Articles tagged with Protein Structure
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study at Umea University has successfully captured a protein structure previously impossible to study, providing insights into enzymes' catalytic capabilities. The discovery enables the development of designed enzymes for new chemical reactions in biotechnology.
A team from Harvard Medical School has revealed the atomic level structure of VSV polymerase protein L, a key component in RNA virus replication. This finding provides insights into how these viruses copy their genomes inside host cells.
The tool collects non-redundant PTM data across all known members of a protein family and projects it onto 3D protein structures to visualize PTM hotspots. By analyzing these hotspots, scientists can prioritize research on proteins with high potential for biological function.
A recent study has provided a more complete picture of how proteins move, laying the foundation for understanding molecular causes of human disease and developing potent drug treatments.
Researchers have identified a structural weakness in antibiotic-resistant bacteria, revealing a potential therapeutic target. The analysis of four beta-lactamase enzymes found that their flexible structures are cooperatively correlated, making them vulnerable to disruption by small molecules.
Researchers have discovered the structure of a key protein on the surface of the mimivirus, aiding efforts to determine its hosts and unknown functions. The R135 protein is similar to an enzyme found in a fungus and may participate in biodegrading lignin, suggesting alternative hosts such as algae.
A new study demonstrates the ability to visualize metabolic enzyme structures at near-atomic detail using cryo-electron microscopy. This advancement has immense implications for drug design and development, revolutionizing the field of structural biology.
Scientists have decoded the molecular basis for mitochondrial membrane folds, which allow cells to use food energy efficiently. The discovery of Mic10, a protein component, reveals its role in controlling transport and insertion into the inner membrane system of mitochondria.
Researchers developed a new computational method called AGGRESCAN3D to study protein aggregation in 3D. The algorithm surpasses limitations of previous methods and offers improved precision in predicting protein aggregation properties.
Researchers found a way to predict protein structures by breaking them into smaller fragments and analyzing their distributions in nature. This discovery could lead to understanding how certain mutations cause disease and developing new treatments.
Researchers at Iowa State University and the Ames Laboratory have discovered two proteins that pump antibiotics out of bacteria, allowing them to resist medications. The study reveals that these efflux pumps are part of a large family of proteins and may help protect cells from certain drugs.
Scientists at the University of Illinois have developed a new lab technique that simultaneously observes protein structure and function in DNA repair. The technique, combining fluorescence microscopy and optical trapping, provides definitive answers to long-debated questions and opens up new avenues for biological engineering.
Moffitt scientists developed a novel technique to analyze the MDMX protein, revealing its auto-inhibitory segment that controls p53 activity. This discovery may help identify patients more likely to respond to an MDMX-targeted cancer drug.
The molecular structure of the cytotoxin from Mycoplasma pneumoniae has been determined, which could lead to the development of effective drugs and vaccines to neutralize its injurious effects. The discovery is a significant breakthrough in understanding respiratory infections such as asthma.
A study by UCSB scientists examined the unique properties of tau, a critical protein in neurons that can form clumps associated with Alzheimer's disease. Researchers found that exposing tau to certain chemicals, such as urea, could prevent aggregation, while another compound, TMAO, accelerated it.
Researchers have developed a molecular mouse-trap technique that aids understanding of cell division and its role in cancer. By studying the structure of proteins involved in chromosome formation, scientists can develop new approaches to analyze complex biological molecules.
Researchers at UNIGE reconcile two dominant endocytosis theories, proposing a balanced interplay between clathrin proteins and other adaptors. The study suggests that clathrins do not dominate the process, but rather contribute to a subtle energy-based deformation of the membrane.
Researchers at the University of Granada have successfully modified a type of lactose protein called beta-lactoglobulin using pulsed light, making it easier to digest. The treatment facilitates digestion, particularly in the small intestine, without altering the protein's functional properties.
The Aquaria project has created a powerful web resource that simplifies the process of gleaning insight from 3D protein structures. The tool offers around 46 million computer models, allowing users to view additional information such as genetic differences mapped onto 3D structures.
Biochemists elucidate protein complex structure in the respiratory chain, a crucial process for cellular energy production. The study reveals how complex I switches between active and inactive forms, shedding light on its role in disease, including Parkinson's and myocardial infarction.
Researchers at Max Planck Institute of Molecular Physiology studied the three-dimensional structure of the ryanodine receptor using electron cryo-microscopy and a new technique for detecting electrons. The high-resolution structure reveals how the protein changes its shape upon binding calcium ions.
Researchers successfully analyzed all known complete proteomes using X-ray crystallography and homology modeling, covering 25% of protein clusters. The study highlights the potential for knowledge-based target selection to increase structural model production, particularly in eukaryotes and archaea.
Case Western Reserve researchers have identified a protein mutation that prevents proper gonadal tissue development, leading to cancer and other issues. The discovery highlights the importance of the SRY protein in regulating male sex determination and has implications for understanding birth defects and cancer.
The structure determination of a lipid scramblase reveals a novel protein architecture that enables the transport of lipids across cell membranes. The discovery provides insight into the activation of the protein by calcium and has implications for understanding previously unknown mechanisms of lipid transport.
Scientists have obtained the first high-resolution structure of HIV's immature form, revealing a surprising arrangement of its building blocks. This breakthrough enables researchers to probe further into potential drug targets and understand how mutations influence virus assembly.
Researchers at Montana State University provided the first blueprint of a bacterium's molecular machinery, showing how bacterial immune systems fight off viruses. By understanding CRISPR mechanisms, scientists can potentially develop therapies for plant, animal, and human diseases.
Researchers have developed a new method to measure structurally modified proteins in complex biological samples, enabling the analysis of thousands of proteins. The method uses a combination of digestion enzymes and Selected Reaction Monitoring to quantify protein quantities and determine structural changes.
Researchers have elucidated the atomic structures of sugar transporters, revealing an 'airlock-like' mechanism that moves sugars in multiple stages. This discovery is crucial for understanding diseases like diabetes and improving crop yields.
EPFL researchers developed a synthetic amino acid that can impact 3D structure of bioactive peptides, enhancing their potency. The amino acid, similar to cysteine, forms bridges influencing overall structure and function of peptides and proteins.
Researchers developed olive oil 'bulking agents' to replace pork fat in hot dogs, maintaining texture and reducing calories. The substitutes contain 55% olive oil, which contains more healthful unsaturated fats, making them suitable for summer BBQs.
Researchers have identified a protein that regulates calcium levels in cells, which could be a promising strategy for fighting cancers. The study reveals how this protein serves as a molecular safety valve to maintain steady calcium levels.
The Protein Data Bank has surpassed 100,000 entries, providing a wealth of structural data for researchers to understand biological mechanisms and discover new medicines. The archive's growth is driven by the efforts of structural biologists worldwide, who continue to deposit new structures and improve the resource.
The study reveals that chaperones, like GroEL and GroES, use a high-speed origami-like mechanism to accelerate protein folding. This process, which was previously thought to be energetically unfavorable, is now understood to be a favorable reaction, allowing proteins to fold faster than they are produced.
Researchers have determined the structure of a protein produced by Candida albicans, a common fungal pathogen that causes yeast infections and other diseases. The discovery could lead to the development of targeted compounds to treat widespread fungal infections.
Dr. Ira Kurtz's research aims to understand the molecular processes affecting kidney function, with a focus on designing specific drugs targeting disease-causing proteins. The goal is to reduce side effects and costs associated with current treatments, which affect millions of people worldwide.
Researchers discovered varied gene expression patterns between male and female athletes, with altered signaling pathways regulating cartilage growth. The findings suggest genetics may play a role in the higher incidence of ACL injuries among females.
SURA honors Dr. Jeffrey Skolnick, a renowned biologist at Georgia Tech, for his groundbreaking research on protein structure and function. His cutting-edge discoveries have the potential to dramatically accelerate and enhance the drug discovery process.
The Vanderbilt team has deciphered the 3-D structure of a key MRSA protein, FosB, which inactivates an antibiotic called fosfomycin. This discovery may enable the design of inhibitors that can improve the effectiveness of fosfomycin and combat MRSA infections.
Researchers have identified the first structure of one of eight human amino acid transporters, known as HATs. This breakthrough provides new insights into their functions and opens up possibilities for developing drugs to tackle various diseases associated with HATs.
Researchers at Cold Spring Harbor Laboratory have discovered two proteins that control the structure of chandelier cells, a type of inhibitory neuron important in epilepsy and schizophrenia. The study found that DOCK7 and ErbB4 regulate axonal projections, allowing one cell to block or modify hundreds of other cells.
Researchers at Duke University have determined the structure of a key part of the HIV envelope protein, gp41 membrane proximal external region (MPER), which previously eluded detailed structural description. This discovery will help focus HIV vaccine development efforts.
A new infrared spectroscopy technique called nano-FTIR has enabled researchers to map the secondary structure of proteins on the nanometer scale. The technique, which combines scanning near-field optical microscopy and FTIR spectroscopy, allows for nanoscale-resolved protein spectroscopy and identification of single protein complexes w...
Rice University researchers have developed a new method to identify previously hidden details about proteins' structures, potentially accelerating novel drug design. By combining structural data and genomic analysis, the team predicted intermediate configurations of proteins that were hard to detect.
Rice University researchers used computer models to study the behavior of misfolded proteins, finding that they can form branching structures similar to those found in spider silk. These structures may be an early stage in the formation of amyloid plaques associated with Alzheimer's disease.
Researchers have determined the atomic resolution structure of a bacterial nanowire protein, revealing its shape and form suggest ways for electrons to shuttle along the wire. The study's findings could lead to new applications such as bacterial fuel cells, carbon cycling, and biocomputers.
Researchers have determined the atomic-level structure of the tripartite HIV envelope protein, a complex target for vaccines. The findings provide insights into the process by which the Env trimer assembles and undergoes shape changes during infection.
A new tool has been developed to resolve the structure of membrane-embedded and membrane-associating proteins by exploiting the unique water dynamics gradient across and above the lipid bilayer. This breakthrough can help determine the location and structure of protein segments at the surface of membranes.
Scientists have identified a protein called MLKL that plays a crucial role in triggering programmed cell death, known as necroptosis. The discovery could lead to the development of new treatments for chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis.
Researchers analyzed X-ray crystal structures of resurrected Precambrian proteins, revealing structural similarity among proteins since life first evolved on Earth. This approach provides insights into protein structure evolution and may aid in designing novel proteins.
Researchers visualized ER sheet stacking revealing a 'parking garage' structure with helical ramps for efficient protein synthesis. This optimized structure allows for maximum space usage within cells.
A new study analyzed dynamical properties in antibiotic resistance enzyme β-lactamase, finding significant evolution across bacterial families without limiting new antibiotic resistance. Minor changes in the enzyme's active site can adapt it to new antibiotics.
Researchers have captured a key step in the molecular 'dance' necessary for cell division by imaging the enzyme that unwinds DNA double helices. The study reveals how this enzyme recruits and interacts with the origin recognition complex, enhancing understanding of essential biological processes.
Researchers have identified a unique protein structure in the chlamydia bug that could lead to novel diagnostic methods and treatments. The discovery may help combat this sexually transmitted disease, which affects an estimated 2.8 million people in the US each year.
McGill University researchers have discovered the three-dimensional structure of the Parkin protein, which protects neurons from cell death due to damaged mitochondria. The study's findings suggest that designing mutations in Parkin could provide better protection for nerve cells and potentially slow disease progression.
Researchers have discovered a target for Schmallenberg virus treatment by identifying the nucleocapsid protein as a key building block that can be blocked to kill the virus. The study, published in Nucleic Acids Research, provides insight into the structure and function of the protein.
Researchers determined the three-dimensional structure of a protein pair, LC8 and Nek9, which plays a crucial role in cell division. This discovery has implications for studying diseases related to cell division processes like cancer.
Scientists have long debated the structure of alpha synuclein, a protein associated with Parkinson's. A new study models its structure, finding that it can rapidly switch between different conformations. The researchers suggest that stabilizing an ordered structure could prevent aggregation and offer a new drug-design strategy.
Researchers have successfully studied the shape of proteins using a novel strategy combining computational modeling and experimental techniques. This breakthrough has implications for understanding protein functions and diseases such as cancer, Parkinson's, and Alzheimer's.
Researchers mapped protein structures and organisms onto a timeline, revealing an 'hourglass' pattern where proteins folded faster over time. This discovery sheds light on the evolutionary drivers behind protein folding and has implications for understanding molecular functions, genetic engineering, and synthetic biology.
Researchers at CNIO have developed new computational methods to study the evolution of proteins and their interactions. These methods enable predictions of molecular relationships and structural changes, with potential applications in cancer treatment and drug development.