Articles tagged with Astrocytes
Researchers at Massachusetts General Hospital found that urate stimulates astrocytes to activate an antioxidant pathway believed to have a role in several neurodegenerative disorders. A phase 3 trial of a urate-elevating drug, led by Dr. Michael Schwarzschild, is planned to enroll 270 patients with early-stage Parkinson's disease.
Researchers found that treating astrocyte nucleus with TGF-beta frees p75NTR protein, allowing critical molecules to enter the nucleus and enabling reactive state. This discovery highlights the importance of nuclear pore complex in brain health and raises possibilities for treating neurological disorders.
A UBC study suggests targeting healthy cells around tumors to stop brain cancer from spreading. The research team found that glioma cells can hijack astrocytes, regulating their environment to stimulate tumor growth and invasion.
A research group at Hiroshima University found that downregulated spinal astrocyte connexin43 expression leads to sustained neuropathic pain following peripheral nerve injury. Restoring Cx43 function via adenovirus vector may reverse mechanical hypersensitivity and modulate glutamatergic neurotransmission.
Scientists have established a model for latent HIV infection of brain cells and identified various compounds that can affect latency. The study aims to develop new therapeutic approaches to silence the virus in brain cells, which could improve clinical care for HIV-1 patients.
Astrocytes play a crucial role in maintaining healthy vascular tone by releasing signals to dilate or constrict blood vessels as needed. This basal control helps regulate blood flow and prevent damage from excessive pressure or calcium levels.
A new study by Naguib Mechawar's team found that networks of astrocytes are altered specifically in areas of the brain associated with mood regulation. The research also discovered unique properties of astrocytes in subcortical brain regions, which may contribute to depression and suicide.
Researchers at the University of Montreal have discovered that astrocytes control the pattern of neuronal electrical activity, determining functions such as chewing, locomotion, and respiration. The study reveals a mechanism by which astrocytes regulate calcium levels, leading to changes in neural function.
Aromatase, an enzyme converting testosterone to estrogen, plays a significant role in the healthy and injured brain. In healthy brains, it helps neurons produce estrogen, maintaining cognitive function. After injury, aromatase expression shifts to astrocytes, aiding their support of stressed neurons and promoting recovery.
Researchers at University of Queensland discovered a molecule called C5aR exacerbates inflammation and tissue damage after spinal cord injury. Administering an experimental drug that inhibits C5aR can improve recovery when given early after injury, potentially treating patients with spinal cord trauma.
Researchers at the University of Bonn have discovered a new cause of temporal lobe epilepsy: astrocyte uncoupling. This leads to hyperexcitability of neurons and epileptic seizures. The study suggests that inflammation plays a role in uncoupling astrocytes, which can be reversed at an early stage.
A new study by the University of Wisconsin-Madison Waisman Center has made significant progress in understanding the role of human astrocytes in neurodegenerative diseases such as ALS and spinal cord injuries. Astrocytes, a type of glial cell, have been found to play a crucial role in neuronal survival and proper nervous system signaling.
Researchers at Gladstone Institutes discovered a new memory regulator in astrocytes, which improved memory in healthy mice and prevented impairments in Alzheimer's disease models. The study suggests that targeting A2A adenosine receptors may offer a potential treatment for improving memory.
A new study by Duke researchers has identified a protein called hevin that plays a critical role in forming brain connections, particularly in the cortex. The discovery sheds light on how disruptions in this process may contribute to conditions such as autism and depression.
A rare connexin mutation has been linked to a baby's disordered breathing, with researchers discovering that astrocytes with the mutation cannot bind to carbon dioxide. This breakthrough could lead to the development of an algorithm to pinpoint when a premature infant's breathing pattern goes south.
The study found that astrocyte hyperactivity is caused by energy carriers like ATP, leading to calcium fluctuations and changes in brain perfusion. The research suggests a novel potential approach for treating Alzheimer's disease by mitigating the hyperactivity of these cells.
Researchers have created a new mouse model that allows them to study human glia in live animals, enabling the development of potential treatments for progressive multifocal leukoencephalopathy (PML). The study found that the JC virus targets astrocytes, leading to inflammation and cell death, which can trigger PML.
Researchers found that aging astrocytes lose ability to protect motor neurons, but replacing old cells with engineered protein improves neuron survival. A specially engineered protein called GDNF increases motor neuron survival when cultured with aging astrocytes.
A recent study published in Nature Neuroscience found that digoxin, a medication used to treat heart failure, may have a strong effect on treating amyotrophic lateral sclerosis (ALS) by blocking an enzyme that destroys nerve cells. The research suggests that reducing the activity of this enzyme or limiting its production can prevent th...
Researchers at Lund University have identified a previously unknown mechanism by which the brain produces new nerve cells after a stroke. Astrocytes, support cells in the brain, can form immature nerve cells that mature into functional neurons.
Scientists have developed a genetically engineered mouse line that allows them to study calcium levels in living brain cells, enabling new research on epilepsy, Alzheimer's, and other neurological diseases. This breakthrough opens up possibilities for new treatments and a deeper understanding of the immune system's role in brain function.
Astrocytes play a vital role in controlling gamma oscillations, which are essential for higher-level brain function and memory. The study found that disabling astrocytes disrupts gamma waves and impairs novel object recognition memory.
The development of the retinal vascular system follows specific rules and is spatially and temporally consistent with retinal neuron function. Astrocyte-vascular wall cell interactions lead to the maturation of the blood-retinal barrier, a crucial component in maintaining retinal health.
Scientists identify astroglial cells as crucial players in Down syndrome's abnormal neuron development and find that an inexpensive antibiotic can correct many abnormalities. They also show that minocycline, a commonly used tetracycline antibiotic, promotes healthy interactions between astroglia and neurons.
A team at Université de Genève identified a new cellular mechanism involving non-neuronal cells called astrocytes that stabilize neuron connections. This process protects synapses and allows learning to leave a mark on memory. The study sheds light on the importance of astrocytes in learning, memory, and neurodegenerative diseases.
A new study reveals that astrocytes regulate inhibitory synapse formation through the protein TGF β1 and CaMK2 signaling. This discovery has significant implications for understanding neurological disorders associated with impaired inhibitory synapses.
Researchers found that adipose-derived stromal cells exhibit increased apoptotic rates and decreased viability when attempting to differentiate into astrocytes. This process is hindered by caspase-dependent apoptosis, a crucial strategy for increasing induction efficiency.
Scientists have identified a novel mechanism of memory loss in Alzheimer's disease and propose new therapeutic targets, including the production and release mechanisms of GABA in reactive astrocytes. A MAO-B inhibitor showed promise in treating Alzheimer's disease model mice for a short time.
Researchers discover that retinal ganglion cells pass on worn-out mitochondria to astrocytes for disposal at the optic nerve head. This process challenges the common understanding of cellular trash management and has implications for diseases like glaucoma, Parkinson's, and Alzheimer's.
A new study reveals that astrocytes can monitor and respond to nearby neural activity, but only when primed by the fight-or-flight chemical norepinephrine. This ability suggests that astrocytes may help control the brain's ability to focus.
Researchers discovered that damaged mitochondria in retinal ganglion cells are transferred to adjacent astrocytes, which then degrade them. This process, dubbed transmitophagy, has significant implications for understanding and treating neurodegenerative disorders.
Researchers discovered specialized astrocyte functions support specific neurons, contributing to neurodegenerative disorders like ALS. The study also found potential links to developmental disorders such as autism and schizophrenia.
Astrocytes are support cells for neurons that provide nutrients and signaling molecules. A new mouse study reveals that astrocytes listen in on neuronal activity only during large bursts of activation, triggering a response with increased calcium levels.
A UCLA study found that increasing Kir4.1 levels in astrocytes improves walking and prolongs survival in a mouse model of Huntington's disease. The discovery could lead to new drug targets for treating the devastating disorder, which affects one in every 20,000 Americans.
A study found that co-culturing dorsal root ganglion neurons with type-2 astrocytes increases neuronal survival rates and process lengths. However, the effect is weaker compared to type-1 astrocytes and oligodendrocyte precursor cells.
A new study by Nationwide Children's Hospital researchers has identified a potential culprit in the death of motor neurons in Lou Gehrig's disease. Inhibiting nuclear factor-kappa B (NF-ƘB) in microglia slowed disease progression by 47 percent, suggesting a new target for ALS treatment.
Researchers have successfully reprogrammed rat astrocytes into neurons using Mash1, a transcription factor. This method avoids malignant transformation and offers a promising therapeutic strategy for neural regeneration.
Scientists at UT Southwestern Medical Center successfully generate new neurons from adult astrocytes in mice, offering hope for repairing traumatic brain injury or spinal cord damage. The two-step approach uses a transcription factor to reprogram scar-forming astrocytes into neurons, which then mature and persist for months.
Researchers at Columbia University Irving Medical Center found a toxin released by star-shaped brain cells called astrocytes that kills nearby motor neurons, leading to neuron loss in human ALS models. The study suggests new potential for slowing down or stopping the destruction of motor neurons and improving drug targets.
A new study suggests that a population of support cells called astrocytes could provide a promising approach to treat Parkinson's disease. Astrocytes, which are critical to maintaining a healthy environment in the brain, were found to repair multiple types of neurological damage caused by the disease.
Researchers have discovered a novel method of treating traumatic brain injury by stimulating 'caretaker cells' to reduce swelling. The treatment, using compounds like 2-methylthio-ADP and MRS2365, has shown promise in reducing edema and prolonging the life of neurons.
A Stanford study reveals that astrocytes, a mysterious class of brain cells, actively refine nerve-cell circuits by selectively eliminating synapses, much like a sculptor chisels away excess rock to create an artwork. This process is triggered by activity in neurons and persists into adulthood.
Researchers found that disrupting a core clock gene in mice accelerated oxidative stress and inflammation in nerve cells, raising possibilities for therapeutic approaches to delay neurodegeneration. The study suggests the molecular clock plays a crucial role in protecting the brain from damage.
New research shows glial cells and neurons work together to protect the brain from oxidative stress, excitotoxicity, and other dangers. The study reveals a precise calibration system between neurons and astrocytes that ensures protective measures are only taken when needed.
Researchers found combined transplantation of astrocytes and decorin promotes axonal regeneration and growth, inhibiting astrocyte proliferation and glial scar formation. This therapy offers a potential new approach for spinal cord injury repair.
Astrocytes, a type of glial cell, respond to neurological trauma by changing shape and forming scars that can either repair or hinder brain function. The study identified proteins controlling this process, revealing a complex mechanism involved.
A UC Davis study reveals that astrocytes can protect brain tissue and reduce disability due to stroke. The research found that a specific type of astrocyte called Olig2PC-Astros has greater antioxidant effects and improves learning and memory in rats.
Researchers at UC Riverside aim to develop more effective treatments for brain disorders like epilepsy by studying neuronal hyperexcitability and astrocytic swelling. They will investigate the relationship between astrocytic swelling and seizure thresholds using mouse models and modern imaging techniques.
Scientists have developed a method to derive mature human neurons from reprogrammed skin cells, enabling direct disease modeling and customized treatments. The new approach uses astrocytes to guide the growth of neurons, leading to more effective cell differentiation and improved neural function.
Researchers develop new methods to visualize calcium signals in entire astrocytes, revealing their role in modulating synaptic activity and regulating local blood flow. These findings pave the way for future exploration of astrocytic physiology.
Researchers at Duke University Medical Center found that new astrocytes produced from stem cells after brain injury are effective in promoting recovery. These cells make their way to the injured area to form an organized scar, which stops bleeding and allows tissue recovery.
Researchers at Tufts University School of Medicine found that modifying astrocyte signals can limit the spread of damage after an ischemic brain stroke. By regulating neurotransmitter pathways, astrocytes play a critical role in the spread of damage following stroke.
Scientists have found that mild traumatic brain injuries can lead to swelling, reduced blood flow, and death of neurons. Astrocytes, which supply nutrients to neurons, swell quickly and significantly, smothering them and their branches. This secondary damage can occur within hours of the initial injury.
The study demonstrates that when transplanted into mice, human glial cells can influence communication within the brain, allowing animals to learn more rapidly. Human astrocytes are found to have unique functional advantages and play a significant role in integrating and coordinating neural activity.
Researchers at Tel Aviv University discovered that astrocytes play a key role in brain communications, integrating messages and connecting neuronal circuits. This new framework offers insight into brain disease and disorders, such as epilepsy and Alzheimer's, which are linked to malfunctions in brain connectivity.
Researchers will use a novel model and emerging technology to study astrocytes in autism spectrum disorders, providing a framework for future strategies. The grant supports Trapp's work on mechanisms of neurodegeneration and repair in multiple sclerosis and related conditions.
Researchers created motor neurons and astrocytes from a patient's skin cells, revealing that abnormal TDP-43 protein causes astrocyte death. This finding provides fresh insight into the mechanisms of motor neurone disease, a devastating condition with no cure or effective treatment.
Researchers at Tufts University have found that astrocytes regulate a neurotransmitter involved in sleep, which may lead to the development of effective and fast-acting antidepressant drugs. The study suggests that mimicking sleep deprivation in mice by manipulating astrocytes can rapidly improve depressive-like symptoms.
A new study reveals that the tripartite synapse model, long accepted by the scientific community, is incorrect in adult brains. The model, which proposes that multiple cells collaborate to move signals in the central nervous system, does not accurately represent brain signaling beyond development.
Researchers at Salk Institute discover diabetes increases amyloid beta and tau protein levels, leading to accelerated brain aging. The study suggests the neurovascular system as a potential therapeutic target for early-stage Alzheimer's treatment.