Articles tagged with Proteomes
A major milestone in proteomics research has been achieved with the creation of a vast library of over 330,000 synthetic peptides representing all canonical human proteins. This achievement is expected to enhance protein identification and quantification by alleviating current issues in this field.
The Human SRMAtlas provides highly specific mass spectrometry assays for targeted identification and reproducible quantification of any human protein. This resource enables the measurement of 99.7% of the annotated human proteins, revolutionizing systems-level understanding of physiology and disease.
Researchers create new tool to define metabolic differences between individuals, paving the way for precision medicine. By combining genetic and protein data, scientists can better understand how patients respond to medication and tailor treatments accordingly.
A recent CSIRO study maps the boundaries of the 'dark proteome', a region of proteins with completely unknown structure. The research identifies surprising features in nearly half of the eukaryotic proteome, including associations with secretory tissues and disulfide bonding.
Researchers aim to advance understanding of intrinsically disordered proteins controlling cellular behavior and potential cures for devastating diseases such as Parkinson's and Alzheimer's. The initiative seeks to raise awareness about the societal impacts of these understudied proteins and develop new therapies.
A new study reveals that protein aggregates accumulate in the proteome of C. elegans as it ages, overwhelming the machinery of protein quality control and impairing cell function. However, long-lived worms deposit surplus proteins in insoluble aggregates enriched with molecular chaperones, which may help maintain healthy aging.
Researchers developed a new technique to compare human milk and rhesus macaque monkey milk proteomes. The study identified 524 human milk proteins and 518 in macaque milk, revealing 88 common proteins at different levels. Human milk contains higher levels of proteins aiding fat digestion and increasing iron absorption.
Researchers successfully analyzed all known complete proteomes using X-ray crystallography and homology modeling, covering 25% of protein clusters. The study highlights the potential for knowledge-based target selection to increase structural model production, particularly in eukaryotes and archaea.
The Human Proteome Organization (HUPO) and Elsevier's new open-access journal, Translational Proteomics, have formed a partnership to promote translational proteomics research. The journal aims to link basic sciences to clinical research, with a focus on rapid dissemination of novel discoveries.
Researchers at Columbia University have developed a new technique to visualize protein synthesis in live cells, enabling the study of complex biological processes such as long-term memory and disease mechanisms. The method harnesses deuterium-labeled amino acids to track newly synthesized proteins, providing unprecedented insights into...
Researchers have created a comprehensive map of the tuberculosis protein, allowing scientists to pinpoint specific proteins and discover new ones. This resource may aid in the development of new therapies and early detection methods, targeting the main target for medication: pathogen proteins.
A new study uses proteomics to analyze the composition of gymnosperm pollination drops, revealing species-specific germination media and anti-microbial proteins. This research provides a metabolic fingerprint, enabling further research into seed plant evolution and pollen-ovule interactions.
The Chromosome-Centric Human Proteome Project (C-HPP) is a 10-year effort to map and describe human proteins. The project aims to provide a full catalogue of proteins with practical applications in novel drug targets, diagnostic biomarkers, and understanding cellular regulators.
The Chromosome-Centric Human Proteome Project (C-HPP) is an ambitious international initiative that aims to identify and profile all human proteins. The project, which involves 20 scientific teams, will focus on 'missing' proteins and determine their functions in health and disease.
A new study found that many commercial beers, including some labeled as low-gluten, contain significant levels of gluten. Two beers labeled 'low-gluten' had as much gluten as regular beer, highlighting the need for accurate testing.
Cola detectives use protein testing to verify natural ingredients in premium soft drinks, detecting plant proteins in drinks claiming 'organic agave syrup and cola nut extracts'. Coca Cola products, without natural cola extract claims, have no detected protein, giving consumers a certificate of authenticity.
A study found that plants growing in contaminated soil near the Chernobyl Nuclear Power Plant adapt by altering certain proteins involved in cell signaling, allowing them to thrive in highly radioactive environments. Only about five percent of proteins were altered, suggesting a surprising resilience.
Researchers identified 20 barley proteins, 40 yeast proteins, and two corn proteins, revealing the largest portrait of the beer proteome. These findings may help brewers optimize fermentation processes and enhance beer's flavor and aroma.
Researchers found that plants growing in contaminated soil near Chernobyl have limited biochemical changes, suggesting adaptations to withstand radiation. These findings provide new insights into the mechanisms enabling plant survival in highly radioactive environments.
A new study has discovered that capsaicin, a compound found in chili peppers, can cause weight loss and fight fat buildup by triggering certain beneficial protein changes in the body. The research, published in ACS' Journal of Proteome Research, suggests that capsaicin may lead to new treatments for obesity.
Researchers analyzed bed bug saliva proteins to understand their role in feeding and potential medical applications. The study found unique enzymes that characterize the saliva profile of Cimex lectularius, a blood-feeding insect with over 250 million-year survival success.
A study found that calorie-restricted diets alter proteins in abdominal subcutaneous fat cells, which could serve as markers for improving or tracking therapy effects. Volunteers who lost an average of 21 pounds showed changes in protein levels, offering new insights into the mechanisms behind these diets.
A clinical trial found that eating about an ounce and a half of dark chocolate daily for two weeks reduced stress hormone levels and corrected other stress-related biochemical imbalances. This study provides strong evidence for the potential benefits of dark chocolate in reducing emotional stress.
Scientists have assembled the largest-ever collection of liver proteins, which could become a roadmap for finding new biomarkers and treatments for liver disease, including hepatitis. The database includes 6,788 non-redundant proteins, many of which are related to diseases in the nervous system.
A team led by Dr. Amanda Paulovich aims to develop a method to measure the products of genes, which are the over 100,000 proteins in the human body. The project, called hPDQ, has the potential to create ways to measure large fractions of human proteins, facilitating drug development and personalized medicine.
Dick Smith, a PNNL scientist, received the Human Proteome Organization's Discovery Award for his pioneering work in developing proteomics tools. His breakthroughs have enabled faster analysis of samples and improved detection of diseases, paving the way for better cures.
Researchers at Burnham Institute have developed a novel method to analyze the proteome of yeast, identifying 4,600 proteins. This breakthrough can lead to the discovery of new biomarkers for diseases and inform protein expression changes in response to stimuli.
Researchers have catalogued the complete salivary proteome, a set of proteins in human ductal saliva, which tracks closely with that of blood. This breakthrough promises less invasive and costly disease diagnosis and treatment monitoring.
Scientists have identified salivary proteins and RNA sequences that are highly discriminatory for oral cancer and Sjögren's Syndrome. The use of saliva as a diagnostic tool is only a few years away, with the potential to revolutionize disease detection.
Researchers have identified 381 proteins in the sperm of fruit flies, providing a new understanding of how sex evolved. This discovery could lead to breakthroughs in male infertility treatment.
Proteome Systems has received a $20 million grant from the US government to develop therapeutic compounds for treating radiation damage. The company's 'catalytic scavenger compounds' show potential in preventing radiation-induced tissue damage and are expected to protect victims of radiation exposure, including first responders.
The US government has awarded a $20 million grant to develop novel synthetic catalytic scavengers (SCS) to protect against and treat the effects of radiation exposure. Proteome Systems will provide its SCS compounds for clinical application, aiming to create medical products for victims of radiological terrorism or radiation accidents.
HUPO scientists have created a master proteomics database from human blood plasma, which will help answer key questions about protein identification and analysis. The project's long-term goals include identifying all protein constituents of human blood plasma and determining variation across populations.
A team of scientists at North Carolina State University and Yale University have analyzed the function of all proteins in yeast, discovering novel protein interactions that will require further examination. This breakthrough could lead to better understanding of protein functions in more complex organisms, including humans.