Articles tagged with Rna Binding Proteins
A new research training group will investigate intrinsically disordered proteins, crucial for human function and disease development. The group aims to unravel protein structures and functions using state-of-the-art techniques.
Researchers found a critical structure within TDP-43 that causes nerve cell death in ALS and FTD. Modifying this structure could lead to new therapies for these devastating diseases.
Researchers discovered that impaired FUS protein-protein interactions contribute to ALS degeneration, but drug-induced autophagy reduces pathological processes linked to aberrantly accumulated FUS. Stimulating autophagy rescued RNA-binding proteins and reduced neuronal death in cell culture experiments.
Scientists at Hebrew University create decoy molecules that trick RNA-binding proteins into binding with them, inhibiting their cancer-promoting activity. The technology has shown promise in slowing or stopping the growth of brain and breast cancer cells in mice.
Researchers identified a link between the RNA-binding protein PUM2 and age-related decline in cellular function. Targeting PUM2 restored mitochondrial dynamics and mitophagy, leading to improved mitochondrial function and increased lifespan.
Researchers at the University of Illinois have discovered how damaged liver cells repair themselves by reprogramming into an early stage of postnatal organ development. The findings reveal that injured liver cells undergo partial reprogramming, which is regulated by a specific RNA-binding protein called ESRP2.
A study by Columbia University researchers found that rogue RNA-binding proteins, including TDP-43, FUS, and hnRNP A1, accumulate in the brains of patients with ALS and frontotemporal dementia. This discovery suggests a common disease mechanism between inherited and sporadic forms of both diseases.
Researchers at the University of Delaware have discovered a protein, Celf1, that triggers degradation in the eye lens, allowing clear vision. The study reveals the molecular mechanism behind this complex process, shedding light on how cells degrade their own nuclei and DNA without killing themselves.
A Penn study reveals that nuclear-import receptors can reverse the formation of disease-causing protein clumps in brain disorders like frontotemporal dementia and ALS. By increasing NIR expression, researchers were able to dissolve clumps, return functional proteins to the nucleus and extend lifespan in fruitfly models.
An international team of neuroscientists has discovered a basic molecular mechanism that better understands Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), by investigating how cells change. This research could lead to new therapies for the debilitating disease.
Researchers at Syracuse University are making progress in understanding the disease mechanism of ALS by studying ubiquitin and Ubiquilin-2 protein interactions. They found that ubiquitin eliminates droplets of UBQLN2, a protein-encoding gene linked to ALS and dementia.
Researchers have validated five new genes responsible for Amyotrophic Lateral Sclerosis (ALS), a fatal neurological disorder. The study uses AI-powered technology to accelerate the discovery of new treatments by identifying key proteins linked to the disease.
Researchers found that reduced levels of Staufen2 are associated with a specific impairment of memory in rats. The study shows that Staufen2 plays a crucial role in conveying messenger RNAs to synapses, which is essential for learning and memory formation.
Scientists have created a first simple and standardized research tool to study protein aggregation in live cells. The tool, called yTRAP, allows researchers to quantify, manipulate, and track protein aggregates in yeast cells.
Researchers uncover how a fruit fly protein binds to multiple types of RNA, revealing new insights into its multifunctional role. The study may help explain the diverse functions of RNA-binding proteins implicated in cancer and neurodegenerative diseases.
Researchers at Penn have identified a mechanism by which mitochondria can drive changes in nuclear gene expression associated with tumor progression. The epigenetic process involves a protein triggered by mitochondrial oxidative or metabolic stress, leading to reduced cancer gene expression when blocked.
Researchers have identified the functions of two sibling RNA-binding proteins in neural stem cells and neurons. PTBP1 and PTBP2 serve both redundant and unique roles in brain development, contributing to neuronal differentiation. This discovery has implications for fine-tuning stem cell therapeutic strategies for neurologic disorders.
Researchers at Berkeley Lab discovered a complex system of cell regulation that acts as quality control for genetic information transport out of the nucleus. They found that proteins associated with aberrant strands of genetic code are regulated, enabling gateway proteins to recognize and block them from exiting the nucleus.
Researchers discovered that cytomegalovirus (CMV) hijacks the molecular machinery in human cells to survive and replicate, relying on the human protein CPEB1. Suppressing CPEB1 levels during CMV infection reverses harmful cellular changes and reduces viral production tenfold.
Researchers discovered damage to RNA-binding protein hnRNP A2/B1 contributes to ALS by scrambling cellular messaging systems. The study provides a new therapeutic target for treating the disease.
Researchers at St. Jude Children's Research Hospital discovered that toxic peptides from ALS and FTD can incapacitate membrane-less organelles, leading to tissue degeneration. The study provides new insights into the molecular mechanisms of these debilitating diseases.
A groundbreaking study found that keeping a specific RNA binding protein, TDP-43, from moving inside nerve cells can prevent cell death and disease progression in ALS and other neurodegenerative disorders. The researchers developed small proteins to block the protein's localization, preventing toxicity and disease progression in mice.
Researchers at Australian National University have identified over 1,000 RNA-binding proteins in the heart that could lead to a cure for heart disease. These proteins interact with RNA and play a crucial role in regulating genome function.
Researchers led by Salil Lachke are investigating cellular processes controlling protein production in eye lenses to prevent cataracts. The team aims to build a biological gene regulatory circuit and understand the role of RNA-binding proteins in lens development.
A study by Jeremy Sanford's lab at UC Santa Cruz identified an extensive malignancy-associated gene expression circuit regulated by IGF2BP3 in pancreatic cancer cells. The protein drives metastasis by influencing the expression of genes involved in cancer biology, including cell migration and proliferation.
A new system allows scientists to image RNA inside living cells, monitor its activity and even control it. The modular components enable easy performance of a wide variety of RNA manipulations.
Researchers discovered that B cells rely on RNA binding proteins ZFP36L1 and ZFP36L2 to induce quiescence, allowing them to 'rest up' between developmental events. This mechanism is crucial for proper B cell development, as seen in mice where a 98% reduction of mature B cells was observed when these proteins were absent.
A team of researchers at UT Southwestern Medical Center has identified a second role for RNA-binding proteins, which may contribute to neurological diseases such as autism and epilepsy. The study suggests that these proteins play a key regulatory role in translating messenger RNA into proteins.
A study found that IGF2BP3 promotes B cell proliferation in B-cell acute lymphoblastic leukemia by regulating oncogenes like MYC. The RNA binding protein is reactivated in some cancer cells, making it an attractive target for cancer-fighting drugs.
Scientists identify protein interference with nucleocytoplasmic transport as essential for causing ALS and FTD. Toxic dipeptide repeat proteins translate from repeat-containing RNA disrupt normal cellular function.
Researchers at the University of Surrey have discovered a new link between gene regulation and metabolism in baker's yeast and roundworms. The findings, published in Nature Structural & Molecular Biology, could lead to more effective therapies for diseases like cancer and neurodegenerative disorders.
Researchers identify reversible phase transitions in FUS protein, leading to aggregation and trapping of other proteins. Disrupting these assemblies can rescue impaired motility and prolong lifespan in ALS models.
Researchers discovered a new way in which ALS kills nerve cells by disrupting protein synthesis, highlighting the importance of RNA-binding proteins in disease progression. The study provides a potential key to treating both ALS and dementia.
Scientists at MIT have found a mechanism by which cancer cells develop resistance to chemotherapy drugs. The MK2 pathway takes over when p53 is disabled, allowing cells to continue dividing even with extensive DNA damage. Measuring the levels of specific RNAs could help predict patients' response to chemotherapy.
Researchers have discovered that RNA-binding protein ROQUIN regulates the stability of thousands of mRNA molecules, including those involved in cellular inflammation and stress responses. By binding to these mRNAs, ROQUIN influences the activity of the key mediator NF-kappaB, which is essential for regulating gene expression.
A new study reveals how synchronized gene activation is achieved in developing neurons through a TTP/miR-9 regulatory pair, which limits messenger destabilization and ensures coordinated accumulation of neuronal proteins.
Researchers discovered that epigenetic modifications to mRNA act as a structural switch allowing RNA-binding proteins to recognize inaccessible regions. This phenomenon, known as the m6A switch, affects practically all RNA-protein interactions, with widespread implications for gene expression and regulation.
A team of scientists identified a key mechanism by which proteins change shape in response to different conditions. This discovery has significant implications for understanding how to manipulate proteins, which could lead to breakthroughs in treating diseases.
Researchers at MIT have identified a link between Musashi proteins and the regulation of cancer cell proliferation. The study found that these RNA-binding proteins can force cells into an epithelial state associated with increased growth, making them a promising target for diagnostic markers and potential treatments.
Scientists have unraveled a molecular mechanism of mRNA recognition, essential for understanding differential gene regulation in male and female organisms. This principle represents an essential and widespread mechanism of gene regulation in higher organisms.
A study led by UC San Diego scientists reveals a new way in which RNA-binding proteins govern regulated gene expression, expanding potential targets for therapies. The discovery challenges existing models and has implications for the treatment of neurodevelopmental disorders and certain cancers.
Researchers have identified a link between VCP gene mutations and toxic protein buildup in ALS patients, providing a new approach for developing treatments against the devastating disease. The study suggests that activating autophagy to clear stress granules could offer a new strategy for treating neurodegenerative diseases.
A team of researchers has created the first-ever compendium of RNA-binding sequences, which will become a valuable resource for researchers studying human genetics. The study reveals similarities between humans and fruit flies in terms of binding sequences, suggesting that many proteins bind to similar sequences across species.
Researchers have found new candidate disease proteins for neurodegenerative disorders, including two RNA-binding proteins with prion-like segments associated with inherited forms of ALS and multisystem proteinopathy. Mutations in these proteins accelerate the formation of self-organizing fibrils that contribute to disease.
Researchers cracked the molecular code for pentatricopeptide repeat (PPR) proteins, which recognize and bind specific RNA molecules. This discovery enables the potential for new treatments of genetic diseases and precise control over gene expression.
Researchers at Boston University School of Medicine have identified a new group of RNA-binding proteins that accumulate in the brains of patients with Alzheimer's disease. These findings may lead to novel diagnostic approaches and a better understanding of the disease progression.
Researchers analyzed six RNA binding proteins that control genetic splicing, discovering they work together to regulate thousands of genes. The study highlights the importance of these proteins in maintaining cell homeostasis and may offer clues for rational drug design.
Researchers at University of Pennsylvania School of Medicine discovered a new human gene, TAF15, similar to TDP-43 and FUS, that may contribute to ALS pathology. The study used yeast as a model organism to identify potential disease genes associated with the neurodegenerative disease.
Researchers have discovered that defects in RNA biology contribute to the development of ALS, a disease caused by misfolded proteins. The study found that genes related to stress granules can rescue FUS-related toxicity, suggesting new targets for developing drugs.
A new platform has been developed to study how specialized proteins regulate RNA in living, intact cells. By identifying every sequence within every strand of RNA to which proteins bind, researchers can now address questions about how differences in RNA explain the vast differences between humans and worms.
Researchers have uncovered an extensive network of regulatory interactions influencing protein production and placement in cells. A pervasive system of biological regulation, similar to transcription factors, guides the fates of most protein-coding RNA molecules by recognizing specific sequences.
Researchers found that levels of CUGBP1 increase early in affected cells, playing a key role in the disorder. Myotonic dystrophy type 1 is associated with increased binds of muscleblind like (MBNL) protein, trapping genetic material and regulating gene expression.
A new neurodegenerative syndrome, fragile X-associated tremor/ataxia syndrome, has been identified as triggered by the interplay of two proteins binding to messenger RNA. Individuals with this condition exhibit higher levels of mRNA and experience tremors, balance issues, and difficulty with daily activities.
A new technology allows researchers to observe RNA metabolism in live cells, enabling the identification of RNA-binding proteins and their interactions with specific RNAs. This breakthrough has the potential to reveal disease-associated RNAs, which could lead to new therapeutic targets.
Researchers identified Staufen2 as essential for maintaining synapses in nerve cells. The absence of Staufen2 leads to impaired signal transmission and altered synapse structure, suggesting mRNA transport is crucial for their maintenance.
In eukaryotic cells, RINGO/Spy controls transcription and translation through protein-protein interactions. It inhibits the activity of the translation initiation factor eIF4E, leading to reduced protein synthesis.
Researchers have developed a new technique called CLIP, which helps identify target RNAs regulated by RNA-binding proteins like Nova. This technique has potential to aid in understanding the cause of many human diseases, including Fragile X syndrome.
Researchers have developed a new method called CLIP to catalog RNA targets regulated by RNA binding proteins in rare brain diseases. The study identifies an astonishing set of 340 Nova RNA tags, shedding light on the role of RNA splicing in POMA and other disorders.
Researchers developed Antibody Positioned RNA Amplification (APRA) to analyze RNA binding proteins, identifying mRNAs encoding proteins involved in signal transmission and neuron maturation. The technique has great potential for targeting specific RNA binding proteins and studying disease states.
Scientists have discovered a chain of cellular events that occurs in plant cells when exposed to environmental stress, ultimately leading to the production of protective proteins. The research, led by Sarah M. Assmann, found that a hormone called abscisic acid regulates the processing of RNA molecules involved in stress response.