Articles tagged with Misfolded Proteins
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Researchers developed a new technique to predict which proteins are prone to misfold and at what point the folding process breaks down. This could help identify causes of amyloid-related diseases and provide insights into more prevalent conditions like cancer and heart disease.
A team of researchers discovered that prions can have a beneficial effect on the evolution of yeast cells, allowing them to survive in new environments. This occurs when prions alter the reading of genetic information, leading to changes in the cell's phenotype.
Researchers at McGill University have identified a central enzyme that can sense subtle changes in protein folding, enabling the removal of misfolded proteins from cells. This discovery may lead to innovative prevention and treatment strategies for neurodegenerative diseases such as Alzheimer's and Parkinson's.
Researchers found that HDAC inhibitors and DPDTB can inhibit aggresomes formed by mutant SOD protein, suggesting a potential new therapeutic approach for ALS. This study may lead to alleviating ALS symptoms and prolonging life span in transgenic mice models.
Researchers confirm that shape change accounts for strain differences in prions, laying groundwork for strategies to block disease. Prion shape underlies ability to jump between species, according to new finding.
A new hypothesis suggests that Alzheimer's disease arises from inflammation, leading to the creation of abnormal metabolites that modify amyloid beta proteins. These misfolded proteins accumulate into fibrils and plaques, causing neuronal loss and contributing to the disease.
Researchers found that elevated molecular chaperones promote longevity in C. elegans, a roundworm whose biochemical environment is similar to humans. This suggests that brief exposure to environmental and physiological stress can have long-term benefits to cells by unleashing molecular chaperones.
Researchers used baker's yeast to model Parkinson's disease, showing how a small amount of alpha-synuclein protein can cause deadly clusters. The study may lead to improved quality-control mechanisms in cells that normally dispose of misfolded proteins.
Researchers develop method to prevent amyloid formation by stabilizing the native state of proteins, preventing disease-associated subunits from contributing to fibril formation. This approach has potential therapeutic applications for various amyloid diseases, including familial amyloid polyneuropathy and cardiac disorders.
A research team has visualized the interactions between molecular chaperones and protein aggregates, shedding light on how these protective proteins prevent disease. The study provides new insights into neurodegenerative diseases and could lead to the development of effective drugs.
Researchers propose a more heterogeneous model of protein folding, which offers alternative pathways to the traditional view. This new understanding may lead to drugs that mimic molecular chaperones' role in fending off neurodegenerative diseases.
A newly discovered molecular protein plays a crucial role in determining whether proteins with improperly folded structures are refolded or degraded, according to University of North Carolina researchers. This finding has significant implications for understanding heart attack, heart failure, stroke, and neurodegenerative diseases.
Researchers discovered that misfolded yeast prion proteins can alter protein synthesis and unveil silent genes, generating novel traits. By ignoring natural genetic stop signals, yeast may gain advantageous properties such as increased antibiotic resistance.
Researchers at the University of Chicago found that prions enable yeast to acquire multiple genetic changes simultaneously, leading to novel characteristics and growth properties. This discovery has broad implications for understanding evolutionary processes and how organisms respond to environmental fluctuations.
Scientists at Northwestern University discovered that polyglutamine aggregates are toxic and can bring healthy proteins to aggregate with them. The growth of these aggregates can be suppressed by molecular chaperones called heat shock proteins. This finding provides a new model for understanding the common pathology of neurodegenerativ...
Researchers at NIAID's Rocky Mountain Laboratories have identified a new class of compounds that slow the development of prion diseases in mice. The compounds, which include drugs used in cancer therapy, block the conversion of normal prion protein to an altered form, delaying disease progression. If successful in humans, this treatmen...
A study has found that an enzyme involved in normal protein folding also regulates enzymes responsible for folding proteins in healthy cells. This discovery suggests a potential connection between protein misfolding and Alzheimer's disease, with implications for treatment. The researchers identified presenilin-1 as a key player in this...
Deep-sea animals have higher concentrations of trimethylamine oxide (TMAO), a compound that helps proteins withstand high pressures and misfolded proteins. TMAO's protective power extends beyond sea creatures to humans, with potential applications in cystic fibrosis treatment.
Scientists at NIAID's Rocky Mountain Laboratories discovered a section of the prion protein that can prevent misfolding and progression to disease. This finding opens possibilities for therapy in animals and may one day help prevent degenerative brain diseases such as Alzheimer's and Parkinson's.
Researchers describe the first case of sporadic fatal insomnia (SFI), a neurologic disorder matching Shakespeare's witches' curse, caused by protein misfolding rather than a mutant gene. The condition's symptoms and neuropathology are identical to those of fatal familial insomnia.
Scientists at Penn School Medicine found that chaperonins, huge protein molecules, catch and unfold misfolded proteins to protect cells. This process takes place within 13 seconds and helps prevent cellular harm caused by protein misfolding disorders like mad cow's disease.
Researchers created a computational model to capture the process of one protein interfering with another's folding. This reveals the mechanisms behind 'protein adultery', where amino acids from different proteins link, causing diseases like Alzheimer's and mad cow syndrome.
Researchers created a protein-like model that unfolded and refolded itself to reveal common features among folding pathways. The study provides new clues to understanding how proteins achieve their stable structures quickly and reliably.
Researchers have successfully developed a novel therapy that uses a fusion protein to selectively kill HIV-infected cells by triggering a chain of suicidal events. This approach has potential applications in treating other infectious diseases such as hepatitis C and malaria, and may also be used to target cancer cells.
Researchers at the University of Chicago found a protein molecule that transmits genetic traits without DNA or RNA in yeast, forming long fibers like those seen in neurodegenerative diseases. This discovery sheds light on the mechanism behind these devastating brain disorders.