Articles tagged with Focal Adhesions
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a composite bioabsorbable hemostatic sponge inspired by mussels and extracellular matrix. The sponge quickly absorbs blood and firmly adheres to tissues, enhancing hemostatic performance. It promotes wound stabilization, accelerates blood clotting, and reduces inflammation and tissue damage.
A newly discovered mechanism has identified a key protein, AP2A1, that toggles between 'young' and 'old' cell states. By suppressing AP2A1 in older cells, researchers were able to reverse senescence and promote cellular rejuvenation. This breakthrough may lead to new treatment targets for diseases associated with old age.
Scientists discover a dynamic paxillin-integrin interaction that enables flexible yet stable cell cohesion. This finding may lead to the development of new medical agents targeting cellular adhesion points.
S100A11 plays a specific role in the initiation of focal adhesion site disassembly, rather than the disassembly process itself. The protein is recruited to adhesion sites through a force-dependent mechanism involving non-muscle myosin II-driven stress fiber contraction and intracellular Ca2+ influx.
Researchers at Tokyo Medical and Dental University identify a novel focal adhesion remodeling process that strengthens cell-matrix adhesion in response to genotoxic stress. This mechanism involves the replacement of FAK with FRNK, leading to increased firm cell attachment.
Research led by Daniel Lietha has uncovered the structural basis of Focal Adhesion Kinase (FAK) activation on lipid membranes. FAK is activated when localized to the cell membrane, where it interacts with specific phosphoinositide lipids, leading to autophosphorylation and activation.
A team of researchers has systematically characterized 145 regulatory proteins that control the cytoskeleton's dynamic remodeling process. This comprehensive database reveals a new perspective on how these proteins work together to coordinate processes such as cell division, differentiation, embryonic development, and wound healing.
Researchers at the University of Turku have used super-resolution microscopy to study focal adhesions in human pluripotent stem cells. The study reveals novel features in the ultrastructure of these adhesions, which may be important for maintaining pluripotency. Abrogation of focal adhesion structure leads to a speeded-up exit from the...
Researchers developed a novel microscopy technique to analyze cellular focal adhesions, providing real-time information on dynamic processes. This breakthrough enables better understanding of cell proliferation, differentiation, and migration, which can aid cancer treatment and tissue engineering applications.
Cells form early adhesions from integrin clusters, a consistent size of 100 nanometres, even on soft or hard surfaces. These modular units enable cells to sense and migrate on surfaces with different rigidity, a hallmark of metastasis.
FAK coordinates movement of migrating cancer cells by balancing the number of invadopodia that create a path for migration and the number of focal adhesions that hold the cell back. In its absence, breast cancer cells sprout extra invadopodia and form large, sticky focal adhesions.
Scientists have observed paxillin moving from cell surface hubs to the nucleus, highlighting its role in signaling and controlled cell growth. This discovery sheds light on paxillin's interactions with other proteins and its potential involvement in diseases such as cancer.