Articles tagged with Leptin
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Research reveals that women with bulimia who have a more chronic disease and engage in frequent bingeing and vomiting have lower leptin levels. The findings suggest that factors other than body weight changes may impair leptin secretion, highlighting the need for longer-term studies on the topic.
Researchers uncover the role of parasympathetic innervation in fat distribution, revealing functional implications for obesity. Additionally, studies explore the molecular mechanisms behind long QT-3 syndrome, immunodeficiencies, and intestinal lymphocyte recruitment, shedding light on novel therapeutic targets.
A recent study identified stearoyl-CoA desaturase-1 (SCD-1) as a key enzyme involved in fat storage, specifically in the liver. Leptin, a hormone produced by fat tissue, represses SCD-1 levels, leading to decreased fat accumulation and increased energy expenditure.
A team of researchers found that a deficiency in the SCD-1 enzyme can counteract leptin's effects on weight gain, increasing energy expenditure and promoting fat burning. This discovery suggests a potential novel strategy for treating obesity and fatty liver diseases.
Research found that African populations with a fish-rich diet had lower leptin levels compared to those on a vegetarian diet. This association suggests that consuming fish may improve the body's sensitivity to leptin, which could help prevent obesity and related health issues.
Research found that chronic alcohol consumption led to a decrease in survival of melanoma-bearing mice due to body fat loss, suggesting potential risks for human cancer patients. The study also highlights the role of leptin in modulating immune function and cancer progression.
A new research study identifies a protein called PTP1B that helps overcome leptin resistance, a common issue in obese individuals. The knockout mice lacking PTP1B displayed increased energy expenditure and were resistant to high-fat diets.
Scientists have found a potential mechanism for obesity resistance in mice lacking the fat-making enzyme DGAT1. These mice are more sensitive to leptin and insulin, leading to lower tissue triglyceride levels and increased sensitivity to insulin, resulting in weight loss despite high-fat diets.
Scientists at Michigan Medicine have discovered that leptin is linked to blood clot formation, particularly in obese individuals. Knowing how to block this interaction could help prevent heart attacks and strokes.
A recent study published in JCI Journals reveals a significant connection between the brain and bone health, with implications for osteoporosis treatment. The findings suggest that certain neurological factors contribute to the development of bone disorders, opening up new avenues for therapy.
Researchers report significant improvements in patients with rare fat disorders who received leptin replacement therapy, including reduced triglyceride levels and liver fat accumulation. The therapy also controlled severe insulin resistance and improved blood glucose levels in most participants.
A recent study reveals a critical link between obesity and type 2 diabetes through the AMPK pathway and leptin hormone. Researchers found that AMPK activation, triggered by leptin, inhibits an enzyme involved in fat metabolism, increasing fat burning.
Research suggests that leptin, a hormone involved in weight regulation, may be more closely tied to mental factors than previously thought. Studies have found that alterations in brain structure and function may play a key role in leptin-related obesity.
Researchers found that adding leptin to sibutramine increased weight loss in obese rats, as it prevented a decrease in leptin levels that normally occurs with weight loss. This study provides new clues on how to overcome the plateau effect and may lead to successful treatments for obesity.
A study found that leptin treatment reduced appetite and increased feelings of fullness in obese men. However, the participants did not experience significant weight loss, suggesting that reduced appetite may not be representative of overall food intake.
Researchers discovered two converging pathways regulated by leptin, which modulate energy expenditure through the TRH promoter. Thyroid hormone also suppresses TRH production, integrating various signals to control energy metabolism.
Scientists have identified a number of genes specifically regulated by the hormone leptin, which is produced by fat tissue and secreted into the bloodstream. These findings offer new insights into how leptin causes fat loss and decreased appetite, and may also provide new targets for drugs designed to stimulate weight loss.
Researchers discovered a group of genes controlled by leptin that regulate fat tissue mass and body weight. The study found that leptin influences fatty acid synthesis through the regulation of SREBP-1, identifying potential therapeutic targets for treating obesity.
A Harvard study finds that regular vigorous exercise lowers leptin levels in both normal-weight and overweight men, which may reduce the risk of heart disease. Men who were more physically active had lower leptin levels, regardless of their weight or diet.
Researchers discovered a novel pathway controlling bone formation and density through the brain's hypothalamus, where leptin acts as a natural bone inhibitor. This finding offers potential treatment approaches for osteoporosis by manipulating the leptin pathway.
Researchers have found a potential link between leptin and high blood pressure in a study of over 300 healthy adults. Higher levels of leptin were associated with higher diastolic blood pressure, suggesting that leptin may play a role in regulating blood pressure.
Researchers have shown how the fat hormone leptin works in the brain to trigger nerve cells that control eating. Leptin activates 'anorectic' nerve cells releasing appetite-suppressing neuropeptides, while inhibiting 'orexigenic' cells that release appetite-regulatory neuropeptides.
A study found that leptin decreases in response to energy deficit in women, leading to increased hunger and desire to eat. Leptin's role in regulating food intake is supported by the association between leptin levels and self-reported hunger.
Researchers at the University of Illinois found that zinc deficiency can exacerbate anorexia by increasing neuropeptide Y production and decreasing leptin levels. Zinc supplements have shown to increase recovery rates, supporting its potential as a treatment for anorexia.
Elevated plasma leptin levels in obese individuals may indicate resistance to leptin's appetite-suppressing effects. Additionally, new evidence suggests a link between leptin concentrations and blood glucose changes, potentially connecting obesity and adult-onset diabetes.
Research found large differences in mean plasma leptin concentrations among Nigerian, Jamaican, and US black populations. Women showed higher leptin levels than men at every level of body fat. The study also suggests an exponential response of leptin to increases in body fat stores.
Researchers have identified genetic and biological factors that influence a person's propensity toward obesity, suggesting a link between hormonal imbalances and weight gain. These findings may lead to tailored drug treatments, enabling physicians to detect predispositions and treat obesity with precision.
Researchers found that oral administration of a steroid hormone boosts circulating leptin levels in humans, with higher levels observed in obese individuals. The study suggests that overweight people still have leptin reserves and may benefit from high-dose leptin therapy.
Researchers found leptin in human breast milk, which correlates with the amount of body fat in lactating mothers. The hormone may play a role in infant development and potentially influence weight gain or obesity later in life.
OHSU scientists find obese mice resistant to increasing leptin levels, contrary to previous hypothesis that higher leptin would suppress appetite. The study sheds new light on the role of leptin in body weight regulation and raises questions about its potential therapeutic value for obesity treatment.
Scientists found that blocking melanocortin-4 receptors impaired leptin's ability to reduce food intake and promote weight loss. Activating the receptor may help treat obesity by overcoming leptin resistance, a common cause of excessive weight gain.
Researchers at the University of Georgia have made a groundbreaking discovery that leptin causes the programmed death of fat cells. This finding could play a significant role in the development of new treatments for obesity, as rats injected with leptin stay thin even after treatment is stopped.
A study published in the Proceedings of the National Academy of Sciences found that mice with resistance to leptin are more likely to become obese. The researchers used a novel technique called ICV infusion to deliver leptin directly into the brain, which resulted in significant weight loss and fat reduction in lean mice.
Female patients with acute anorexia nervosa exhibit low plasma leptin concentrations, reflecting restricted energy intake. Leptin levels increase upon weight gain, but drop again after weight loss, suggesting a complex relationship between leptin regulation and weight fluctuations in these individuals.
A study found that low leptin levels are associated with the absence of menstruation in underweight female students. The research suggests a critical leptin level is needed to maintain menstruation, with implications for eating disorders and other physiological and psychological conditions.
Research reveals low leptin levels in restrained eaters, particularly in underweight females, who have higher cognitive restraint scores. The study found a negative correlation between leptin levels and cognitive restraint scores in these individuals.
Researchers found that leptin reduces insulin secretion in pancreatic beta cells by interacting with receptors and activating ion channels. The study suggests that treatment with leptin or sensitizing drugs may help prevent diabetes in obese individuals with fasting hyper-insulinemia.
A new Weizmann Institute of Science study finds that high levels of leptin disrupt insulin's activities, leading to raised blood sugar levels. Researchers discovered that excessive leptin suppresses insulin's ability to slow down gluconeogenesis, a process that can cause diabetes-related symptoms.
Researchers at the University of Washington have discovered a hormonal link between nutrition and reproduction, with leptin serving as a metabolic signal to the reproductive system. The study provides an explanation for how the body's energy stores determine reproductive readiness.
A new class of drugs may be able to target the leptin loop, a key component in obesity and metabolic disorders. By bypassing this loop, these drugs could potentially provide a new treatment option for individuals struggling with weight-related health issues.