Articles tagged with Cell Adhesion
A team of researchers at Kyoto University has discovered that the protein ZO-1 plays a crucial role in collective cell migration by riding ERK activation waves to podosomes on the basal cell surface. This movement enhances force generation, extracellular matrix degradation, and invasive cell migration.
Biologists have discovered that the talin protein is crucial for successful cell adhesion in animals, a mechanism likely developed from single-celled organisms. The study reveals the evolutionary conservation of this ancient adhesion mechanism, providing new insights into the origins of animal tissues and organs.
Scientists at The University of Osaka developed a novel hydrogel that supports the efficient 3D culture of human induced pluripotent stem cells. This new material combines the properties of fibrin and laminin-511, creating a potent, xeno-free scaffold with strong cell adhesion.
A team of Japanese researchers has identified shootin1b as a protein that promotes cell migration in glioblastoma, the most common and difficult-to-treat brain tumor. By suppressing abnormal activity of shootin1b, the study suggests a potential target for preventing glioblastoma spread.
A team of scientists from the University of Konstanz has identified the PPM1F enzyme as essential for cell migration in both embryonic development and tumor cell invasion. The study found that increased levels of PPM1F enhance the invasive potential of cancer cells, while its absence impairs cell adhesion and migration.
Chinese scientists enhance adhesion of top layers to improve flexible tandem solar cells' performance by utilizing an antisolvent-seeding strategy. The new approach resulted in a stable efficiency of 24.6%, one of the highest reported values for flexible thin-film solar cells.
Researchers discovered a previously unknown mechanism in mechanical cell competition, where stronger "winner" cells exert more mechanical forces to outcompete weaker "loser" cells. The finding challenges classical interpretation of cell competition and suggests that active resistance to elimination is the key factor in survival.
Researchers create microfluidic device to sort tumor cells based on adhesive strength, revealing potential method to predict aggressive cancer behavior. The study's findings offer a promising approach for personalizing treatment plans and identifying high-risk patients.
Researchers at Kobe University discovered that the molecule afadin plays a crucial role in cell adhesion by facilitating droplet formation. This process is essential for organs to form properly and tissues to develop, with significant implications for cancer metastasis and tissue engineering.
A novel bifacial linker, potassium benzyl(trifluoro)borate (BnBF3K), has been developed to prevent heterointerfacial delamination in flexible perovskite solar cells. This study significantly enhances device performance and mechanical stability by optimizing adhesion at the SnO2/perovskite interface.
Researchers developed surface-modified apatite coatings using pH control to enhance cell adhesion and improve the biocompatibility of implants. The study found that controlling the nanoscale surface layer of apatite nanoparticles leads to better binding affinity with biological tissues.
Researchers at the University of Pennsylvania have developed a protein called Melt that can be toggled by temperature, allowing for precise control over cellular pathways. The breakthrough enables non-invasive therapy options for cancer treatment and basic research, potentially leading to more targeted and less toxic treatments.
Researchers at Leipzig University developed a new standardised numberinng system for adhesion G-protein coupled receptors (GPCRs) to improve comparability and analysis. The system is based on AI analysis of over 14,000 modelled structures and facilitates deeper insights into disease-relevant mutations in GAIN domains.
Physical signals from mechanical forces play a crucial role in determining the fate of cells being extruded from tissues. The study reveals that the intensity and duration of these forces determine whether dead or live cells are eliminated, with implications for tissue homeostasis and cancer progression.
Developing neurons rely on multiple signaling pathways to migrate from the germinal zone. An antagonistic circuit between Netrin-1 'pushing' and Siah2 'pulling' ensures proper cerebellum development by balancing adhesion and guidance cues.
Researchers have developed an artificial adhesion system that closely mimics natural biological interactions, enabling precise control over its strength under varying forces. The innovative 'fish-hook' bond has vast potential in materials science and medicine, inspiring responsive materials and force-sensitive drug delivery systems.
Scientists have identified new ways that bacteria interact with each other in the oral microbiome, finding that certain species bind more strongly than others. This groundbreaking discovery could lead to new insights into disease and the development of novel therapies.
Researchers from Brazil's Center for Research on Redox Processes in Biomedicine found that high blood sugar can cause thrombosis by altering endothelial function and promoting platelet adhesion. They identified a specific molecular mechanism involving protein disulfide isomerase A1 as a key regulator of this process.
Scientists create synthetic biology approach to mechanistically study tissue patterning and engineer organoid structures by combining morphogens with cell adhesion control. The model system reveals a key feature of E-cadherin for forming sharp boundaries in synthetic tissue domains.
Endomimetics is developing a Bionanomatrix coating to accelerate aneurysm occlusion and minimize thrombus formation in brain aneurysm patients. The coating promotes endothelialization through five synergistic elements, reducing inflammatory responses and platelet adhesion.
A new type of mussel-inspired adhesive has been developed that can be deactivated 'on command' through oxidation, allowing for efficient repair and recycling. The biobased adhesive loses its stickiness without becoming dramatically hydrophobic, making it easier to remove.
A $1.9 million NIH grant will support research on closing cellular gaps, with implications for wound healing and cellular regeneration therapies. The goal is to develop a theoretical understanding of the process, enabling control over individual factors and potential applications in regenerating heart cells.
A team of researchers led by Associate Professor Ken Natsuga found that cell-cell adhesion governs pattern formation in keratinocytes. Starvation also plays a crucial role in the formation of these patterns, which are influenced by cell proliferation and differentiation.
Terasaki Institute scientists have created a novel bioink derived from egg whites, offering abundant proteins and excellent biocompatibility. This breakthrough technology has the potential to create more accurate tissue models for drug testing and develop functional tissue replacements for regenerative medicine applications.
The team, led by Professor Shoji Takeuchi, created a layer of skin that can bind to complex forms of humanoid robots, granting them increased mobility and self-healing abilities. The research has potential applications in the cosmetics industry, medical research, and robotics.
Cell contraction, not adhesion, drives human embryo compaction, a crucial step in normal development. Defective contractility prevents implantation and ART success.
Neotame has been shown to cause previously healthy gut bacteria to become diseased and invade the gut wall, potentially leading to irritable bowel syndrome and sepsis. The study also found a breakdown of the epithelial barrier, which forms part of the gut wall.
HKU researchers created Quantum-Enhanced Diamond Molecular Tension Microscopy (QDMTM) to study cell adhesion forces, offering enhanced sensitivity and precision. The technique differentiates cells in various adhesion states, aligning with previous findings.
Researchers found that macroalgae acquired new genes for cell adhesion, differentiation, communication, and transport from viruses, which played a critical role in their evolution to multicellularity. The study provides valuable genomic resources for further studies on the biology of macroalgae.
Leipzig scientists have identified a new adhesion GPCR gene in fruit flies that affects midgut development and promotes the growth of enterocytes. The study also shows a link between intestinal development and heart function, with the loss of this receptor accelerating heart rate and causing dangerous palpitations.
S100A11 plays a specific role in the initiation of focal adhesion site disassembly, rather than the disassembly process itself. The protein is recruited to adhesion sites through a force-dependent mechanism involving non-muscle myosin II-driven stress fiber contraction and intracellular Ca2+ influx.
Researchers from Incheon National University create gelatin patches that generate molecular oxygen to accelerate wound healing. The new hydrogels demonstrate improved coagulation, blood closure, and neovascularization in both in vitro and in vivo experiments.
A Kyoto University team reveals the Dumpy protein as the key factor in controlling 3D tissue structures through external cues. This finding challenges traditional understanding of morphogenesis and opens up new avenues for manufacturing controllable 3D tissue folding with coordinated cell behaviors.
Researchers from Osaka University developed a fluorescent sensor to visualize Pcdh interactions in live neurons, allowing for the first time to observe dissociation of these interactions. This technique has potential applications in understanding brain disorders such as autism and epilepsy.
Researchers at the University of Münster have developed a new method to study the function of individual molecules during mechanical stress in cells. They used a light-sensitive molecule to alter proteins and apply short light pulses to control their movement, allowing them to investigate the mechanical significance of these proteins.
Researchers found that cells store extra 'skin' in folds and bumps on their surface to rapidly deploy temporary protrusions. This allows cells to move safely while maintaining cell volume and membrane integrity.
Researchers have elucidated the mechanism of CELSR cadherin dimerization, revealing a twisted cell-cell adhesion molecule complex structure. The extracellular domains of CELSR cadherins exhibited strand- and globule-like portions, which bound through strand-like structures in an antiparallel orientation.
Researchers have developed a new ear tube design that combines liquid-infused materials with optimized geometry to improve treatment outcomes for patients with ear infections. The design enables better performance and reduces complications such as impaired hearing and scarring of the eardrum.
Scientists discovered the molecular basis of CAMSAP3's role in stabilizing microtubules, which is critical for cell survival and various cellular processes. The findings provide a key concept to understanding how microtubule dynamics control cellular phenomena.
Researchers from Osaka University developed a new fluorescent sensor system to visualize N-cadherin-mediated interactions between living cells. The INCIDER system enables accurate tracking of temporal changes in these interactions, with a fluorescence signal 70 times stronger than existing methods.
Researchers at UCSF's Cell Design Institute engineered cells with customized adhesion molecules to form complex multicellular ensembles in predictable ways. The discovery represents a major step toward building tissues and organs through regenerative medicine.
Researchers at HKU have developed a novel technique to measure the rotational and translational motion of cell markers with high precision. This breakthrough technology uses single nitrogen-vacancy centers in nanodiamonds to tackle the long-standing challenge in mechanobiology research.
Researchers have successfully blocked the adhesion mechanism of Bartonella henselae bacteria, preventing cell infection. The discovery offers a promising new approach to combat highly resistant infectious agents like Acinetobacter baumannii.
A Virginia Tech graduate student has been awarded a two-year grant to explore a synthetic molecule as a basis for treating arrhythmias. The research aims to identify a combination of the molecule that could prevent arrhythmic incidents and potentially even sudden cardiac death.
A KAUST-led research team identified two drug treatments that boost the activity of molecules involved in cell adhesion, enhancing the ability of blood-forming stem cells to enter the bloodstream and produce new blood. This breakthrough could lead to improved bone marrow transplant success for leukemia patients.
Researchers at Brigham and Women's Hospital identified Basal Cell Adhesion Molecule (BCAM) as a key population of proliferative cells involved in corneal regeneration. BCAM plays a crucial role in mediating corneal differentiation, which could lead to future medical therapies for corneal disease.
Researchers developed a monoclonal antibody that binds E-cadherin, strengthening cell adhesion and preventing cancer metastasis. The antibody, 19A11, has two binding modes that increase adhesive strength through salt bridge formation.
The study reveals multiple dimeric structures of cadherins in solution, including W-, cross-, and S-shaped dimers. The researchers propose a novel conformation, the S-shaped dimer, and suggest that binding mechanism progresses through sliding motion followed by flipping motion to form stable SS-dimers.
A team of scientists discovered a mathematical principle explaining how cells connect to form tissues and organs, shedding light on embryonic development and organ formation. The study found that epithelial cells can adopt complex three-dimensional shapes like scutoids, which determine cellular connectivity and tissue properties.
Researchers have deciphered the exact bacterial adhesion mechanism using Bartonella henselae, revealing a key role for trimeric autotransporter adhesins and their interaction with fibronectin. Experimental blocking of these processes almost entirely prevents bacterial adhesion.
A new molecule called embigin has been discovered to regulate sebaceous gland progenitor cell function. Embigin binds to fibronectin and directs transport proteins for lipid synthesis, playing a crucial role in sebum production.
Researchers investigated the effects of treatment with exogenous Humanin G on inflammation markers in AMD and normal retinal cells. The study found reduced levels of inflammatory proteins in AMD plasma and treated cybrids, highlighting the positive effects of Humanin G.
Researchers found phosphatidylinositol bisphosphate (PIP2) essential for epithelial cell-cell adhesion and maintaining cellular identity. PIP2 regulates epithelial properties by recruiting Par3 to the plasma membrane, facilitating the formation of adherens junctions and preventing epithelial-mesenchymal transformation.
Researchers at Duke University have developed a device that manipulates particles and cells using complex sound waves, enabling selective pairing of individual cells to measure adhesion forces. This technology could lead to personalized medicine by allowing doctors to determine treatment for individual cancer patients.
Researchers discovered that a specific osmolyte causes kidney cells to undergo an EMT transformation, leading to renal failure. The team found a way to prevent this change by arresting focal adhesion rearrangement, suggesting a new approach to enhance therapeutic value of common osmolytes.
Researchers have produced double-sided spider silk fibers that can attract nerve cells and stimulate their growth. The fibers were created using a biotechnological approach and modified with different proteins to make one side more attractive to cells, while the other side could be used to attach factors or substances.
Researchers have discovered that intestinal bacteria can lead to more severe adhesions after abdominal surgery. The study found that mesothelial cells and EGFR signaling play a crucial role in the formation of these adhesions. The findings suggest that targeting EGFR may be a potential approach to reducing adhesion risk.
A team of researchers from Japan has developed a platform using nanofibers to capture and control the migration of brain tumor cells, including glioblastoma multiforme. The study found that varying fiber densities can slow or speed up cell movement, leading to the creation of 'cell traps' that can restrict tumor cell growth.
Researchers have discovered the molecular mechanisms behind stem cell rolling in blood vessels, a complex process that slows down cells using long tethers. The findings offer new insights into improving stem cell transplantations and developing treatments for metastasizing cancers.
Researchers at UNSW Sydney have found the specific protein responsible for keeping cells attached to collagen, a key finding for cancer research. The discovery could lead to new directions for cancer treatment by targeting the protein tropomyosin, which is involved in forming the anchor's chain.