Articles tagged with Cell Adhesion
Researchers at UC San Diego identified fractalkine as a new therapeutic target for treating type 2 diabetes. Administering the protein stimulated insulin secretion and improved glucose tolerance in mouse models and human islets.
GW researcher Xiaoyan Zheng is studying the mechanism involved in the hedgehog signaling pathway's regulation of cell-cell adhesion and segregation. The goal is to find better ways to treat diseases related to these interactions, such as cancer.
Researchers found a new aspect of cell adhesion involving integrins, which are strengthened by cyclical applications of force, prolonging bond lifetimes and shedding light on possible mechanisms for sensing extracellular topography.
Iowa State researchers identify three types of cell-to-cell bonds, each reacting differently to a pulling force. The findings, published in the Proceedings of the National Academy of Sciences, have implications for understanding diseases such as cancer and cardiovascular problems.
Researchers discovered that boosting a specific cell adhesion pathway with a common cellular chemical could improve muscle structure and function in zebrafish with muscular dystrophy. This finding holds promise for the development of new therapies for patients with congenital muscular dystrophies.
Researchers at NYU developed a method to replicate the mechanical properties of tissues using an oil-in-water solution, mimicking cell-to-cell adhesion. This breakthrough has potential industrial applications in biocompatible products and pharmaceuticals.
A serendipitous accident in shipping a donated human retina led to the discovery of a previously undetected mechanism causing choroidal neovascularization, a leading cause of vision loss. Researchers found that adhesion defects play a crucial role in maintaining the retina's structure and preventing blood vessel invasion.
A team of University of Iowa researchers found that a lack of gamma-protocadherin cell adhesion molecules in the cerebral cortex disrupts neural circuitry formation. This discovery may help understand causes of human developmental disorders like autism, mental retardation, and schizophrenia.
Researchers at the University of Kentucky have identified a key protein interaction that promotes metastasis in triple-negative breast cancer. Snail interacts with G9a to suppress E-cadherin expression, which is critical for cell adhesion and preventing tumor spread.
Researchers have discovered that a bacterial photoresponsive protein can resist the adhesion of mammalian cells, opening up new possibilities for biosensor applications and surface modification in regenerative medicine. This finding provides a novel non-fouling substance that distinguishes it from other anti-fouling substances.
Researchers have found that adding a specific protein from Listeria to a probiotic can decrease the risk of infection by 46%. The breakthrough could lead to the development of a pill or drink to prevent Listeria infections, primarily affecting pregnant women and those with weakened immune systems.
Researchers from Nagoya University used a micro putter to test the adhesion of yeast cells on various surfaces. They found that dead cells stuck less than living cells, supporting the 'cell adhesion model'. This study could lead to new methods for evaluating cell health and developing effective treatments.
Researchers at KIT have successfully cultivated cells on three-dimensional structures with precise control over adhesion and cell shape. The team developed a special polymer scaffold using the Direct Laser Writing Method, which allows for the growth of individual cells in specific locations.
The Einstein research aims to understand the role of proteins in normal biological processes and disease pathways. The project will focus on determining the structures of thousands of biomedically important proteins.
Researchers discovered that specific cadherin molecules expand molecular diversity and specificity in cell-cell adhesion, shedding light on autism and mental retardation. The study's findings could lead to a better understanding of synapse formation and brain circuit assembly during normal development.
The researchers created a library of micromolded, hexagonally spaced elastomeric micropost arrays to study the effects of substrate flexibility on stem cell development and adhesion. The system allowed them to modulate the rigidity and flexibility of the substrate surface without changing its adhesive properties.
Researchers at Penn find that mechanical forces reinforce and grow endothelial cell connections, creating stronger adhesions. This discovery has implications for therapies targeting vascular dysfunction in diseases like septic shock and diabetes.
Researchers discovered that cell shape influences stem-cell fate, with star shapes promoting bone formation and flower shapes promoting fat production. The study offers a promising direction for further investigation into stem-cell therapies.
Scientists at the University of Connecticut Health Center have visualized the movement of Lyme disease-causing microbes within feeding ticks. The study found that these microbes undergo a biphasic mode of dissemination, first forming networks of nonmotile organisms and then becoming motile invasive organisms.
Researchers controlled cell orientation on a micropatterned surface based on a delicate material technique. The study used photolithography to generate a surface with cell-adhesive stripes in an adhesion-resistant background, allowing for semi-quantitative description of cell orientation.
Researchers used RNA interference to suppress MMP-2 expression in pancreatic cancer cells, leading to reduced adhesion and invasion without affecting cell proliferation and apoptosis. This finding suggests that inhibiting MMP-2 via RNA interference could be an effective therapeutic strategy for managing pancreatic tumors.
A study reveals a mechanism that controls cell adhesion and movement in tissues, which may be defective in diseases like cancer. The research found that the amount of adhesive protein E-Cadherin is controlled by its trafficking inside cells.
Researchers have designed an implantable cell retriever and reprogrammer that can isolate and manipulate specific cell populations with great efficiency. The device uses the mechanics of blood flow to capture viable stem cells, which are rare in the bloodstream.
A research team led by Dr. Alexandre Prat has identified a new therapeutic target for multiple sclerosis, ALCAM/CD166, which plays a major role in the migration of immune cells to the brain. The study suggests that blocking this molecule could dampen neuroinflammation and decrease lesions characteristic of MS.
Researchers at University of Pennsylvania devise nanoscale system to observe how individual cells react to external forces. The study shows that cells respond to outside forces and demonstrate a remote response from the cell’s internal forces., The findings prove useful for understanding tissue growth, function, and disease.
Scientists at UC San Diego discovered how cells of higher organisms change their movement speed, a discovery that may help prevent cancer cells from spreading. The study found that the frequency of the cell's motility cycle determines its crawling speed.
Scientists have observed paxillin moving from cell surface hubs to the nucleus, highlighting its role in signaling and controlled cell growth. This discovery sheds light on paxillin's interactions with other proteins and its potential involvement in diseases such as cancer.
Researchers use computer simulations to study the effect of adhesive patch size and density on cell adhesion. They found that protrusion height is the most critical factor, with small increases leading to faster adhesion rates.
Researchers at Rensselaer Polytechnic Institute have identified a crucial signaling pathway involved in tissue growth and wound healing. The discovery provides new insights into how cells interact during tissue remodeling and may lead to novel therapeutics for diseases such as cancer and arthritis.
Berkeley researchers have created a highly selective cell adhesion system using single-stranded synthetic DNA, enabling precise patterns of multiple cell types. The technique enables the attachment of different cell types to specific locations on a surface based on nucleotide sequences.
Scientists investigate bacterial adhesion to iron oxide surfaces using dual-strategy approach, combining protein pinpointing and random mutagenesis. The goal is to understand genetic, biochemical, and regulatory processes controlling cell attachment, with potential applications for environmental remediation and metal biotransformation.
Researchers have discovered that specific proteins in the fruit fly eye play a crucial role in organ development, including kidney formation. These proteins, Roughest and Hibris, are also found in human kidneys and are essential for proper filtration and filtering of unwanted molecules.
Georgia Tech researchers reveal that biomaterial surface chemistry influences cell behavior by altering adhesion proteins. This discovery can lead to the development of novel, rationally-designed biomaterials that control interactions between cells and materials.
Dr. Erkki Ruoslahti's pioneering work on cell adhesion has led to significant discoveries in cancer biology and its applications to various diseases. His contributions have elucidated the etiology and developed therapy for serious conditions like malignant tumors, heart attack, stroke, and osteoporosis.
A team of researchers from Duke University has successfully used micromanipulation to study the separation of sister chromatids in cell division. Their experiments revealed that chromatids are initially attached but then separate at their centers, with linkages playing a crucial role in their separation.
Researchers at UCSB discovered a key mechanism by which E. coli bacteria adhere to the urinary tract. The finding sheds light on the mechanisms driving urinary tract infections, allowing for potential new treatments and survival strategies under stressful conditions.
Researchers at RIKEN Center for Developmental Biology challenged the view that RET-independent GFRá1 signaling plays a significant physiological role in either development or regeneration. Studies on mice lacking RET-independent GFRá1 revealed no developmental defects, suggesting that this receptor complex is not essential.
Researchers found that ALCAM gene expression is significantly lower in higher-grade tumors and those with a worse prognosis. This suggests that decreased ALCAM expression indicates a more aggressive phenotype and poor prognosis in breast cancer.
A team of researchers has developed a new technique to directly measure protein binding forces, clarifying the role of membrane-anchored protein NCAM in cell adhesion. Their study reveals that NCAM forms two adhesive configurations, which are validated by experimental results and contribute to spatially distinct bonds.
A study by Yamamoto and colleagues found that the SLAYGLR sequence of osteopontin facilitates monocyte migration to arthritic joints, leading to inflammation and arthritis suppression. The findings support a critical role for osteopontin in rheumatoid arthritis pathogenesis.
Scientists report evidence of catch bonds regulating white blood cell activity, offering potential targets for anti-inflammatory compounds and cancer metastasis control. Researchers discovered prolonged bond lifetimes with increasing force, contrary to initial theories.
Researchers have identified two compounds, NAP and SAL, that can prevent ethanol's disruption of L1-mediated cell adhesion, a critical process for brain development. These findings bring the study of fetal alcohol syndrome closer to effective interventions.
Researchers at UC Davis discover that c-reactive protein inhibits protective enzyme eNOS, leading to increased plaque formation and heart disease risk. This finding supports the need for new screening guidelines and highlights the importance of measuring c-reactive protein levels in high-risk groups.
Researchers at the Weizmann Institute found that Nr-CAM expression is associated with human melanoma and colon cancer development, contributing to tumorigenesis. The gene's role in cell proliferation and tumor formation was confirmed through DNA microarray analysis and animal studies.
Researchers have discovered a new mechanism that triggers blood cell adhesion in sickle cell disease, with P-selectin playing a key role. Inhibiting P-selectin has shown promise in reducing adhesion and potentially preventing pain crises and organ failure.
Researchers have identified key molecules on the surface of blood cells that guide them to their rightful targets in the body's tissues. This process, known as cell trafficking, is crucial for the proper function of the immune response and helps prevent cancerous cells from spreading.
Researchers at Penn State used atomic force microscopy to study the surface of glass and found that molecular-scale roughness is a key factor in bacterial adhesion. The study suggests that traditional theories on bacterial adhesion may need to be revised.
Certain long-chain alcohols can reverse ethanol's antiadhesive effects on nerve cells, suggesting potential medications to reduce the damaging effects of alcohol. The findings may lead to a better understanding and prevention of fetal alcohol syndrome and its related neurotoxic effects.
A recent study reveals a new parameter regulating cell attachment, which is influenced by the physical properties of the surrounding environment. The rigidity of the matrix affects cell adhesion dynamics, leading to the formation of different types of adhesions.
Researchers at the University of Chicago discovered how neighboring skin cells adhere to form sealed barriers, a critical function for maintaining body fluids and keeping germs out. The study found that calcium concentration plays a crucial role in this process, enabling the formation of adherence junctions and 'puncta' between cells.
Researchers at UT Southwestern Medical Center discovered that vitamin E can prevent the early stages of plaque formation by inhibiting the attachment of white blood cells to endothelial cells. Vitamin E's antioxidant properties help reduce the risk of atherosclerosis, or hardening of the arteries.