Articles tagged with Ubiquitination
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have identified a new class of small molecules that boost the cell's natural recycling machinery to destroy an immune-modulating enzyme called IDO1. This approach takes a bolder approach than traditional drug design, eliminating disease-causing proteins altogether and opening up new possibilities for cancer treatment.
Researchers discovered that brain enzyme OTULIN regulates tau protein accumulation and has implications for treating neurodegenerative diseases. The study revealed OTULIN's role in controlling gene expression and RNA metabolism, suggesting a potential therapeutic target.
Researchers explore how plants use ubiquitination to fend off pathogens, developing molecular tools for disease resistance. The team aims to design synthetic E3 ligases that can switch on immune pathways and target pathogen proteins, enhancing crop resilience.
A new study reveals how a promising Parkinson's drug works by inhibiting the enzyme USP30, which prevents damaged mitochondria from being degraded. This breakthrough could lead to targeted therapies for Parkinson's disease and chronic kidney disease.
Researchers from the Chinese Academy of Sciences uncover the mechanism behind strigolactone perception, which regulates rice tiller development in response to nitrogen levels. The study reveals a unique 'gas and brake' mechanism that allows for smart regulation of SL signaling.
Researchers developed a simple, cost-effective method to study ubiquitination, a critical protein modification process involved in diverse cellular functions. The Ub-POD method quickly labels targets of E3 ligase enzymes directly in human cells, allowing for the identification of new substrates and expanding therapeutic options for dis...
A study characterizes the ubiquitination of Nrf1, a transcription factor, triggered by deglycosylating enzymes, leading to its inactivation and preventing it from functioning properly. This process is associated with proteasome dysfunction and age-related neurodegenerative diseases.
Researchers identify UBE2J1's role in degrading the androgen receptor, a key player in prostate cancer progression. The study suggests targeting this ubiquitination machinery may help overcome antiandrogen resistance in cancer therapy.
Prolonged endosomal defects lead to cell death, but the effects on cellular signaling were poorly understood. Endosomal stress caused by USP8 depletion induces immune responses and activates NF-kB- and Nrf2-mediated gene expression.
The researchers identified that the flexibility of a protein hinge plays a crucial role in the transfer of proteins in key cell processes. They found that a flexible hinge allows ubiquitination to take place by facilitating the rearrangement of the protein around it.
A study published in Molecular Cell describes how bacteria build a form of ubiquitin that helps cells communicate. The research sheds light on how different enzymes impact this protein during infection, providing an important first step towards understanding its role in diseases like Parkinson's and breast cancer.
Researchers from Max Planck Institute identified mechanisms of deubiquitinating enzymes acting as Fubi proteases, regulating ribosomal protein maturation and modulating immune responses. This discovery expands understanding of post-translational modification systems and their roles in cellular processes.
Scientists at Münster University identified specific modifications to the influenza A virus polymerase that are triggered by host cell proteins, such as ubiquitin. These stable modifications may lead to the development of medicines resistant to viral mutations.
The research team at the University of Würzburg has reported the first structures of UBA6 in complex with either ATP or FAT10, shedding light on its dual recognition capability. The study also identified UBA6 variants that selectively abolish the activation of either ubiquitin or FAT10.
A new study reveals that the protein CHIP can regulate insulin receptor signals more efficiently alone than in a paired state. This finding suggests that maintaining a balance between monomeric and dimeric states of CHIP is crucial for proper cellular function.
Researchers from the University of Chicago used cryo-electron microscopy to study protein degradation in yeast, describing the structure of a key enzyme involved in ubiquitination. The study provides new insights into the process and its potential role in human diseases such as aging and neurodegeneration.
Researchers have identified distinct ubiquitination patterns that underlie cell recovery following different environmental stressors. For heat stress, ubiquitination primes cells to dismantle stress granules and reinitiate normal cellular activities after stress has been removed.
Researchers found that Mind bomb-2 (MIB2) ubiquitinates and stabilizes the anti-apoptotic protein cFLIP, preventing excessive cell death. This discovery may lead to new therapeutic strategies for treating cancers and neurodegenerative diseases.
A new biomarker for Alzheimer's disease has been identified in the blood of patients, according to a recent study published in IJMS. The Ube2h gene was found to have increased specific expression in the blood of AD patients and AD model mice.
Research reveals a new mechanism for controlling DNA methylation in cells, involving the ubiquitination of PAF15, which is crucial for maintaining DNA methylation and inhibiting cancer cell proliferation. The discovery has significant implications for the development of new inhibitors of DNA methyltransferase
Researchers have developed a new 'ubiquitin clipping' technique to study protein modifications, revealing branched ubiquitin chains are common and could impact diseases like cancer and neurodegenerative disorders. The technique enables detailed experimentation, providing insights into disease mechanisms and potential drug targets.
Researchers develop new technology to analyze how cells remove damaged mitochondria, providing a clearer picture of the dynamics involved. This discovery sets the stage for detailed studies of mitochondrial damage, cell death, and disease.
Researchers at Tokyo Medical and Dental University develop a new system to visualize ubiquitin assembly in real time, revealing new insights into the molecular details of autophagy. The technique allows for the study of previously unexplored residues involved in forming ubiquitin chains.
Researchers discovered that endothelial cells lining blood vessels are not as effective at removing invading bacteria via xenophagy, a process used by epithelial cells. The study suggests that targeting the ubiquitination pathway could lead to new approaches for fighting infections like GAS.
Researchers developed a novel technology to tackle the 'secret ubiquitin code' by enabling systematic analysis of linear ubiquitination targets. This breakthrough will improve understanding of linear ubiquitination's role in diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
Researchers at Goethe University Frankfurt discovered a new ubiquitination mechanism in Legionella bacteria that affects cellular processes and causes cell death. This mechanism reveals a broader role of ubiquitin in regulating life processes and may lead to new strategies for developing antibacterial agents.
A team of researchers identified a single enzyme that can independently control ubiquitination, a crucial cellular process. This finding has the potential to lead to the development of new therapeutic targets for diseases, including infection.
A study published in Nature Communications reveals that the protein dDsk2, a ubiquitin receptor, plays a key role in regulating gene expression. This discovery opens up new avenues for understanding the link between dDsk2 and neurodegenerative diseases such as Alzheimer's and Huntington's.
Richard A. Flavell and Ruslan Medzhitov have been awarded the 2013 Vilcek Prize for Biomedical Science for their pioneering work on the fundamental roles of the innate immune system. Their research has led to important insights into immune responses, with implications for various fields of biomedical studies.
Researchers have identified a key enzyme, TRC8, that enables cytomegalovirus to shut down an antiviral defense by destroying the MHC I protein. This allows the virus to evade immune system surveillance and trigger an immune response.
TRAF6 plays a key role in activating Akt, a signaling molecule associated with cancer growth. Ubiquitination of Akt is required for its activation and hyperactivation in mutant forms is linked to cancer development.
A Purdue University scientist has discovered a key process in cell growth that can lead to the formation of tumors. The research found that an overabundance of the polo-like kinase 1 molecule during cell growth, as well as a shortage of the p53 molecule, will lead to tumor formation.
A study identifies RNF6 as a protein that modifies androgen receptor activity in hormone-refractory prostate cancer. Inhibition of RNF6 shows promise as a new strategy for treating advanced prostate cancer, which no longer responds to traditional therapies.
Researchers at Cold Spring Harbor Laboratory have identified a protein called Asr1 that 'glues' ubiquitin to specific spots in the DNA-copying enzyme, causing it to be jettisoned and inactivating gene transcription. This discovery sheds light on how ubiquitin regulates gene activity.
Researchers have gained insight into how cells accessorize their proteins to regulate function, a process critical for life. By studying the attachment of NEDD8 to cullin-RING, scientists have found that it transforms the enzyme into an activated form that can attach ubiquitin to target proteins.
Researchers at Helmholtz Munich have found that ubiquitin attaches to Malt1 protein in T cells upon antigen stimulation, regulating immune defense. This process is reversible and helps prevent over-activation of T cells, a common cause of chronic diseases.
Researchers at Goethe University Frankfurt have identified a novel Ub conjugation reaction that allows for more efficient manipulation of key proteins in the treatment of cancer and other diseases. This discovery provides a basis for novel therapeutic approaches that are more specific than existing drugs like Bortezomib.
At Université de Montréal, researchers demonstrated real-time monitoring of ubiquitination on living cells using the BRET technique, shedding new light on the role of ubiquitin in protein degradation. This breakthrough has significant implications for understanding health and developing targeted therapeutic molecules.
Researchers at UNC Health Care have identified a new mechanism by which Polycomb group proteins silence genes in cancer cells. The study found that ubiquitination of histone H2A is involved in this process, providing insight into gene expression regulation and potential targets for cancer treatment.