Keratinocytes

Molecular thermometers on skin cells detect heat and camphor

Researchers at Scripps Research Institute have discovered TRPV3, a protein that detects warm temperatures through skin cells, not sensory neurons. The receptor is activated by both thermal heat and the compound camphor, leading to new insights into pain sensation and potential drug targets.

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Possible new cure for psoriasis

Researchers at the University of Bonn have found a new effective therapy for psoriasis by blocking the division of epidermis cells. The treatment, which uses metalloproteinase inhibitors, has shown no toxic side effects and may provide a promising solution for the condition.

'Warm to the touch' gene found

Researchers at Scripps Research Institute have identified the first temperature-sensing molecule found in keratinocytes, the major type of cell in the skin, which can detect warm and hot temperatures above 33°C. This discovery opens up new possibilities for pain therapeutics.

Molecular insight into wound healing

Researchers identify PPARbeta as a key gene regulator in the cellular response to inflammation and wound healing. The protein is crucial for keratinocyte differentiation and migration, enabling effective wound healing.