Articles tagged with Ribozymes
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Scientists capture unprecedented detail of a large RNA molecule assembling itself into a functional machine, overcoming kinetic traps. The research reveals the dynamic process, including subtle movements that prompt each domain to enter at precisely the right moment.
A team of researchers has uncovered the three-dimensional structure of a ribozyme called SAMURI, which can chemically modify other RNA molecules and influence their function. The study's findings could provide new directions for the development of RNA-based therapeutics.
A NASA-funded discovery reveals that RNA can produce both left- and right-handed proteins, challenging the notion that life initially favored one over the other. This finding deepens the mystery of life's handedness and suggests that homochirality may have emerged through later evolutionary pressures.
A team at Penn State developed an experimental pipeline called Cleavage High-Throughput Assay (CHiTA) that can test the activity of thousands of predicted twister ribozymes. The study identified approximately 94% of tested ribozymes as active, revealing their function can persist even with slight imperfections.
Researchers demonstrate the first cross-chiral exponential amplification of an RNA enzyme, potentially leading to the development of cross-chiral therapeutics and biotechnologies. The discovery suggests that a bioengineer can create a new form of biochemical evolution by using both left- and right-handed molecules.
Researchers at Tokyo University of Science discovered a new ribozyme, R3C ligase, that catalyzes the formation of a 3',5'-phosphodiester linkage between two RNA molecules. This finding sheds light on the molecular evolution of RNA and its potential applications in nanobiotechnology.
Researchers at Salk Institute unveil an RNA enzyme that can accurately copy functional RNA strands and allow new variants to emerge over time. This discovery brings scientists closer to producing autonomous RNA life in the laboratory, potentially revolutionizing our understanding of the origins of life.
Researchers have discovered the atomic structure of an RNA replicase using cryogenic electron microscopy, shedding light on a primordial 'RNA world' that kick-started evolution. The study provides structural insight into an ancient RNA machine thought to reside at the origin of life.
A new ribozyme called SAMURI can precisely modify RNA molecules, making them accessible for click chemistry. This allows researchers to label and visualize RNA pathways in living cells, enhancing their understanding of RNA interactions and functions.
A team led by Prof. ZHANG Kaiming solved six conformations in the second-step self-splicing of Tetrahymena ribozyme, revealing its mechanism on an atomic level. The researchers used cryo-EM to resolve RNA structures, providing insights into the advantages of this technique for studying heterogeneous molecules.
Researchers at Cambridge University have successfully created artificial enzymes, known as XNAzymes, that can target and destroy the genetic code of SARS-CoV-2, a promising approach to develop new antiviral drugs. The engineered enzymes are highly specific and can be programmed to attack mutated RNAs involved in cancer or other diseases.
Researchers at OIST Graduate University have experimentally shown the concept of a neutral network, vital for increasing diversity, by designing and testing over 120,000 RNA variants. They found a large number of accessible pathways between two variants, challenging previous theoretical predictions.
A new system developed at Stanford University and SLAC National Accelerator Laboratory determines the 3D structures of RNA-only molecules with high resolution, applying it to a ribozyme from pond scum and a piece of viral RNA from SARS-CoV-2. The study reveals tiny pockets in the viral RNA that could be targeted for COVID-19 treatments.
Researchers demonstrate that basic features of simple polymers and prebiotic environment can give rise to selection processes that reduce disorder. They identify specific base sequences that enable oligomers to fold into particular shapes, leading to the emergence of catalytically active complexes like ribozymes.
Scientists at the University of Würzburg have developed a ribozyme that can transfer methyl groups to target RNAs, shedding light on an interesting aspect of evolution. The discovery may mimic a ribozyme that could have been lost in nature, and has potential applications for understanding RNA structure and function.
Researchers at LMU München report a hydrothermal mechanism that could have promoted the prebiotic evolution of self-replicating molecules. In an experiment, warm water circulation through pores stimulates RNA strand replication, overcoming the initial problem of double-stranded RNA formation.
A team of scientists discovered ribozymes that utilize the prebiotically plausible 2-aminoimidazole group to catalyze RNA synthesis. This finding implies a complex interplay between nonenzymatic and enzymatic RNA synthesis during Earth's origin, challenging existing theories.
Researchers evolved an RNA polymerase ribozyme that can synthesize its own ancestor, a class I ligase enzyme, in three separate RNA strands. However, the synthesized ligases were often free from function-disabling mutations and exhibited poor fidelity of synthesis.
Scientists at Scripps Research Institute have developed a molecular switch that enables precise control of gene therapy doses. The technique involves embedding an RNA molecule called a hammerhead ribozyme into the genes used in gene therapies, allowing doctors to regulate the dosing level.
Researchers at Massachusetts General Hospital have discovered that jumping genes, such as B2 and ALU, cut themselves in response to stress. This discovery has significant implications for understanding stress responses in the body, particularly in relation to developing new treatments for infections, cancer, and autoimmune diseases.
Researchers from the University of Konstanz develop an RNA-based inducible system for switching on genes in C. elegans, closing a significant gap in the research on genetic switches. The new approach establishes a novel inducible disease model for Huntington's disease, opening up new opportunities for research and application.
Researchers found that short RNA molecules can form liquid crystals, encouraging growth into longer chains. The discovery suggests an 'RNA world' where liquid crystals guided the assembly of primordial biomolecules.
Researchers from Medical Research Council crack how first life on Earth replicated itself using a new type of genetic replication system. The system uses a triplet code to copy folded RNA, enabling the replication of ribozymes and supporting simple living systems.
Researchers at TSRI successfully created a ribozyme capable of synthesizing complex RNA molecules with mixed sequences, showing promise for replicating the ancient RNA world. The new ribozyme can perform both RNA synthesis and replication, a crucial step towards creating a self-sustaining RNA-based life form.
Researchers at OIST Graduate University have developed an efficient approach to study ribozyme mutants, revealing key findings about the structure and properties of these RNA molecules. The study found that ribozymes are highly robust against mutations, potentially explaining their widespread presence across different forms of life.
A recent SISSA/CNR-IOM study reconstructed the cleavage process for group II introns using computer simulations, shedding light on the human spliceosome's complex mechanism. The research provides valuable information for fighting diseases related to aberrant splicing, such as cancer and neurodegenerative disorders.
Researchers at Scripps Research Institute have devised an enzyme with unique properties that may have contributed to the origin of life on Earth. The new ribozyme works by knitting together a 'copy' strand of RNA using an original template, with the ability to make copies of its own left-hand mirror image.
Researchers from UNC School of Medicine challenge the widely-held theory that RNA self-replicated without protein enzymes, instead suggesting a 'Peptide-RNA World' scenario where proteins accelerated key chemical reactions. The study's findings support the idea that ancient protein enzymes played a vital role in life's emergence.
Researchers at UC Berkeley successfully repurposed Salmonella to safely transport virus-stopping enzymes into cells, effectively treating mice infected with cytomegalovirus. The new technique uses a live but weakened bacteria as a vector for the ribozyme that can stop the gene activity of cytomegalovirus.
Researchers have made a breakthrough in developing a new gene-targeting therapy that uses an RNA enzyme to inhibit strains of the herpes simplex virus. The technique has shown promise in experiments with mice and rabbits, but further research is needed before it can be attempted in people infected with herpes.
Researchers at UCSC have identified a novel type of gene regulation in mammals involving hammerhead ribozymes, which control the activity of important immune response and bone metabolism genes. The discovery challenges previous views on gene expression and suggests a more versatile role for RNA molecules.
A lead-specific DNAzyme uses the 'lock and key' reaction mechanism, but switches to 'induced fit' in the presence of zinc or magnesium. This discovery could lead to faster and more sensitive sensors.
Researchers at UC Santa Cruz determine the 3D structure of an RNA enzyme, or ribozyme, that carries out a fundamental reaction required to make new RNA molecules. The discovery provides insight into what may have been the first self-replicating molecule to arise billions of years ago.
The study reveals that water molecules trapped inside RNA enzymes form hydrogen bonds with other water molecules or parts of the molecule, creating a domino effect that modifies the structure elsewhere. This network-like behavior is essential for the enzyme's activity.
Researchers at UCSC's RNA Center have obtained a near-atomic resolution image of the three-dimensional shape of a ribozyme, revealing how functional groups of RNA mediate acid-base chemical catalysis. This breakthrough sheds new light on the 'RNA World' hypothesis and has implications for understanding the origins of life.
Researchers found that riboorganisms, which use RNA for genetic information and metabolic reactions, can have a much bigger genome than previously believed. This discovery greatly relaxes the conditions necessary for the first living organisms to develop, allowing them to contain more than 100 genes.
Researchers have developed a novel gene regulation strategy using ribozymes, which can be controlled with virtually any drug, offering a safer alternative to existing methods. The technique enables the easy turn on and off of genes, allowing for potential applications in therapeutic and research settings.
Researchers have developed a way to study single molecules of RNA enzymes, also known as ribozymes. They found that modifications anywhere on the molecule affect catalysis rates, even far from the active site. This discovery may lead to practical applications in designing biological sensors for various purposes.
A new ribozyme package has been shown to be effective against the hepatitis B virus in an animal model, reducing viral production by over 80% in just three to five days. The treatment uses a specialized cassette that targets and destroys the virus's RNA, making it a promising approach for fighting other viruses as well.
Scientists have overcome technical difficulties by linking ribozymes to helicases, allowing for efficient inhibition of target RNAs and enabling the development of a method for investigating random RNA functions.
Researchers at Stanford University have developed nanocircles that can shut down specific genes in living bacteria, paving the way for potential use in genetic therapy. The study demonstrates that nanocircles can act as a Trojan horse to target and inhibit disease-causing genes.
Researchers have discovered a new target for treating cancer cells that rely on survivin to survive. This finding offers new hope for patients with cancer who are struggling with this aggressive protein.
IDX1's role in regulating glucose levels and insulin sensitivity has been identified, shedding light on potential therapeutic targets. Further research is needed to fully understand the mechanisms by which IDX1 influences diabetes progression.
Researchers have designed a new genetic weapon called ribozymes to treat inherited human blindness by slowing the progression of retinitis pigmentosa. The treatment targets the autosomal-dominant form of the disease and has shown significant protection of eye cells in lab rats.
Researchers have found an RNA molecule capable of making a nucleotide building block, providing strong evidence for the RNA world view. This discovery supports the theory that in early evolution, RNA molecules carried out functions now considered to be the domains of DNA and proteins.
The company has validated the VEGF receptor as a key target in pathological angiogenesis and expects to submit an Investigational New Drug (IND) Application for clinical trials in cancer by the end of 1998. RPI.4610 has shown activity in multiple animal models, including inhibition of tumor growth and metastasis.