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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Green algae move to the beat

Max Planck researchers demonstrate how the green alga Chlamydomonas synchronizes its two flagella using a resourceful rocking movement. The resulting mechanism is based solely on the coupling of the two movements, with no special sensors or chemical signals required.

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Buckling up to turn

Researchers at MIT used high-speed video to record individual marine bacteria and found that a small flexible rod called the hook bucks during forward swims, causing the cell to tumble and reorient. This unusual mechanism helps bacteria navigate toward food in nutrient-sparse ocean waters.

Clinging to crevices, E. coli thrive

Researchers found that E. coli flagella can act as biological grappling hooks, reaching deep into nanoscale crevices and latching the bacteria in place. This ability to stick to any surface at all allows bacteria to survive on medical implants.

Sperm length variation is not a good sign for fertility

A new study by Brown University researchers found that men with more consistently made sperm have better swimming abilities. The research suggests that variability in sperm length may be a sign of trouble with the production process, potentially affecting fertility.

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The ins and outs of building the sperm tail

Researchers from Instituto Gulbenkian de Ciência describe the steps involved in making a motile flagellum in fruit fly sperm cells. The process involves the formation of a critical protein structure called the central microtubule pair, essential for coordinated movement.

Potential chink in armor of African sleeping sickness parasite: It's social

Researchers discovered that Trypanosoma brucei parasites can sense their environment, exchange messages, and coordinate movements when seeded onto a surface. This social behavior opens up new avenues for understanding other supposedly solitary parasites like those responsible for malaria and epidemic diarrhea.

BBS proteins shown to run an export business that protects cilia

Researchers found that BBS proteins remove excess signaling molecules to prevent damage to cilia, suggesting a new mechanism for the protein complex's function. The study suggests that BBS patients may experience cilia dysfunction due to the buildup of disruptive proteins.

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Team finds a better way to watch bacteria swim

Scientists have created a new approach to studying bacterial swimming, using optical traps, microfluidic chambers and fluorescence to track Escherichia coli movement. The method allows researchers to trap bacteria and modify their environment without hindering movement, providing insights into the mechanics of bacterial swimming.

Synchronized swimming of algae

Researchers found individual algal cells can regulate flagellar beating in synchrony to control swimming trajectories, exhibiting two distinct modes: synchronous and unsynchronised. This study reveals hydrodynamic interactions as the driving force behind synchronization.

Microscopic 'clutch' puts flagellum in neutral

Researchers at Indiana University and Harvard University have discovered a protein called EpsE that acts like a clutch to temporarily stop the rotation of a bacterium's flagellum. The discovery sheds light on how bacteria balance movement and biofilm formation, which can be crucial in combating bacterial infections.

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Yale Cell Biologist Joel Rosenbaum, to receive Prestigious Wilson Award

Joel Rosenbaum's research has made significant advances in understanding the assembly, maintenance and function of cilia and flagella, leading to a deeper understanding of polycystic kidney disease (PKD). His work has also revealed the importance of primary non-motile cilia in signaling pathways.

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Algae's protein 'tails' create motion – and aid munching

Researchers found that flagella in algae allow for active nutrient gathering, concentrating nutrients just ahead of the moving colony. This discovery explains how single-celled life forms can evolve into larger multicellular organisms like Volvox, a colony of up to 50,000 cells.

The beginning of the end of flagella

The discovery of protein EB1 at the tip of Chlamydomonas flagella sheds new light on intraflagellar transport (IFT) and its regulation. IFT is crucial for flagellar growth and maintenance, and EB1 may play a key role in controlling the molecular transport system responsible for IFT.

UMass microbiology team probes bacterium's surprising survival tactics

The UMass microbiology team found that Geobacter metallireducens has a built-in sensor to locate metals and can grow flagella to swim towards them. The bacteria use these strategies to survive in natural environments, and their genome revealed genes for flagella growth, allowing them to transform metal into an insoluble form.

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