Articles tagged with Blood Cells
Researchers have found a new way to make leukemic stem cells vulnerable by specifically dislodging them from their niches, allowing for potential treatment against chronic myeloid leukemia. The approach uses an RNA molecule complex to prevent the cancer stem cell's retention in its tumor-supporting niche.
Researchers create nanoparticles that can target specific genes in bone marrow cells, showing promise for treating heart disease by reducing inflammation. The approach could also enhance stem cell yields for patients undergoing transplants.
Researchers found that gene activity increases when forces are applied perpendicularly to a cell, but decreases when forces are applied along the long axis. The findings could provide insights into diseases such as fibrosis and cardiovascular disease.
Scientists discover that stressed liver cells quickly become senescent after hemorrhagic shock, a condition that accounts for 30-40% of trauma-related deaths. This rapid transition to senescence may help prevent organ failure, but drugs targeting senescent cells can be lethal in the context of injury.
Researchers identified a second path to defeating chronic myelogenous leukemia by disrupting the Gdpd3 gene, which regulates quiescence of CML stem cells. This approach reduces leukemia relapse rates even when BCR-ABL1 oncogene is not disrupted.
Researchers at KAUST developed a new fluorescent multiplex cell rolling assay (FMCR) to analyze cell adhesion, speeding up the process and enabling analysis of multiple cell types. The technique has applications in studying cellular processes in inflammation or cancer cell metastasis.
A study published in Neurosurgery found a high incidence of COVID-19 in patients presenting with stroke, including younger individuals without known risk factors. The mortality rate for these patients was significantly higher than typical, with 42.8% dying from their strokes.
A novel protein, thrombospondin-1 (Thbs1), plays a crucial role in mechanotransduction in blood vessel walls, enabling cells to adapt to changing mechanical forces. The absence of Thbs1 can lead to weakened blood vessel walls, increasing the risk of cardiovascular disease.
A team of researchers from RIKEN has developed a new single-cell RNA sequencing method called Quartz-seq2 that outperforms other methods in terms of accuracy and reproducibility. The method was benchmarked against 13 different methods using a set of approximately 3,000 cells, and it scored highest on the benchmark.
Researchers found that adrenomedullin helps resolve lung damage and pulmonary hypertension caused by oxygen exposure in mice, suggesting a potential new therapy for bronchopulmonary dysplasia (BPD) and pulmonary hypertension. Adrenomedullin may also improve the quality of life of BPD-associated PH patients.
A genetic mutation in SRSF2 disrupts DNA's message sending process, leading to excessive NMD activity that destroys healthy blood cells. This excessive activity is a hallmark of blood cancer. Researchers discovered an effective treatment approach using antisense oligonucleotide therapy.
A new study found HIV hides in every organ site, including the brain and liver, causing inflammation-related diseases. The study used serial blood samples from terminally ill participants with HIV to identify where HIV hides, shedding light on potential new therapies.
A new study may help develop personalized blood stem cells for treating leukemias and other conditions. By amplifying a regular gene, researchers can push pluripotent stem cells to produce more blood cells.
Researchers at Yale University found that cancer-causing gene mutations can cause rapid cell division, leading to malignant cancer traits. In one form of blood cancer, normal cells with these mutations can remain healthy unless they divide quickly, suggesting a new mechanism for cancer development.
Researchers can now visualize data from samples containing tens of millions of cells with unprecedented resolution, pinpointing previously undetectable features that distinguish diseased samples from controls. This advancement may lead to discovery of novel cell types to therapeutically target diseases.
A new method called VarID quantifies gene expression variability across groups of similar or related cell states, revealing the dynamics of biological noise during cell differentiation. This approach may help understand how gene expression noise regulates development and cell fate decisions.
Acute myeloid leukemia (AML)-M7 is the most aggressive subtype of leukemia affecting children, with a poor prognosis. Research reveals that this disease develops specifically in young patients due to differences in fetal cells, and that targeting surrounding proteins may improve treatments.
A plant-based compound closely related to resveratrol has been found to enhance gene delivery to hematopoietic stem cells, reducing antiviral restriction at endosomes. This breakthrough enables faster and more efficient treatments for diseases such as sickle cell anemia and leukemia.
Researchers at the Buck Institute identified 44 specific senescence-associated proteins involved in blood clotting, marking the first time cellular senescence has been associated with age-related blood clots. Senescent cells accumulate over time, spewing out inflammatory proteins that lead to chronic inflammation.
Researchers at Weill Cornell Medicine have illuminated the basic mechanism of Piezo proteins, which function as sensors in the body for mechanical stimuli. The discovery provides insights into the roles of Piezo proteins in human diseases and potential new therapeutic strategies.
Researchers at the University of Gothenburg have discovered a new type of force that minimizes light usage in optical tweezers, reducing photo damage to cells. This breakthrough enables more realistic experiments with longer cell lifespans.
Ben-Gurion University researchers develop a human blood-brain barrier chip with stem cells, recreating the natural physiology of the BBB. The chip is used to model neurological disorders such as multiple sclerosis, epilepsy, and Alzheimer's disease.
Researchers used zebrafish and human cells to determine how blood stem cells receive Wnt signaling, discovering the crucial role of the epidermal growth factor receptor. This finding may advance laboratory development of blood stem cells, potentially leading to off-the-shelf treatments for patients with blood diseases.
Researchers have developed a method to identify potential targets for new drugs using live blood cells from patients with mental health disorders. The approach has the potential to accelerate drug discovery and personalized medicine for neuropsychiatric disorders, reducing animal testing and improving treatment outcomes.
Researchers have developed a new micro-device that enables the study of blood cells and tiny particles as if they were inside the human body. The device uses a mini-vortex to spin cells, allowing for tailored experiments in drug development and disease research.
A study suggests that hyperosmotic stress can be used to diagnose ME/CFS, a condition characterized by persistent fatigue and other symptoms. The researchers developed a blood-based assay that measures changes in electrical impedance in response to plasma salt concentrations.
The new light-field microscopy system captures biological processes in 3D at high speeds, resolving dynamics within hearts and neuronal cells. This technique overcomes previous limitations, enabling researchers to study dynamic processes on millisecond timescales.
Parvalbumin-containing cells have been found to regulate blood flow and volume in different brain regions, pulling back excess supply when activated. This discovery sheds new light on the role of these cells in neurovascular coupling and their potential involvement in neurological disorders.
Researchers discovered how a specific TET2 gene mutation obstructs healthy blood cell maturation in mice. The study provides crucial knowledge to develop treatments for haematological disorders and targets the common mutation found in leukaemia patients.
Researchers at Osaka University discovered Ragnase-1's crucial role in regulating hematopoietic stem and progenitor cells. The study reveals how Ragnase-1's post-transcriptional regulation maintains blood cell homeostasis, preventing excessive proliferation associated with leukemia.
Researchers at UVA Health System found that perivascular cells are essential for complete blood vessel formation. The discovery offers new direction for treating conditions like diabetes and heart attacks by growing functional blood vessels.
Scientists have found that sugar molecules serve as channels for cellular communication, allowing cells to interact with proteins and other cells. This discovery was made using atomic force microscopy and provides new insights into the role of cell membranes in function.
Researchers developed a microfluidic device that can isolate individual cancer cells from patient blood samples using size separation. The device has high efficiency and reliability, with recovery rates of up to 93% for small-cell-lung cancer cells.
A study at Cedars-Sinai Medical Center found that transplanting young bone marrow into old mice preserved their memory and learning abilities. The research suggests that specific properties of youthful blood cells may be responsible for this effect.
Researchers identified a critical vulnerability in AML patients with CEBPA mutations, where functional inhibition of the MLL1 complex leads to cell death. Targeting this complex could potentially release a block in normal blood cell maturation and restore healthy blood cells.
Researchers found blood cells retain intrinsic age nearly two decades after transplant, using epigenetic patterns to calculate cellular age. The study suggests blood cells could be the master clock of human aging, with implications for understanding age-associated diseases and developing new therapies.
Researchers at the National Eye Institute have developed a patient-specific stem cell-based therapy that prevents blindness in animal models of geographic atrophy, a leading cause of vision loss among people age 65 and older. The therapy successfully integrates transplanted cells into the retina and restores photoreceptor health.
Researchers from UNIGE analyzed skin and blood cells from five women, identifying 55 genes that escape inactivation of the second X chromosome. The team found that XIST gene expression is key to inactivation, but also discovered five other genes playing a crucial role in the mechanism.
Researchers precisely cut a widespread DNA region from the genome using genome editing, revealing its role in cardiovascular disease. The 9p21.3 haplotype causes abnormalities in vascular smooth muscle cells, leading to heart attacks and stroke. This breakthrough may lead to new treatments for millions worldwide.
A new type of skeletal stem cell has been discovered in the 'resting zone' of the epiphyseal growth plate, which is a crucial cartilaginous tissue for bone growth. These cells are found to be active and produce both cartilage and bone, as well as support blood cell production.
Researchers have identified distinct differences between heart muscle cells that fail and those that adapt to high blood pressure. Cells that adapted were thicker, needed more energy, and could keep the heart beating, while failing cells became stretched out and weak.
Research reveals that diabetics' enzyme can flip blood vessel cells, creating gaps three times more permeable than normal. Controlling this process could ease swelling, nerve pain, and infection risks.
Researchers at the Walter and Eliza Hall Institute have produced the first definitive 3D image of how insulin binds to its receptor on the surface of cells. This image could inform the design of faster-acting and longer-lasting insulin therapies, potentially benefiting millions worldwide.
Researchers at UNIGE discovered that α and δ cells can take over insulin production when β cells are damaged, leading to a phenomenon of cell plasticity. This finding opens the door to new treatments by harnessing the body's regenerative capacities.
A team of researchers found that blood serum triggers spontaneous movement and growth in dormant skin cells, paving the way for new insights into wound healing mechanisms. The study reveals that blood plays a key role in initiating cell migration and proliferation even without a visible wound.
A new study approach reveals that healthy adults have between 50,000 and 200,000 blood-creating stem cells in their bone marrow. This finding opens up new opportunities for studying how stem cells change during ageing and disease, and may lead to insights into cancer development and effective stem cell therapies.
Researchers at the University of Basel have found that endothelial cells can migrate within vessel sprouts while remaining firmly attached to each other. This process allows for the formation of a complex network of blood vessels that pass through the body from head to toe.
Researchers at the University of Exeter discovered new compounds that can reverse key aspects of human cell aging by targeting mitochondria. The findings, published in the journal Aging, show a significant reduction in senescent cells and potential therapeutic applications for anti-aging treatments.
The CNIC is leading a five-year Leducq Network project investigating genetic and environmental factors that promote clonal hematopoiesis and its link to cardiovascular disease. The project aims to understand the impact of clones on cardiovascular health and explore ways to modify their effects.
Researchers at Duke University have developed a sound wave-based platform that can separate circulating tumor cells from blood samples with high efficiency, making it suitable for clinical use. The technology uses acoustic force to push larger cancer cells into a separate channel, preserving the functions and native states of the cells.
New research published in The Journal of Physiology reveals that exercise can reduce chronic inflammation in obese individuals. By changing the characteristics of their blood-forming stem cells, exercise decreases the number of blood cells associated with inflammation.
In certain fish and frogs, cellular umbrellas shade fragile stem cells from the sun's harmful rays. This discovery highlights an important tool some aquatic animals use to keep crucial blood-cell-producing stem cells safe.
Researchers from CNRS and INSERM identify 'primitive mast cells' generated in yolk sac during embryonic development. These cells play a crucial role in shaping the body's immune response, contradicting previous theories on mast cell origin.
Researchers at University of Illinois Chicago have created atrial cells from pluripotent stem cells using vitamin A. This breakthrough enables better study of atrial fibrillation and potential personalized treatments.
Hemophilia B can be treated for life with a single injection containing disease-free liver cells that produce the missing clotting factor. The finding uses stem-cell strategies and CRISPR/Cas9 gene editing to repair mutations in the patient's FIX gene, allowing normal blood clotting.
A team of scientists led by Alex Schier has developed a new method to trace the entire history of individual cell differentiation. They discovered that cells can leave their initial path and change their identity, leading to a more flexible developmental program than previously thought.
Researchers have discovered a balance between two sets of transcription factors that instruct blood vessel cells to become blood stem cells during embryonic development. The findings could aid research into creating new blood cells for transplants and understanding cancer metastasis.
Researchers developed a novel non-invasive diagnostic method for endometriosis based on menstrual blood, reducing the need for invasive abdominal surgery and improving early diagnosis. The study found that stem cells in menstrual blood of women with endometriosis were different from those of healthy women.
Researchers at Duke-NUS Medical School investigated the role of phosphatidylinositol lipids and proteins in asymmetric cell division, a process vital for producing mature brain cells. They discovered a new protein called Vibrator, which plays a key role in this complex process.
Researchers found a connection between oxygen deprivation in bone cells and abnormally heavy bones, as well as low glucose levels. This discovery may lead to new treatments for conditions like osteoporosis, diabetes, and obesity.