Articles tagged with Nuclear Proteins
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Salk researchers discover that manipulating nuclear pores can increase their numbers in healthy cells, mimicking those found in cancer cells. This breakthrough could lead to a new way to fight cancer by targeting nuclear pores.
A study by Massachusetts General Hospital researchers found that the abnormal form of tau associated with Alzheimer's disease disrupts communication between a neuron's nucleus and cytoplasm. This disruption leads to brain cell dysfunction and death, contributing to neuronal loss in Alzheimer's disease.
International researchers led by Tokyo Medical and Dental University investigated the RSRSP stretch of the regulatory protein RBM20, finding it essential for nuclear localization and splicing regulation. The study suggests that phosphorylation of specific serine residues in this region is crucial for RBM20's function.
Researchers discovered that Kapβ2, a nuclear localization signal, plays a crucial role in transporting the FUS protein into the nucleus. The study found that when this system fails, FUS proteins aggregate and form toxic droplets, contributing to neurodegenerative diseases like familial ALS.
A cellular traffic jam affects neurons in most ALS forms, with TDP-43 causing transport defects and disrupting protein import. A drug, KPT-335, may compensate for these disruptions, showing promise for treatment.
Researchers investigated molecular mechanisms behind squamous cell carcinoma, revealing NUP62's role in regulating ΔNp63α nuclear transport. This mechanism is crucial for maintaining SCC cells' undifferentiated status and proliferation.
A study associates schizophrenia with defective processing of messenger RNA in cells, suggesting a link between the spliceosome complex and brain dysfunctions. The researchers found altered proteins in two brain regions, including those involved in calcium-mediated signaling and myelination.
Scientists at the University of Basel report that shuttling proteins, known as importins, control nuclear pore function, rather than the other way around. Importin alpha and beta cooperate to open and close the pore like a revolving door.
Researchers found that traffic jams in the nucleus kill brain cells in Huntington's disease. Drugs clearing up these disruptions restored normal transport and saved cells.
A new study reveals that the nuclear membrane acts as an active regulatory structure, influencing gene expression and contributing to diseases like leukemia, heart disease, and aging disorders. The discovery provides insight into the critical role of nucleoporins in regulating genomic sites.
Researchers find nucleoporins, proteins that guard the nucleus, also regulate gene expression and control stem cell differentiation into neurons. The discovery sheds new light on genetic diseases caused by mutations in these proteins.
Rockefeller University scientists have uncovered crucial steps in the nuclear pore complex's dilation and constriction mechanism. Transport factor karyopherin initiates ring dilation by stabilizing Nup58, allowing larger molecules to pass through.
Nuclear pores serve as transcription factories for genes, regulating their production speed. The discovery reveals a new role for these microscopic structures in the cell nucleus.
A mutant protein variant called Progerin impairs cells by reducing nuclear levels of RanGTPase and limiting nuclear import of large cargoes. This exclusion may contribute to cellular defects in Hutchinson-Gilford Progeria syndrome (HGPS).
A novel nuclear protein called Trnp1 triggers the expansion and folding of the cerebral cortex in mice, supporting tangential expansion and ordered formation of neurons. The findings imply that Trnp1 controls both expansion and folding and serves as a starting point for dissecting cellular and molecular interactions.
Researchers have discovered that nuclear envelope proteins vary greatly between cells in different organs of the body, interacting with specific proteins to cause illness in some organs but not others. This variation may provide insights into rare muscle diseases like Emery-Dreifuss muscular dystrophy and other heritable conditions.
A team of researchers has developed a biomimetic nanopore that selectively transports individual proteins across its surface, mirroring the behavior of natural nuclear pores. The study uses functionalized key proteins to create a synthetic pore that can be used as a testing platform for drug delivery into a cell's nucleus.
Researchers found that proteins importing structural material and regulating its import determine cell size. By manipulating these proteins, they can make a smaller species' nuclei balloon up to the size of a larger one. This discovery could lead to new insights into nuclear size regulation in cancer cells.
Research reveals that nuclear matrix proteins are differentially expressed during HMBA-induced differentiation of gastric cancer cells. Eight proteins were down-regulated while seven were up-regulated, with prohibitin, nucleophosmin, and hnRNP A2/B1 being significantly decreased in treated human gastric cancer cells.
Researchers at Salk Institute found that nucleoporins, proteins in nuclear pore complexes, act as transcription factors regulating genes during early development. They also offer new insights into cancer mechanisms and potential markers for causes of cancer.
Researchers have determined the structure of a protein within its natural environment, Escherichia coli, for the first time using nuclear magnetic resonance (NMR) spectroscopy. This milestone advances our understanding of molecular biology and opens new avenues for investigating protein interactions in living systems.
Researchers at the Salk Institute found that stable proteins within the nucleus's control structures can become damaged with age, leading to impaired function and contributing to cellular aging. This discovery provides new insights into the aging process and may lead to novel approaches for treating neurodegenerative diseases.
A new highly sensitive NMR technique using a microscopic detector decreases protein sample size by several orders of magnitude, making it possible to diagnose diseases like Alzheimer's and Huntington's at an early stage. The technology could lead to the development of tabletop NMR devices in every research laboratory and medical office.
Brüschweiler recognized for fundamental contributions to nuclear magnetic resonance spectroscopy and its applications in protein characterization, leading to a deeper understanding of protein behavior and potential disease treatments.
Clathrin is found to play a role in regulating nuclear morphology and gene expression in plants. The study reveals that clathrin is involved in the formation of nuclear structures and influences gene regulation pathways.
Researchers developed an automated technique to track and analyze protein NuMA in breast tissue, identifying a pattern between normal and malignant cells. The new imaging tool aims to determine cancer subtypes, predict tumor behavior, and guide personalized treatment.
A new study has identified three nuclear proteins that are unique to the bladders of animals with interstitial cystitis (IC), a chronic pelvic pain disorder. The proteins, transgelin (SM-22), ras suppressor protein (RSU-1) and GAPDH, were found to be down-regulated in IC-model bladders after instillation with hydrochloric acid.
A study at TSRI identifies 62 new proteins in the inner nuclear membrane linked to 14 rare diseases, including muscular dystrophy and Charcot-Marie-Tooth disease. This discovery has significant implications for understanding the underlying causes of these devastating conditions and developing new therapeutic strategies.
U of MN researchers identified proteins FRGY2a and FRGY2b that disassemble nucleoli without other protein help. This discovery may lead to understanding normal cell development and human diseases.
Researchers at TSRI report a novel synergistic folding mechanism in two transcriptional proteins, CBP and p160, which become active when brought together. This discovery sheds light on the biological functions of intrinsically unstructured proteins and their role in cancer and other diseases.
Researchers have developed a new method for studying viral entry, which reveals that key steps occur much faster than previously believed. The study found that viruses can penetrate cells within minutes, using the cell's own transportation system to reach the nucleus.
A University of Cincinnati biochemist has discovered that the V3 loop region of the HIV gp120 protein is structurally flexible, changing its shape as needed to bind to host cells. This finding rules out using a fixed structure as a target for anti-HIV drugs, making it harder to develop effective treatments.
The Hauptman-Woodward Medical Research Institute and University at Buffalo have received $3.13 million to develop new methods for determining protein structure, crucial for designing new drugs. Researchers will use X-ray crystallography and NMR spectroscopy to determine protein structures.
Researchers found that FRAP regulates a membrane-to-cytoplasm communication network, governing cellular response to outside stimuli. The protein must shuttle between the nucleus and cytoplasm to function properly.
The Protein Structure Initiative aims to determine protein form and function, improving health and disease understanding. The project uses x-ray crystallography, NMR, and computation to identify protein structures in minimal organisms.
The NIGMS Structural Genomics Awards will support seven research centers in determining the structures of thousands of proteins over the next decade. The project aims to advance our understanding of biological processes and develop new treatments for diseases.
A NY pilot study is pushing the Human Genome Project towards developing promising drug targets for disease. The initiative uses recent advances in computational biology to quickly analyze and categorize proteins, focusing on those that cause or treat diseases.
A Brandeis University researcher has mapped the structure of ephemeral protein 'switches' that play a critical role in transforming mild-mannered bacteria into lethal parasites. This finding raises the prospect of a novel kind of antibiotic to combat growing resistance among many bacteria.
A new study has found that a molecular traffic signal, HIV matrix protein, controls two opposing functions regulating the virus' life cycle. This discovery provides new targets for creating molecular gridlock and halting virus growth.
A study by MGH researchers has identified a gene malfunction that appears central to the development of type 1 diabetes. The malfunction affects the Lmp2 protein, which is required for immune system cells to recognize self-proteins, leading to an autoimmune reaction.
Researchers at the University of Michigan have identified a key mechanism by which some viruses, including Kaposi's sarcoma-associated herpesvirus, can hide in human cells for extended periods. The study reveals that a protein called LANA binds to host chromosomes, allowing viral DNA to remain dormant until the immune system is weakened.
Günter Blobel's work on protein signaling discovered the importance of signal sequences in targeting proteins to their proper intracellular destinations. His research has led to a deeper understanding of protein trafficking, with implications for drug delivery and cellular processes.
Researchers have developed a new family of chemicals that bind specifically to the gp41 pocket, halting HIV's ability to infect cells. The compounds, created using mirror-image phage display, show promise as potential oral treatments for HIV, with advantages including reduced cell membrane penetration and lower likelihood of resistance.
The nuclear pore complex is a highly regulated structure composed of around 50-100 different proteins that control the transport of macromolecules between the nucleus and cytoplasm. Ran protein plays a crucial role in this process, binding selectively to transport factors to regulate cargo molecules across the nuclear pore.
Researchers identified SLBP1 and SLBP2 proteins in frog oocytes, which act as biochemical switches triggering histone synthesis crucial for embryogenesis. The study provides new insights into the process of embryogenesis and its relation to stored RNA activation.
A team of researchers has identified the normal function of a protein associated with spinal muscular atrophy (SMA), an inherited neuromuscular disease that is the most common genetic cause of infant mortality. The study, published in the journal Cell, also developed cell-based assays to search for potential therapeutic compounds.
Researchers have discovered a novel function of the Survival Motor Neuron (SMN) protein essential for mRNA production in all cells. This finding links SMN deficiency to spinal muscular atrophy, a leading genetic cause of infant death, and paves the way for potential therapeutic interventions.
The study, led by Ming-Daw Tsai, used nuclear magnetic resonance spectroscopy to determine the 3D structure of the p16 protein. The researchers aim to develop a drug that mimics p16 to treat cancer, which is expected to target more than 70 different types of cancer.
Scientists have determined the 3D molecular structure of HIV's nucleocapsid protein, which recognizes and binds to viral RNA. This discovery may lead to the development of highly specific anti-AIDS drugs that can prevent HIV spread and be safe for patients.
Scientists have discovered a common mechanism underlying neurodegenerative diseases, where mutant proteins accumulate in nuclear spaces, recruiting normal proteins and disrupting cellular processes. This finding suggests a single disease mechanism may be responsible for several afflictions.