Articles tagged with Protein Structure
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Researchers at the Kosinski Group used a combination of cryo-electron tomography, single particle cryo-EM, and integrative modelling to create the most complete model of the human NPC to date, covering over 90% of its core. This breakthrough enables scientists to understand the NPC's structure and function in greater detail.
Researchers at USC Dornsife College of Letters, Arts and Sciences have elucidated the structure of a small protein carrying GABA into neurons using cryogenic electron microscopy. This breakthrough could lead to more effective drugs for conditions such as epilepsy, bipolar disorder, schizophrenia, Parkinson's disease, and autism spectru...
Scientists at St. Jude Children's Research Hospital developed an algorithm to identify temperature-sensitive conformations in proteins, revealing the importance of water networks in ligand binding sites. The findings challenge the assumption that well-resolved cryogenic water positions are both precise and accurate.
Researchers from Tokyo University of Science discovered that bony fish head cartilage contains abundant proteoglycans, including aggrecan, with similar CS structures to salmon nasal cartilage. This finding reveals the potential of sturgeon as an alternative source of CSPGs for health food formulations.
Researchers discovered a specific glycoprotein, RPTP zeta S3L, that connects to CD33 receptors in the brain, limiting its ability to clean up harmful proteins. This finding may lead to new drug targets and early diagnostics for Alzheimer's disease.
Scientists found a connection between the SARS-CoV-2 virus and the production of misfolded proteins called amyloids, which can cause complex symptoms and damage in organs such as the heart and kidneys. The researchers' discovery may help explain why COVID-19 often affects multiple parts of the body.
Researchers from Max Planck Institute have determined the 3D structural details of the human CCAN complex, highlighting its unique features and implications for interactions with centromere protein A. This discovery raises fundamental questions about creating artificial chromosomes.
Researchers determined the 3D structure of NTCP, a protein crucial for liver function and HBV/HDV infection. The study reveals two essential conformations: one 'open' pore for bile salt binding and a 'closed' conformation preventing virus recognition.
A team of researchers from Kumamoto University has developed a transformable polyrotaxane carrier that can facilitate genome editing using Cas9RNP with high efficiency. The carrier, called amino-PRX, is multi-step transformable and has low cytotoxicity, making it an enormously promising candidate for safe and efficient delivery.
Researchers at the University of Missouri are applying AI to analyze protein dynamics, identifying potential target sites for new drug therapies. The approach can simulate protein changes related to conditions like cancer, enhancing the chances of successful therapies.
The new computational tool, AF2Complex, predicts the structure of protein complexes and their interactions, offering insights into biomolecular mechanisms. The model is based on AlphaFold 2 and performs well in predicting protein structures and complex formations.
Scientists have discovered a shapeshifting volcano virus with remarkable properties that let it alter its shape. This finding could lead to new ways to deliver drugs and vaccines, with implications for understanding how viruses evolved and potentially creating new technologies.
Researchers used new techniques to uncover the Tetrahymena electron transport chain, revealing gaps in our knowledge of a major branch of life. The study highlights the power of structural biology and shows potential as a discovery tool for biodiversity research.
University of Ottawa scientists, collaborating with Yale researchers, have discovered the hidden influence of a single variation between histone H3.1 and H3.3 proteins. This finding could expand our understanding of DNA damage repair and its role in diseases like cancers and sponastrine dysplasia.
A team of scientists successfully investigated the electronic structure of tautomeric mixtures using inelastic X-ray scattering (RIXS) at BESSY II. They can now experimentally separate the signal of each individual molecule, providing detailed insight into their functionality and chemical properties.
Researchers at Karolinska Institutet have found a way to stabilize the cancer-suppressing protein p53 by adding a spider silk protein, creating a more potent variant. This discovery has potential as an approach for cancer therapy.
Researchers at UC Santa Cruz confirm their bioengineered RSV protein vaccine stimulates a stronger antibody response than the native G protein. The engineered protein is recognized by human RSV-fighting antibodies and may lead to an effective vaccine for severe respiratory disease in children and the elderly.
Researchers at Bielefeld University have identified five key characteristics of mitosis in the microalga Volvox carteri, including a porous nuclear envelope and crucial centrosome function. They used confocal laser scanning microscopy to capture high-resolution images of live cell division and gain insights into the complex process.
Using a novel method to arrange molecules, Northwestern University researchers have created a material that performs even better than the glue they were trying to mimic. The protein-like polymer can be used as an adhesive in biomedical contexts, such as wound healing or repair.
Researchers have solved the structure of seipin, a protein essential for proper fat storage in humans. The study reveals two conformations of seipin, which create and grow lipid droplets used for energy storage.
Researchers have discovered the structure of C.difficile's protective armor, a chain-mail like layer that prevents molecules from entering the cell. This discovery opens the possibility of designing specific drugs to target the armor and kill the cell.
Multiple system atrophy (MSA) is a fatal neurodegenerative movement disorder with no effective treatments, progressing rapidly and impairing critical physiological functions. The researchers will investigate how misfolded protein aggregates contribute to disease pathogenesis using the NIH grant.
A team of scientists from Martin-Luther-University Halle-Wittenberg and the Max Planck Institute discovered the essential final step in mRNA production. The process involves 16 proteins that precisely control the structure of mRNA, which determines protein function and disease risk.
Researchers at Scripps Research have revealed the three-dimensional structure of Flycatcher1, a protein channel in Venus flytraps that enables snapping shut. The structure shows similarities to other mechanosensitive ion channels found in various organisms, including plants and bacteria.
Researchers have discovered new details about HIV's structure, including the position of envelope spike proteins and glycan shields. The findings may help in designing a vaccine that can protect against AIDS.
Researchers have solved atomic-level structures of the muscle-type nicotinic acetylcholine receptor, a crucial step in understanding its function. The new findings could lead to breakthroughs in treating neurological disorders such as congenital myasthenic syndrome and myasthenia gravis.
Researchers have developed an AI-based method to analyze cryo-electron microscopy data, enabling the simultaneous examination of multiple protein complexes in cells. This breakthrough can lead to a better understanding of protein functions and potentially create new treatments for diseases like Alzheimer's and cancer.
USTC researchers develop a method named SCUBA for de novo protein design, employing a novel statistical learning strategy to generate protein main chain structures with high designability. This approach enables the creation of novel protein structures not observed in nature, expanding the diversity of accessible protein geometries.
Scientists at the University of Münster and Max Planck Institute have clarified the molecular basis for cellular degradation processes by elucidating the 3D structure of Mon1/Ccz1. The complex determines which vesicles deliver their content to the lysosome, a key step in protein regulation.
A genome study found significant variation in human ribosomal RNA (rRNA) genes based on geographic ancestry, particularly in the 28S rRNA segment. This discovery suggests that these variants may be important for understanding cancer development and functionally assessing their impact on ribosome functions.
Scientists have discovered families of proteins that can predict liver transplant rejection, allowing for early detection and modification of immunosuppression. The Blood Proteoform Atlas outlines over 56,000 protein molecules associated with immune cell proteins that change with rejection.
A recent review highlights the potential of structural proteomics in understanding pathological processes and predicting drug candidates for neurodegenerative diseases. The field combines protein chemistry and mass spectrometry to determine protein structure and interactions, which can lead to breakthroughs in treating serious health c...
Researchers are developing new methods to identify and characterize unknown proteins, including those with multiple forms and modifications. Artificial intelligence-based tools are also helping predict protein structures and functions, providing clues to their roles in health and disease.
Researchers have determined the precise structural changes in omicron's spike protein, which allows it to evade antibodies against previous variants. The findings provide a blueprint for designing new countermeasures, such as vaccines or therapeutics, against omicron and future coronavirus variants.
Scientists at UC Berkeley developed a new structure prediction method that modeled 500 secreted proteins in fungal pathogen Magnaporthe oryzae. The method revealed novel sequence-unrelated effectors and common folds among plant pathogens.
Scientists have successfully engineered protein needles that can self-assemble into lattice structures and ordered monomeric states. The study's findings provide insights into protein-protein interactions and could lead to the development of biocompatible materials and targeted drug transports.
Scientists at Osaka Prefecture University have identified specific parts of the dog allergen Can f 1 that can trigger an immune response in people. The researchers used X-ray crystallography to determine the structure of the protein and found several potential epitopes, or regions, that could be targeted by a vaccine.
Researchers at Washington University in St. Louis described for the first time the structure of CcsBA, a protein that transports heme and attaches it to cytochromes. The study revealed two conformational states of CcsBA, allowing scientists to characterize the enzyme mechanism.
Researchers at Goethe University and the Max Planck Institute of Biophysics have gained new insights into how mitochondrial complex I facilitates proton transfer through water molecules. The study's high-resolution structure data enabled computer simulations that shed light on the protein's dynamics during its catalytic cycle.
Researchers used room-temperature crystallography to study photosynthetic bacteria's proteins, discovering they are 'remarkably robust' and more efficient than previously thought. The study sheds new insight into the mechanism of electron transfer early in photosynthesis.
Researchers have visualized the first structure of a human cell death complex linked to autoimmune and inflammatory diseases. The discovery could lead to new treatments for inflammatory bowel disease, renal injury, diabetes, and other conditions. The study reveals how RIPK3 proteins regulate necroptosis, a type of inflammatory cell death.
Researchers identify a molecular culprit for COVID-19's seasonal nature, finding a galectin-like structure on the spike protein that responds to external seasonal patterns. This discovery could help predict future mutations and potentially pave the way for new therapeutics or vaccines.
Researchers have determined the molecular structure of TDP-43 aggregates extracted from human brains, shedding light on its role in neurodegenerative diseases like ALS. The discovery may lead to the development of targeted therapies and diagnostic tests.
Scientists have uncovered the structure of a Black Widow neurotoxin using cryo-electron microscopy, which could lead to the development of an antidote and new pesticides. The findings are a major breakthrough in understanding the molecular mechanism of the toxin.
Researchers at A*STAR's Institute of Molecular and Cell Biology have discovered a novel protein therapy using Agrin to promote wound healing and repair. The study found that timely induction or exogenous supplementation of Agrin accelerates the healing process, preserving the mechanical architecture of injured skin layers.
A team of researchers, including those from Rensselaer Polytechnic Institute and the University of Washington, have developed a neural network that can predict protein shapes with high accuracy. The network was trained on random protein sequences and generated 2,000 new proteins, many of which were successfully produced in the lab.
A team of scientists has created a neural network that can predict and generate new protein structures using deep learning. The network, trained on random protein sequences, can produce stable protein shapes with remarkable accuracy.
Researchers have discovered that specific regions of HAT family proteins determine which amino acids they bind to, leading to unique functions in cell growth and diseases like cancer and neurodegenerative disorders. This knowledge will enable efforts to develop compounds targeting these proteins for therapy.
A new computational tool allows precise prediction of protein interfaces for COVID-19 and human interactions. This breakthrough enables researchers to better understand virus development, identify high-risk populations, and develop targeted drugs.
Scientists have clarified phytochrome's atomic-scale resolution, unlocking its role in regulating bacterial pathogenicities. The study provides a new photoactivation model explaining the signaling mechanism of black rot disease.
Researchers at Massachusetts General Hospital have uncovered important details about Shigella's translocon, a pore that injects bacterial proteins into infected cells. The findings may help develop an effective strategy to block this critical component of infection and prevent diseases like dysentery.
Cryo-EM study reveals details of DNA repair mechanism translesion synthesis (TLS), allowing cells to survive with mutations. Key protein complex Pol K - PCNA interaction modulated by ubiquitination facilitates recruitment of TLS polymerase to damage sites.
Researchers have uncovered how a viral RNA changes shape to hijack host proteins, revealing the role of cryogenic electron microscopy in making this discovery possible. The study highlights the emerging power of cryo-EM to visualize multifunctional dynamic RNA structures.
Researchers developed AI models to predict protein interactions, identifying over 100 probable complexes and 700 previously uncharacterized ones. This breakthrough could lead to new treatments for human disease.
Paxlovid demonstrates significant efficacy against SARS-CoV-2 virus, reducing hospitalization and death risks in adult patients by up to 89%. The treatment's development involved cutting-edge X-ray technology from the Advanced Photon Source.
A new analytical technique combines quantum physics and molecular biology to track biomolecule changes in less than a trillionth of a second. By analyzing the collective movement of atoms, researchers were able to reduce 6000 dimensions to four and characterize conical intersections of quantum states in complex molecules.
Scientists have developed a software that adds missing sugar components to protein models created with AlphaFold, enabling more accurate structural predictions. This breakthrough has the potential to revolutionize workflows in biology, allowing scientists to understand proteins and their mutations faster than ever.
Researchers at the University of Waterloo have created a deep neural network that detects disease biomarkers with high accuracy, achieving 98 per cent detection of peptide features. This breakthrough could enable earlier and more accurate disease detection through tissue sample analysis.
Researchers developed a new NMR spectroscopic method to map IDP function more easily, fast, and accurately. The method sheds light on mechanisms of diseases like Parkinson's, Alzheimer's, and type 2 diabetes.
Researchers at Arizona State University have refined cryogenic electron microscopy to produce more accurate structures of biological samples. The new method uses a statistical approach to model transitory structures, which can play a vital role in biological processes.