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Tracing down linear ubiquitination

Researchers developed a novel technology to tackle the 'secret ubiquitin code' by enabling systematic analysis of linear ubiquitination targets. This breakthrough will improve understanding of linear ubiquitination's role in diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.

SourceGoethe University Frankfurt·JournalNature Methods·DateMar 20, 2017

A greasy way to take better protein snapshots

Researchers at RIKEN developed a new technique to analyze protein structures by suspending crystals in a greasy substance, enabling the use of smaller samples and faster data collection. This breakthrough could lead to improved understanding of dangerous proteins, such as those containing mercury.

SourceRIKEN·JournalNature Methods·DateNov 10, 2014

Sometimes the average just isn't good enough

Researchers used computer simulation to analyze X-ray crystallographic data and found that current software programs underestimate the level of dynamics in proteins. This could lead to more accurate pictures of protein structures and improved development of medicines.

SourceUniversity of Vienna·JournalNature Communications·DateFeb 10, 2014