Articles tagged with Fibroblasts
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new radiotracer successfully detected 100% of primary tumors across multiple cancer types, outperforming the current standard. It also showed promise in detecting lymph node and distant metastases, offering a promising alternative for diagnosis and treatment.
Researchers used a biomimetic model to study wound healing in burn and laceration wounds. Fibroblasts were found to clear away damaged tissue before depositing new material, but this process was slower in burn wounds due to more tissue damage. Therapies that promote wound clearance could accelerate healing.
A Tohoku University study found that soft gingiva is more likely to cause inflammation, hindering the development of collagen fibers. This discovery has implications for the development of advanced biomaterials and microdevices to control local inflammation.
Researchers at Indiana University School of Medicine have identified a new type of cell called the vasculogenic fibroblast, which can help create new blood vessels for treatment. This discovery could lead to improved treatments for ischemic diseases such as diabetic wounds.
Researchers at MUSC Hollings Cancer Center discovered the cellular origin of normal pancreatic fibroblasts and cancer-associated fibroblasts, which play a key role in tumor progression. The findings suggest that targeting cancer-associated fibroblasts holds exciting potential for therapeutic benefits.
Researchers found that regorafenib, a dual PDGFR α/β inhibitor, modifies the cancer microenvironment and enhances the efficacy of anti-PD-1 immunotherapy in advanced gastric cancers. This combination therapy boosts tumor infiltrating immune cells and reduces tumor fibroblasts.
Researchers at the University of Colorado School of Medicine have discovered a new mechanism for slowing scarring of heart tissue, a process known as cardiac fibrosis. The study's findings suggest that inhibiting the degradation of eicosanoids may be a promising approach to preventing or reversing cardiac fibrosis.
Researchers developed a customizable, strontium-loaded scaffold that promotes wound healing by stimulating gingival fibroblast activity. The scaffold increased cellular activity of isolated cells while showing minimal toxicity over four days.
Researchers found that glutaminase inhibitor BPTES selectively eliminates senescent dermal fibroblasts, improving skin aging phenotype by increasing collagen density and cell proliferation. The study suggests BPTES as a potential therapeutic agent for skin aging, offering new treatment options.
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
Researchers at the University of Alabama at Birmingham have identified TBX20 as a vital regulator of direct human cardiac reprogramming. Adding TBX20 to existing cocktails improves contractility and mitochondrial function in reprogrammed heart muscle cells, suggesting a therapeutic potential for TBX20.
A new therapy has been discovered to overcome treatment resistance in aggressive breast cancer by targeting fibroblasts and enhancing the immune response. The therapy, FAP-IL2v, binds to fibroblast-expressed molecules, allowing the immune system to break through the tumor's protective microenvironment and eliminate cancer cells.
Researchers at UNC School of Medicine have discovered a new method for reprogramming scar tissue cells into healthy heart muscle cells, using the protein Ascl1 and its partner Mef2c. This breakthrough could lead to new treatments for heart failure and other cardiovascular diseases.
A Phase I/II study found tofacitinib effective in improving skin and organ issues in systemic sclerosis patients. The drug was well-tolerated, with minimal impact on T-cells, suggesting potential repurposing for treatment.
Researchers at the University of Zurich have developed a new immunotherapy strategy to eliminate fibroblasts in targeted manner, reducing lung and liver fibrosis in mice. The treatment triggers an immune response via cytotoxic T-cells, eliminating activated connective tissue cells while leaving resting cells undamaged.
Researchers at Moffitt Cancer Center have discovered that cancer-associated fibroblasts can both promote and inhibit drug sensitivity in non-small cell lung cancer cells, depending on the type of tumor cell and drug used. The study suggests that targeting specific signaling pathways, such as the insulin-like growth factor (IGF) pathway...
Researchers discovered distinct genetic mutations in heart failure patients, identifying potential targets for personalized treatment and improving patient care. The study's findings hold enormous potential for rethinking how to treat heart failure by understanding its root causes and the mutations that lead to changes in heart function.
A study published in Nature Physics reveals that specialized cell movement may explain the progression of cancer and cystic fibrosis. Cells with ruffled edges sense viscosity and adapt to increase their speed, moving faster through mucus than blood. This discovery sheds light on disease mechanisms and potential treatments.
Researchers discovered cancer cells produce a unique collagen that alters the tumor microbiome and promotes cancer progression. Loss of this collagen reduces cancer cell proliferation and boosts anti-tumor immune response, offering a potential therapeutic strategy.
Researchers identified DNA damage-inducible transcript 4 (DDIT4) as a critical factor regulated by histone deacetylase 4 (HDAC4) in skin aging. Overexpression of HDAC4 rescued cells from senescence, while DDIT4 overexpression reversed changes associated with aging.
A new PET imaging agent, <sup>68</sup> Ga-FAPI-46, has been shown to predict the severity of cardiac remodeling after a heart attack by identifying active fibrosis. This biomarker has potential to aid in diagnosis and treatment selection for patients with heart failure.
New research reveals that age-induced changes in lung fibroblasts reactivate dormant melanoma cells, promoting growth and metastasis. The study found that WNT5A signaling pathway regulates tumor cell dormancy and metastasis initiation, with increased sFRP1 secretion facilitating reactivation in the aged lung.
Researchers found that severe asthma patients produce growth factors that block corticosteroids from working, leading to frequent breathing problems. This discovery may lead to new treatments targeting these growth factors to improve outcomes for patients with severe asthma.
Scientists have discovered a small molecule that bypasses ADAR1 suppression and directly activates tumor cell death by ZBP1, inducing highly immunogenic cell death and destroying fibroblasts supporting tumor growth. This approach has the potential to improve the effectiveness of immunotherapy in treating therapy-resistant tumors.
Researchers at Weill Cornell Medicine found that tumors recruit nearby cells called fibroblasts to work as their enablers by releasing lactate. This finding suggests that future drug treatments could target this defense mechanism to help cancer patients.
A study published in JCI Insight reveals that epigenetic drugs targeting BRD4 significantly reduce scarring in patients with scleroderma. The findings could lead to repurposing these drugs for faster relief from debilitating symptoms of this chronic disease.
Researchers at EPFL's School of Life Sciences have identified a critical link between cellular lipids and the determination of cell fate. They found that changes in lipid composition can influence the behavior of cells in response to external stimuli, even if the original cell type is identical.
Researchers developed new method to visualize CNS fibroblasts and their intercellular interactions in the CNS. The technique provides a detailed picture of CNS fibroblasts, including their location, size, morphology, and gene/protein expression patterns.
Researchers have discovered two distinct classes of cancer-associated fibroblasts that accumulate in the pancreatic tumor microenvironment and play opposing roles. The study suggests that targeting these unique cell populations may improve treatment outcomes for pancreatic cancer patients.
Researchers at RCSI University of Medicine and Health Sciences have discovered that platelets can form a provisional fibronectin matrix, similar to fibroblasts, which has potential implications for maintaining blood clot integrity during vascular repair. This finding challenges existing paradigms in wound healing.
Researchers at UC San Diego have made a groundbreaking discovery about the role of fibroblasts, or fat cells, in controlling bacteria and developing acne. These findings could lead to more targeted treatment options for acne, which affects up to 50 million Americans each year.
Researchers from the University of Pennsylvania and Oak Ridge National Laboratory have identified a cascade of inflammatory signaling that precedes skin ulcers in atopic dermatitis. A mouse model lacking an activator of NF-kB signaling led to the development of skin lesions, shedding light on the early stages of the condition.
Researchers at Brown University have developed a new laboratory test model to investigate fibrosis treatments without the use of animals. The model uses human cells and replicates not only the structure of human tissue but also its mechanics, enabling scientists to study the underlying mechanisms of fibrosis and test potential treatments.
Researchers have identified a molecular mechanism underlying liver cirrhosis, a deadly disease poorly understood. The discovery, made using genetically modified mice, reveals that the lack of MCRS1 protein leads to bile acid accumulation and fibrosis, opening new avenues for treatment.
Researchers have developed a 3D cell culturing platform that allows study of lung fibroblasts and their microenvironment, enabling measurement of cell behaviors and microenvironment changes involved in IPF disease progression. The system's versatility enables personalized medicine and potential applications in studying other diseases.
Scientists discovered an important protective response in the heart that can prevent excessive scarring after a heart attack. The study found that this reactive response can limit cardiac fibrosis by preventing oxidant build-up in heart cells, potentially leading to new therapies to repair scarring damage.
A new study identifies three functional subtypes of cancer-associated fibroblasts (CAF) in lung cancer, which correspond to patients' treatment responses. These subtypes have distinct biological functions and therapeutic implications, suggesting that CAFs could serve as a key to enhancing personalized treatment for lung cancer patients.
The MUSC Hollings Cancer Center researchers are exploring the role of macroenvironment in pancreatic cancer-induced cachexia to address this debilitating condition. The team aims to provide new biological insight, which will be coordinated by four cores within the program project grant.
A recent study published at Masonic Medical Research Institute found that electrocution-induced physiological stress can lead to overlapping cardiac conditions in individuals. The research used human induced pluripotent stem cells to investigate the mechanisms behind these conditions, shedding light on potential new treatments.
The study found that the Wntless (Wls) gene plays a critical role in heart regeneration in mice by facilitating signal molecule secretion from cardiomyocytes to cardiac fibroblasts. This promotes heart functional recovery by suppressing CF activation and reducing scar formation.
This study characterizes the aging-associated miRNA profile in murine cardiac fibroblasts, revealing a significant decrease in miRNAs generated by the Meg3-Mirg locus. The findings suggest that this repression is a common feature of aging across multiple organs, highlighting the robustness of miRNA modulation during this process.
Researchers discovered that skin fibroblasts from FTD patients exhibit pathological RNA foci, p62 protein-containing vesicles, and defective energy metabolism, which could lead to the development of novel biomarkers and treatments. These findings may also be useful in testing drug effects on FTD patients.
Researchers reprogrammed whale cells into neuronal cells to investigate the neurotoxic effects of an environmental pollutant. The study found that exposure to the pollutant led to apoptosis and disrupted cellular signaling pathways, ultimately causing neurodegeneration.
Researchers found that alphaCT1 molecule improves scar appearance by influencing fibroblast behavior, causing them to stretch and change direction. This can lead to more pliable tissue, reducing scarring in surgical procedures. The findings have potential to revolutionize plastic surgery and advance wound healing treatments.
A subset of fibroblasts in lungs of people with idiopathic pulmonary fibrosis (IPF) produce a protein called meflin, which protects against cell aging and fibrosis. Further research could lead to novel therapies for lung fibrosis.
Researchers at Gladstone Institutes have discovered a master switch for fibrosis in the heart, which they believe could be used to treat and prevent heart failure. The study suggests that blocking this gene, MEOX1, could prevent fibrosis in other organs as well.
Researchers developed a new PET/CT radiotracer that targets activated fibroblasts in lungs, enabling direct imaging of pulmonary fibrosis. The study showed promising results, suggesting the radiotracer's potential to reduce lung biopsies and improve disease management.
Researchers from the University of Tsukuba have demonstrated the direct conversion of scar tissue cells to heart muscle cells in mice after a heart attack. This breakthrough finding suggests that fibroblasts can be directly reprogrammed into cardiomyocytes, potentially preventing heart failure and death.
A new study has identified interleukin 11 as a key player in the development of colorectal cancer. IL-11-producing cells, known as cancer-associated fibroblasts, were found to promote tumor growth and support the disease microenvironment.
Researchers have identified a connection between perivascular fibroblast cells and ALS disease onset, suggesting a correlation between elevated protein marker SPP1 levels and aggressive disease process. This discovery has potential implications for earlier diagnoses and future treatments.
Researchers at Nagoya University have discovered two types of fibroblasts, meflin and gremlin 1, that play a crucial role in regulating colorectal cancer progression. Altering the balance between these cells could be an effective strategy for preventing cancer progression.
Researchers observed fibroblasts circling the edge of the wound for about 50 hours, when cells began to close the void. Fibroblasts were found to be the primary drivers of wound closure, with endothelial cells playing a supporting role.
Researchers found that certain chemotherapeutic agents can promote tissue overgrowth in normal tissues, while an innate immune signaling pathway in fibroblasts causes stem cells to proliferate. This discovery has broad implications for diseases associated with the immune system, including psoriasis and cancer.
A study published in Circulation journal reveals that a specific population of cardiac fibroblasts, called Reparative Cardiac Fibroblasts (RCF), play a crucial role in repairing damaged heart tissue after a myocardial infarction. The RCF cells produce a protein called CTHRC1, which is essential for the healing process.
A study by Cima and Clinica Universidad de Navarra has identified reparative cardiac fibroblasts that play a crucial role in repairing the heart after an infarction. These cells are activated when a patient suffers a heart attack, producing a collagen scar to prevent rupture of the ventricular wall.
Researchers at UT Health San Antonio discovered that childhood chemotherapy changes the function of cells that repair heart injury, leading to increased risk of heart failure in survivors. The study found that damage to these cells may contribute to late effects seen in childhood cancer survivors when they become adults.
Researchers found that fibroblast growth factor 1 repairs damaged perineuronal nets in the brain, a critical response required for sustained diabetes remission. The discovery sheds light on the intricate biology of the brain's response to the protein and may lead to more effective diabetes treatments.
Cardiac fibroblasts can be directly reprogrammed to form beating heart muscle cells on soft surfaces that match the elasticity of native myocardium. This approach shows increased functional maturation and spontaneously beating iCMs, with implications for treating heart failure and myocardial infarction.
Researchers isolated fibroblast cells from a stranded finless porpoise to predict the threat of environmental pollutants to its population. The study found that pollutants like PCBs and DDTs induce cell death and can cause cytotoxicity, apoptosis, and reduced cell viability.
Researchers at Terasaki Institute for Biomedical Innovation have identified collagen V as a key factor regulating cardiac scar tissue size after a heart attack. The study found that fibroblasts without collagen V produce larger, more irregularly-structured scars, leading to reduced shrinkage and increased risk of complications.