Articles tagged with Protein Folding
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A Harvard Medical School scientist has developed a new approach using deep learning to predict protein structure from amino acid sequence. This method achieves accuracy comparable to current state-of-the-art methods but at speeds upward of a million times faster.
Researchers develop a new method to create detailed structural models of proteins using force-driven simulations, reducing computational power requirements. The technique, inspired by metallurgy, allows for faster computation and more accurate results than existing approaches.
This year's awards recognize Professor Minoru Kanehisa for his work on the KEGG database, Professor Anthony Kossiakoff for his technological achievements in protein structure and function, Professor Hao Wu for her groundbreaking signal transduction research, Professor Shahriar Mobashery for his discovery of new antibiotics, and Profess...
Franz-Ulrich Hartl and Arthur L. Horwich's pioneering discoveries on assisted protein folding highlighted the importance of cellular quality assurance. They elucidated key aspects of the chaperone machinery and its role in neurodegenerative diseases, such as Alzheimer's dementia and Parkinson's disease.
Researchers have identified a key pathway, ufmylation, that regulates plasma cell development and antibody production. By targeting this pathway, scientists hope to develop more effective vaccines and treatments for autoimmune diseases like lupus and arthritis.
Researchers have obtained the highest-resolution structure of the fungal protein Hsp104, a hexameric AAA+ protein that helps repair misfolded proteins. The study's findings reveal a helical structure for Hsp104 hexamers, contrary to previous beliefs, and provide new insights into its function.
Researchers developed a method using fluorescent compound AggTag to identify intermediate forms of proteins that misfold and aggregate in live cells, which are believed to contribute to neurodegenerative diseases such as Alzheimer's and Parkinson's. The method allows for simultaneous detection of multiple proteins with distinct colors.
Researchers surveyed known enzyme structures and found that active sites often have conflicting instructions, allowing for a balance between stability and functionality. This 'extended frustration' extends beyond the first shell of amino acids, supporting catalytic ability and enabling enzymes to modify target molecules efficiently.
Researchers discovered that specific RNAs interact with multiple proteins, promoting aggregation and altering RNA splicing. This finding has implications for understanding complex diseases like Fragile X Tremor Syndrome.
The discovery of glucose-regulated protein GRP94 as a chaperone assisting proinsulin folding has significant implications for understanding insulin production. Removing GRP94 from beta cells impaired insulin secretion, suggesting its specialized function in maintaining cellular response to misfolded proinsulin.
Researchers discovered a new class of complex folding molecules that form spontaneously without evolution or design. The molecules' unique structure suggests that complexity can emerge on its own, potentially revolutionizing our understanding of molecular folding and the origin of life.
New research allows for fully automated design of DNA staple sequences, enabling the creation of complex nanostructures with ease. This breakthrough advances the field of DNA origami, opening up new possibilities for applications in material science and medicine.
Researchers found significant differences between bacterial and eukaryotic Hsp70s, including variations in binding interfaces and cycles of domain docking and undocking. These findings suggest that eukaryotic Hsp70s have evolved to be more flexible and efficient in their function.
A study published in Science Translational Medicine found that removing the appendix early in life can lower the risk of developing Parkinson's disease. The appendix acts as a reservoir for disease-associated proteins, and appendectomy delays disease progression by an average of 3.6 years.
The Biophysical Society has honored 10 distinguished members as 2019 Society Fellows for their groundbreaking work on cytoskeleton filaments, protein folding, single-molecule methods, and cellular dynamics. These individuals have made significant contributions to the field of biophysics.
The FAT10 protein has a unique structure with two domains and a flexible linker, allowing it to regulate degradation in an efficient manner. This finding has significant implications for potential cancer therapies, as FAT10's presence is associated with aggressive tumor growth.
Scientists at Ludwig-Maximilians-Universität München have created novel DNA aptamers that enable the use of smaller fluorescent labels in super-resolution microscopy. This breakthrough allows for high-resolution imaging of protein networks within individual cells, paving the way for new insights into biological processes.
A team of researchers from Rice University and Baylor College of Medicine has discovered a weak link in the flu virus protein hemagglutinin that could be targeted by therapeutic drugs. By analyzing the protein's mechanism of attachment to host cells, they propose a new approach for developing universal vaccines.
Researchers have successfully measured biomolecule folding in water using a new technique, providing insights into protein structure and folding in environments similar to those in cells. The technique could lead to better understanding of diseases such as Alzheimer's, which are related to incorrect protein folding.
Researchers propose native state is a 'fortunate trap' that prevents spontaneous folding into fibril state, associated with Alzheimer's and Parkinson's diseases. The amyloid state is more stable thermodynamically, but kinetic barriers prevent its formation.
A Kanazawa University-led team used high-speed atomic force microscopy to study GroEL's mechanism, finding two alternative pathways for the protein-GroES interaction. The research suggests a more active role for the football-shaped structure in protein folding, challenging conventional models of molecular chaperone function.
Scientists create three-dimensional maps of DNA in cells to understand genome organization and gene expression. The study reveals that genes cluster together around specific nuclear bodies, influencing gene activity.
Rice University researchers develop a molecular modeling framework that combines experimental data with coarse-grained simulations, enabling more accurate protein dynamics modeling. The technique reveals unanticipated molecular properties and can be scaled up to larger systems, reducing simulation time by hours.
Researchers have identified a disproportionate number of sialic acid-containing glycans in lancehead viper venom, which may aid in venom solubility and increase toxin half-life. This discovery could lead to the development of more effective antivenom treatments for snake envenoming.
Researchers have developed a new tool that can work in both non-reproductive cells and egg-producing cells using the Gal4/UAS two-component activation system. The UASz vector has been shown to express about 4 times higher than UASp in the egg-producing system, overcoming previous limitations.
Researchers from Medical Research Council crack how first life on Earth replicated itself using a new type of genetic replication system. The system uses a triplet code to copy folded RNA, enabling the replication of ribozymes and supporting simple living systems.
Researchers at the University of Wisconsin-Madison have detected CWD prions in soil and water samples from sites where deer congregate. The study suggests that environmental reservoirs of prions could serve as an additional transmission route for CWD, highlighting the need for further research on the disease's spread and persistence.
The Biochemical Society has announced the winners of its annual awards, recognizing established and early-career researchers in cell biology, endocrinology, and plant sciences. The award recipients include Dr Melina Schuh, Professor Dame Caroline Dean, and Professor R. John Ellis.
Researchers at LMU München have developed a synthetic DNA sequence that can inhibit the activities of several DNA-processing enzymes, including HIV integrase. The artificial DNA mimic successfully competes with its natural counterpart, demonstrating potential for new treatments of retroviral diseases.
The Protein Society has awarded three researchers with prestigious prizes: Jane and Dave Richardson, Yifan Cheng, and Susan Marqusee. The winners have made groundbreaking contributions in protein structure determination, cryo-EM, and protein folding. Their work has significantly advanced our understanding of biology.
Scientists have developed a way to stabilize proteins outside of their native environments, creating mats that can trap chemical pollution. The research demonstrates a unique path toward exploiting protein power in synthetic systems.
Researchers at CSIRO Australia and Deakin University have successfully replicated a unique protein in platypus milk that has antibacterial properties. The discovery could help combat superbugs and save lives.
Elevated GRP78 expression is linked to resistance to chemotherapy and poor prognosis in various cancers. The unfolded protein response regulates cell survival through GRP78, which modulates the PI3K/AKT pathway.
Researchers at Penn develop a technology to track protein shape changes, which could lead to improved drug treatments and earlier detection of neurodegenerative diseases. By labeling proteins with probes, they can observe movement and create computational models for atomic-level detail.
The study reveals the importance of sugary appendages on protein surfaces, which differ in composition and branching. The researchers discovered the three-dimensional structure of oligosaccharyltransferase, providing insight into eukaryotic N-glycosylation.
Researchers have identified a key gene, Ufbp1, that helps maintain healthy Paneth cells in the small intestine, which are essential for a balanced gut microbiome. The study found that when this gene is knocked out, Paneth cells die and good bacteria levels decrease, leading to inflammatory bowel disease.
Misfolding proteins accumulate in the pancreas, killing cells. Researchers use nanodiscs to study these proteins at the atomic level, gaining insights into their toxicity. This work may lead to the development of new drugs targeting incorrectly folding proteins.
Researchers have created large-scale, programmable self-folding DNA and RNA structures using user-friendly software tools. The new nanostructures can be successfully cloned and amplified inside living cells, offering a low-cost high-scale production strategy for manufacturing the nanostructures.
The protein Trigger factor recognizes a partner with unstable domains to form a stable protein duo. Chaperones like TF help folding of other proteins.
A new algorithm can speed up protein-folding simulations, allowing researchers to model phenomena that were previously out of reach. This technique can help scientists better understand and treat diseases like Alzheimer's, which is associated with amyloid-beta protein fragments forming hard plaques that disrupt neurons.
A study published in Nature Communications reveals that membralin plays a crucial role in regulating the cell's machinery for producing beta-amyloid, the protein responsible for neuronal death in Alzheimer's disease. The researchers found that membranes with lower levels of this protein are associated with increased neurodegeneration a...
Researchers develop a novel method for folding and protecting recombinant proteins using a protein-in-a-protein technology. This innovation improves functional protein yields and protects against various denaturants, offering potential applications in the biologics and pharmaceutical industries.
Researchers at RUDN University have synthesized new compounds with potential antitumor and antiviral activity from isoxazoles. The compounds, which include a central five-membered heterocycle, exhibit varying properties depending on the arrangement of substituents.
An international team of experts has made a fundamental discovery by transforming amyloid fibrils into crystals, a process previously thought to be impossible. The transformation involves untwisting the fibril to form an elongated, matchstick-like crystal with unprecedented stability.
Researchers at CRAG have discovered a key gene (HsfA2) that activates chaperone synthesis to rescue cells from toxic effects of misfolded proteins. This mechanism is similar to those found in human nerve cells and may help understand and treat protein-misfolding diseases.
A team of scientists at the University of Arizona has discovered that a newly evolved yeast protein can fold into a compact three-dimensional structure, contrary to the long-held assumption that such proteins are incomplete and 'works-in-progress',
Researchers at Rice University have created a platform to study polymer folding dynamics using magnetic beads. The new method allows for the observation of complex behaviors, such as bending and coiling, in semiflexible fibers like actin and DNA.
Researchers developed a genome-scale model that predicts how E. coli cells respond to temperature changes and genetic mutations, highlighting the importance of chaperone networks in adaptive cell modeling for precision medicine.
Researchers found that proteins remain fully or partially unfolded for parts of their lives, contradicting the long-held belief they must fold into complicated shapes to fulfill functions. The study suggests these unfolded proteins may reduce unwanted interactions by being expanded, potentially preventing dysfunction and disease.
Researchers at the University of Notre Dame have developed a new analysis procedure to better understand how intrinsically disordered proteins (IDPs) function in cells. The study finds that most IDPs are more disordered than previously thought, which could lead to new strategies for preventing protein misfolding diseases.
Researchers found that flu viruses can evolve rapidly due to their ability to hijack host chaperone proteins, which help mutated viral proteins fold and function. Targeting these proteins could delay viral evolution and decelerate escape from existing drugs and vaccines.
A new study reveals that endoplasmic reticulum-associated degradation plays a crucial role in controlling hormone levels and systemic water balance. The research found that misfolded proteins can lead to hormone imbalance and diseases such as diabetes insipidus, highlighting the importance of protein folding and quality control.
Researchers at UMass Amherst have characterized the functional dance of a protein-folding chaperone's interdomain linker. The study used computational techniques to simulate the movement of the linker and revealed its role in facilitating proper function, including binding sites for potential therapeutic targets.
Researchers created three-dimensional structures that mimic natural enzymes, shedding light on folding processes and potential treatments for diseases like Alzheimer's and Parkinson's. The breakthrough allows for the analysis of misfolded proteins, a key factor in these conditions.
The Biophysical Society has announced its 2018 Society Fellows, recognizing distinguished members who have made significant contributions to the field of biophysics. The 2018 Fellows include Patricia Bassereau, James Bowie, Astrid Graslund, Roderick MacKinnon, and others.
Edward O'Brien's research aims to understand how the speed of protein assembly affects its structure and function, a question that was once considered unresolved by scientists. His team is developing computer simulations to model protein translation and explore the origins and consequences of translation rate changes on protein behavior.
The unfolded protein response (UPR) is an adaptive biochemical process linked to cell homeostasis, crucial for maintaining normal physiological function. Prolonged ER stress can push the UPR past beneficial functions, contributing to various disease states, making it a global target for novel therapeutic intervention.
Scientists from University of Washington and University of Toronto have developed new high-throughput approach to test folding stability of thousands of computationally designed proteins. This study led to the design of 2,788 stable protein structures with potential bioengineering and synthetic biology applications.
The study used FReI to investigate the folding stability and dynamics of proteins in hydrogels, revealing that hydrogels increase protein stability, speed up folding relaxation, and promote irreversible binding. The findings suggest that proteins may be destabilized when interacting with hydrogels.
Researchers from ITMO University and Hebrew University have developed a method to recover protein structure after chemical denaturation, working for both specific molecules and multiprotein systems. The technology simplifies and cheapens the production of drug proteins for Alzheimer's and Parkinson's treatment.