Articles tagged with Hair Cells
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New findings suggest that the tectorial membrane in the inner ear varies in rigidity along its length, allowing it to respond to different sound frequencies. This variation enables the distinction of sounds at various frequencies, potentially leading to improved hearing aid design.
Researchers at Stanford University School of Medicine are exploring stem cell transplants as a potential treatment for hearing loss. The goal is to develop a cure for deafness, with a focus on drug therapy and stem cell transplantation into the inner ear.
Researchers found that otoferlin is essential for a late step of neurotransmitter release and may act as the major calcium sensor triggering membrane fusion at the inner hair cell ribbon synapse. The study suggests cochlear implants could benefit individuals with otoferlin-linked deafness.
Researchers identified three proteins that determine an individual's hair pattern during embryonic development. They also found that hyperactivating one of these proteins in mice led to abnormal fur growth, providing insights into male-pattern baldness and ectodermal dysplasia.
Scientists at the University of Pennsylvania School of Medicine have isolated a novel population of multipotent adult stem cells from human hair follicles. These cells can differentiate into nerve cells, smooth muscle cells, and melanocytes, offering potential treatments for various disorders.
Researchers have identified protocadherin-15 as a likely player in the moment-of-truth reaction in which sound is converted into electrical signals. The findings may help understand why some people temporarily lose their hearing after being exposed to loud noise, only to regain it a day or two later.
Scientists have made significant progress in understanding how to regenerate hair cells in the inner ear, a major breakthrough in the quest for new treatments for acquired hearing loss. The study found that blocking the Rb protein can promote hair cell regeneration, with specific areas of the inner ear exhibiting different responses.
Researchers at the University of Michigan have developed a novel method to weaken Gram-negative bacteria, including E. coli, making them susceptible to existing antibiotics. The approach, which involves genetic modification, has shown promising results in reducing antibiotic doses needed to kill the bacteria.
Researchers at EPFL discover that stem cells within hair follicles can develop into various cell types needed for hair growth and follicle replacement. This breakthrough has significant implications for regenerative medicine and could potentially be used to regenerate hair on patients with severe burns.
Researchers at Emory University Health Sciences Center discovered the PCP pathway's role in shaping cochlea and hair cells. The study reveals that mutations in this pathway impact hearing and offers new insights into developing hearing restoration therapies.
Tributyltin oxide (TBT) affects the mechanical activity of outer hair cells, which boost incoming sound energy to inner hair cells. The study found rapid and profound effects of TBT on outer hair cell membrane chloride ion exchange.
Hair cell regeneration is a promising approach to treating hearing loss and related neurodegenerative disorders. Researchers have discovered that specific genes, including Rb, play a crucial role in halting the cell cycle, allowing for hair cell regeneration.
Scientists have discovered a gene that acts as a 'brake' on hair-cell regeneration in the inner ear. By deleting this gene, hair cells can proliferate and potentially regenerate, providing new hope for treating age-related hearing loss. This breakthrough opens up new avenues for research and potential clinical applications.
Researchers have discovered that glial cells play a previously unidentified role in regulating the development of sensory hair cell precursors in zebrafish. This finding increases understanding of nerve cell development and may lead to potential regenerative therapies for human hearing disorders.
Researchers at Howard Hughes Medical Institute find that TRPA1, a protein known for its role in sensory transduction, also forms a spring-like structure in hair cells, amplifying auditory signals. The discovery sheds light on the mechanism of hearing and could lead to new treatments for hearing loss.
Researchers at Harvard Medical School have identified TRPA1 as the hair-cell transduction channel, which converts sound vibrations into nerve signals. The discovery has significant implications for understanding normal hearing and inherited forms of deafness, potentially leading to new treatments.
Researchers at Rockefeller University have successfully isolated a single mouse skin cell that can differentiate into various epidermal tissues, including hair and sebaceous glands. The study's findings hold promise for potential future applications in treating human skin and hair conditions.
Researchers have identified stem cells in skin that can self-renew and differentiate into multiple cell types, offering new insights into regenerative medicine. The discovery holds promise for treating hair loss and wound healing.
Stanford researchers discovered a type of molecular motor that provides the proper amount of tension in inner ear sensors to respond to sound. The motor anchors itself and maintains tension, implying its role in cellular organization, such as chromosome separation during cell division.
Researchers discovered that sensory cells in mouse inner ear develop rapidly between days 16 and 17 of gestation, mirroring human fetal development. Understanding this process is crucial for regenerating sensory hair cells in the human ear.
Researchers discover genetic connection between hair and hair channels, finding that GATA-3 is crucial for hair channel development. Without this protein, mice grew short and stubby coats, highlighting the importance of the hair channel for proper hair growth.
Sensory hair cells convert mechanical energy into electrical signals through transduction channels. A new report identifies NompC as a vertebrate homologue of a previously known channel, required for mechanosensation in zebrafish and possibly other animals.
Scientists have successfully induced the growth of new sensory hair cells in adult guinea pigs using gene therapy. The Math1 gene was inserted into non-sensory epithelial cells lining the inner ear, leading to the formation of new hair cells and attracting the growth of new fibers from auditory neurons.
Scientists measured over 1,800 genes in sensory cells from the chicken inner ear, revealing significant differences between the cochlea and utricle. The study provides new insights into the causes of aging-related hearing loss and may lead to therapy that replaces lost sensory hair cells.
A newly discovered protein called desmoglein 4 (DSG4) holds cells together as they change into different types of hair follicle cells. The gene's absence leads to thin, sparse hair that breaks easily in people and mice, highlighting its potential role in treating excessive or absent hair growth.
A team of researchers found that the absence of a specific gene, Ink4d, causes progressive hearing loss in mice by triggering the death of sensory hair cells. This finding suggests that humans with similar genetic mutations may be more susceptible to hearing loss due to trauma.
A new gene, Otopetrin 1, has been identified as contributing to the loss of balance. The gene helps regulate otoconia, which detect gravity and maintain balance. Mutations in this gene can lead to balance disorders, but understanding its development may help stimulate otoconia regeneration.
Researchers at Johns Hopkins Medicine have made a breakthrough discovery in understanding how we hear, revealing that tiny 'hair cells' release a barrage of chemical packets to an adjacent nerve when sound is detected. This finding could improve the design and programming of hearing aids and cochlear implants.
Researchers at the University of Buffalo have discovered that cells 'wiggle' at high speeds when exposed to voltage changes, without relying on special proteins or lipids. This fundamental property of cells opens up new avenues for studying cell motility and its potential applications in medicine.
Scientists have made significant progress in understanding how birds regenerate their hair cells, a process that could lead to new treatments for human deafness. By studying the sequence of events involved in this process, researchers hope to develop strategies to prevent or reverse certain forms of hearing loss.
A specific gene, espin, is linked to deafness and abnormal behaviors in jerker mice. The mutated gene affects hair cell function, leading to false signals sent to the brain, which causes animals to move erratically.
Researchers at Northwestern University have successfully cloned a gene called Prestin, which codes for a protein that plays a critical role in the functioning of outer hair cells. The discovery could hold promise for treating hearing disorders and developing new biocompatible motors for nanotechnology applications.
University of Michigan scientists have found that salicylate can prevent deafness in guinea pigs exposed to aminoglycoside antibiotics. The study suggests that moderate doses of aspirin could be effective in preventing hearing loss and damage caused by these antibiotics.
Scientists have discovered the gene responsible for triggering embryonic cells in the inner ear to develop into sound- and motion-sensing hair cells. The Math1 gene signals precursor cells in the inner ear to become hair cells, which cover inner ear surfaces like wheat in a Kansas field.
Researchers discovered that mammalian support cells can proliferate when an enzyme inhibitor is absent, paving the way for potential hair-cell regeneration. This breakthrough offers hope for restoring hearing in humans and other mammals who suffer from noise-induced hearing loss.
The Notch signaling pathway is a key regulator controlling the proper development of many different cell types. In mice without Jagged2, there is a significant increase in hair cell density and a decrease in supporting cells.
Scientists have identified eight genes necessary for vertebrate sensory hair cell function in a study of zebrafish mutants with balance problems. These genes are specifically involved in the production of extracellular potential generation, a key measure of hair cell function.