Articles tagged with Blood Cells
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Researchers have developed a fast and easy test that can track the aging process of red blood cells after storage, potentially improving the quality of blood transfusions. The device uses surface acoustic waves to detect changes in metabolites associated with aging cells.
Researchers have created a comprehensive map of the DNA sequences that control gene expression in human cells, identifying 2.37 million potential regulatory elements. This registry reveals previously unrecognized classes of elements and illuminates how noncoding genetic variation contributes to cell type-specific traits.
Researchers found that methylene blue can reverse brain damage caused by cerebral malaria and identified a nine-gene blood signature to diagnose the disease. The study's findings offer new clues on immune processes involved in brain injury and suggest potential for early intervention and clearer treatment decisions.
A new study found that extensive wildfires in the LA area caused changes in firefighters' immune systems and inflammatory response pathways. The research identified 60 changes in serum proteome, affecting various bodily functions.
Researchers have developed a blood test that detects Parkinson's disease by analyzing the activity of immune cells. The study found 22 genes whose expression was altered in patients with Parkinson's, suggesting potential diagnostic markers and insights into the disease's mechanisms.
Researchers developed a real-time QPM processing algorithm on an embedded GPU system, enabling rapid blood profiling for point-of-care diagnostics. The system can analyze over 100,000 cells in under 3 minutes and reported highly accurate results with an average error of less than 5 percent.
Researchers from USC Neurorestoration Center and Caltech created a simple, noninvasive device using laser technology to measure brain blood flow. The tool has already been tested with humans in small proof of concept studies demonstrating its utility for assessing stroke risk and detecting brain injury.
Researchers at Tokyo University of Science identified genes that predict CD8+ T cell expansion in cancer immunotherapy. A 'signature gene set' or 'expansion signature' was found to identify primed T cells for growth, predicting treatment response and offering a potential guide for new therapies.
Researchers at the University of Cambridge have developed a new lab-grown human embryo model that replicates early human development, including the production of blood stem cells. The 'hematoids' model mimics the natural developmental process, offering potential medical advances in screening drugs and studying blood disorders.
Researchers discover that genetic glitches in the blood system, caused by aging, can spark obesity, diabetes, and fatty liver disease. Simple blood tests may help identify at-risk individuals to prevent chronic illnesses.
A new study has mapped thousands of proteins in human blood to reveal unique molecular fingerprints for each individual. This atlas will enable blood tests to distinguish troubling signs from common ones, and provide a baseline for comparison that healthcare providers can use to flag early deviations.
Researchers found tiny air pollution particles sticking to red blood cells after exposure to roadside pollution, which can travel to organs like brain and heart. Wearing an FFP2 face mask reduces the amount of particles stuck to red blood cells.
Double negative T cells (DNT cells) play an indispensable role in suppressing intestinal inflammation, acting as antigen-presenting cells. Their impaired function may contribute to the pathogenesis of Crohn’s disease, suggesting they could be a potential therapeutic target.
A UCLA research team led by Dr. Donald Kohn has developed a one-time stem cell gene therapy treatment for alpha thalassemia major that could be curative. The therapy involves adding the missing alpha-globin gene to patient cells using a viral vector, enabling them to produce functional hemoglobin.
Scientists have solved a mystery vexing biological chemists for over 30 years by determining 3D structures of blood clotting proteins using cryo-electron microscopy. The discovery sheds light on how the cascade of events that leads to blood clotting is triggered, with potential implications for anticoagulant drugs like Warfarin.
A team of Virginia Tech researchers has discovered new insights into blood thinners and bone builders, heparin. The findings may lead to designing safer and more reliable heparin therapies. Heparin's molecular composition affects its ability to bind calcium, influencing its effectiveness in biomineralization and blood clotting.
A multicenter study found significant variation in how US hospitals define blood culture contamination, which can lead to inaccurate diagnoses and unnecessary treatments. The study suggests that standardizing definitions could improve the accuracy of diagnoses and optimize treatments.
Researchers at Institute of Science Tokyo found that basophils suppress lung inflammation during ARDS recovery, suggesting potential treatment strategies. Basophils release interleukin-4, which helps immune cells coordinate responses and alleviate lung inflammation.
Researchers have developed a blood test that can detect ALS up to a decade before symptoms appear, offering new avenues for early diagnosis and potential treatment. The test has been shown to be highly accurate, detecting changes in blood proteins indicative of the disease.
Scientists have developed a new approach to analyze proteins in individual cells during blood cell formation, bypassing mRNA intermediates. This study reveals the correlation between mRNA levels and protein expression, shedding light on the role of essential proteins in maintaining stem cell populations.
Researchers at University of Pennsylvania discover red blood cells contribute to clot contraction, shrinking and stabilizing blood clots. The finding opens door to new strategies for studying and treating clotting disorders, such as excessive bleeding or dangerous clots like those seen in strokes.
A study from The University of Tokyo predicts HSC quality based on real-time cellular behavior using advanced imaging technology and machine learning. The researchers discovered previously hidden diversity within HSC populations and found that kinetic features could predict the expression levels of a key gene related to 'stemness'.
Researchers at EHU developed a portable, cost-effective system for generating high-quality platelet-rich plasma (PRP), minimizing platelet activation and preserving therapeutic efficacy. The device uses gravity sedimentation and can extract up to 300 micro-liters of PRP from 1 milliliter of blood in just 40 minutes.
A study reveals that metal-organic frameworks (MOFs) can be toxic to mice, causing disruptions in blood cell formation and immune balance. The researchers found that the MOFs suppressed production of certain cells but also triggered a rebound effect, leading to increased inflammation.
Researchers at Stanford University developed a new technique called the milli-spinner thrombectomy that significantly improves success rates in treating strokes and other clot-related diseases. The milli-spinner can reduce clots to as little as 5% of their original volume, making it a promising tool for improving patient outcomes.
Researchers at A.C.Camargo Cancer Center developed a more powerful version of CAR-T cells by inhibiting the epigenetic alterations that made them inefficient against non-Hodgkin's lymphoma and acute lymphoblastic leukemia. This modification resulted in improved treatment efficacy, tumor elimination, and reduced side effects.
A new DNA-based blood test using PhasED-Seq technology detects minimal residual disease (MRD) in B-cell malignancies, offering a powerful tool for early detection and monitoring treatment response. The assay demonstrates exceptional performance and high accuracy in detecting cancer cells in the bloodstream.
A team of scientists has identified seven genes that can transform embryonic stem cells into blood precursor cells, paving the way for a new era in regenerative medicine. The research, published in the journal Blood, uses an unbiased genome-wide screen to uncover the genes involved in hematopoietic stem cell fate.
A systematic review and meta-analysis found that individuals with blood type A have a significantly higher risk of developing breast cancer compared to those with blood type O. The research, which pooled data from over 13,000 breast cancer patients and 717,000 controls, suggests an 18% increased risk associated with blood type A.
A study using NHANES data found that inflammation, rather than diet and exercise, has the strongest association with telomere shortening. Managing chronic inflammation may be key to preserving telomere length and promoting healthy aging.
A new finger prick test for Alzheimer's disease has shown strong performance in a European study, measuring biomarkers in blood from superficial vessels. The test could soon be implemented globally, increasing accessibility to Alzheimer's testing without the need for high-sensitivity analyses.
Researchers tracked the long-term dynamics of transplanted stem cells in patients' bodies up to three decades post-transplant. They found that younger donors produce more vital stem cells, while older donors experience reduced immunity and higher relapse risk. The study provides new insights into donor selection and transplant success.
Researchers discover a molecular mechanism controlling PAX5, key regulator of B-cell maturation. Increasing SIRT7 activity may boost PAX5 levels in leukemic cells, inducing cell death.
A new epigenetic clock based on cheek cells accurately predicts mortality risk, outperforming previous clocks trained on blood data. The study found that specific methylation sites are linked to human mortality, and future research is needed to identify associations with age-related diseases.
A retrospective analysis of over 2,600 patients found that Black children were more likely to suffer severe graft-versus-host disease but overall survival rates improved across all racial groups. The study suggests that cord blood transplants are a vital lifeline for many patients and improve care for those without a matched donor.
Researchers from the Linda Crnic Institute for Down Syndrome identified lower oxygen availability and dysregulated red blood cell function in individuals with Down syndrome. The study highlights potential targets for effective medical interventions to improve oxygen physiology in this population.
Scientists have discovered 17 new genes involved in clonal haematopoiesis, a process associated with ageing linked to increased risks of blood cancers. The findings highlight the clinical significance of these genes in driving mutant blood cell clones, offering new avenues for studying disease development and promoting healthier ageing.
Researchers at UC Santa Cruz discovered a secondary population of platelets that appears with aging, exhibiting hyperreactive behavior and unique molecular properties. This 'shortcut' pathway bypasses normal differentiation processes, producing problematic cells that can cause blood clotting diseases.
Researchers at San Diego Zoo Wildlife Alliance have made a groundbreaking discovery that establishes individual baseline values for African elephant blood cell counts, enabling earlier detection and intervention of clinical EEHV infection. This study provides a tool for elephant care facilities to improve preventive medicine and lifesa...
Researchers at USC Stem Cell lab discovered nearly 40 genes associated with immune cell production, including those related to diseases like myelodysplastic syndrome. The study found that gene activity was linked to specific levels of immune cell production, offering insights for improving bone marrow transplantation strategies.
The CytoTracker Leukometer device quickly counts white blood cells with a single drop of blood, enabling near-patient testing and improving triaging for infections. The device has been clinically validated and shown to be at least 97% accurate, meeting clinical standards.
Researchers discuss clonal hematopoiesis, a condition where cells harbor somatic mutations, and its association with aging, solid tumors, and treatment outcomes. Emerging evidence suggests that CH may play a role in cancer development and survival.
Researchers identify microbial enzyme bilirubin reductase that converts bilirubin into urobilinogen, causing urine's yellow color. The discovery sheds light on the gut microbiome's role in ailments like jaundice and IBD.
A team of researchers at Tokyo Medical and Dental University has identified a gene called Rasip1 as crucial for blood cell development. SOX17, a transcription factor, is found to activate Rasip1, leading to the formation of hematopoietic stem cells and associated hematopoietic activity.
Research by the Peter Doherty Institute found that inflammation alters plasma composition, hindering parasite maturation. This work reveals a new mechanism slowing down malaria parasite development in the bloodstream.
A breakthrough treatment targeting bone marrow cancer cells destroyed 90% of multiple myeloma cells in laboratory tests and 60% in human tissue samples. Researchers developed lipid-based nanoparticles containing RNA molecules that silence the CKAP5 gene, inhibiting cancer cell division.
Researchers propose lab-on-a-chip platforms to continuously monitor stored RBC quality and match units to patient needs. This technology aims to improve transfusion safety and efficacy, particularly for critically ill patients and those on chronic transfusion regimens.
A new study by North Carolina State University researchers finds that sucralose-6-acetate, a chemical formed when we digest sucralose, is genotoxic and breaks up DNA. The chemical is also present in trace amounts in the sweetener itself, posing potential health risks.
A team led by Professor Satoshi Yamazaki has established a novel culture system that supports long-term ex vivo expansion of human hematopoietic stem cells (HSCs), overcoming previous limitations. The new system, which uses chemically-defined cell culture media, significantly improves HSC growth and proliferation.
Researchers at Indiana University School of Medicine discovered a strong association between obesity and clonal hematopoiesis of indeterminate potential (CHIP), a blood condition that increases the risk of blood cancer. The study found that obesity causes inflammation, which can lead to rapid growth of mutated blood cells.
A study published in the Journal of Experimental Medicine reveals a unique subset of fibroblastic reticular cells in omental milky spots crucial for immune cell recruitment to prevent sepsis. These cells regulate the display of CXCL12, recruiting lymphocytes to sites of inflammation.
Researchers found that p53 mutations in blood cells increase the risk of developing coronary heart disease and peripheral artery disease. The study provides solid evidence for the link between acquired p53 gene mutations and cardiovascular disease, suggesting a potential new risk factor.
Researchers have discovered that ancient crocodilian hemoglobin required 21 interconnected mutations to develop its hyper-efficient oxygen-binding properties. This complexity, not found in other vertebrates, enabled crocodilians to exploit their onboard oxygen stores for extended periods underwater.
Researchers have characterized the functional significance of DDX41 in molecular processes underlying cancer. The study reveals that DDX41 serves crucial functions in transcriptional processes, RNA splicing, and genomic integrity maintenance, which may hold significance in treating hematopoietic malignancies.
Researchers at UVA Cancer Center have identified interleukin-1 as a crucial contributor to the development of myelofibrosis, a potentially deadly bone marrow cancer. Targeting this cytokine could prevent myelofibrosis from progressing and spare bone marrow scarring.
Researchers found that liquid biopsies can detect clonal haematopoiesis, a condition placing patients at higher risk of developing myelodysplastic syndrome or acute myeloid leukaemia. The study suggests that these patients should be referred for further evaluation to uncover actual risk and identify potential diagnostic pathways.
A study found that impairing mitochondria in two different ways can cause severe anemia. Researchers used mouse models to investigate the role of mitochondria in blood cell differentiation and found that disrupting mitochondrial function and dynamics causes anemia through distinct mechanisms.
Scientists from NTU Singapore have discovered that telomeres are stacked in columns like a spring, leaving DNA exposed to damage. This finding could improve understanding of how humans age and develop cancer, with potential treatments for diseases caused by dysfunctional telomeres.
Scientists have successfully delivered a common blood pressure medication directly to the inner membrane of mitochondria, targeting energy-producing parts of cells. The new method uses the body's natural transport system to deliver drugs more precisely, potentially improving therapy efficacy and reducing negative side effects.
A new blood test has shown promising results for detecting multiple types of cancer from tumor DNA in the blood, enabling early detection and potentially changing cancer screening practices. The test's accuracy and effectiveness have been demonstrated in a recent study, with high sensitivity and specificity rates.