Articles tagged with Protein Interactions
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A team at Cellzome developed a novel approach to systematically use protein interaction maps in drug discovery, enabling researchers to better assess protein roles and predict drug effects. The yeast proteomic map provides a framework for integrating data from literature and experiments.
A team of researchers led by Jeannie T. Lee has identified the CTCF protein as a central regulator of X-chromosome inactivation, sparking new insights into the mechanism behind this process. The discovery sheds light on how the developing embryo chooses which X chromosome to inactivate.
Researchers at UMass challenged a 60-year-old theory on polymer crystallization, finding that lengthy polymers never achieve total crystallinity due to reaching equilibrium. This breakthrough may lead to better control of material flexibility and shed light on the protein-folding problem.
University of North Carolina at Chapel Hill researchers have found evidence that alcohol inhibits the actions of key proteins called N-methyl-D-aspartic acid (NMDA) receptors in specific regions of the brain. This new interaction affects brain regions involved in memory formation and higher mental functions.
The study examined the impact of alcohol on NMDA receptors in the brain, finding that it inhibits or prevents Fos protein induction. This suggests that alcohol acts by modifying these receptors, which could be linked to the development of symptoms and susceptibility to alcoholism.
Yale researchers have created a microchip that can analyze virtually all yeast proteins, holding promise for advances in studying protein function in other organisms. The technology allows for faster understanding of protein interactions and could lead to breakthroughs in diagnostic methods, drug discovery, and therapies.
Hopkins researchers found that parkin, aS and synphilin interact, with mutations disturbing this interaction leading to Lewy body formation and nerve cell death. Understanding these interactions may help identify targets for new treatments.
The Cables protein inhibits cell growth through a chain reaction effect, prompting decreased division. Its expression may thwart uncontrolled cell growth indicative of cancer.
Researchers at Scripps Research Institute develop a therapy to prevent misfolding diseases by incorporating a protein suppressor into the diseased protein, stabilizing it and preventing fibril formation. This approach may also work for other diseases with similar protein-protein interactions.
The RANKL cytokine at 2.6 Å resolution provides detailed information on its structure and function in the body. Researchers used this high-resolution imaging technique to study RANKL's role in bone formation and immune system regulation.
Scientists discovered that Alzheimer's and Parkinson's proteins interact to accelerate disease progression, causing cognitive and motor function destruction. The study found that Abeta, a metabolic breakdown product of hAPP, enhances the accumulation of hSYN in brain cells.
Researchers have discovered two distinct pathways leading to cell death in the diseased kidney, which could lead to new therapeutic targets for kidney disease. These findings provide a better understanding of kidney pathology and may enable the development of more effective treatments.
UT Southwestern Medical Center has acquired a custom-crafted cryo-electron microscope to propel its cell-research capabilities. The new technology enables the analysis of sub-cell structures at sites in the cell where processes take place, providing valuable insights into cellular biology and disease mechanisms.
Researchers identified BONZAI1 as a central player in Arabidopsis plant growth homeostasis. The gene influences plant size at different temperatures, with mutant cells failing to grow normally at cooler temps. A related protein, BAP1, was also found to interact with BONZAI1 and is more highly expressed at lower temps.
Researchers from UNC School of Medicine and Pharmacy have developed a new method to calculate protein stability, which could improve drug design and engineering. The approach uses computational manipulations to predict the effects of amino acid mutations on protein stability.
Researchers found a new protein supercomplex linking PSI and PSII in cyanobacteria, increasing light harvesting ability by 72%. This adaptation enables oxygen production even in low iron conditions, with significant global environmental implications. The discovery suggests an evolutionary link between the two photosynthetic complexes.
A team of scientists at North Carolina State University and Yale University have analyzed the function of all proteins in yeast, discovering novel protein interactions that will require further examination. This breakthrough could lead to better understanding of protein functions in more complex organisms, including humans.
Researchers at the University of Pennsylvania School of Medicine found that activation of vitamin A receptors can regulate the human circadian clock. This discovery provides an important clue to how the master clock in the brain regulates distal organs by controlling clocks throughout the body.
Researchers identify gC1qR as a binding partner for Hepatitis C core protein, allowing the virus to evade immune response and persist in the body. The interaction between gC1qR and core protein may provide new targets for developing therapies to combat chronic hepatitis C.
Streptococcal bacteria use the bacterial capsule containing hyaluronic acid to bind to epithelial cells of the pharynx and cause sore throats. Suppression of CD44 levels or use of antibodies/ exogenous hyaluronic acid can block this interaction.
Scientists used a new measurement technique to study muscle movement at the molecular level, shedding light on how myosin and actin interact. The technique, called luminescence resonance energy transfer, provided direct evidence for the lever-arm model of muscle contraction.