Articles tagged with Breast Cancer Cells
Metformin activates fat metabolism that promotes survival of dormant breast cancer cells during estrogen deprivation, suggesting context-dependent effects on cancer cells. This discovery informs ongoing clinical trials and guides the development of new therapeutic targets to selectively kill cancer cells.
Researchers describe a possible mechanism linking obesity and breast cancer, proposing that fatty acid binding protein (FABP4) drives tumor growth. Elevated FABP4 levels in obese individuals promote breast cancer development through direct interaction with cancer cells.
Research at the University of Helsinki reveals that extracellular forces play a significant role in maintaining epithelial cell connections. The study found that mechanical tension activates an intracellular signalling pathway, driving the formation of actomyosin structures.
Researchers developed a novel computational tool called Millefy to visualize heterogeneity in RNA biology between single cells. The study reveals that even small differences in RNA processing can significantly impact cell behavior, offering new insights into why patients with the same disease respond differently.
A new study found that the protein peptidyl arginine deiminase 4 (PAD4) promotes breast cancer metastasis in mice when expressed in cancer cells. PAD4 enables immune cells to trap bacteria, but its role in breast cancer has been unclear.
Researchers have identified a new target in 'normal cells' for a potential treatment of triple negative breast cancer. Using PIK3Cδ inhibitors, the study found a reduction in tumour growth and improved survival outcomes when levels of the protein were controlled in surrounding healthy tissue.
A new imaging agent has been developed to identify cancer cells and their supporting compromised cells. The compound binds to activated annexin A2 protein present in many solid tumors, allowing for targeted imaging and potential dual targeting of the tumor and surrounding cells with chemotherapy drugs.
Researchers at Chalmers University of Technology identified Atox1 as a copper-binding protein that facilitates breast cancer cell migration. High Atox1 levels in tumours are linked to lower survival times, suggesting it may be a biomarker for disease aggressiveness.
Researchers have discovered that breast cancer cells change their metabolism to move to other parts of the body, a finding that could lead to new strategies for preventing the spread of cancer. This shift in metabolism may be targeted with drugs to prevent metastasis and improve survival rates.
A recent study found that radiation can trigger an inflammatory response in breast cancer cells, leading to the survival and growth of triple-negative breast cancer cells. This finding highlights the importance of understanding the microenvironment in cancer development.
Researchers discovered that healthy lung cells support the survival of breast cancer cells, allowing them to form secondary tumours. Targeting the growth of cell protrusions on breast cancer cells can prevent secondary tumour formation.
A Cornell-led team employed a statistical modeling technique from physics to analyze breast tumor cells' behavior in the microenvironment. They found that chemokine CCL19 caused targeted cancer cells to move faster and increased heterogeneity.
Scientists use electrospun synthetics to mimic the extracellular matrix, standardizing research conditions. The study reveals that different types of breast cancer cells grow best in specific cellular environments.
Researchers at the University of Oxford have identified six previously unknown cell types in human Fallopian tubes using single-cell RNA sequencing, which may lead to a screening tool for ovarian cancer. The discovery sheds new light on the complexity of ovarian cancers and could lead to personalized treatments.
A new therapy option has been identified for early-stage breast cancer using the radiopharmaceutical 223RaCl2, which delays the growth of disseminated tumor cells. The treatment shows promise in delaying tumor progression and may be an adjuvant therapy option for select patients.
Researchers are developing a new non-invasive test that analyzes breast milk to detect breast cancer in its earliest stages in high-risk breastfeeding women. The study aims to identify profiles of breast cells that may indicate increased risk of breast disease and shed light on breast cancer development.
A team at Tohoku University discovered that BACH1 facilitates pancreatic cancer spread by reducing cell-to-cell adhesion. Silencing or overexpressing BACH1 in pancreatic cancer cells reduced metastasis and improved survival rates.
Researchers at IU Simon Cancer Center aim to improve understanding of hematopoietic stem cell function in the bone marrow using CD166. The team is investigating CD166's role in sustaining stem cell function and identifying a molecule that allows separation of osteomacs from macrophages.
Researchers developed a new compound that targets microRNA-21, a molecule linked to aggressive breast cancer, awakening its self-destruct system and killing cancer cells while leaving healthy cells unaffected. In mouse models, the compound showed promise in reducing breast cancer spread and decreasing invasiveness in other cancers.
UMass Amherst researchers discovered that benzophenone-3 and propylparaben can cause DNA damage in breast cells with estrogen receptors, even at low concentrations. This finding suggests a new mechanism by which estrogens and xenoestrogens may promote breast cancer.
New research suggests lactate is a catalyst that triggers cancer forming process in mutated cells. The study's findings open a new door to better understand cancer at the metabolic level and could lead to targeted therapies.
Researchers have identified a driver of bone loss related to cancer treatment, found that cell senescence drives bone loss beyond estrogen alone. Two investigational drugs can stop this process, improving quality of life for cancer patients.
Researchers have discovered that the protein deltaNp63 plays a vital role in supplying energy to the mammary gland during puberty, while also being implicated in aggressive forms of cancer. The findings suggest that targeting this protein could be a viable approach for treating triple-negative breast cancer without affecting normal dev...
A metabolic inhibitor called OSI-027 induces catastrophic macropinocytosis in human cancer cells, reducing tumor growth when combined with chemotherapy. The study suggests that targeting the mTOR pathway may be an effective approach to treat drug-resistant cancers.
Researchers at Dartmouth's Norris Cotton Cancer Center found that breast cancer cells can take up large quantities of fat from the bloodstream through a novel mechanism called endocytosis of lipoproteins. This uptake provides a reliable source of energy for cancer cell proliferation.
Hyperactive FOXA1 signaling triggers genome-wide reprogramming in endocrine-resistant breast cancer cells, leading to enhanced resistance to treatment and metastatic behaviors. An inhibitor of HIF-2a reduces migration and invasion of these cells, providing a potential therapeutic strategy.
Researchers at Duke University Medical Center developed a new technique to visualize how pre-cancerous stem cells spread throughout the colon, illuminating key differences in their growth patterns. The study found that newborns are more sensitive to mutations, leading to rapid field cancerization and increased cancer risk.
Researchers at Lancaster University have developed a new AI diagnostic tool for breast cancer using Raman spectroscopy to identify unique chemical fingerprints of different types of breast cancers. The algorithm successfully predicted diagnostic patterns for four subtypes with high accuracy, ranging between 70% and 100%.
Researchers have identified a splicing factor called TRA2B as a key driver of triple negative breast cancer's ability to grow and spread. Blocking TRA2B expression in cells has been shown to prevent metastasis, providing a potential new treatment avenue for this devastating form of breast cancer.
Researchers on Australia's first space research mission to the International Space Station will investigate how microgravity affects aggressive cancers like ovarian, breast, and lung cancer. The mission may lead to new treatments that enhance existing therapies.
Scientists at UCSF discovered that blocking the activity of MMP9 can prevent breast cancer from spreading to distant organs. The researchers found that MMP9 helps create a hospitable environment for cancer cells to form new tumors by remodeling healthy tissue and transforming it into safe havens.
Researchers have discovered 37 essential FOXA1 binding sites in T47D cells, which act as enhancers to regulate gene expression. The team also developed a machine learning model to predict important transcription factor binding sites, offering promising insights into cancer biology and potential clinical applications.
Researchers found that oxygen-starved tumor cells have a four times greater probability of becoming viable circulating tumor cells than those under normal oxygen conditions. These cells also have six times the probability of forming lung metastases, suggesting that oxygen starvation enhances their metastatic capabilities.
A team of researchers led by Miguel Quintela-Fandino has discovered the link between FASN and cancer development. They found that FASN is essential for anchorage-independent growth, a hallmark of cancer transformation.
Researchers have identified CEMIP as a key protein promoting brain metastasis in breast and lung cancers. By blocking CEMIP, it may be possible to prevent or treat brain metastases, which are a common cause of cancer deaths. High levels of CEMIP in primary tumors have been linked to a faster progression to brain metastasis.
Using information theory, researchers at UNIGE aim to understand how impaired cellular communication influences cancer development. They propose a new approach to oncology, focusing on restoring proper signaling pathway activity rather than shutting them down.
A new method has been developed to identify aggressive breast cancer by analyzing tumor tissue signatures, showing a correlation with poor outcome in patients. The study used mouse models and bioinformatics expert to isolate macrophages from mice affected by breast cancer and compared them with those from healthy breast tissue.
A new AI-powered analysis has improved understanding of stage 0 breast cancer, identifying which patients are most likely to progress to invasive cancer. The research suggests that some patients may not need radiation therapy, contrary to current prevailing wisdom.
Scientists discovered a new organelle that prevents cancer by ensuring correct genetic material sorting. The organelle's discovery offers a way for doctors to personalize cancer treatments, sparing up to 40% of patients with breast cancer.
A USC study reveals that circulating tumor cells have a unique molecular signature that predicts specific organ targets, such as the brain. The discovery provides potential treatment targets to prevent cancer spread and improves detection and monitoring methods.
Researchers found that cells on a tumor's periphery are softer and more likely to invade surrounding tissues. This softness enables the cells to spread through the body's vasculature, forming 'invasive tips' that break away from the tumor.
A team of researchers has revealed the structure of P-Rex1 bound to Gbg, providing a detailed understanding of how this protein complex promotes cell movement and metastasis. The findings offer important insights into cancer cell migration and regulation, paving the way for potential therapeutic targets.
Researchers identified gamma delta T cells in breast tissue, which are associated with remission and higher survival rates. The study suggests that these cells may be used to develop new treatments for breast cancer.
Researchers used state-of-the-art technology to profile each cell during normal breast development, creating a molecular map to understand how breast tissues are formed and maintained. The team found that cells were already poised to become either basal or luminal cells before birth, with abnormal alterations leading to tumor development.
A recent study found that aggressive breast cancers store large amounts of glycogen, a stored collection of glucose molecules. This stored energy enables the cancer cells to grow and spread. Researchers believe that targeting the enzyme PYG could be a potential target to treat or prevent breast cancer metastasis.
Research discovered that cancer cells with SF3B1 mutations are dependent on external sources of amino acid serine, which can be exploited through a patient-specific 'oncology diet'. A diet low in serine may help shrink tumors in mice with myeloid sarcomas.
A study has identified key proteins in signaling pathways that control tumor growth in lung tissue, paving the way for personalized cancer treatment and new drug development. The research, published in Cell, also reveals new proteins activated by cancer mutations contributing to tumor growth.
A new 3D structure made from protein fibers allows for the reliable growth of patient cancer cells, enabling doctors to test medications on model tumors grown from a patient's own cells. This breakthrough could lead to more effective treatments and better understanding of cancer biology.
Researchers at UC Riverside are developing a novel small molecule that selectively targets the PCNA protein in breast cancer cells. The project aims to create a new series of AOH1160-like molecules to improve the clinical management of breast cancer patients, while sparing non-cancerous cells.
Researchers at UNIGE unveil a mutation mechanism essential for cancer development by linking DNA replication failures in cancer cells to their genetic instability. They successfully corrected the effects of replication stress in diseased cells, showing that this phenomenon is controllable and potentially exploitable for therapy.
Researchers found that breast cancer cells form fake synapses with neurons to secrete glutamate and activate the NMDAR receptor, providing a rationale for brain metastasis. This mechanism may be applicable to prevention and therapy of breast-to-brain metastases.
Researchers at Michigan State University have developed a new approach to delivering enzyme-producing genes that can convert certain drugs into toxic agents and target tumors. The study found that nano-bubbles, or extracellular vesicles, were 14 times more effective at delivery and killed over half of the breast cancer cells in mice.
Researchers at Imperial College London found that hormone treatments can induce a dormant state in breast cancer cells, known as 'sleeper cells'. This could provide clues to why some cancers become resistant to treatment and may lead to new ways of preventing recurrence. Further research is needed to unlock the secrets of these cells.
A new study identifies PoEMs as promoting breast cancer metastasis through the loosening of lymph vessel connections. Removing these cells reduces the ability of breast cancer cells to spread. The findings suggest targeting PoEMs in cancer therapy, specifically targeting cancer-associated lymphatic vessels.
Researchers found that non-cancerous cells in tumor microenvironment regress into stem cell-like state, supporting cancer growth. This 'corruption' of neighboring cells enables cancer to thrive and spread.
Researchers at UT Health San Antonio have identified a novel way to kill cancers caused by inherited BRCA1 mutations. Adding back microRNA 223-3p forces BRCA1-mutant cancer cells to die, offering a potential treatment for inherited breast and ovarian cancer.
Researchers created a deformable nanolipogel-based delivery system for CRISPR knockout of oncogene Lcn2, reducing tumor growth by 77% in human and mouse models. The delivery method shows promise as a precise therapeutic tool for treating triple-negative breast cancer.
Researchers are conducting a phase 1 clinical trial using CAR-T cells, which have been shown to attack and kill cancers. The goal is to learn more about how these super-powered immune cells interact with solid tumors to develop effective treatments for various types of cancer.
Researchers at Ohio State University found that low-intensity electromagnetic fields reduce the ability of specific breast cancer cells to migrate and spread. The study used a lab model to mimic the body environment and discovered that certain drug therapies can enhance the effects of electromagnetic fields on blocking cancer cell meta...
Researchers at Worcester Polytechnic Institute developed a chip made of carbon nanotubes that captures circulating tumor cells (CTCs) with far greater sensitivity than existing technologies. The device can detect early-stage tumors, predict the course of a cancer, and monitor the effects of therapy.