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Up to one-third of antibody drugs are nonspecific, study shows

A study published in mAbs reveals that up to one-third of antibody-based drugs exhibit nonspecific binding to unintended targets, a serious concern for patient safety. The Membrane Proteome Array technology helped identify this issue, challenging the long-held belief in absolute antibody specificity.

SourceIntegral Molecular·JournalmAbs·TypeExperimental study·DateSep 17, 2024
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Biophysicists unravel secrets of genetic switch

Researchers discovered how nonspecific binding plays a critical role in controlling the switch between dormant and virulent states in bacteria. The study used single-molecule techniques to characterize the role of non-specific binding in facilitating the closure of a DNA loop that switches off virulence.

SourceEmory Health Sciences·JournalPhysical Review E·DateAug 30, 2012