Transmembrane Receptors | Topics

Articles tagged with Transmembrane Receptors

Novel therapeutic strategy against melanoma: combined targeting of hedgehog signaling and BRD4

Researchers propose targeting non-canonical HH/GLI signaling to improve response rate and durability of therapeutic effects exerted by SMO inhibition in melanoma. The findings suggest that combined targeting of hedgehog signaling and BRD4 could provide a novel therapeutic option against melanoma.

Researchers discover new insight into a common signaling pathway

Researchers have determined that the conformation of Smad3 protein regulates TGF-ß pathway interaction with other proteins, affecting signal transduction and gene expression. This discovery provides new insight into molecular mechanisms of TGF-ß signaling and potential targets for drug design.