty liver disease. The findings imply that the brain plays a role in liver fat metabolism via the autonomic nervous system, opening up potential new treatment options.
Researchers at Nagoya University have discovered a new treatment for type 1 diabetes that uses leptin to improve insulin-alternative effects in mice. The combination of leptin and a PTP1B inhibitor normalizes blood glucose levels without the need for insulin, reducing hypoglycemia risk.
Researchers discovered that midgestation leptin surge in preeclampsia leads to endothelial dysfunction, blood vessel constriction, and restricted fetal growth. This finding highlights the crucial role of leptin in pregnancy and its potential consequences on maternal and infant cardiovascular health.
A Johns Hopkins-led study found that leptin cancels out the effects of Tamoxifen, making it ineffective for obese patients with breast cancer. Researchers suggest that interventions targeting leptin or Med1 may improve Tamoxifen's success in this group.
Researchers aim to generate a model of brain-fat communication system to regulate metabolism during environmental challenges. The study uses cutting-edge techniques like immunolabeling-enabled imaging to identify new components of neural circuits controlling brown and white fat tissues.
A recent study from the Okinawa Institute of Science and Technology Graduate University identified a crucial protein linked to increased appetite and obesity in mice. The researchers found that mice lacking this protein, XRN1, exhibited leptin resistance, leading to insatiable hunger and weight gain.
Researchers from The Stuber Lab discovered that certain neurons in the brain light up in obese mice, preventing signals that indicate satiety. The study found that these neurons communicate with regions involved in depression and motivation, suggesting a link between eating disorders and addiction.
Scientists discovered impaired leptin transport to the brain via LepR receptors leads to pre-diabetic state and exhausted insulin secretion. Reintroducing leptin restores pancreatic function-promoting action, suggesting a crucial brain role in type 2 diabetes management.
New research reveals that obese mice do not increase the density of blood vessels in the hypothalamus when leptin is absent. However, increasing leptin levels promotes vessel growth via astrocyte activity. This study provides a paradigm shift in understanding how the hypothalamus controls blood pressure in obesity.
Researchers have found that leptin can help mobilize extra fat in the liver, reversing conditions like nonalcoholic steatohepatitis (NASH) in patients with partial lipodystrophy and/or low leptin levels. Leptin therapy showed promise in improving insulin sensitivity and body weight.
A University of Queensland study has found that reduced levels of metabolic hormone leptin are associated with poor vaccine antibody responses in both young and older individuals. The research could lead to the development of new strategies for improving vaccine protection in vulnerable populations.
A recent study found that obesity and a high-salt diet are bigger risks for females, who are more sensitive to salt and have naturally higher levels of hormones like leptin and aldosterone. This can lead to increased blood pressure and cardiovascular disease in young women.
Researchers discovered novel neurocircuitry in mice that links leptin to the brain's dopamine reward system, reducing food intake. The study suggests targeting specific neurons may help treat anorexia nervosa and support dieting in obese individuals.
An international study found a genetic variant reducing leptin production increases obesity risk in young children of African ancestry. In contrast, adults with the same variant are not at higher risk, suggesting leptin plays a critical role in early weight regulation.
New HIV treatments may increase weight, but surprisingly limit cardiovascular risk due to increased leptin levels. Leptin therapy has restored vascular function in patients with lipodystrophy.
Research suggests a hormone called leptin, which regulates appetite and metabolism, also plays a role in how the body fights off COVID-19. Elevated leptin levels can lead to a low-grade systemic inflammatory state, impairing the body's ability to fight infection, particularly in people with obesity.
Researchers found that fat-burning neurons in mice can grow and increase their ability to burn energy when given the hormone leptin. This discovery could lead to new treatments for obesity by targeting these neurons.
Researchers have discovered a molecular accelerator of leptin action in the brain called Sh2b1, which promotes the stimulation of the sympathetic nervous system and activates brown fat. This activation increases energy expenditure and protects against obesity and metabolic disease.
A new study reveals that maternal obesity triggers cellular stress in the endoplasmic reticulum, disrupting hypothalamic development and leading to offspring obesity. Bile acid treatment mitigates these changes, reversing obesity-related metabolic issues in mice offspring.
Researchers found brain damage in obese adolescents related to inflammation, particularly in regions controlling appetite and emotions. The study used MRI to track white matter damage and correlated it with inflammatory markers such as leptin and insulin.
Researchers at UNIGE identified a protein called S100A9 that regulates blood glucose and lipids, improving glucose management and reducing harmful side effects in diabetic mice. A clinical trial is underway to test the safety and efficacy of this new therapy in humans.
Scientists have identified a signaling channel in the carotid body that links obesity to high blood pressure, paving the way for potential new treatments. Blocking this molecule can effectively lower blood pressure in obese mice.
Research found that genetic modifications reducing leptin levels were more common in formula-fed babies, associated with higher body weight and increased risk of obesity. Breastfed infants had lower rates of these modifications, suggesting epigenetic mechanisms may play a role in childhood obesity development.
A new study published in the Journal of Clinical Investigation reveals a previously unknown gut-brain connection that plays a key role in obesity caused by overeating. The research found that increased levels of gastric inhibitory polypeptide (GIP) in the gut inhibit the action of leptin, leading to weight gain.
Researchers discovered a new mutation in the leptin gene associated with severe early-onset obesity. The mutation causes Leptin proteins to be misfolded, rendering them ineffective and leading to excess body fat.
A Yale-led study reveals the mechanisms by which leptin increases appetite in response to low energy levels. The research found that reductions in plasma leptin concentrations stimulate food intake through a chain of events involving the brain, endocrine system, and AgRP neurons.
Exercise and antioxidants such as astaxanthin have been shown to enhance brain function, particularly in the hippocampus region. The study found that mild exercise and astaxanthin are additive and mediated by the hormone leptin, leading to improved memory and neurogenesis.
Researchers found that growth hormone signaling promotes neuroendocrine adaptations during food deprivation, leading to increased appetite and reduced energy metabolism. This discovery provides new insights into the mechanisms behind weight loss and regain, highlighting the importance of GH in maintaining energy balance.
Researchers at Rockefeller University have identified a genetic mechanism that may contribute to 10% of all obesity cases. Alterations in the cellular machinery regulating leptin production can lead to obesity treatable with leptin therapy, and human genetics studies suggest a similar mechanism may contribute to obesity in some patients.
A study published in Nature Medicine reveals that celastrol increases brain sensitivity to leptin, leading to reduced food intake and weight loss. The research identifies a pro-inflammatory signaling pathway involving the IL1R1 receptor as key to understanding celastrol's effects.
Researchers at Johns Hopkins Medicine have successfully delivered the weight-loss hormone leptin through the nose to obese mice, alleviating breathing problems during sleep. The study suggests that nasal delivery may overcome leptin resistance and provide a new treatment option for obstructive sleep apnea.
Research suggests that leptin levels play a crucial role in protecting the cardiovascular system from damage. When leptin levels are optimal, they help restore balance to the body's physiological processes, reducing inflammation and oxidative stress.
A team of researchers has discovered a molecular mechanism that causes leptin resistance in obese individuals, which blocks the brain's ability to recognize when it's full. By blocking this enzyme, MMP-2, scientists hope to develop treatments for obesity-related issues and explore its broader implications.
Researchers at Tufts University have identified the neural circuit in the hypothalamus that mediates leptin's anti-obesity and anti-diabetes effects. The study reveals two distinct mechanisms underlying leptin's inhibition of appetite, providing important insight into how leptin works and how resistance to it develops.
Research suggests that race and pre-pregnancy body mass index (BMI) affect leptin and adiponectin levels, which can predict weight gain during pregnancy. Lower levels of adiponectin are associated with higher risk of gestational diabetes, while higher leptin levels are linked to pre-eclampsia.
Scientists are learning how too little body fat damages the cardiovascular system, similar to obesity. Leptin replacement therapy shows promise in reducing cardiovascular risk and improving metabolic function in individuals with congenital lipodystrophy and other conditions.
A study found that protein tyrosine phosphatase receptor type J (PTPRJ) inhibits leptin signaling, leading to leptin resistance. PTPRJ expression in the hypothalamus is up-regulated by diet-induced obesity, making it a potential target for improving obesity treatment.
Research suggests sugary drinks can lead to leptin resistance in rats, causing them to overeat and gain weight. This phenomenon may also apply to humans, highlighting the potential dangers of frequent sugary drink consumption.